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charlesshale committed Jun 14, 2024
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Expand Up @@ -197,7 +197,7 @@ The chapter presents the following:

In case ORANGE was run in DNA+RNA mode, the alleles will be annotated by RNA fragment support.

- Genomic immune escape analysis (inspired by [this paper](https://www.biorxiv.org/content/10.1101/2022.02.23.481444v1.full.pdf)),
- Genomic immune escape analysis (inspired by [this paper](https://www.nature.com/articles/s41588-023-01367-1)),
with the following mechanism that ORANGE makes an attempt at detecting:
- HLA-1 loss-of-function, detected in case one of the following mutations is present in either HLA-A, HLA-B or HLA-C:
- MACN < 0.3 without the presence of a loss (proxy for LOH)
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