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Fixes #1933 Add urine compartment (#2049)
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* Work in DB. Add event and event group

* WIP #1933 add urine compartment emptying

* Remove reference to gall bladder immediate

* Remove Gallbladder emptying (immediate) event group not used anymiore

* Fixes #1933 add uring compartment emptying

* Add tests

* Fixes #1933 add urine compartment emptying

* Fixes failing test
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msevestre authored Jan 18, 2022
1 parent 7cabd68 commit 69f4c8e
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Showing 31 changed files with 322 additions and 5,222 deletions.
5,231 changes: 148 additions & 5,083 deletions src/Db/Diff/PKSimDB_diff.txt

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148 changes: 79 additions & 69 deletions src/Db/Dump/PKSimDB_dump.txt

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4 changes: 2 additions & 2 deletions src/PKSim.Assets.Images/PKSim.Assets.Images.csproj
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Expand Up @@ -26,8 +26,8 @@
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<ItemGroup>
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4 changes: 2 additions & 2 deletions src/PKSim.Assets/PKSim.Assets.csproj
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Expand Up @@ -26,8 +26,8 @@
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<ItemGroup>
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2 changes: 1 addition & 1 deletion src/PKSim.BatchTool/PKSim.BatchTool.csproj
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Expand Up @@ -63,7 +63,7 @@
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2 changes: 1 addition & 1 deletion src/PKSim.CLI.Core/PKSim.CLI.Core.csproj
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Expand Up @@ -28,7 +28,7 @@

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<PackageReference Include="OSPSuite.Utility" Version="4.0.0.4" />
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<ItemGroup>
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4 changes: 2 additions & 2 deletions src/PKSim.CLI/PKSim.CLI.csproj
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Expand Up @@ -61,8 +61,8 @@
<ItemGroup>
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5 changes: 0 additions & 5 deletions src/PKSim.Core/CoreConstants.cs
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Expand Up @@ -256,11 +256,6 @@ public static class Route
}
}

public static class EventGroup
{
public static readonly string EHCImmediate = "Gallbladder emptying (immediate)";
}

public static class Category
{
public static readonly string DynamicFormulas = "DynamicFormulas";
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2 changes: 1 addition & 1 deletion src/PKSim.Core/Model/UnknownDistributionFormula.cs
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Expand Up @@ -7,7 +7,7 @@ namespace PKSim.Core.Model
{
public class UnknownDistributionFormula : DistributionFormula
{
protected override double CalculateFor(IEnumerable<IObjectReference> usedObjects, IUsingFormula dependentObject)
protected override double CalculateFor(IReadOnlyList<IObjectReference> usedObjects, IUsingFormula dependentObject)
{
return double.NaN;
}
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8 changes: 4 additions & 4 deletions src/PKSim.Core/PKSim.Core.csproj
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Expand Up @@ -30,10 +30,10 @@
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7 changes: 1 addition & 6 deletions src/PKSim.Core/Repositories/IEventGroupRepository.cs
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Expand Up @@ -9,11 +9,6 @@ namespace PKSim.Core.Repositories
/// </summary>
public interface IEventGroupRepository : IStartableRepository<IEventGroupBuilder>
{
/// <summary>
/// Returns all event groups which can be created by user
/// <para></para>
/// (some event groups are e.g. only used for project conversion)
/// </summary>
IEnumerable<IEventGroupBuilder> AllForCreationByUser();

}
}
15 changes: 3 additions & 12 deletions src/PKSim.Infrastructure/ORM/Repositories/EventGroupRepository.cs
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@@ -1,7 +1,6 @@
using System.Collections.Generic;
using System.Linq;
using OSPSuite.Utility.Collections;
using OSPSuite.Core.Domain;
using OSPSuite.Core.Domain.Builder;
using PKSim.Core;
using PKSim.Core.Repositories;
Expand All @@ -15,7 +14,9 @@ public class EventGroupRepository : StartableRepository<IEventGroupBuilder>, IEv
private readonly IFlatContainerToEventGroupBuilderMapper _eventGroupMapper;
private readonly ICache<string, IEventGroupBuilder> _eventGroupBuilders;

public EventGroupRepository(IFlatContainerRepository flatContainerRepo, IFlatContainerToEventGroupBuilderMapper eventGroupMapper)
public EventGroupRepository(
IFlatContainerRepository flatContainerRepo,
IFlatContainerToEventGroupBuilderMapper eventGroupMapper)
{
_flatContainerRepo = flatContainerRepo;
_eventGroupMapper = eventGroupMapper;
Expand All @@ -39,15 +40,5 @@ protected override void DoStart()
_eventGroupBuilders.Add(eventGroupBuilder);
}
}

public IEnumerable<IEventGroupBuilder> AllForCreationByUser()
{
return All().Where(canBeCreatedByUser);
}

private bool canBeCreatedByUser(IEventGroupBuilder eventGroup)
{
return !eventGroup.IsNamed(CoreConstants.EventGroup.EHCImmediate);
}
}
}
16 changes: 8 additions & 8 deletions src/PKSim.Infrastructure/PKSim.Infrastructure.csproj
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Expand Up @@ -41,14 +41,14 @@
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</ItemGroup>

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Expand Up @@ -20,8 +20,8 @@ public SimpleProtocolReportBuilder(IReportGenerator reportGenerator)
protected override void FillUpReport(SimpleProtocol simpleProtocol, ReportPart reportPart)
{
reportPart.Title = PKSimConstants.UI.SimpleProtocolMode;
reportPart.AddToContent(simpleProtocol.ApplicationType.DisplayName);
reportPart.AddToContent(PKSimConstants.UI.ReportIs(PKSimConstants.UI.DosingInterval, simpleProtocol.DosingInterval.DisplayName));
reportPart.AddToContent(simpleProtocol.ApplicationType?.DisplayName);
reportPart.AddToContent(PKSimConstants.UI.ReportIs(PKSimConstants.UI.DosingInterval, simpleProtocol.DosingInterval?.DisplayName));

simpleProtocol.AllParameters().Where(simpleProtocol.ParameterShouldBeExported)
.Each(x => reportPart.AddToContent(_reportGenerator.ReportFor(x)));
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2 changes: 1 addition & 1 deletion src/PKSim.Matlab/PKSim.Matlab.csproj
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Expand Up @@ -27,7 +27,7 @@

<ItemGroup>
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</ItemGroup>

<ItemGroup>
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4 changes: 2 additions & 2 deletions src/PKSim.Presentation/DTO/Parameters/ParameterDTO.cs
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Expand Up @@ -78,9 +78,9 @@ public virtual double Value
{
get
{
var success = Parameter.TryGetValueInDisplayUnit(out var result);
var (result,_) = Parameter.TryGetValueInDisplayUnit();
//Permeability cannot be read in compound as references cannot be resolved
return success ? result : double.NaN;
return result;

}
set
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4 changes: 2 additions & 2 deletions src/PKSim.Presentation/PKSim.Presentation.csproj
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Expand Up @@ -29,8 +29,8 @@
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</ItemGroup>

<ItemGroup>
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Expand Up @@ -82,7 +82,7 @@ public override void ReleaseFrom(IEventPublisher eventPublisher)

public IEnumerable<IEventGroupBuilder> AllTemplates()
{
return _eventGroupRepository.AllForCreationByUser();
return _eventGroupRepository.All();
}

public string DisplayNameFor(IEventGroupBuilder eventTemplate)
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2 changes: 1 addition & 1 deletion src/PKSim.R/PKSim.R.csproj
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Expand Up @@ -50,7 +50,7 @@

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<PackageReference Include="OSPSuite.SimModelSolver_CVODES" Version="4.1.0.8" GeneratePathProperty="true" />
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6 changes: 3 additions & 3 deletions src/PKSim.UI/PKSim.UI.csproj
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Expand Up @@ -51,9 +51,9 @@
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<PackageReference Include="OSPSuite.Core" Version="11.0.40" />
</ItemGroup>

<ItemGroup>
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4 changes: 2 additions & 2 deletions src/PKSim/PKSim.csproj
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Expand Up @@ -76,13 +76,13 @@
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2 changes: 1 addition & 1 deletion tests/PKSim.Matlab.Tests/PKSim.Matlab.Tests.csproj
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Expand Up @@ -23,7 +23,7 @@
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2 changes: 1 addition & 1 deletion tests/PKSim.R.Tests/PKSim.R.Tests.csproj
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Expand Up @@ -23,7 +23,7 @@
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<PackageReference Include="OSPSuite.SimModelSolver_CVODES" Version="4.1.0.8" GeneratePathProperty="true" />
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4 changes: 4 additions & 0 deletions tests/PKSim.Tests/CoreConstantsForSpecs.cs
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Expand Up @@ -34,6 +34,10 @@ public static class Process
public static readonly string LIVERMICROSOMERES = "LiverMicrosomeRes";
}

public static class Events
{
public const string URINARY_BLADDER_EMPTYING = "Urinary bladder emptying";
}
public static class Parameters
{
public const string KINACT = "kinact";
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43 changes: 43 additions & 0 deletions tests/PKSim.Tests/IntegrationTests/SimulationsWithEventsSpecs.cs
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@@ -0,0 +1,43 @@
using FakeItEasy;
using OSPSuite.BDDHelper;
using OSPSuite.BDDHelper.Extensions;
using OSPSuite.Core.Domain;
using OSPSuite.Core.Domain.Builder;
using OSPSuite.Utility.Container;
using OSPSuite.Utility.Extensions;
using PKSim.Core.Model;
using PKSim.Core.Repositories;
using PKSim.Infrastructure;
using IContainer = OSPSuite.Core.Domain.IContainer;

namespace PKSim.IntegrationTests
{
public abstract class concern_for_SimulationsWithEvents : concern_for_IndividualSimulation
{

public override void GlobalContext()
{
base.GlobalContext();
var eventMappingFactory = IoC.Resolve<IEventMappingFactory>();
var eventFactory = IoC.Resolve<IEventFactory>();

_simulation = DomainFactoryForSpecs.CreateModelLessSimulationWith(_individual, _compound, _protocol).DowncastTo<IndividualSimulation>() ;
var pksimEvent = eventFactory.Create(CoreConstantsForSpecs.Events.URINARY_BLADDER_EMPTYING).WithName("Event");
var eventMapping = eventMappingFactory.Create(pksimEvent);
eventMapping.StartTime.ValueInDisplayUnit = 2;
_simulation.AddUsedBuildingBlock(new UsedBuildingBlock(pksimEvent.Id, PKSimBuildingBlockType.Event){BuildingBlock = pksimEvent});
_simulation.EventProperties.AddEventMapping(eventMapping);
}
}

public class When_creating_a_simulation_with_the_urine_emptying_event : concern_for_SimulationsWithEvents
{
[Observation]
public void should_be_able_to_create_a_simulation()
{
DomainFactoryForSpecs.AddModelToSimulation(_simulation);
var simEvent = _simulation.Model.Root.EntityAt<IContainer>(Constants.EVENTS, "Event");
simEvent.ShouldNotBeNull();
}
}
}
2 changes: 1 addition & 1 deletion tests/PKSim.Tests/PKSim.Tests.csproj
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Expand Up @@ -21,7 +21,7 @@
</PackageReference>
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<PackageReference Include="OSPSuite.SimModelSolver_CVODES" Version="4.1.0.8" GeneratePathProperty="true" />
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Expand Up @@ -88,7 +88,6 @@ protected override void Context()
_temp2 = new EventGroupBuilder();
_allTemplates = new List<IEventGroupBuilder> {_temp1, _temp2};
A.CallTo(() => _eventGroupRepository.All()).Returns(_allTemplates);
A.CallTo(() => _eventGroupRepository.AllForCreationByUser()).Returns(_allTemplates);
}

[Observation]
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6 changes: 2 additions & 4 deletions tests/PKSim.Tests/Presentation/ParameterDTOSpecs.cs
Original file line number Diff line number Diff line change
Expand Up @@ -141,10 +141,8 @@ protected override void Context()
base.Context();
_parameter.Value = 20;
_convertedValue = 30;
double res;
A.CallTo(() => _parameter.TryGetValueInDisplayUnit(out res))
.Returns(true)
.AssignsOutAndRefParameters(_convertedValue);
A.CallTo(() => _parameter.TryGetValueInDisplayUnit())
.Returns((_convertedValue, true));
}

[Observation]
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4 changes: 2 additions & 2 deletions tests/PKSim.UI.Starter/PKSim.UI.Starter.csproj
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Expand Up @@ -56,13 +56,13 @@
</ItemGroup>

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</ItemGroup>

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4 changes: 2 additions & 2 deletions tests/PKSim.UI.Tests/PKSim.UI.Tests.csproj
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Expand Up @@ -18,8 +18,8 @@
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</ItemGroup>

<ItemGroup>
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