This project should configure with "Release" not "Debug", Right?

[Sakura-Kinomoto]

Forgive my poor English ,I'm not native speaker.
I using VS2013 to compile vc14_64 project, configure with "Debug", but lib crashed .I try to search the reason, find the function "ffi_call_win64" is crashed during running. This function is declared in a assembly file named "win64_Intel.S". Firstly , I thought I'm not Intel platform but AMD64 platform, so this function did not work, but after my research, they told my that either Intel and AMD platform, they working same on this assembly file. Is that Right?
Then I find why the lib is crashing. Finally I thought configure may cause this issue. I convert "Debug" to "Release" ,the worked successfully.
I want to know ,why configure "Debug" was not working, but "Release" worded.
Thank you.