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Update display of sequences to distinguish exons from introns #3872

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tberardini opened this issue Aug 25, 2023 · 6 comments · Fixed by #4354
Closed

Update display of sequences to distinguish exons from introns #3872

tberardini opened this issue Aug 25, 2023 · 6 comments · Fixed by #4354
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enhancement New feature or request

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@tberardini
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I'd like to be able to distinguish the exon sequences from the introns when working with the downloaded versions.

Describe the solution you'd like

exon sequence = shown in UPPER CASE
intron sequence = shown in lower case

Describe alternatives you've considered

Using the highlighting to guide the manual conversion to lower case. This is not a great solution.

Additional context
This would be for any of the sequence view options where intron sequence is included.

image

@tberardini tberardini added the enhancement New feature or request label Aug 25, 2023
@tberardini
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Checking on when this might rise to the top of the to-do list.

@tberardini
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Checking in again.

@cmdcolin
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@tberardini I proposed a PR here that could try to help #4354

it makes it so the CDS specifically are capitalized. It actually doesn't capitalize UTR parts of the exon, because I figured you might want to know where the coding boundaries are

let me know if that helps or if you think the full exon sequence should be capitalized

You can try out the branch with jbrowse create --branch advanced newfolder

@tberardini
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@cmdcolin This is great. I'm unable to test because I don't have the knowledge to do all that myself. However, the capitalization of the CDS is a great step forward. Maybe one could toggle whether the CDS or the exons are capitalized? Some of the people asking for this feature have wanted to easily see the exon/intron boundaries in the context of the genomic sequence.

@cmdcolin
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good note. i'll check into that.

if you want to try what it looks like on the latest branch, you can visit https://jbrowse.org/code/jb2/main/?session=share-iiDJabvMxM&password=O3Iv3

image

and the other feature request (#3873 ) is getting worked on as well by @carolinebridge-oicr !

@tberardini
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Thanks for that update. This is looking quite good already. I'm also excited that #3873 is moving as well. Thanks so much.

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Labels
enhancement New feature or request
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