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[NTR] granzyme H-associated CD8 T cell #2875

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kennyworkman opened this issue Jan 6, 2025 · 0 comments · Fixed by #2895
Closed

[NTR] granzyme H-associated CD8 T cell #2875

kennyworkman opened this issue Jan 6, 2025 · 0 comments · Fixed by #2895

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@kennyworkman
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Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
granzyme H-associated CD8 T cell

Synonyms (add reference(s), please)
granzyme H+ CD8 T cell - exact synonym PMID: 35389781

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD8 T cell subpopulation characterized by high expression of Granzyme H (GZMH) that is significantly expanded in systemic lupus erythematosus (SLE) patients. These cells exhibit a restricted TCR repertoire and show elevated expression of cytotoxic, exhaustion, and type 1 interferon-stimulated gene signatures compared to controls. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients.
35389781

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
CD8-positive, alpha-beta memory T cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Blood - UBERON:0001969
(Note: paper analyzed PBMCs from SLE patients, so believe this is the correct categorization.)

Your ORCID
0000-0002-3958-7465

Additional notes or concerns
Not a practicing immunologist and defer to the opinions of the experts.
Also opted to leave "alpha-beta" out because it is implied, but curious what the maintainers think.

@Caroline-99 Caroline-99 self-assigned this Jan 10, 2025
@Caroline-99 Caroline-99 added this to the Milestone 20/01/2025 milestone Jan 10, 2025
Caroline-99 added a commit that referenced this issue Jan 10, 2025
Added a new term
@Caroline-99 Caroline-99 linked a pull request Jan 10, 2025 that will close this issue
Caroline-99 added a commit that referenced this issue Jan 13, 2025
* Fixes #2875 NTR-granzyme H-associated CD8 T cell

Added a new term

* Update cl-edit.owl
@github-project-automation github-project-automation bot moved this from To Do to Done in CL_wtgc_ticket_tracker Jan 13, 2025
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