diff --git a/x-pack/test/alerting_api_integration/security_and_spaces/tests/alerting/alerts.ts b/x-pack/test/alerting_api_integration/security_and_spaces/tests/alerting/alerts.ts
index 551498e22d5c8c..d20450f8ec47e9 100644
--- a/x-pack/test/alerting_api_integration/security_and_spaces/tests/alerting/alerts.ts
+++ b/x-pack/test/alerting_api_integration/security_and_spaces/tests/alerting/alerts.ts
@@ -761,7 +761,8 @@ export default function alertTests({ getService }: FtrProviderContext) {
           }
         });
 
-        it(`should unmute all instances when unmuting an alert`, async () => {
+        // Flaky: https://github.com/elastic/kibana/issues/54125
+        it.skip(`should unmute all instances when unmuting an alert`, async () => {
           const testStart = new Date();
           const reference = alertUtils.generateReference();
           const response = await alertUtils.createAlwaysFiringAction({