diff --git a/tools/webpack/shared.js b/tools/webpack/shared.js
index ec12959351151..9cfd335176492 100644
--- a/tools/webpack/shared.js
+++ b/tools/webpack/shared.js
@@ -41,15 +41,6 @@ const getBaseConfig = ( env ) => {
 		watch: env.watch,
 		plugins: [
 			new DefinePlugin( {
-				/*
-				 * These variables are part of https://github.com/WordPress/gutenberg/pull/61486
-				 * They're expected to be released in an upcoming version of Gutenberg.
-				 *
-				 * Defining this before the packages are released is harmless.
-				 *
-				 * @todo Remove the non-globalThis defines here when packages have been upgraded to the globalThis versions.
-				 */
-
 				// Inject the `IS_GUTENBERG_PLUGIN` global, used for feature flagging.
 				'globalThis.IS_GUTENBERG_PLUGIN': JSON.stringify( false ),
 				// Inject the `IS_WORDPRESS_CORE` global, used for feature flagging.
@@ -58,13 +49,6 @@ const getBaseConfig = ( env ) => {
 				'globalThis.SCRIPT_DEBUG': JSON.stringify(
 					mode === 'development'
 				),
-
-				// Inject the `IS_GUTENBERG_PLUGIN` global, used for feature flagging.
-				'process.env.IS_GUTENBERG_PLUGIN': JSON.stringify( false ),
-				// Inject the `IS_WORDPRESS_CORE` global, used for feature flagging.
-				'process.env.IS_WORDPRESS_CORE': JSON.stringify( true ),
-				// Inject the `SCRIPT_DEBUG` global, used for dev versions of JavaScript.
-				SCRIPT_DEBUG: JSON.stringify( mode === 'development' ),
 			} ),
 		],
 	};