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## **1. Introducing the BMC Series SDG Editorial Board Members**
<h2 style="text-align: justify; font-weight: bold;">1. Introducing the BMC Series SDG Editorial Board Members</h2>


**<span style="color: #00A3E0; font-weight: bold;">Role:</span>** Editorial Board Member of <em>BMC Infectious Diseases</em> Journal.

My work focuses on utilizing DNA sequencing technologies and computational tools for pathogen detection, characterization, and antimicrobial resistance surveillance, aligning with the WHO's Sustainable Development Goal 3.
<p style="text-align: justify;">
My work focuses on utilizing DNA sequencing technologies and computational tools for pathogen detection, characterization, and antimicrobial resistance surveillance, aligning with the WHO's Sustainable Development Goal 3.
</p>


**<span style="color: #00A3E0; font-weight: bold;">Blog Link:</span>** [Read Here](https://blogs.biomedcentral.com/bmcseriesblog/2022/01/14/introducing-the-bmc-series-sdg-editorial-board-members-gerald-mboowa/)

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## **2. Advancing Diagnostics for Non-Malarial Febrile Illnesses in HIV-Infected Children**
<h2 style="text-align: justify; font-weight: bold;">2. Advancing Diagnostics for Non-Malarial Febrile Illnesses in HIV-Infected Children</h2>


This study, funded under the EDCTP Career Development Fellow, enrolled 144 HIV-infected children presenting with NMFI at the Baylor Children’s Clinic in Uganda.
<p style="text-align: justify;">
This study, funded under the EDCTP Career Development Fellow, enrolled 144 HIV-infected children presenting with NMFI at the Baylor Children’s Clinic in Uganda.
</p>

**<span style="color: #00A3E0; font-weight: bold;">Newsletter Link:</span>** [Read Here](https://www.edctp.org/project/advancing-diagnostics-for-non-malarial-febrile-illnesses-in-hiv-infected-children/)

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## **3. Implementation of Next-Generation Sequencing-Based HIV Drug Resistance Testing**
<h2 style="text-align: justify; font-weight: bold;">3. Implementation of Next-Generation Sequencing-Based HIV Drug Resistance Testing</h2>


<p style="text-align: justify;">
<strong><span style="color: #00A3E0;">Focus:</span></strong> Enhancing Antiretroviral Treatment Monitoring and Public Health Outcomes
This blog discusses the integration of Next-Generation Sequencing (NGS) into HIV drug resistance testing, highlighting its superior sensitivity in detecting resistance mutations enabling timely adjustments to antiretroviral therapy.
</p>

**<span style="color: #00A3E0; font-weight: bold;">Focus:</span>** Enhancing Antiretroviral Treatment Monitoring and Public Health Outcomes
This blog discusses the integration of Next-Generation Sequencing (NGS) into HIV drug resistance testing, highlighting its superior sensitivity in detecting resistance mutations enabling timely adjustments to antiretroviral therapy.

**<span style="color: #00A3E0; font-weight: bold;">Blog Link:</span>** [Read Here](https://microbiologysociety.org/blog/implementation-of-next-generation-sequencing-based-hiv-drug-resistance-testing-enhancing-antiretroviral-treatment-monitoring-and-public-health-outcomes.html)

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## **4. WHO EPI-WIN: Pathogen Genomics in Health Emergencies – Spotlight Cholera**
<h2 style="text-align: justify; font-weight: bold;">4. WHO EPI-WIN: Pathogen Genomics in Health Emergencies – Spotlight Cholera</h2>


**<span style="color: #00A3E0; font-weight: bold;">Date:</span>** December 12, 2024
The WHO hosted a webinar on pathogen genomics for managing cholera outbreaks. Key topics included:
Expand All @@ -53,7 +65,8 @@ The WHO hosted a webinar on pathogen genomics for managing cholera outbreaks. Ke

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## **5. Africa Pathogen Data Management & Exchange Platform**
<h2 style="text-align: justify; font-weight: bold;">5. Africa Pathogen Data Management & Exchange Platform</h2>


**<span style="color: #00A3E0; font-weight: bold;">Event:</span>** PHA4GE Conference 2023
**<span style="color: #00A3E0; font-weight: bold;">Date:</span>** October 30 - November 1, 2023
Expand All @@ -67,67 +80,95 @@ The conference explored topics related to public health and genomics.

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## **6. What can we do better for the pandemics that may come?**
<h2 style="text-align: justify; font-weight: bold;">6. What can we do better for the pandemics that may come?</h2>


<p style="text-align: justify;">
The interview emphasizes the critical role of genomics in understanding and combating the COVID-19 pandemic. It highlights how genomic sequencing has enabled rapid identification of the SARS-CoV-2 virus, facilitating the development of diagnostic tests and vaccines. The piece also discusses the importance of global collaboration in genomic surveillance to monitor viral mutations and prepare for future pandemics.
</p>

The interview emphasizes the critical role of genomics in understanding and combating the COVID-19 pandemic. It highlights how genomic sequencing has enabled rapid identification of the SARS-CoV-2 virus, facilitating the development of diagnostic tests and vaccines. The piece also discusses the importance of global collaboration in genomic surveillance to monitor viral mutations and prepare for future pandemics.

**<span style="color: #00A3E0; font-weight: bold;">Q & A Link:</span>** [Watch Here](https://www.futurelearn.com/info/courses/genomics-covid-19/0/steps/289332)

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## **7. World Health Summit Africa Regional Meeting**
<h2 style="text-align: justify; font-weight: bold;">7. World Health Summit Africa Regional Meeting</h2>


<p style="text-align: justify;">
The presentation showcases the power of genomics in the fight against COVID-19 and discusses how genomic sequencing has been pivotal in identifying SARS-CoV-2 variants, understanding transmission patterns, and informing public health interventions. Experts highlight the importance of global collaboration and data sharing to monitor viral mutations and develop effective vaccines. The presentation underscores the need for continued investment in genomic surveillance to manage the current pandemic and prepare for future outbreaks.
</p>

The presentation show cases the power of genomics in the fight against COVID-19 and discusses how genomic sequencing has been pivotal in identifying SARS-CoV-2 variants, understanding transmission patterns, and informing public health interventions. Experts highlight the importance of global collaboration and data sharing to monitor viral mutations and develop effective vaccines. The presentation underscores the need for continued investment in genomic surveillance to manage the current pandemic and prepare for future outbreaks.

**<span style="color: #00A3E0; font-weight: bold;">Presentation Link:</span>** [Watch Here](https://www.youtube.com/watch?v=Fbm4FQKqIPs)

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## **8. Rising Antimicrobial Resistance in Uganda's National Referral Hospital Demands Immediate Action**
<h2 style="text-align: justify; font-weight: bold;">8. Rising Antimicrobial Resistance in Uganda's National Referral Hospital Demands Immediate Action</h2>


<p style="text-align: justify;">
A study conducted at Mulago National Referral Hospital in Uganda from 2014 to 2018 revealed a significant increase in antimicrobial resistance (AMR) among patients in surgical wards. Resistance levels to commonly used antibiotics, including penicillins, cephalosporins, and carbapenems, escalated dramatically during this period. The findings underscore the urgent need to enhance infection prevention and control practices, implement robust antibiotic stewardship programs, and strengthen laboratory capacities to provide timely culture and sensitivity testing.
</p>

A study conducted at Mulago National Referral Hospital in Uganda from 2014 to 2018 revealed a significant increase in antimicrobial resistance (AMR) among patients in surgical wards. Resistance levels to commonly used antibiotics, including penicillins, cephalosporins, and carbapenems, escalated dramatically during this period. The findings underscore the urgent need to enhance infection prevention and control practices, implement robust antibiotic stewardship programs, and strengthen laboratory capacities to provide timely culture and sensitivity testing.

**<span style="color: #00A3E0; font-weight: bold;">Dissemination of AMR Policy brief:</span>** [Watch Here](https://www.youtube.com/watch?v=LJGrV75hhgo&list=PL0AD2eggSrnYo5MO-f6-P_544e9Ly2wrS&index=3)

**<span style="color: #00A3E0; font-weight: bold;">Summary of AMR Policy brief:</span>** [Read Here](https://bit.ly/3u23Hu5)

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## **9. Laboratory capacity strengthening for genomic sequencing in LMICs**
<h2 style="text-align: justify; font-weight: bold;">9. Laboratory Capacity Strengthening for Genomic Sequencing in LMICs</h2>



<p style="text-align: justify;">
The Mérieux Foundation and the London School of Hygiene & Tropical Medicine (LSHTM) co-hosted a two-hour webinar on September 15, 2021, at 3 PM (CET), focusing on strengthening laboratory capacity for genomic sequencing in low- and middle-income countries (LMICs).
</p>

The Mérieux Foundation and the London School of Hygiene & Tropical Medicine (LSHTM) co-hosted a two-hour webinar on September 15, 2021, at 3 PM (CET), focusing on strengthening laboratory capacity for genomic sequencing in low- and middle-income countries (LMICs).

**<span style="color: #00A3E0; font-weight: bold;">Q & A Link:</span>** [Watch Here](https://www.youtube.com/watch?v=zB6P57yoeJQ)


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## **10. My Science Journey: How to Make Your Inroads in Science**
<h2 style="text-align: justify; font-weight: bold;">10. My Science Journey: How to Make Your Inroads in Science</h2>


<p style="text-align: justify;">
My science journey has been driven by curiosity, persistence, and a willingness to learn from both successes and failures. I have built a strong foundation by seeking mentorship, collaborating on research, and embracing new opportunities. By staying adaptable and continuously refining my skills, I strive to make meaningful contributions and establish myself in the scientific community.
</p>

My science journey has been driven by curiosity, persistence, and a willingness to learn from both successes and failures. I have built a strong foundation by seeking mentorship, collaborating on research, and embracing new opportunities. By staying adaptable and continuously refining my skills, I strive to make meaningful contributions and establish myself in the scientific community.

**<span style="color: #00A3E0; font-weight: bold;">Webinar Presentation:</span>** [Watch Here](https://www.youtube.com/watch?v=lUumnB5JS60)

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## **11. My PhD Defense Presentation**
<h2 style="text-align: justify; font-weight: bold;">11. My PhD Defense Presentation</h2>


**<span style="color: #00A3E0; font-weight: bold;">Research Topic:</span>**

Identifying host-genetic factors influencing the progression of HIV disease in Ugandan and Botswana pediatric populations.
**<span style="color: #00A3E0; font-weight: bold;">Funding:</span>** Collaborative African Genomics Network (CAfGEN) of Human Heredity & Health in Africa (H3Africa) and THRiVE consortium.
<p style="text-align: justify;">
Identifying host-genetic factors influencing the progression of HIV disease in Ugandan and Botswana pediatric populations.
<strong><span style="color: #00A3E0;">Funding:</span></strong> Collaborative African Genomics Network (CAfGEN) of Human Heredity & Health in Africa (H3Africa) and THRiVE consortium.
</p>


**<span style="color: #00A3E0; font-weight: bold;">PhD Defense:</span>** [Watch Here](https://www.youtube.com/watch?v=nAXN6JNu8Ng&t=2133s)

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## **12. Researcher studies how long it takes for HIV positive person to develop AIDS**
<h2 style="text-align: justify; font-weight: bold;">12. Researcher Studies How Long It Takes for an HIV-Positive Person to Develop AIDS</h2>



<p style="text-align: justify;">
The progression from HIV infection to AIDS varies among individuals and is influenced by several factors, including genetics. The research I conducted while at Makerere University categorized HIV-infected children into two distinct groups based on disease progression rates:
</p>

The progression from HIV infection to AIDS varies among individuals and is influenced by several factors, including genetics. The research I conducted while at Makerere University catergorised HIV-infected children into two distinct groups based on disease progression rates:

<pre>
🔹 **Rapid Progressors (RP):**
Expand All @@ -139,21 +180,32 @@ The progression from HIV infection to AIDS varies among individuals and is influ
post-infection without treatment.
</pre>

My study involved analyzing blood samples from 314 participants, comprising 173 rapid progressors and 141 non-progressors. By examining their genetic profiles, I aimed to identify genetic markers associated with the rate of disease progression. The findings suggested that certain genetic factors influenced an individual's susceptibility to rapid HIV-disease progression.
<p style="text-align: justify;">
My study involved analyzing blood samples from 314 participants, comprising 173 rapid progressors and 141 non-progressors. By examining their genetic profiles, I aimed to identify genetic markers associated with the rate of disease progression. The findings suggested that certain genetic factors influenced an individual's susceptibility to rapid HIV-disease progression.
</p>

Understanding these genetic factors can assist healthcare providers in prioritizing treatment for those most at risk of rapid progression, especially in settings where access to antiretroviral therapy (ART) is limited. While current guidelines recommend initiating ART for all individuals diagnosed with HIV, insights from such research could inform strategies to optimize treatment allocation and management.
<p style="text-align: justify;">
Understanding these genetic factors can assist healthcare providers in prioritizing treatment for those most at risk of rapid progression, especially in settings where access to antiretroviral therapy (ART) is limited. While current guidelines recommend initiating ART for all individuals diagnosed with HIV, insights from such research could inform strategies to optimize treatment allocation and management.
</p>

<p style="text-align: justify;">
Continued research in this area is crucial for developing personalized treatment approaches and improving outcomes for individuals living with HIV.
</p>

Continued research in this area is crucial for developing personalized treatment approaches and improving outcomes for individuals living with HIV.

**<span style="color: #00A3E0; font-weight: bold;">The Independent | News Paper:</span>** [Read Here](https://www.independent.co.ug/researcher-studies-how-long-it-takes-for-hiv-positive-person-to-develop-aids/)

**<span style="color: #00A3E0; font-weight: bold;">Genes can determine the years a person living with HIV will take to develop AIDS if not on treatment :</span>** [Watch Here](https://www.youtube.com/watch?v=xAmK9bsXLQg)

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## **13. Successes & failures of grant applications**
<h2 style="text-align: justify; font-weight: bold;">13. Successes & Failures of Grant Applications</h2>


<p style="text-align: justify;">
The presentation looks at successes and failures of grant writing, providing an in-depth analysis of the common pitfalls and effective strategies in the grant application process. It emphasizes the importance of aligning proposals with funding agency priorities, clearly articulating objectives, and demonstrating the potential impact of the proposed work. The guide also highlights the value of thorough preparation, understanding reviewer expectations, and the necessity of resilience in the face of rejection, encouraging applicants to view unsuccessful attempts as learning opportunities for future submissions.
</p>

The presentation looks at successes and failures of grant writing provides an in-depth analysis of the common pitfalls and effective strategies in the grant application process. It emphasizes the importance of aligning proposals with funding agency priorities, clearly articulating objectives, and demonstrating the potential impact of the proposed work. The guide also highlights the value of thorough preparation, understanding reviewer expectations, and the necessity of resilience in the face of rejection, encouraging applicants to view unsuccessful attempts as learning opportunities for future submissions.

**<span style="color: #00A3E0; font-weight: bold;">Topic:</span>** H3Africa: Successes and failures of grants writing 15 Sept 2020.

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