Add perturbation signature calculation from replicate control cells #695
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PR Checklist
docs
is updatedDescription of changes
As discussed, we would like to have an alternative to the standard Mixscape perturbation signature calculation. Instead of using the X nearest control cells as a reference, this approach considers all control cells within the same replicate. This change (and the corresponding test) is introduced in this PR. Specifically, I added the parameter
ref_selection_mode
to theperturbation_signature
method, allowing users to select which mode to use:nn
for the standard approach ormanual
for selection via the specified replicate method (I’m open to suggestions for better names!).