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Linx: renamed from sv-linx
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charlesshale committed Jun 21, 2021
1 parent 9c2d1e6 commit 942b508
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2 changes: 1 addition & 1 deletion README.md
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Expand Up @@ -9,7 +9,7 @@ More detailed descriptions of the following algorithms are available from the li
- [COBALT](./cobalt/README.md)
- [GRIPSS](./gripss/README.md)
- [PURPLE](./purple/README.md)
- [Linx](./sv-linx/README.md)
- [Linx](./linx/README.md)
- [Isofox](./isofox/README.md)
- [SERVE](./serve/README.md)
- [PROTECT](./protect/README.md)
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2 changes: 1 addition & 1 deletion isofox/README.md
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Expand Up @@ -195,7 +195,7 @@ The output file is approximately 120MB.
To annotate SVs with gene information and to support fusion detection, ISOFOX uses gene, transcript, exon and protein domain information from the Ensembl database.
To improve performance, this data is first extracted into 4 CSV data files and then loaded into memory each time ISOFOX runs.

These files can be downloaded from the Hartwig resources page, or generated using the Hartwig LINX application (see https://github.com/hartwigmedical/hmftools/blob/master/sv-linx/README.md for instructions).
These files can be downloaded from the Hartwig resources page, or generated using the Hartwig LINX application (see https://github.com/hartwigmedical/hmftools/blob/master/linx/README.md for instructions).

Note that the ensembl gene cache currently generates for standard autosomes and sex chromosomes only (alt contigs and MT chromosomes are excluded).

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8 changes: 4 additions & 4 deletions sv-linx/README.md → linx/README.md
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Expand Up @@ -100,7 +100,7 @@ log_debug | logs in debug mode
Single sample - Load SVs and purple data from file, upload Linx results to database:

```
java -jar sv-linx.jar
java -jar linx.jar
-sample SAMPLE_ID
-ref_genome_version 37
-sv_vcf /path_to_purple_vcf/
Expand All @@ -121,7 +121,7 @@ java -jar sv-linx.jar
Single sample - query SVs and purple data from database, upload Linx results to database:

```
java -jar sv-linx.jar
java -jar linx.jar
-sample SAMPLE_ID
-db_url [db_url] -db_user [username] -db_pass [password]
-output_dir /path_to_sample_data/
Expand All @@ -141,7 +141,7 @@ Cohort analysis - run all samples by sampleId in provided file, query SVs and pu
Write Linx results to cohort files, no upload to database:

```
java -jar sv-linx.jar
java -jar linx.jar
-sample cohort_sample_ids.csv
-db_url [db_url] -db_user [username] -db_pass [password]
-output_dir /path_to_sample_data/
Expand All @@ -162,7 +162,7 @@ To improve performance, this data is first extracted into 4 CSV data files and t
To generate these 4 data files, first run Linx with these command line options:

```
java -cp sv-linx.jar com.hartwig.hmftools.linx.gene.GenerateEnsemblDataCache
java -cp linx.jar com.hartwig.hmftools.linx.gene.GenerateEnsemblDataCache
-ensembl_db [see below] -ensembl_user "anonymous" -ensembl_pass ""
-output_dir /path_to_write_data_files/ -ref_genome_version [37 or 38]
```
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4 changes: 2 additions & 2 deletions sv-linx/pom.xml → linx/pom.xml
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Expand Up @@ -8,9 +8,9 @@
<version>local-SNAPSHOT</version>
</parent>

<artifactId>sv-linx</artifactId>
<artifactId>linx</artifactId>
<packaging>jar</packaging>
<version>${sv-linx.version}</version>
<version>${linx.version}</version>
<name>HMF Tools - Linx</name>

<dependencies>
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8 changes: 4 additions & 4 deletions pom.xml
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Expand Up @@ -23,7 +23,7 @@
<module>cobalt</module>
<module>purple</module>
<module>sage</module>
<module>sv-linx</module>
<module>linx</module>
<module>sv-tools</module>
<module>virus-interpreter</module>
<module>neo</module>
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<purple.version>3.1</purple.version>
<gripss.version>1.11</gripss.version>
<lilac.version>1.0</lilac.version>
<sv-linx.version>1.16</sv-linx.version>
<linx.version>1.16</linx.version>
<sv-tools.version>1.0</sv-tools.version>
<virus-interpreter.version>1.0</virus-interpreter.version>
<health-checker.version>3.2</health-checker.version>
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</dependency>
<dependency>
<groupId>com.hartwig</groupId>
<artifactId>sv-linx</artifactId>
<version>${sv-linx.version}</version>
<artifactId>linx</artifactId>
<version>${linx.version}</version>
</dependency>
<dependency>
<groupId>com.hartwig</groupId>
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4 changes: 2 additions & 2 deletions protect/README.md
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Expand Up @@ -35,12 +35,12 @@ gene inactivation is considered applicable in case of a deletion.

#### Homozygous disruptions

When a gene has been homozygously disrupted according to [LINX](../sv-linx/README.md), evidence is applicable when it has been defined
When a gene has been homozygously disrupted according to [LINX](../linx/README.md), evidence is applicable when it has been defined
on a gene level with event either inactivation, deletion or any mutation.

#### Fusions

For fusions that are deemed reportable according to [LINX](../sv-linx/README.md) the following matching is performed:
For fusions that are deemed reportable according to [LINX](../linx/README.md) the following matching is performed:
- Evidence defined on a promiscuous gene level is always considered applicable if a fusion with that gene is reported either in 5' or 3'
position.
- Evidence that is applicable on an exact fusion pair has to match with the actual fusion pair, and also has to match the (optional)
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2 changes: 1 addition & 1 deletion purple/DriverCatalog.md
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Expand Up @@ -2,7 +2,7 @@

If a gene panel is configured, PURPLE will compile a catalog of drivers including point mutations and copy number events. To include point mutations in the driver catalog, the somatic VCF must be annotated with SnpEff.

Running [LINX](https://github.com/hartwigmedical/hmftools/tree/master/sv-linx) enriches the PURPLE driver catalog with the addition of both homozygous disruption drivers and fusions
Running [LINX](https://github.com/hartwigmedical/hmftools/tree/master/linx) enriches the PURPLE driver catalog with the addition of both homozygous disruption drivers and fusions

## Gene Panel Configuration

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2 changes: 1 addition & 1 deletion sv-tools/pom.xml
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Expand Up @@ -24,7 +24,7 @@
</dependency>
<dependency>
<groupId>com.hartwig</groupId>
<artifactId>sv-linx</artifactId>
<artifactId>linx</artifactId>
</dependency>
<dependency>
<groupId>org.jooq</groupId>
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