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I noticed a potential year-off-by-one date error in 32 recently submitted German sequences. Off-by-one year errors have been regularly observed in SARS-CoV-2 sequences from a range of labs, so it is not unexpected that this can also happen in mpox sequences.
The common ancestor of the 32 sequences has only 1 extra SNP compared to summer 2022 sequences. Yet all sequences are supposed to be collected more than 1 year later. With a clock rate of around 12 SNPs/year, this indicates a likely date entry error.
Other sequences from the same submitters dated to 2023 are in line with the clock and cluster with other 2023 sequences from other labs. This is notably not the case here: no other lab has submitted sequences from this putative 2023 lineage.
The text was updated successfully, but these errors were encountered:
Release data: 2023-11-03, 2023-11-05, 2024-01-15
Submitter: Brinkmann,A.,Kohl,C.,Schrick,L.,Michel,J.,Schaade,L.,Nitsche,A.
Submitting institution: Robert Koch Institut
Country: Germany
NCBI virus link: https://www.ncbi.nlm.nih.gov/labs/virus/vssi/#/virus?SeqType_s=Nucleotide&VirusLineage_ss=Monkeypox%20virus,%20taxid:10244&Authors_idx%20q.op%3DAND=viscardi&CreateDate_dt=2024-01-09T00:00:00.00Z%20TO%202024-01-20T23:59:59.00Z
Example Genbank: https://www.ncbi.nlm.nih.gov/nuccore/OR743494
Status: Submitter contacted (2024-01-21), submitter double checked and confirmed dates are correct (2024-01-22)
List of Genbank accessions
I noticed a potential year-off-by-one date error in 32 recently submitted German sequences. Off-by-one year errors have been regularly observed in SARS-CoV-2 sequences from a range of labs, so it is not unexpected that this can also happen in mpox sequences.
The common ancestor of the 32 sequences has only 1 extra SNP compared to summer 2022 sequences. Yet all sequences are supposed to be collected more than 1 year later. With a clock rate of around 12 SNPs/year, this indicates a likely date entry error.
Other sequences from the same submitters dated to 2023 are in line with the clock and cluster with other 2023 sequences from other labs. This is notably not the case here: no other lab has submitted sequences from this putative 2023 lineage.
The text was updated successfully, but these errors were encountered: