CD19 high-throughput mutagenesis

Repository with the analysis of the paper:

High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance

by Cortés-López, Schulz, Enculescu et al.

Preprint: doi.org/10.1101/2021.10.08.463671

This repository:

List of analyses and links to corresponding folder:

• Orlando et al Isoform re-analysis
• DNA Demultiplexing
• Variant calling
• RNA Demultiplexing
• Cryptic isoforms
• MaxEnt analysis
• SpliceAI analysis
• DeepRipe analysis
• Other RBP analysis
• External variants collection

Most of the analyses require the CD19 exon 1-3 minigene annotation:

CD19 minigene