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v1.3

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@ythuang0522 ythuang0522 released this 25 Aug 15:54
· 168 commits to main since this release

Major change

This version mainly improved the phasing accuracy, especially at low-coverage depth (10-20x). The underlying graph model now creates and considers multiple edges from local/flanking SNPs during phasing (see below), which increases the phasing accuracy and robustness at regions of dense ONT errors.
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As such the running time increases ~20% on average (2.5-8 minutes for 10-60x with 8 Cores on SSD). The block N50 becomes larger at 10-30x and slightly smaller at 50-60x when compared with previous version. The phasing accuracy (SW: switch error rate) improved at all coverage.
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Minor change

  1. The haplolag now writes the Phred-scaled phasing quality of each read in the tagged BAM (e.g., PQ:i:40), which was discussed at #19.

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  1. The program will prompt the user if missing the reference genome. #18