Covid-19 (SARS-CoV-2) coronavirus information // on May 18, 2020
MAPS
Maps show the global distrributions, infection rates, death rates per country our county/provence
- COVID19 Live Interactive Dashboard (https://datastudio.google.com/embed/reporting/f56febd8-5c42-4191-bcea-87a3396f4508/page/k1XIB) - Google Data Studio map probably the most sophisticated map around in early March 2020, created by a single citizen scientist (Goh Kok Han, hi@gohkokhan.com), shows the failure of public organizations across the world to activate data scientists on the spot to deal with emerging threats
- Johns Hopkins (https://coronavirus.jhu.edu/map.html) - one of the earlier interactive maps by a private US entity
- WHO Map (https://who.maps.arcgis.com/apps/opsdashboard/index.html#/c88e37cfc43b4ed3baf977d77e4a0667) - WHO map covering the novel coronavirus (COVID-19) situation
- IBM News Explorer (http://news-explorer.mybluemix.net/?query=COVID-19&type=person) - map collecting COVID-19 news sources.
- [NextStrain] - Genomic epidemiology map of the novel coronavirus
Coronavirus Surface surivival time
How long does the coronavirus survive on air, plastics, steel and other surfaces (up to 24 hours on cardboard to up to two or three days on plastic and stainless steel)
- Wired article (https://www.wired.com/story/how-long-does-the-coronavirus-last-on-surfaces/) - card board, plastics and steel [PDF]
Death rates
Death rates depend on age and country including rapid responses and health service services provided. Covid-19 (SARS-CoV-2) currently most severly affects those with an age of 50 and older
- COVID19 Live Interactive Dashboard (https://datastudio.google.com/embed/reporting/f56febd8-5c42-4191-bcea-87a3396f4508/page/k1XIB) - currently up to 9% (age dependent)
Detection and sequencing
There are several PCR based detection techniques available.
Treatments and drugs available
There are several drugs that are recommended by the CDC (US) that can be used for current and immediate treatment of specific viral infectionns, including SARS and COVID. They include remdesivir, lopinavir and ritonavir. Other drugs include antiretorvirals such as Ribavirin. However they do only work in specific cases and for specific strains.
- Sciencemag aritcle on UC Davis Medical Center (Sacramento) treatment by Dr. George Thompson treating a patient sucesfully with remdesivir intravenously administered (https://www.sciencemag.org/news/2020/03/did-experimental-drug-help-us-coronavirus-patient)
- CAS review article on key proteins, targets and drugs [Review] - Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases (March 12 2020)
- [GHHDI WIKI] - repository of compound libraries, drugs and treatments for COVID-19. GHDDI (The Global Health Drug Discovery Institute) was jointly founded by Tsinghua University, the Bill & Melinda Gates Foundation, and the Beijing Municipal Government.
Future drugs
There are a number of expermimental drugs and future drugs available such as DNA based medication including INO-4800 and RNA based drugs such as mRNA-1273. Companies include Medicago, Johnson & Johnson. CureVac as well as INOVIO Pharmaceuticals.
- Medicago (https://www.medicago.com/en/newsroom/)
- CureVac (https://www.curevac.com/)
WHO responses
Drugs, targets and future therapeutics
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This is an excellent ACS CAS review (Chemical Abstracts Service) from 16th March 2020 containing drugs that are currently used for treatment: remdesivir, lopinavir, ritonavir, baricitinib, ribavirin, chloroquine and others and protein targets such as 3CLpro, PLpro, RdRp, S protein, TMPRSS2, ACE2, AT2 as well as siRNAs Targeting Replicase and RNA Polymerases with associated sequences and references "Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases" https://pubs.acs.org/doi/10.1021/acscentsci.0c00272
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Review article that contains drugs prodrugs, host-based anti-CoV treatment options as well as nucleic acid synthesis inhibitors. (JAN 2020) "Recent discovery and development of inhibitors targeting coronaviruses" https://www.sciencedirect.com/science/article/pii/S1359644620300416
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WHO Landscape analysis of 30 therapeutics as of 17 February 2020, for SARS, COVID-19, MERS-CoV and others covering also clinical trials (Phase 1 and Phase 2) https://www.who.int/blueprint/priority-diseases/key-action/Table_of_therapeutics_Appendix_17022020.pdf (edited)
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Therapeutics, Ongoing vaccine development for 2019-nCoV and completed vaccine trial of SARS-CoV and MERS-CoV "Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review" https://www.mdpi.com/2077-0383/9/3/623/pdf