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GLASS Consortium. Longitudinal molecular trajectories of diffuse glioma in adults. Nature 2019 #933
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This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. Thank you for your contributions. |
This issue has been automatically marked as stale because it has not had recent activity. It will be closed if no further activity occurs. Thank you for your contributions. |
Initial comments on review:
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Hi @tmazor, thank you for reviewing the data. This study has multisector samples (data is at aliquot level) and we initially had included the complete dataset - all the aliquots per sample from synapse https://www.synapse.org/#!Synapse:syn17038081/wiki/ hence the inconsistencies when compared to the supp 7, 8 tables of the paper. We have now updated the study to the Fixes made: |
This looks much better! Thanks for the updates @rmadupuri . I reviewed all my original comments, and everything seems to be resolved except for the first one. Cancer Type Detailed looks much better, but it looks like grade 2/3 tumors are all classified as Astro, Oligo or Oligoastro. Those OncoTree codes really refer to grade 2 tumors, and the grade 3 tumors should be the corresponding Anaplastic OncoTree codes. Unless there's a reason not to? I know there are studies in the public portal using the Anaplastic codes. Also, upon further review, I'm actually thinking that Cancer Type Detailed should be populated based on the WHO Classification rather than Grade+Histology as I had originally suggested. Some additional things I've noticed:
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Hi @tmazor! Thank you again for the review and apologies for the delayed response. We have fixed the issues above.
We have released this study to public here - https://www.cbioportal.org/study/summary?id=difg_glass_2019. Shared the link to the authors too. Thank you! |
https://www.nature.com/articles/s41586-019-1775-1
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