Initial implementation

.gitattributes

@@ -0,0 +1,63 @@
+###############################################################################
+# Set default behavior to automatically normalize line endings.
+###############################################################################
+* text=auto
+
+###############################################################################
+# Set default behavior for command prompt diff.
+#
+# This is need for earlier builds of msysgit that does not have it on by
+# default for csharp files.
+# Note: This is only used by command line
+###############################################################################
+#*.cs     diff=csharp
+
+###############################################################################
+# Set the merge driver for project and solution files
+#
+# Merging from the command prompt will add diff markers to the files if there
+# are conflicts (Merging from VS is not affected by the settings below, in VS
+# the diff markers are never inserted). Diff markers may cause the following 
+# file extensions to fail to load in VS. An alternative would be to treat
+# these files as binary and thus will always conflict and require user
+# intervention with every merge. To do so, just uncomment the entries below
+###############################################################################
+#*.sln       merge=binary
+#*.csproj    merge=binary
+#*.vbproj    merge=binary
+#*.vcxproj   merge=binary
+#*.vcproj    merge=binary
+#*.dbproj    merge=binary
+#*.fsproj    merge=binary
+#*.lsproj    merge=binary
+#*.wixproj   merge=binary
+#*.modelproj merge=binary
+#*.sqlproj   merge=binary
+#*.wwaproj   merge=binary
+
+###############################################################################
+# behavior for image files
+#
+# image files are treated as binary by default.
+###############################################################################
+#*.jpg   binary
+#*.png   binary
+#*.gif   binary
+
+###############################################################################
+# diff behavior for common document formats
+# 
+# Convert binary document formats to text before diffing them. This feature
+# is only available from the command line. Turn it on by uncommenting the 
+# entries below.
+###############################################################################
+#*.doc   diff=astextplain
+#*.DOC   diff=astextplain
+#*.docx  diff=astextplain
+#*.DOCX  diff=astextplain
+#*.dot   diff=astextplain
+#*.DOT   diff=astextplain
+#*.pdf   diff=astextplain
+#*.PDF   diff=astextplain
+#*.rtf   diff=astextplain
+#*.RTF   diff=astextplain

.gitignore

@@ -1,7 +1,5 @@
 ## Ignore Visual Studio temporary files, build results, and
 ## files generated by popular Visual Studio add-ons.
-##
-## Get latest from https://github.com/github/gitignore/blob/master/VisualStudio.gitignore
 
 # User-specific files
 *.suo
@@ -42,11 +40,10 @@ TestResult.xml
 [Rr]eleasePS/
 dlldata.c
 
-# .NET Core
+# DNX
 project.lock.json
 project.fragment.lock.json
 artifacts/
-**/Properties/launchSettings.json
 
 *_i.c
 *_p.c
@@ -113,10 +110,6 @@ _TeamCity*
 # DotCover is a Code Coverage Tool
 *.dotCover
 
-# Visual Studio code coverage results
-*.coverage
-*.coveragexml
-
 # NCrunch
 _NCrunch_*
 .*crunch*.local.xml
@@ -150,7 +143,7 @@ publish/
 *.azurePubxml
 # TODO: Comment the next line if you want to checkin your web deploy settings
 # but database connection strings (with potential passwords) will be unencrypted
-*.pubxml
+#*.pubxml
 *.publishproj
 
 # Microsoft Azure Web App publish settings. Comment the next line if you want to
@@ -166,7 +159,7 @@ PublishScripts/
 !**/packages/build/
 # Uncomment if necessary however generally it will be regenerated when needed
 #!**/packages/repositories.config
-# NuGet v3's project.json files produces more ignorable files
+# NuGet v3's project.json files produces more ignoreable files
 *.nuget.props
 *.nuget.targets
 
@@ -199,6 +192,7 @@ ClientBin/
 *.jfm
 *.pfx
 *.publishsettings
+node_modules/
 orleans.codegen.cs
 
 # Since there are multiple workflows, uncomment next line to ignore bower_components
@@ -219,7 +213,6 @@ UpgradeLog*.htm
 # SQL Server files
 *.mdf
 *.ldf
-*.ndf
 
 # Business Intelligence projects
 *.rdl.data
@@ -234,20 +227,13 @@ FakesAssemblies/
 
 # Node.js Tools for Visual Studio
 .ntvs_analysis.dat
-node_modules/
-
-# Typescript v1 declaration files
-typings/
 
 # Visual Studio 6 build log
 *.plg
 
 # Visual Studio 6 workspace options file
 *.opt
 
-# Visual Studio 6 auto-generated workspace file (contains which files were open etc.)
-*.vbw
-
 # Visual Studio LightSwitch build output
 **/*.HTMLClient/GeneratedArtifacts
 **/*.DesktopClient/GeneratedArtifacts
@@ -272,17 +258,4 @@ paket-files/
 
 # Python Tools for Visual Studio (PTVS)
 __pycache__/
-*.pyc
-
-# Cake - Uncomment if you are using it
-# tools/**
-# !tools/packages.config
-
-# Telerik's JustMock configuration file
-*.jmconfig
-
-# BizTalk build output
-*.btp.cs
-*.btm.cs
-*.odx.cs
-*.xsd.cs
+*.pyc

PoulinTheil.sln

@@ -0,0 +1,25 @@
+
+Microsoft Visual Studio Solution File, Format Version 12.00
+# Visual Studio 15
+VisualStudioVersion = 15.0.27004.2010
+MinimumVisualStudioVersion = 10.0.40219.1
+Project("{FAE04EC0-301F-11D3-BF4B-00C04F79EFBC}") = "PoulinTheil", "PoulinTheil\PoulinTheil.csproj", "{306322FA-BC8A-445B-B669-60CD884209EA}"
+EndProject
+Global
+	GlobalSection(SolutionConfigurationPlatforms) = preSolution
+		Debug|Any CPU = Debug|Any CPU
+		Release|Any CPU = Release|Any CPU
+	EndGlobalSection
+	GlobalSection(ProjectConfigurationPlatforms) = postSolution
+		{306322FA-BC8A-445B-B669-60CD884209EA}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
+		{306322FA-BC8A-445B-B669-60CD884209EA}.Debug|Any CPU.Build.0 = Debug|Any CPU
+		{306322FA-BC8A-445B-B669-60CD884209EA}.Release|Any CPU.ActiveCfg = Release|Any CPU
+		{306322FA-BC8A-445B-B669-60CD884209EA}.Release|Any CPU.Build.0 = Release|Any CPU
+	EndGlobalSection
+	GlobalSection(SolutionProperties) = preSolution
+		HideSolutionNode = FALSE
+	EndGlobalSection
+	GlobalSection(ExtensibilityGlobals) = postSolution
+		SolutionGuid = {E6E2A606-BD31-4197-8301-5CCA0CA41A3B}
+	EndGlobalSection
+EndGlobal

PoulinTheil/ExcelFunctions.cs

@@ -0,0 +1,122 @@
+using ExcelDna.Integration;
+using System.Collections.Generic;
+using System.Linq;
+using static System.Math;
+
+namespace PoulinTheil
+{
+  public class ExcelFunctions
+  {
+    [ExcelFunction(Description = "Pt:p at steady state, assuming a homogenous distribution and passive diffusion of drugs in tissues, from a ratio of solubility and macromolecular binding between tissues and plasma.")]
+    public static object Ptp_Eq11(
+      [ExcelArgument("rat|rabbit|mouse")] string species,
+      [ExcelArgument("brain|heart|lung|muscle|skin|intestine|spleen|bone")] string tissue,
+      [ExcelArgument("Log vegetable oil:water partition coefficient")] double logKvow,
+      [ExcelArgument("Unbound fraction in lipid non-depleted plasma")] double fup
+      )
+    {
+      species = species.Trim().ToLowerInvariant();
+      tissue = tissue.Trim().ToLowerInvariant();
+
+      if (tissue == "plasma") return ExcelError.ExcelErrorValue;
+      if(!_Vw.ContainsKey(tissue) || !_Vw.First().Value.ContainsKey(species)) return ExcelError.ExcelErrorValue;
+      var Vwt = _Vw[tissue][species];
+      var Vnt = _Vn[tissue][species];
+      var Vpht = _Vph[tissue][species];
+      if (double.IsNaN(Vwt) || double.IsNaN(Vnt) || double.IsNaN(Vpht)) return ExcelError.ExcelErrorNA;
+
+      var Vwp = _Vw["plasma"][species];
+      var Vnp = _Vn["plasma"][species];
+      var Vphp = _Vph["plasma"][species];
+
+      if (fup <= 0.0) return ExcelError.ExcelErrorDiv0;
+      var nKaCmp = (1.0 / fup) - 1.0;
+      var nKaCmt = nKaCmp * 0.5;
+      var fut = 1.0 / (1.0 + nKaCmt);
+
+      var Kvow = Pow(10, logKvow);
+
+      var StSw = Kvow * (Vnt + 0.3 * Vpht) + (Vwt + 0.7 * Vpht);
+      var SpSw = Kvow * (Vnp + 0.3 * Vphp) + (Vwp + 0.7 * Vphp);
+
+      var P = (StSw / SpSw) * (fup / fut);
+
+      return P;
+    }
+
+    [ExcelFunction(Description = "Pt:p, assuming non-homogenous distribution, of drugs residing predominantly in the interstitial space of tissues.")]
+    public static object Ptp_Eq14(
+      [ExcelArgument("brain|heart|lung|muscle|skin|intestine|spleen|bone")] string tissue,
+      [ExcelArgument("Unbound fraction in lipid non-depleted plasma")] double fup
+      )
+    {
+      tissue = tissue.Trim().ToLowerInvariant();
+
+      if (tissue == "plasma") return ExcelError.ExcelErrorValue;
+      if (!_Ft.ContainsKey(tissue)) return ExcelError.ExcelErrorValue;
+      var Ft = _Ft[tissue];
+
+      if (fup <= 0.0) return ExcelError.ExcelErrorDiv0;
+      var nKaCmp = (1.0 / fup) - 1.0;
+      var nKaCmt = nKaCmp * 0.5;
+      var fut = 1.0 / (1.0 + nKaCmt);
+
+      var P = (Ft / _Fp) * (fup / fut);
+
+      return P;
+    }
+
+    private static IDictionary<string, IDictionary<string, double>> _Vw = new SortedDictionary<string, IDictionary<string, double>>
+    {
+      ["plasma"] = new SortedDictionary<string, double> { ["rabbit"] = 0.94, ["rat"] = 0.96, ["mouse"] = 0.96 },
+      ["brain"] = new SortedDictionary<string, double> { ["rabbit"] = 0.74, ["rat"] = 0.75, ["mouse"] = 0.71 },
+      ["heart"] = new SortedDictionary<string, double> { ["rabbit"] = 0.79, ["rat"] = 0.77, ["mouse"] = 0.78 },
+      ["lung"] = new SortedDictionary<string, double> { ["rabbit"] = 0.78, ["rat"] = 0.78, ["mouse"] = 0.81 },
+      ["muscle"] = new SortedDictionary<string, double> { ["rabbit"] = 0.77, ["rat"] = 0.74, ["mouse"] = 0.67 },
+      ["skin"] = new SortedDictionary<string, double> { ["rabbit"] = 0.70, ["rat"] = 0.70, ["mouse"] = double.NaN },
+      ["intestine"] = new SortedDictionary<string, double> { ["rabbit"] = 0.70, ["rat"] = 0.70, ["mouse"] = 0.70 },
+      ["spleen"] = new SortedDictionary<string, double> { ["rabbit"] = double.NaN, ["rat"] = 0.77, ["mouse"] = 0.79 },
+      ["bone"] = new SortedDictionary<string, double> { ["rabbit"] = 0.35, ["rat"] = 0.35, ["mouse"] = double.NaN },
+    };
+
+    private static IDictionary<string, IDictionary<string, double>> _Vn = new SortedDictionary<string, IDictionary<string, double>>
+    {
+      ["plasma"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0015, ["rat"] = 0.00147, ["mouse"] = 0.0026 },
+      ["brain"] = new SortedDictionary<string, double> { ["rabbit"] = 0.05, ["rat"] = 0.0393, ["mouse"] = 0.031 },
+      ["heart"] = new SortedDictionary<string, double> { ["rabbit"] = 0.031, ["rat"] = 0.0117, ["mouse"] = 0.017 },
+      ["lung"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0332, ["rat"] = 0.0199, ["mouse"] = 0.0218 },
+      ["muscle"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0338, ["rat"] = 0.009, ["mouse"] = 0.0167 },
+      ["skin"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0205, ["rat"] = 0.0205, ["mouse"] = double.NaN },
+      ["intestine"] = new SortedDictionary<string, double> { ["rabbit"] = 0.032, ["rat"] = 0.032, ["mouse"] = 0.032 },
+      ["spleen"] = new SortedDictionary<string, double> { ["rabbit"] = double.NaN, ["rat"] = 0.0077, ["mouse"] = 0.0120 },
+      ["bone"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0222, ["rat"] = 0.0222, ["mouse"] = double.NaN },
+    };
+
+    private static IDictionary<string, IDictionary<string, double>> _Vph = new SortedDictionary<string, IDictionary<string, double>>
+    {
+      ["plasma"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0012, ["rat"] = 0.00083, ["mouse"] = 0.0032 },
+      ["brain"] = new SortedDictionary<string, double> { ["rabbit"] = 0.064, ["rat"] = 0.0532, ["mouse"] = 0.05 },
+      ["heart"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0082, ["rat"] = 0.0141, ["mouse"] = 0.014 },
+      ["lung"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0142, ["rat"] = 0.0170, ["mouse"] = 0.0162 },
+      ["muscle"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0062, ["rat"] = 0.01, ["mouse"] = 0.0273 },
+      ["skin"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0155, ["rat"] = 0.0155, ["mouse"] = double.NaN },
+      ["intestine"] = new SortedDictionary<string, double> { ["rabbit"] = 0.015, ["rat"] = 0.015, ["mouse"] = 0.015 },
+      ["spleen"] = new SortedDictionary<string, double> { ["rabbit"] = double.NaN, ["rat"] = 0.0136, ["mouse"] = 0.0107 },
+      ["bone"] = new SortedDictionary<string, double> { ["rabbit"] = 0.0005, ["rat"] = 0.0005, ["mouse"] = double.NaN },
+    };
+
+    private static IDictionary<string, double> _Ft = new SortedDictionary<string, double>
+    {
+      ["brain"] = 0.17,
+      ["heart"] = 0.1,
+      ["lung"] = 0.188,
+      ["muscle"] = 0.12,
+      ["skin"] = 0.302,
+      ["intestine"] = 0.094,
+      ["spleen"] = 0.15,
+      ["bone"] = 0.1,
+    };
+
+    private static double _Fp = 0.63;
+  }
+}

PoulinTheil/PoulinTheil-AddIn.dna

@@ -0,0 +1,20 @@
+<DnaLibrary Name="PoulinTheil Add-In" RuntimeVersion="v4.0">
+  <ExternalLibrary Path="PoulinTheil.dll" ExplicitExports="false" LoadFromBytes="true" Pack="true" />
+
+  <!-- 
+       The RuntimeVersion attribute above allows two settings:
+       * RuntimeVersion="v2.0" - for .NET 2.0, 3.0 and 3.5
+       * RuntimeVersion="v4.0" - for .NET 4 and 4.5
+
+       Additional referenced assemblies can be specified by adding 'Reference' tags. 
+       These libraries will not be examined and registered with Excel as add-in libraries, 
+       but will be packed into the -packed.xll file and loaded at runtime as needed.
+       For example:
+
+       <Reference Path="Another.Library.dll" Pack="true" />
+
+       Excel-DNA also allows the xml for ribbon UI extensions to be specified in the .dna file.
+       See the main Excel-DNA site at http://excel-dna.net for downloads of the full distribution.
+  -->
+
+</DnaLibrary>