diff --git a/drf_spectacular/plumbing.py b/drf_spectacular/plumbing.py
index 179d80cb..b7da5b75 100644
--- a/drf_spectacular/plumbing.py
+++ b/drf_spectacular/plumbing.py
@@ -769,13 +769,18 @@ def load_enum_name_overrides():
             choices = [c.value for c in choices]
         normalized_choices = []
         for choice in choices:
-            if isinstance(choice, str):
+            # Allow None values in the simple values list case
+            if isinstance(choice, str) or choice is None:
                 normalized_choices.append((choice, choice))  # simple choice list
             elif isinstance(choice[1], (list, tuple)):
                 normalized_choices.extend(choice[1])  # categorized nested choices
             else:
                 normalized_choices.append(choice)  # normal 2-tuple form
-        overrides[list_hash(list(dict(normalized_choices).keys()))] = name
+
+        # Get all of choice values that should be used in the hash, blank and None values get excluded
+        # in the post-processing hook for enum overrides, so we do the same here to ensure the hashes match
+        hashable_values = list(value for value in dict(normalized_choices).keys() if value not in ['', None])
+        overrides[list_hash(hashable_values)] = name
 
     if len(spectacular_settings.ENUM_NAME_OVERRIDES) != len(overrides):
         error(
diff --git a/tests/test_postprocessing.py b/tests/test_postprocessing.py
index a3c1990a..3ef0c3fc 100644
--- a/tests/test_postprocessing.py
+++ b/tests/test_postprocessing.py
@@ -24,6 +24,15 @@
     ('cn', 'cn'),
 )
 
+blank_null_language_choices = (
+    ('en', 'en'),
+    ('es', 'es'),
+    ('ru', 'ru'),
+    ('cn', 'cn'),
+    ('', 'not provided'),
+    (None, 'unknown'),
+)
+
 vote_choices = (
     (1, 'Positive'),
     (0, 'Neutral'),
@@ -45,6 +54,29 @@ class LanguageChoices(TextChoices):
     EN = 'en'
 
 
+blank_null_language_list = ['en', '', None]
+
+
+class BlankNullLanguageEnum(Enum):
+    EN = 'en'
+    BLANK = ''
+    NULL = None
+
+
+class BlankNullLanguageStrEnum(str, Enum):
+    EN = 'en'
+    BLANK = ''
+    # These will still be included since the values get cast to strings so 'None' != None
+    NULL = None
+
+
+class BlankNullLanguageChoices(TextChoices):
+    EN = 'en'
+    BLANK = ''
+    # These will still be included since the values get cast to strings so 'None' != None
+    NULL = None
+
+
 class ASerializer(serializers.Serializer):
     language = serializers.ChoiceField(choices=language_choices)
     vote = serializers.ChoiceField(choices=vote_choices)
@@ -96,6 +128,40 @@ class XView(generics.RetrieveAPIView):
     assert len(schema['components']['schemas']) == 2
 
 
+@mock.patch('drf_spectacular.settings.spectacular_settings.ENUM_NAME_OVERRIDES', {
+    'LanguageEnum': 'tests.test_postprocessing.blank_null_language_choices'
+})
+def test_global_enum_naming_override_with_blank_and_none(no_warnings, clear_caches):
+    """Test that choices with blank values can still have their name overridden."""
+    class XSerializer(serializers.Serializer):
+        foo = serializers.ChoiceField(choices=blank_null_language_choices)
+        bar = serializers.ChoiceField(choices=blank_null_language_choices)
+
+    class XView(generics.RetrieveAPIView):
+        serializer_class = XSerializer
+
+    schema = generate_schema('/x', view=XView)
+    foo_data = schema['components']['schemas']['X']['properties']['foo']
+    bar_data = schema['components']['schemas']['X']['properties']['bar']
+
+    assert len(foo_data['oneOf']) == 3
+    assert len(bar_data['oneOf']) == 3
+
+    foo_ref_values = [ref_object['$ref'] for ref_object in foo_data['oneOf']]
+    bar_ref_values = [ref_object['$ref'] for ref_object in bar_data['oneOf']]
+
+    assert foo_ref_values == [
+        '#/components/schemas/LanguageEnum',
+        '#/components/schemas/BlankEnum',
+        '#/components/schemas/NullEnum'
+    ]
+    assert bar_ref_values == [
+        '#/components/schemas/LanguageEnum',
+        '#/components/schemas/BlankEnum',
+        '#/components/schemas/NullEnum'
+    ]
+
+
 def test_enum_name_reuse_warning(capsys):
     class XSerializer(serializers.Serializer):
         foo = serializers.ChoiceField(choices=language_choices)
@@ -191,6 +257,31 @@ def test_enum_override_variations(no_warnings):
             assert list_hash(['en']) in load_enum_name_overrides()
 
 
+def test_enum_override_variations_with_blank_and_null(no_warnings):
+    enum_override_variations = [
+        'blank_null_language_list',
+        'BlankNullLanguageEnum',
+        ('BlankNullLanguageStrEnum', ['en', 'None'])
+    ]
+    if DJANGO_VERSION > '3':
+        enum_override_variations += [
+            ('BlankNullLanguageChoices', ['en', 'None']),
+            ('BlankNullLanguageChoices.choices', ['en', 'None'])
+        ]
+
+    for variation in enum_override_variations:
+        expected_hashed_keys = ['en']
+        if isinstance(variation, (list, tuple, )):
+            variation, expected_hashed_keys = variation
+        with mock.patch(
+            'drf_spectacular.settings.spectacular_settings.ENUM_NAME_OVERRIDES',
+            {'LanguageEnum': f'tests.test_postprocessing.{variation}'}
+        ):
+            load_enum_name_overrides.cache_clear()
+            # Should match after None and blank strings are removed
+            assert list_hash(expected_hashed_keys) in load_enum_name_overrides()
+
+
 @mock.patch('drf_spectacular.settings.spectacular_settings.ENUM_NAME_OVERRIDES', {
     'LanguageEnum': 'tests.test_postprocessing.NOTEXISTING'
 })