Formulas: Repalce C*V with M

[Yuri05]

In some formulas, where amount of drug or protein is used, it is written in the form Concentration*Volume
Because internally concentration is always calculated as Amount/Volume, this results in the calculation of Amount/Volume*Volume, which is inefficient.

So C*V should be replaced with M (amount). Will also make the formulas more readable

calculation_method	formula_rate	formula
LinksCommon	BrainPgPToPlasma_Hill	Min(CP * f_int * V * kcat * (fu * max(C_pls;0))^alpha / ( Km^alpha + (fu * max(C_pls;0))^alpha) ; P_endothelial * SA * fu * C_pls) + CP * f_int * V * kcat * (K_water_int * max(C_int;0))^alpha / (Km^alpha + (K_water_int * max(C_int;0))^alpha)
LinksCommon	BrainPgPToPlasma_MM	Min(CP * f_int * V * kcat  / ( Km + C_pls * fu) ; P_endothelial * SA)* C_pls * fu + CP * f_int * V * kcat * K_water_int * C_int / (Km + K_water_int * C_int)
LinksCommon	LiverActiveEffluxToBile_Hill	(1-EHC_ContinuousFraction) * CP * f_cell * V * kcat * (K_water_cell * max(C_cell;0))^alpha / (Km^alpha + (K_water_cell * max(C_cell;0))^alpha)
LinksCommon	LiverActiveEffluxToBile_MM	(1-EHC_ContinuousFraction) * CP * f_cell * V * kcat * K_water_cell * C_cell / (Km + K_water_cell * C_cell)
LinksCommon	LiverActiveEffluxToDuodenum_Hill	EHC_ContinuousFraction * CP * f_cell * V * kcat * (K_water_cell * max(C_cell;0))^alpha / (Km^alpha + (K_water_cell * max(C_cell;0))^alpha)
LinksCommon	LiverActiveEffluxToDuodenum_MM	EHC_ContinuousFraction * CP * f_cell * V * kcat * K_water_cell * C_cell / (Km + K_water_cell * C_cell)
LinksCommon	MetabolizationSpecific_MM	**** kcat *** V** * K_water * C / (Km + K_water * C)
LinksCommon	PgpSpecific_Hill	Min(CP * f_cell * V * kcat * (K_water_int * max(C_int;0))^alpha / ( Km^alpha + (K_water_int * max(C_int;0))^alpha) ; PA_int_cell * K_water_int * C_int) + CP * f_cell * V * kcat * (K_water_cell * max(C_cell;0))^alpha / (Km^alpha + (K_water_cell * max(C_cell;0))^alpha)
LinksCommon	PgpSpecific_MM	Min(CP * f_cell * V * kcat  / ( Km + C_int * K_water_int) ; PA_int_cell )* C_int *K_water_int + CP * f_cell * V * kcat * K_water_cell * C_cell / (Km + K_water_cell * C_cell)
Observer_PKSim_2Poren	OBS_Concentration_liv_bc	(C_bc_prp * V_bc_prp + C_bc_prc * V_bc_prc)/(V_bc_prp+V_bc_prc)
Observer_PKSim_2Poren	OBS_Concentration_liv_cell	(C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_cell_prp+V_cell_prc)
Observer_PKSim_2Poren	OBS_Concentration_liv_end	(C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(V_end_prp+V_end_prc)
Observer_PKSim_2Poren	OBS_Concentration_liv_int	(C_int_prp * V_int_prp + C_int_prc * V_int_prc)/(V_int_prp+V_int_prc)
Observer_PKSim_2Poren	OBS_Concentration_liv_pls	(C_pls_prp * V_pls_prp + C_pls_prc * V_pls_prc)/(V_pls_prp+V_pls_prc)
Observer_PKSim_2Poren	OBS_InterstitialUnbound_liv	(C_int_prp * K_water_int_prp * V_int_prp + C_int_prc * K_water_int_prc * V_int_prc)/(V_int_prp+V_int_prc)
Observer_PKSim_2Poren	OBS_IntracellularUnbound_liv	(C_cell_prp * K_water_cell_prp * V_cell_prp + C_cell_prc * K_water_cell_prc * V_cell_prc)/(V_cell_prp+V_cell_prc)
Observer_PKSim_2Poren	OBS_Tissue_liv	(C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc + C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(V_int_prp+V_int_prc+V_cell_prp+V_cell_prc+V_end_prp+V_end_prc)
Observer_PKSim_2Poren	OBS_WholeOrgan	(fBloodForSampling*(V_plsC_pls + V_bcC_bc) + V_endC_end + V_intC_int + V_cellC_cell)/(fBloodForSampling(V_pls+V_bc) + V_end + V_int + V_cell)
Observer_PKSim_2Poren	OBS_WholeOrgan_incl_FcRn_Complex	(fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bcC_bc) + V_end(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cellC_cell)/(fBloodForSampling(V_pls+V_bc) + V_end + V_int + V_cell)
Observer_PKSim_2Poren	OBS_WholeOrgan_incl_FcRn_Complex_liv	(fBloodForSampling*((C_pls_prp + C_pls_prp_Complex) * V_pls_prp + (C_pls_prc + C_pls_prc_Complex) * V_pls_prc +  C_bc_prp * V_bc_prp + C_bc_prc * V_bc_prc) +  (C_int_prp + C_int_prp_Complex) * V_int_prp + (C_int_prc + C_int_prc_Complex) * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc + (C_end_prp + C_end_prp_Complex) * V_end_prp + (C_end_prc + C_end_prc_Complex) * V_end_prc)/(fBloodForSampling*(V_pls_prp+V_pls_prc+V_bc_prp+V_bc_prc)+V_int_prp+V_int_prc+V_cell_prp+V_cell_prc+V_end_prp+V_end_prc)
Observer_PKSim_2Poren	OBS_WholeOrgan_liv	(fBloodForSampling*(C_pls_prp * V_pls_prp + C_pls_prc * V_pls_prc + C_bc_prp * V_bc_prp + C_bc_prc * V_bc_prc) + C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc + C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(fBloodForSampling*(V_pls_prp+V_pls_prc+V_bc_prp+V_bc_prc)+V_int_prp+V_int_prc+V_cell_prp+V_cell_prc+V_end_prp+V_end_prc)
Observer_PKSim_4Comp	OBS_Concentration_liv_bc	(C_bc_prp * V_bc_prp + C_bc_prc * V_bc_prc)/(V_bc_prp+V_bc_prc)
Observer_PKSim_4Comp	OBS_Concentration_liv_cell	(C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_cell_prp+V_cell_prc)
Observer_PKSim_4Comp	OBS_Concentration_liv_end	(C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(V_end_prp+V_end_prc)
Observer_PKSim_4Comp	OBS_Concentration_liv_int	(C_int_prp * V_int_prp + C_int_prc * V_int_prc)/(V_int_prp+V_int_prc)
Observer_PKSim_4Comp	OBS_Concentration_liv_pls	(C_pls_prp * V_pls_prp + C_pls_prc * V_pls_prc)/(V_pls_prp+V_pls_prc)
Observer_PKSim_4Comp	OBS_InterstitialUnbound_liv	(C_int_prp * K_water_int_prp * V_int_prp + C_int_prc * K_water_int_prc * V_int_prc)/(V_int_prp+V_int_prc)
Observer_PKSim_4Comp	OBS_IntracellularUnbound_liv	(C_cell_prp * K_water_cell_prp * V_cell_prp + C_cell_prc * K_water_cell_prc * V_cell_prc)/(V_cell_prp+V_cell_prc)
Observer_PKSim_4Comp	OBS_Tissue_liv	(C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_int_prp+V_int_prc+V_cell_prp)
LinksCommon	ClearanceKidneyPls	V * CLspec * C_pls * fu

[msevestre]

on it