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Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)

modeldb.science/127507

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Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
Fig2a2.hoc		Fig2a2.hoc
Fig2b2.hoc		Fig2b2.hoc
Fig2f2.hoc		Fig2f2.hoc
Fig6a_dashed-line_trace.hoc		Fig6a_dashed-line_trace.hoc
Fig6a_solid_trace.hoc		Fig6a_solid_trace.hoc
README.html		README.html
cabal.mod		cabal.mod
dopaminergic.hoc		dopaminergic.hoc
final.hoc		final.hoc
fixnseg.hoc		fixnseg.hoc
mosinit.hoc		mosinit.hoc
nabalan.mod		nabalan.mod
newcachan.mod		newcachan.mod
newhh3.mod		newhh3.mod
newkca.mod		newkca.mod
newleak.mod		newleak.mod
pump.mod		pump.mod
run_and_graph.ses		run_and_graph.ses
screenshot2a2.jpg		screenshot2a2.jpg
screenshot2b2.jpg		screenshot2b2.jpg
screenshot2f2.jpg		screenshot2f2.jpg
screenshot6a_d.jpg		screenshot6a_d.jpg
screenshot6a_s.jpg		screenshot6a_s.jpg
stim.mod		stim.mod

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<HTML><PRE>
Dopaminergic (DA) neuron model with a morphologicaly realistic
dendritic architecture. The model captures several salient features of
DA neurons under several pharmacological manipulations and exhibits
depolarization block for sufficiently high current pulses into the
soma.

The model refers to the paper:

Anna Y. Kuznetsova, Marco A. Huertas, Alexey S. Kuznetsov, Carlos
A. Paladini and Carmen C. Canavier (2010) Regulation of firing
frequency in a computational model of a midbrain dopaminergic neuron
J Comput Neurosci. 2010 Jun;28(3):389-403.

The files included here correspond to the morphologically realistic
reconstructed model (see Figure 1 in paper) and reproduce results
presented in the paper:
1) Fig2a2.hoc			Figure 2 (a2)
2) Fig2b2.hoc			Figure 2 (b2)
3) Fig2f2.hoc				Figure 2 (f2)
4) Fig6a_solid_trace            Figure 6a: solid line corresponding to
                                100 pA stimulation current
5) Fig6a_dashed-line_trace      Figure 6a: dashed line corresponding
                                to 500 pA stimulation current

The first three examples illustrate spontaneous firing of the model DA
neuron in control (1) and after blocking SK channel (2) and Na
channels (3).

Last two files show the response of the model DA neuron to simulated
current pulse to the soma for 100 pA (4) and 500 pA (5). In the last
case one can observe depolarization block.

You can run the simulation either by auto-launching from ModelDB, or
by first compiling the mechanisms as follows:

a) Under LINUX
	Type

	nrnivmodl

	Then type 

	nrngui mosinit.hoc

b) Under Windows

	Run mknrndll to compile the mod files in the top level
	directory.

c) Under MAC - OS X

	Drag and drop the archive file on the mknrndll icon (in the
	NEURON application folder).

------------------------------
If running the individual files listed above:
Once Neuron has been started on your platform select in the main manu
	Tools -> RunControl
	Graph -> Voltage axis
then select 
	File -> load hoc
and choose the file you want to run. Finally press Init & Run.
------------------------------

If auto-launched then press a button corresponding to the figure
desired and you can generate figures like these:
Fig 2a2:
<img src="./screenshot2a2.jpg" alt="screenshot 2a2">

Fig 2b2:
<img src="./screenshot2b2.jpg" alt="screenshot 2b2">

Fig 2f2:
<img src="./screenshot2f2.jpg" alt="screenshot 2f2">

Fig 6a (solid trace):
<img src="./screenshot6a_s.jpg" alt="screenshot 6a solid">

Fig 6a (dashed trace):
<img src="./screenshot6a_d.jpg" alt="screenshot 6a dashed">