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Perhaps this is bold of me since I'm a homebrew noob, but I believe this formula is a goner (at least at the minute) I took a quick look to see if I could resolve its Big Sur bottling issue. It probably isn't too hard to fix the exact compile failure, but:
Since it looks like this formula is long-unmaintained, probably the best thing to do is to put it out of its misery. I know most other py2-dependent formulas are long-ago disabled. I don't know enough about this particular package to know if it requires py2 for its basic functionality, but getting a complete build on top of homebrew's py3 support would probably require some serious effort.