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Introduce low quality clonal mutations #77

Merged
merged 8 commits into from
Jan 4, 2023
Merged

Introduce low quality clonal mutations #77

merged 8 commits into from
Jan 4, 2023

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priesgo
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@priesgo priesgo commented Jan 3, 2023

Changes the classification of mutations from filter to VAF.
The new thresholds are:

  • 0.02 for low frequency mutations
  • 0.5 for subclonal (intrahost) mutations
  • 0.8 for low quality clonal

Related to #56 and TRON-Bioinformatics/covigator-ngs-pipeline#42

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codecov bot commented Jan 3, 2023

Codecov Report

Base: 82.28% // Head: 83.00% // Increases project coverage by +0.72% 🎉

Coverage data is based on head (11a4c71) compared to base (9a939de).
Patch coverage: 100.00% of modified lines in pull request are covered.

Additional details and impacted files
@@             Coverage Diff             @@
##           develop      #77      +/-   ##
===========================================
+ Coverage    82.28%   83.00%   +0.72%     
===========================================
  Files           46       46              
  Lines         4024     4173     +149     
===========================================
+ Hits          3311     3464     +153     
+ Misses         713      709       -4     
Impacted Files Coverage Δ
covigator/pipeline/ena_pipeline.py 47.82% <ø> (ø)
covigator/configuration.py 85.83% <100.00%> (+0.36%) ⬆️
covigator/database/model.py 98.76% <100.00%> (+0.28%) ⬆️
covigator/pipeline/vcf_loader.py 94.82% <100.00%> (+2.86%) ⬆️
covigator/tests/unit_tests/abstract_test.py 94.73% <100.00%> (+0.50%) ⬆️
covigator/tests/unit_tests/test_vcf_loader.py 100.00% <100.00%> (ø)

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@priesgo priesgo merged commit 53fcae2 into develop Jan 4, 2023
@priesgo priesgo deleted the 56/lq-clonal branch January 4, 2023 10:15
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priesgo commented Jan 4, 2023

resolves #56

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Change threshold for low frequency mutations to 2 % and store mutations >= 50 % and < 80 % in different table
1 participant