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@jsh58 jsh58 released this 14 Jan 15:55
· 21 commits to master since this release
  • The null statistical model was changed to the log-normal distribution. This was determined to be a more appropriate choice than other distributions (including the previously used exponential) from examining ChIP-seq control samples.

  • The minimum length (-l) is now a regular peak-calling parameter, not an alternative peak-calling method. The default value is 0bp. Those who prefer peak-calling by minimum length and not AUC can run -a 0 -l <int>.

  • Two convenience options were added:

    • -X: option to skip peak-calling, but perform all alignment parsing (including identifying PCR duplicates)
    • -P: option to call peaks directly from a bedgraph-ish log file (-f) produced by a previous Genrich run