bHub_sim

A repository for simulating islets of Langerhans beta-cells hub phenomenon. This repository supports the results published in https://doi.org/10.1080/19382014.2018.1493316.

Requirements

• Python 2.7 or Python 3.4+
• Python libraries: numpy matplotlib neuron

neuron can be downloaded and installed here.

How to run simulation

This repository is organised this the following way:

• models contains all the models used in the study, written in neuron readable format. It includes beta cell models and gap junction models.
• morphologies contains the x, y, z Cartesian coordinates of the cells in islets of Langerhans, including mouse and human.
• src, src-local, src-mpi, src-test-pcaer, src-delta-cell-sim contain the 'run' scripts for the simulations.
• test_package contains some quick tests (small examples) of the neuron package.
• output is a placeholder for the outputs (raw traces of the simulated membrane potential and intracellular calcium) from the 'run' scripts in the srcs.