Skip to content

Commit

Permalink
WIP: Added some more text, references and figures to the initial vers…
Browse files Browse the repository at this point in the history
…ion of the JOSS paper. ALive-research#260
  • Loading branch information
olevs committed Dec 20, 2023
1 parent b7e9cd7 commit f05a6de
Show file tree
Hide file tree
Showing 2 changed files with 90 additions and 47 deletions.
43 changes: 39 additions & 4 deletions paper.bib
Original file line number Diff line number Diff line change
@@ -1,4 +1,4 @@
@article{10.1038/sj.bjc.6603033,
@article{Simmonds:2006,
year = {2006},
title = {{Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies}},
author = {Simmonds, P C and Primrose, J N and Colquitt, J L and Garden, O J and Poston, G J and Rees, M},
Expand All @@ -12,7 +12,7 @@ @article{10.1038/sj.bjc.6603033
volume = {94}
}

@article{10.1007/s11548-013-0937-0,
@article{Hansen:2014,
year = {2014},
title = {{Impact of model-based risk analysis for liver surgery planning}},
author = {Hansen, C. and Zidowitz, S. and Preim, B. and Stavrou, G. and Oldhafer, K. J. and Hahn, H. K.},
Expand All @@ -25,7 +25,7 @@ @article{10.1007/s11548-013-0937-0
volume = {9}
}

@article{10.1007/s00464-010-0915-3,
@article{Lamata:2010,
year = {2010},
title = {{Use of the Resection Map system as guidance during hepatectomy}},
author = {Lamata, Pablo and Lamata, Félix and Sojar, Valentin and Makowski, Piotr and Massoptier, Laurent and Casciaro, Sergio and Ali, Wajid and Stüdeli, Thomas and Declerck, Jérôme and Elle, Ole Jakob and Elle, Ole Jackov and Edwin, Bjørn and Edwin, Björn},
Expand All @@ -39,7 +39,7 @@ @article{10.1007/s00464-010-0915-3
volume = {24}
}

@article{10.1016/j.cmpb.2017.03.019,
@article{Palomar:2017,
year = {2017},
rating = {0},
title = {{A novel method for planning liver resections using deformable Bézier surfaces and distance maps}},
Expand All @@ -54,3 +54,38 @@ @article{10.1016/j.cmpb.2017.03.019
language = {English},
month = {06}
}

@book{Preim:2013,
title={Visual computing for medicine: theory, algorithms, and applications},
author={Preim, Bernhard and Botha, Charl P},
year={2013},
publisher={Newnes}
}
@article{Warmann:2016,
title={Computer-assisted surgery planning in children with complex liver tumors identifies variability of the classical Couinaud classification},
author={Warmann, Steven W and Schenk, Andrea and Schaefer, Juergen F and Ebinger, Martin and Blumenstock, Gunnar and Tsiflikas, Ilias and Fuchs, Joerg},
journal={Journal of Pediatric Surgery},
volume={51},
number={11},
pages={1801--1806},
year={2016},
publisher={Elsevier}
}
@article{Bismuth:2013,
title={Revisiting liver anatomy and terminology of hepatectomies},
author={Bismuth, Henri},
journal={Annals of surgery},
volume={257},
number={3},
pages={383--386},
year={2013},
publisher={LWW}
}
@incollection{Kikinis:2013,
title={3D Slicer: a platform for subject-specific image analysis, visualization, and clinical support},
author={Kikinis, Ron and Pieper, Steve D and Vosburgh, Kirby G},
booktitle={Intraoperative imaging and image-guided therapy},
pages={277--289},
year={2013},
publisher={Springer}
}
94 changes: 51 additions & 43 deletions paper.md
Original file line number Diff line number Diff line change
Expand Up @@ -8,7 +8,7 @@ tags:
- Geometric modelling
authors:
- name: Rafael Palomar
orcid: 0000-0000-0000-0000
orcid: 0000-0002-9136-4154
equal-contrib: true
corresponding: true
affiliation: "1, 2" # (Multiple affiliations must be quoted)
Expand All @@ -21,15 +21,11 @@ authors:
equal-contrib: true # (This is how you can denote equal contributions between multiple authors)
affiliation: 1
- name: Ole V. Solberg
orcid: 0000-0000-0000-0000
orcid: 0009-0004-9488-3621
equal-contrib: true # (This is how you can denote equal contributions between multiple authors)
affiliation: 3
- name: Geir Arne Tangen
orcid: 0000-0000-0000-0000
affiliation: 3
- given-names: Ludwig
dropping-particle: van
surname: Beethoven
orcid: 0000-0003-0032-8500
affiliation: 3
affiliations:
- name: The Intervention Centre, Oslo University Hospital, Oslo, Norway
Expand All @@ -50,7 +46,7 @@ aas-journal: Astrophysical Journal <- The name of the AAS journal.
# Summary

This paper introduces SlicerLiver, a software extension to the [3D Slicer](https://slicer.org "3D Slicer")
image computing platform. The software address challenges in liver surgery planning by
image computing platform [@Kikinis:2013]. The software address challenges in liver surgery planning by
applying geometric modeling and artificial intelligence to generate liver tumor
resection plans for complex cases, developing parameterized patient-specific
vascular models, and creating computational methods for resection visualization
Expand All @@ -63,49 +59,62 @@ planning and potentially improving patient outcomes.

Liver cancer, both primary and secondary types, is a global health concern with
increasing incidence rates [1]. Surgical resection is the most effective treatment
for some of these cancers [2], and the evolution of computer-assisted surgical systems
for some of these cancers [@Simmonds:2006], and the evolution of computer-assisted surgical systems
over the past two decades has significantly improved tumor localization and surgeons
confidence during surgery [3], [4]. However, despite these advances, several challenges
confidence during surgery [@Hansen:2014], [@Lamata:2010]. However, despite these advances, several challenges
remain in liver surgical practice.
While patient-specific 3D models are systematically generated for surgical planning
and guidance, surgery planning remains a manual process. This is particularly problematic
for patients with multiple metastases, where manual surgery planning becomes intricate.
The current techniques for planning virtual resections, namely, drawing-on-slices and
deformable surfaces [5], [6], have shown limitations. Therefore, there is a pressing
deformable surfaces [@Preim:2013], [@Palomar:2017], have shown limitations. Therefore, there is a pressing
need for new algorithms capable of generating precise, rapid, and straightforward
resection plans, even in complex cases.


# Mathematics

Single dollars ($) are required for inline mathematics e.g. $f(x) = e^{\pi/x}$

Double dollars make self-standing equations:

$$\Theta(x) = \left\{\begin{array}{l}
0\textrm{ if } x < 0\cr
1\textrm{ else}
\end{array}\right.$$

You can also use plain \LaTeX for equations
\begin{equation}\label{eq:fourier}
\hat f(\omega) = \int_{-\infty}^{\infty} f(x) e^{i\omega x} dx
\end{equation}
and refer to \autoref{eq:fourier} from text.

# Citations

Citations to entries in paper.bib should be in
[rMarkdown](http://rmarkdown.rstudio.com/authoring_bibliographies_and_citations.html)
format.

If you want to cite a software repository URL (e.g. something on GitHub without a preferred
citation) then you can do it with the example BibTeX entry below for @fidgit.

For a quick reference, the following citation commands can be used:
- `@author:2001` -> "Author et al. (2001)"
- `[@author:2001]` -> "(Author et al., 2001)"
- `[@author1:2001; @author2:2001]` -> "(Author1 et al., 2001; Author2 et al., 2002)"
# Implementation

# Results

**Improved Definition of Virtual Resections**
We developed computer-aided preoperative planning systems \autoref{fig:1},
streamlining the resection planning process and introducing
real-time 3D cutting path visualization. Our approach empowers surgeons to make decisions based on individual patient
needs, enhancing outcomes for both atypical and anatomical
resections. Notably, our proposed a new resection method
aiming to obtain better parenchyma preservation compared to
existing methods.
**Improved Visualization of Virtual Resections**
We successfully implemented the Resectograms method (Fig. 1.b),
a real-time 2D representation of resections within the ALive
project. The Resectogram provides an intuitive and occlusionfree visualization of virtual liver resection plans, with three
components: resection cross-section, resection anatomy segments, and resection safety margins. Notably, Resectograms
effectively identify and characterize invalid resection types due
to inadequate visualization during virtual planning, thus improving surgical accuracy and decision-making. Resectograms
enhance the liver surgery workflow, empowering surgeons with
valuable insights for optimized liver resection strategies and
improved patient outcomes.
**Improved Classification of Liver Segments**
As part of the ALive project, our study introduces a novel approach to
segmenting liver functional segments \autoref{fig:3}. The method
uses the liver morphology, the interior vascular network,
and user-defined landmarks to provide enhanced flexibility in
marker placement, distinguishing it from existing methods. By
departing from the standardized Couinaud classification, our
approach enables a more individualized representation of liver
segmental distribution. Particularly noteworthy is the method’s
accurate estimation of the challenging Segment 1, resulting in
a comprehensive and precise segmentation of the caudate lobe.
While improvements, particularly in automating the landmark
marking process, are needed, our approach holds significant
promise for improving liver surgery planning and has the
potential to optimize surgical outcomes within the broader
context of the ALive project.



![Specification of a virtual resection with visualization of safety margins.\label{fig:1}](Screenshots/Slicer-Liver_screenshot_04.png)
![Visializing liver segments.\label{fig:3}](Screenshots/Slicer-Liver_screenshot_14.jpg)

# Figures

Expand All @@ -117,8 +126,7 @@ Figure sizes can be customized by adding an optional second parameter:
![Caption for example figure.](figure.png){ width=20% }

# Acknowledgements
This work was conducted as part of the ALive project, funded by the Research Council of Norway under IKTPLUSS (grant nr. 311393).

We acknowledge contributions from Brigitta Sipocz, Syrtis Major, and Semyeong
Oh, and support from Kathryn Johnston during the genesis of this project.

# References

0 comments on commit f05a6de

Please sign in to comment.