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redux v1.1

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@hmftools-release-bot hmftools-release-bot released this 16 Feb 21:21
· 218 commits to master since this release

Changes from MarkDups:

Functional

  • write MSI jitter files for Sage
  • unmap secondaries and drop from BAM
  • drop supplementaries with alignment score < 30 (BWA default)

Technical:

  • optimised UMI collapsing, MSI jitter analysis and BAM writing
  • significantly lower memory usage
  • handle hard-clipped reads
  • use 'redux' in TSV output files

Bugs:

  • fixes a couple of minor & rare issues which could result in either dropped or duplicate reads
    -unmap read in unmap region if map becomes unmapped and vice versa

Config:

  • requires samtools instead of sambamba for final BAM concatenation