Co-transmission-of-cholinergic-interneurons: Mouse models that differ in neurotransmitter release from striatal cholinergic interneurons

This dataset has data files from 5-Choice Serial Reaction Time (5-CSRT), Pairwise Visual Discrimination (PVD), and Extinction cognitive behavioral tasks for 4 mouse lines that differ in neurotransmitter release from striatal cholinergic interneurons (ACh or Glu). D2CreVGLUT3fx and ChATIRESVGLUT3fx mice and their wild-type controls were evaluated at 3-7 months of age in the PVD task to assess discrimination and reversal learning. Immediately after (still within 3-7 months of age) these same mice were evaluated using the Extinction task to assess their ability to extinguish a response. D2CreVAChTfx mice and their wild-type controls were evaluated at 5-7 months of age in the 5-CSRT task to assess attention. Immediately after (still within 3-7 months of age) these same mice were evaluated using the Extinction task. VAChTfx control mice that were virally injected with GFP or Cre in the dorsal striatum were evaluated at 6-12 months in the PVD task, followed by the 5-CSRT task (approximately at 8-14 months of age).

COMMON METADATA:

Dataset type: Cognitive Behavioral Data from Touchscreen Technology
Source: https://mousebytes.ca
DOI: https://doi.org/10.1172/JCI138532
Animal Specie: Mouse
Animal Sex: Male, Female
Animal age (month): "3-6" generally, "7-10" for VAChT^flox/flox PVD, "11-13" for VAChT^flox/flox 5-Choice
Animal strain: VGLUT3^D2-Cre-flox/flox, VGLUT3^ChAT-IRES-flox/flox, VAChT^flox/flox, VAChT^D2-Cre-flox/flox
Animal Genotype: VGLUT3^D2-Cre-flox/flox, VGLUT3^flox/flox, VAChT^D2-Cre-flox/flox, VAChT^flox/flox, VGLUT3^ChAT-IRES-flox/flox
Housing: Single-housed
Light Cycle: Diurnal light cycle
Intervention: Stereotaxic viral injection of AAV-Cre in the dorsomedial striatum of control VAChT^flox/flox mice; Stereotaxic viral injection of AAV-GFP in the dorsomedial striatum of control VAChT^flox/flox mice (control surgery for mice injected with AAV-Cre)

AGGREGATED DATA:

File Name: OK_D2CreVGLUT3fx_PVD.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=a2356d1f-cf92-44fa-b54e-15e8b3897acf
Cognitive Task: Pairwise Visual Discrimination (PVD)
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_ChATIRESVGLUT3fx_PVD.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=5119ff8d-9ce5-4596-a55b-33786e99ca94
Cognitive Task: Pairwise Visual Discrimination (PVD)
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_VAChTfx_Virus_PVD.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=80c93593-1ea9-472e-b757-00290fedfb71
Cognitive Task: Pairwise Visual Discrimination (PVD)
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_D2CreVAChTfx_5Choice.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=1a37e2db-933d-4c65-bb48-d57f6335447f
Cognitive Task: 5-Choice
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_VAChTfx_Virus_5Choice.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=1abae187-6da7-4ee6-b4a9-c01bb774c526
Cognitive Task: 5-Choice
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_D2CreVGLUT3fx_Extinction_training.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=cdc4c151-3a06-4b25-a4a9-2db901c0cbb3
Cognitive Task: Extinction, Training
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_D2CreVGLUT3fx_Extinction_probe.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=841e871b-1a1c-4169-8b19-b69953344d70
Cognitive Task: Extinction, Probe
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_D2CreVAChTfx_Extinction_training.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=9aa65f4d-6deb-4c4d-8e8f-e34c60f39a61
Cognitive Task: Extinction, Training
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_D2CreVAChTfx_Extinction_probe.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=1e2e2aa5-6fd8-4ae1-bce2-af95c8b1c44d
Cognitive Task: Extinction, Probe
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_ChATIRESVGLUT3fx_Extinction_training.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=b8071be1-be7c-411c-80cb-d447acbc5393
Cognitive Task: Extinction, Training
Aggregation Function: Mean
Trial by Trial: No

File Name: OK_ChATIRESVGLUT3fx_Extinction_probe.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=1b2ea0c4-c8ed-4371-9e4e-c0368b81d80d
Cognitive Task: Extinction, Probe
Aggregation Function: Mean
Trial by Trial: No

TRIAL BY TRIAL DATA:

File Name: OK_D2CreVGLUT3fx_PVD_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=6b5d77b5-baf4-4dd9-b527-c4a259194de2
Cognitive Task: Pairwise Visual Discrimination (PVD)
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_ChATIRESVGLUT3fx_PVD_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=baac070b-904d-4d55-831c-638cabc2ae75
Cognitive Task: Pairwise Visual Discrimination (PVD)
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_VAChTfx_Virus_PVD_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=93891b4d-58c2-4885-896a-05136d5467d2
Cognitive Task: Pairwise Visual Discrimination (PVD)
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_D2CreVAChTfx_5Choice_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=41a72769-9819-4602-871f-620e814decfd
Cognitive Task: 5-Choice
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_VAChTfx_Virus_5Choice_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=71d19e33-0120-42e4-be18-7c1c1cef694c
Cognitive Task: 5-Choice
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_D2CreVGLUT3fx_Extinction_training_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=56749ccf-0457-49ce-b1da-078fd909a7a5
Cognitive Task: Extinction, Training
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_D2CreVGLUT3fx_Extinction_probe_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=95876b04-babc-47b1-bd7b-ac308ec1ca47
Cognitive Task: Extinction, Probe
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_D2CreVAChTfx_Extinction_training_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=0a129d4a-1c7d-4f52-a7c9-601bc4d556d5
Cognitive Task: Extinction, Training
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_D2CreVAChTfx_Extinction_probe_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=9abaafcc-39b5-403a-9727-6e484f115cb6
Cognitive Task: Extinction, Probe
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_ChATIRESVGLUT3fx_Extinction_training_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=e6789550-7c51-4abb-a28b-e8e20ea0b656
Cognitive Task: Extinction, Training
Aggregation Function: N/A
Trial by Trial: Yes

File Name: OK_ChATIRESVGLUT3fx_Extinction_probe_trial.csv
PI: Dr. Marco Prado, Robarts Research Institute (University of Western Ontario)
Data Link: https://mousebytes.ca/data-link?linkguid=e31fedcc-48f8-48cd-a4fd-62e8846ba6a4
Cognitive Task: Extinction, Probe
Aggregation Function: N/A
Trial by Trial: Yes