diff --git a/drf_spectacular/openapi.py b/drf_spectacular/openapi.py
index a850b6f4..372879e3 100644
--- a/drf_spectacular/openapi.py
+++ b/drf_spectacular/openapi.py
@@ -1078,7 +1078,7 @@ def _get_response_for_code(self, serializer, status_code, media_types=None):
         if (
             self._is_list_view(serializer)
             and get_override(serializer, 'many') is not False
-            and '200' <= status_code < '300'
+            and ('200' <= status_code < '300' or spectacular_settings.ENABLE_LIST_MECHANICS_ON_NON_2XX)
         ):
             schema = build_array_type(schema)
             paginator = self._get_paginator()
diff --git a/drf_spectacular/settings.py b/drf_spectacular/settings.py
index 0a2eae6f..cc3d5573 100644
--- a/drf_spectacular/settings.py
+++ b/drf_spectacular/settings.py
@@ -107,6 +107,12 @@
     # the order they arrived. Accepts either True, False, or a callable for sort's key arg.
     'SORT_OPERATION_PARAMETERS': True,
 
+    # @extend_schema allows to specify status codes besides 200. This functionality is usually used
+    # to describe error responses, which rarely make use of list mechanics. Therefore, we suppress
+    # listing (pagination and filtering) on non-2XX status codes by default. Toggle this to enable
+    # list responses with ListSerializers/many=True irrespective of the status code.
+    'ENABLE_LIST_MECHANICS_ON_NON_2XX': False,
+
     # Option for turning off error and warn messages
     'DISABLE_ERRORS_AND_WARNINGS': False,
 
diff --git a/tests/test_regressions.py b/tests/test_regressions.py
index a95b07db..80420c5b 100644
--- a/tests/test_regressions.py
+++ b/tests/test_regressions.py
@@ -2027,7 +2027,7 @@ def get(self, request):
     }
 
 
-def test_serializer_method_field_with_functools_partial():
+def test_serializer_method_field_with_functools_partial(no_warnings):
     class XSerializer(serializers.Serializer):
         foo = serializers.SerializerMethodField()
         bar = serializers.SerializerMethodField()
@@ -2052,3 +2052,27 @@ def view_func(request, format=None):
         'foo': {'type': 'string', 'format': 'date', 'readOnly': True},
         'bar': {'type': 'integer', 'readOnly': True}
     }
+
+
+@mock.patch(
+    'drf_spectacular.settings.spectacular_settings.ENABLE_LIST_MECHANICS_ON_NON_2XX', True
+)
+def test_disable_list_mechanics_on_non_2XX(no_warnings):
+    @extend_schema(
+        request=SimpleSerializer,
+        responses={
+            200: SimpleSerializer(many=True),
+            400: SimpleSerializer(many=True),
+        }
+    )
+    @api_view(['POST'])
+    def view_func(request, format=None):
+        pass  # pragma: no cover
+
+    schema = generate_schema('/x/', view_function=view_func)
+    assert get_response_schema(schema['paths']['/x/']['post'], status='200') == {
+        'type': 'array', 'items': {'$ref': '#/components/schemas/Simple'}
+    }
+    assert get_response_schema(schema['paths']['/x/']['post'], status='400') == {
+        'type': 'array', 'items': {'$ref': '#/components/schemas/Simple'}
+    }