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Ancestry reports mitochondrial (MT/Chr26) SNPs as diploid (e.g. "GG", with two identical alleles), even though there is just one mitochondrial genome, with multiple copies. 23andme reports as haploid (e.g. "G"). When 23andme and Ancestry files are merged in lineage, the csv output has a single allele for all 23andme SNPs but two alleles for any that are present on Ancestry (including SNPs present on both).
Suggest that, for consistency, all MT SNPs be reported with a single allele, and any heterozygosity in Ancestry calls (due to heteroplasmy, which I've never yet seen) be reported as an error.
The text was updated successfully, but these errors were encountered:
Ancestry reports mitochondrial (MT/Chr26) SNPs as diploid (e.g. "GG", with two identical alleles), even though there is just one mitochondrial genome, with multiple copies. 23andme reports as haploid (e.g. "G"). When 23andme and Ancestry files are merged in lineage, the csv output has a single allele for all 23andme SNPs but two alleles for any that are present on Ancestry (including SNPs present on both).
Suggest that, for consistency, all MT SNPs be reported with a single allele, and any heterozygosity in Ancestry calls (due to heteroplasmy, which I've never yet seen) be reported as an error.
The text was updated successfully, but these errors were encountered: