Matlab code of the mouse ventricular myocyte with myofilament contraction

The Morotti et al. model of mouse ventricular myocyte (J Physiol. 2014 Mar 15;592(6):1181-97, available for 
download on this website) is here modified to integrate the Negroni et al. model of myofilament contraction
in rabbit ventricular myocytes (J Mol Cell Cardiol. 2015 Apr;81:162-75, also available for download on this website).
This model was used to investigate the compartmentalization of cAMP/PKA signaling in Surdo et al. (Nat Commun. 2017).

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Contents:

readme.txt				 	this file

	.m files - model components

morotti_et_al_masterCompute.m		 	loads initial conditions (see below) and runs the simulation
morotti_et_al_masterODEfile.m		 	integrates the following model components:
morotti_et_al_barODEfile.m		 	- beta-adrenergic (PKA) phosphorylation module
morotti_et_al_camkiiODEfile.m		 	- CaMKII phosphorylation module
morotti_et_al_camODEfile.m		 	- CaM module
morotti_et_al_eccODEfile.m		 	- excitation-contraction coupling module (with myofilament)

	.mat files - initial conditions (isotonic contraction at 1-Hz pacing)

yfin_mouse_myofil_isoT_control_1Hz	 	control model (steady-state, Ligtot = 0 uM)
yfin_mouse_myofil_isoT_IBMX_1Hz_120s	 	120 s with Ligtot = 0.1 uM (uMyo, uXBCa & uXBcy = 1)
yfin_mouse_myofil_isoT_ISOall_1Hz_120s	 	120 s with Ligtot = 0.1 uM (uMyo, uXBCa & uXBcy = 0.5)
yfin_mouse_myofil_isoT_ISOxbca_1Hz_120s	 	120 s with Ligtot = 0.1 uM (uXBCa = 0.5; uMyo & uXBcy = 1) 
yfin_mouse_myofil_isoT_ISOxbcy_1Hz_120s	 	120 s Ligtot = 0.1 uM (uXBcy = 0.5; uMyo & uXBCa = 1)  
yfin_mouse_myofil_isoT_ISOtitin_1Hz_120s 	120 s with Ligtot = 0.1 uM (uMyo = 0.5; XBCa & uXBcy = 1)
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Note that Ligtot (default value 0 uM) is defined in 'morotti_et_al_masterCompute.m', and uMyo, uXBCa & uXBcy
(default value 1) are defined in 'morotti_et_al_eccODEfile.m'.
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References:

N.C. Surdo, M. Berrera, A. Koschinski, M. Brescia, M.R. Machado, C. Carr, S. Morotti, E. Grandi, P. Wright,
D.M. Bers, J. Gorelik, S. Pantano, M. Zaccolo.
FRET biosensor uncovers cAMP nano-domains at ß-adrenergic targets that dictate precise tuning of cardiac contractility.
Nat Commun. 2017 Apr 20;8:15031. doi: https://doi.org/10.1038/ncomms15031

S. Morotti, A.G. Edwards, A.D. McCulloch, D.M. Bers, E. Grandi.
A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.
J Physiol. 2014 Mar 15;592(6):1181-97. doi: https://doi.org/10.1113/jphysiol.2013.266676

J.A. Negroni, S. Morotti, E.C. Lascano, A.V. Gomes, E. Grandi, J.L. Puglisi, D.M. Bers.
ß-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model.
J Mol Cell Cardiol. 2015 Apr;81:162-75. doi: https://doi.org/10.1016/j.yjmcc.2015.02.014

Please, cite the above papers when using this model.