Number of cells/g tissue missing for monkey and minipig

[StephanSchaller]

For total hepatic clearance processes (in vitro hepatocytes), the "Number of cells/g tissue" is missing for monkey and minipig.
Is this a bug or is no value reported (in literature)?

Same for "microsomal protein/g liver" in the "in vitro liver microsomes" processes (monkey, minipig and mouse).

[msevestre]

no value reported (at least not according to the DB)

[StephanSchaller]

Okay, we will look into it

[Yuri05]

Duplicate of #1427?

[StephanSchaller]

Duplicate of #1427?

Half of it, true, #1427 covers microsomal protein, but PK-Sim also needs an update for #cells/g Liver for monkey and minipig

[StephanSchaller]

So, is it the same issue for the cells/g liver, that we had values in V7.3 but these got lost for V8?

We now have a list with literature sources we can provide...

[msevestre]

So, is it the same issue for the cells/g liver, that we had values in V7.3 but these got lost for V8?

eh? Nothing was lost between versions. I have no idea how you can infer this conclusion from the #1427 thread lol

[StephanSchaller]

Yeah, yeah... I mis-read the reply from J-Herz... these were hi own values...

Anyway, how would you want the values for this thread/topic provided?

[msevestre]

Table? Then we can update the DB:)

[StephanSchaller]

Hepatocellularity V1.zip

Is this usable?

[msevestre]

also misssing for cattle

[msevestre]

@StephanSchaller Is there a reference for this value?

[StephanSchaller]

@Yuri05 , @msevestre , we can take this. Can you assigne Rob, Ben or Pavel in the next Dev Meeting