diff --git a/e2e/__tests__/calc/calc.component.ts b/e2e/__tests__/calc/calc.component.ts
index ecca06d89c..ca029c9e3e 100644
--- a/e2e/__tests__/calc/calc.component.ts
+++ b/e2e/__tests__/calc/calc.component.ts
@@ -1,5 +1,6 @@
 import { Component, Input } from '@angular/core';
-import * as image from 'e2e/test-app-v10/src/assets/its_something.png';
+
+import image from './its_something.png';
 
 @Component({
   selector: 'app-calc',
diff --git a/e2e/__tests__/calc/its_something.png b/e2e/__tests__/calc/its_something.png
new file mode 100644
index 0000000000..9f046efe98
Binary files /dev/null and b/e2e/__tests__/calc/its_something.png differ
diff --git a/e2e/__tests__/forward-ref/forward-ref.spec.ts b/e2e/__tests__/forward-ref/forward-ref.spec.ts
index 984fe59a33..da5681b5af 100644
--- a/e2e/__tests__/forward-ref/forward-ref.spec.ts
+++ b/e2e/__tests__/forward-ref/forward-ref.spec.ts
@@ -1,12 +1,10 @@
 import { forwardRef, Inject, Injector } from '@angular/core';
 
-const shouldSkipTest = process.env.NG_VERSION === 'v9' || process.env.ISOLATED_MODULES === 'true';
+const shouldSkipTest = process.env.ISOLATED_MODULES === 'true';
 const skipTest = shouldSkipTest ? test.skip : test;
 
 if (shouldSkipTest) {
-  process.stdout.write(
-    '\nforwardRef only works in non-isolatedModules mode with ES2015 in Angular 10+, with Angular 9 requires ES5\n',
-  );
+  process.stdout.write('\nforwardRef only works in non-isolatedModules mode\n');
 }
 
 skipTest('forwardRef should work', () => {
diff --git a/e2e/__tests__/heroes/hero.service.spec.ts b/e2e/__tests__/heroes/hero.service.spec.ts
index b58d09a00d..70d6fb8531 100644
--- a/e2e/__tests__/heroes/hero.service.spec.ts
+++ b/e2e/__tests__/heroes/hero.service.spec.ts
@@ -1,6 +1,7 @@
 import { HttpClientModule, HttpErrorResponse, HttpRequest } from '@angular/common/http';
 import { HttpClientTestingModule, HttpTestingController } from '@angular/common/http/testing';
 import { inject, TestBed } from '@angular/core/testing';
+import { jest } from '@jest/globals';
 
 import { heroesUrl, HeroService } from './hero.service';
 
diff --git a/e2e/__tests__/heroes/heroes.component.spec.ts b/e2e/__tests__/heroes/heroes.component.spec.ts
index 1b3192f8ef..02ec41e43b 100644
--- a/e2e/__tests__/heroes/heroes.component.spec.ts
+++ b/e2e/__tests__/heroes/heroes.component.spec.ts
@@ -1,4 +1,5 @@
 import { async, ComponentFixture } from '@angular/core/testing';
+import { jest } from '@jest/globals';
 import { Subject } from 'rxjs';
 
 import { ConfigureFn, configureTests } from '../__helpers__';
diff --git a/e2e/test-app-v10/jest-esm-iso.config.js b/e2e/test-app-v10/jest-esm-iso.config.js
index d29930b6e2..98289d0076 100644
--- a/e2e/test-app-v10/jest-esm-iso.config.js
+++ b/e2e/test-app-v10/jest-esm-iso.config.js
@@ -4,6 +4,7 @@ const baseConfig = require('./jest.config');
 /** @type {import('ts-jest/dist/types').ProjectConfigTsJest} */
 module.exports = {
   ...baseConfig,
+  extensionsToTreatAsEsm: ['.ts'],
   globals: {
     'ts-jest': {
       tsconfig: '<rootDir>/tsconfig-esm.spec.json',
@@ -12,4 +13,9 @@ module.exports = {
       isolatedModules: true,
     }
   },
+  moduleNameMapper: {
+    ...baseConfig.moduleNameMapper,
+    'tslib': '<rootDir>/node_modules/tslib/tslib.es6.js',
+  },
+  transformIgnorePatterns: ['node_modules/(?!tslib)'],
 };
diff --git a/e2e/test-app-v10/package.json b/e2e/test-app-v10/package.json
index aed7c60244..a4f19d5ab6 100644
--- a/e2e/test-app-v10/package.json
+++ b/e2e/test-app-v10/package.json
@@ -5,8 +5,9 @@
     "ng": "ng",
     "start": "ng serve",
     "build": "ng build",
-    "test-cjs-uniso": "jest --clearCache && jest -c=jest-cjs-uniso.config.js -u",
+    "test-cjs-uniso": "jest --clearCache && jest -c=jest-cjs-uniso.config.js",
     "test-cjs-iso": "jest --clearCache && jest -c=jest-cjs-iso.config.js",
+    "test-esm-iso": "jest --clearCache && node --experimental-vm-modules ./node_modules/jest/bin/jest.js -c=jest-esm-iso.config.js",
     "lint": "ng lint"
   },
   "private": true,
@@ -37,4 +38,4 @@
     "ts-node": "^9.1.1",
     "typescript": "~4.0.5"
   }
-}
\ No newline at end of file
+}
diff --git a/e2e/test-app-v10/tsconfig-esm.spec.json b/e2e/test-app-v10/tsconfig-esm.spec.json
index 22c1218935..5583ce3450 100644
--- a/e2e/test-app-v10/tsconfig-esm.spec.json
+++ b/e2e/test-app-v10/tsconfig-esm.spec.json
@@ -2,7 +2,6 @@
 {
   "extends": "./tsconfig.spec.json",
   "compilerOptions": {
-    "module": "ESNext",
-    "esModuleInterop": true
+    "module": "ESNext"
   },
 }
diff --git a/e2e/test-app-v10/tsconfig.spec.json b/e2e/test-app-v10/tsconfig.spec.json
index 94aacaaded..770989bc88 100644
--- a/e2e/test-app-v10/tsconfig.spec.json
+++ b/e2e/test-app-v10/tsconfig.spec.json
@@ -8,7 +8,9 @@
       "jquery",
       "node"
     ],
-    "allowJs": true
+    "allowJs": true,
+    "esModuleInterop": true,
+    "allowSyntheticDefaultImports": true
   },
   "files": [
     "src/global.ts"
diff --git a/e2e/test-app-v11/jest-esm-iso.config.js b/e2e/test-app-v11/jest-esm-iso.config.js
index d29930b6e2..98289d0076 100644
--- a/e2e/test-app-v11/jest-esm-iso.config.js
+++ b/e2e/test-app-v11/jest-esm-iso.config.js
@@ -4,6 +4,7 @@ const baseConfig = require('./jest.config');
 /** @type {import('ts-jest/dist/types').ProjectConfigTsJest} */
 module.exports = {
   ...baseConfig,
+  extensionsToTreatAsEsm: ['.ts'],
   globals: {
     'ts-jest': {
       tsconfig: '<rootDir>/tsconfig-esm.spec.json',
@@ -12,4 +13,9 @@ module.exports = {
       isolatedModules: true,
     }
   },
+  moduleNameMapper: {
+    ...baseConfig.moduleNameMapper,
+    'tslib': '<rootDir>/node_modules/tslib/tslib.es6.js',
+  },
+  transformIgnorePatterns: ['node_modules/(?!tslib)'],
 };
diff --git a/e2e/test-app-v11/package.json b/e2e/test-app-v11/package.json
index 8a637fcc51..d198c88577 100644
--- a/e2e/test-app-v11/package.json
+++ b/e2e/test-app-v11/package.json
@@ -7,6 +7,7 @@
     "build": "ng build",
     "test-cjs-uniso": "jest --clearCache && jest -c=jest-cjs-uniso.config.js",
     "test-cjs-iso": "jest --clearCache && jest -c=jest-cjs-iso.config.js",
+    "test-esm-iso": "jest --clearCache && node --experimental-vm-modules ./node_modules/jest/bin/jest.js -c=jest-esm-iso.config.js",
     "lint": "ng lint"
   },
   "private": true,
@@ -37,4 +38,4 @@
     "ts-node": "^9.1.1",
     "typescript": "~4.0.5"
   }
-}
\ No newline at end of file
+}
diff --git a/e2e/test-app-v11/tsconfig-esm.spec.json b/e2e/test-app-v11/tsconfig-esm.spec.json
index 22c1218935..5583ce3450 100644
--- a/e2e/test-app-v11/tsconfig-esm.spec.json
+++ b/e2e/test-app-v11/tsconfig-esm.spec.json
@@ -2,7 +2,6 @@
 {
   "extends": "./tsconfig.spec.json",
   "compilerOptions": {
-    "module": "ESNext",
-    "esModuleInterop": true
+    "module": "ESNext"
   },
 }
diff --git a/e2e/test-app-v11/tsconfig.spec.json b/e2e/test-app-v11/tsconfig.spec.json
index 94aacaaded..770989bc88 100644
--- a/e2e/test-app-v11/tsconfig.spec.json
+++ b/e2e/test-app-v11/tsconfig.spec.json
@@ -8,7 +8,9 @@
       "jquery",
       "node"
     ],
-    "allowJs": true
+    "allowJs": true,
+    "esModuleInterop": true,
+    "allowSyntheticDefaultImports": true
   },
   "files": [
     "src/global.ts"
diff --git a/e2e/test-app-v9/jest-esm-iso.config.js b/e2e/test-app-v9/jest-esm-iso.config.js
index d29930b6e2..98289d0076 100644
--- a/e2e/test-app-v9/jest-esm-iso.config.js
+++ b/e2e/test-app-v9/jest-esm-iso.config.js
@@ -4,6 +4,7 @@ const baseConfig = require('./jest.config');
 /** @type {import('ts-jest/dist/types').ProjectConfigTsJest} */
 module.exports = {
   ...baseConfig,
+  extensionsToTreatAsEsm: ['.ts'],
   globals: {
     'ts-jest': {
       tsconfig: '<rootDir>/tsconfig-esm.spec.json',
@@ -12,4 +13,9 @@ module.exports = {
       isolatedModules: true,
     }
   },
+  moduleNameMapper: {
+    ...baseConfig.moduleNameMapper,
+    'tslib': '<rootDir>/node_modules/tslib/tslib.es6.js',
+  },
+  transformIgnorePatterns: ['node_modules/(?!tslib)'],
 };
diff --git a/e2e/test-app-v9/package.json b/e2e/test-app-v9/package.json
index 5ed61ffb63..a68d09d47c 100644
--- a/e2e/test-app-v9/package.json
+++ b/e2e/test-app-v9/package.json
@@ -7,6 +7,7 @@
     "build": "ng build",
     "test-cjs-uniso": "jest --clearCache && jest -c=jest-cjs-uniso.config.js",
     "test-cjs-iso": "jest --clearCache && jest -c=jest-cjs-iso.config.js",
+    "test-esm-iso": "jest --clearCache && node --experimental-vm-modules ./node_modules/jest/bin/jest.js -c=jest-esm-iso.config.js",
     "lint": "ng lint"
   },
   "private": true,
@@ -37,4 +38,4 @@
     "ts-node": "^9.1.1",
     "typescript": "~3.8.3"
   }
-}
\ No newline at end of file
+}
diff --git a/e2e/test-app-v9/tsconfig-esm.spec.json b/e2e/test-app-v9/tsconfig-esm.spec.json
index 22c1218935..5583ce3450 100644
--- a/e2e/test-app-v9/tsconfig-esm.spec.json
+++ b/e2e/test-app-v9/tsconfig-esm.spec.json
@@ -2,7 +2,6 @@
 {
   "extends": "./tsconfig.spec.json",
   "compilerOptions": {
-    "module": "ESNext",
-    "esModuleInterop": true
+    "module": "ESNext"
   },
 }
diff --git a/e2e/test-app-v9/tsconfig.spec.json b/e2e/test-app-v9/tsconfig.spec.json
index 94aacaaded..770989bc88 100644
--- a/e2e/test-app-v9/tsconfig.spec.json
+++ b/e2e/test-app-v9/tsconfig.spec.json
@@ -8,7 +8,9 @@
       "jquery",
       "node"
     ],
-    "allowJs": true
+    "allowJs": true,
+    "esModuleInterop": true,
+    "allowSyntheticDefaultImports": true
   },
   "files": [
     "src/global.ts"
diff --git a/scripts/e2e.js b/scripts/e2e.js
index 579f5ca10a..46a0abe0cc 100755
--- a/scripts/e2e.js
+++ b/scripts/e2e.js
@@ -24,11 +24,6 @@ const executeTest = (projectRealPath) => {
   logger.log('='.repeat(20), `${projectPkg.name}@${projectPkg.version}`, 'in', projectRealPath, '='.repeat(20));
   logger.log();
 
-  logger.log('setting NG_VERSION environment variable');
-  logger.log();
-  const projectName = projectRealPath.match(/([^\\/]*)\/*$/)[1];
-  process.env.NG_VERSION = projectName.substring(projectName.lastIndexOf('-') + 1);
-
   // then we install it in the repo
   logger.log('ensuring all dependencies of target project are installed');
   logger.log();
@@ -61,14 +56,14 @@ const executeTest = (projectRealPath) => {
   // then we can run the tests
   const cmdCjsUnIso = ['yarn', 'test-cjs-uniso'];
   const cmdCjsIso = ['yarn', 'test-cjs-iso'];
-  // const cmdESMIso = ['yarn', 'test-esm-iso'];
+  const cmdESMIso = ['yarn', 'test-esm-iso'];
   if (jestArgs.length) {
     cmdCjsUnIso.push('--');
     cmdCjsIso.push('--');
-    // cmdESMIso.push('--');
+    cmdESMIso.push('--');
     cmdCjsUnIso.push(...jestArgs);
     cmdCjsIso.push(...jestArgs);
-    // cmdESMIso.push(...jestArgs);
+    cmdESMIso.push(...jestArgs);
   }
 
   logger.log('STARTING NONE ISOLATED MODULES TESTS');
@@ -98,19 +93,20 @@ const executeTest = (projectRealPath) => {
     env: process.env,
   });
 
-  // logger.log('starting the ESM tests using:', ...cmdCjsIso);
-  // logger.log();
-  //
-  // execa.sync(cmdESMIso.shift(), cmdESMIso, {
-  //   cwd: projectRealPath,
-  //   stdio: 'inherit',
-  //   env: process.env,
-  // });
+  logger.log();
+  logger.log('starting the ESM tests using:', ...cmdESMIso);
+  logger.log();
+
+  execa.sync(cmdESMIso.shift(), cmdESMIso, {
+    cwd: projectRealPath,
+    stdio: 'inherit',
+    env: process.env,
+  });
 
+  logger.log();
   logger.log('cleaning up');
 
   execa.sync('rimraf', [testCasesDest]);
-  delete process.env.NG_VERSION;
   delete process.env.ISOLATED_MODULES;
 };