diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 00000000..2d647dcf
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,57 @@
+[build-system]
+requires = ["setuptools>=61.2", "setuptools_scm[toml]>=3.4.3"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "securesystemslib"
+authors = [{name = "https://www.updateframework.com", email = "theupdateframework@googlegroups.com"}]
+license = {text = "MIT"}
+description = "A library that provides cryptographic and general-purpose routines for Secure Systems Lab projects at NYU"
+readme = "README.rst"
+keywords = [
+    "cryptography",
+    "keys",
+    "signatures",
+    "rsa",
+    "ed25519",
+    "ecdsa",
+]
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: MIT License",
+    "Natural Language :: English",
+    "Operating System :: POSIX",
+    "Operating System :: POSIX :: Linux",
+    "Operating System :: MacOS :: MacOS X",
+    "Operating System :: Microsoft :: Windows",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3.7",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: Implementation :: CPython",
+    "Topic :: Security",
+    "Topic :: Software Development",
+]
+requires-python = "~=3.7"
+dynamic = ["version"]
+
+[project.urls]
+Homepage = "https://github.com/secure-systems-lab/securesystemslib"
+Source = "https://github.com/secure-systems-lab/securesystemslib"
+Issues = "https://github.com/secure-systems-lab/securesystemslib/issues"
+
+[project.optional-dependencies]
+crypto = ["cryptography>=37.0.0"]
+pynacl = ["pynacl>1.2.0"]
+PySPX = ["PySPX==0.5.0"]
+
+[tool.setuptools]
+include-package-data = true
+
+[tool.setuptools.packages.find]
+exclude = ["tests"] # debian
+namespaces = false
+
+[tool.setuptools_scm]
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 75f102df..00000000
--- a/setup.py
+++ /dev/null
@@ -1,109 +0,0 @@
-#! /usr/bin/env python
-
-"""
-<Program Name>
-  setup.py
-
-<Author>
-  Vladimir Diaz <vladimir.v.diaz@gmail.com>
-
-<Started>
-  December 7, 2016.
-
-<Copyright>
-  See LICENSE for licensing information.
-
-<Purpose>
-  BUILD SOURCE DISTRIBUTION
-
-  The following shell command generates a securesystemslib source archive that
-  can be distributed to other users.  The packaged source is saved to the
-  'dist' folder in the current directory.
-
-  $ python setup.py sdist
-
-
-  INSTALLATION OPTIONS
-
-  pip - installing and managing Python packages (recommended):
-
-  # Installing from Python Package Index (https://pypi.python.org/pypi).
-  $ pip install securesystemslib
-
-  # Installing from local source archive.
-  $ pip install <path to archive>
-
-  # Or from the root directory of the unpacked archive.
-  $ pip install .
-
-  Alternate installation options:
-
-  Navigate to the root directory of the unpacked archive and
-  run one of the following shell commands:
-
-  Install to the global site-packages directory.
-  $ python setup.py install
-
-  Install to the user site-packages directory.
-  $ python setup.py install --user
-
-  Install to a chosen directory.
-  $ python setup.py install --home=<directory>
-
-
-  Note: The last two installation options may require modification of
-  Python's search path (i.e., 'sys.path') or updating an OS environment
-  variable.  For example, installing to the user site-packages directory might
-  result in the installation of scripts to '~/.local/bin'.  The user may
-  then be required to update his $PATH variable:
-  $ export PATH=$PATH:~/.local/bin
-"""
-
-from setuptools import find_packages, setup
-
-with open("README.rst") as file_object:
-    long_description = file_object.read()
-
-setup(
-    name="securesystemslib",
-    version="0.25.0",
-    description="A library that provides cryptographic and general-purpose"
-    " routines for Secure Systems Lab projects at NYU",
-    license="MIT",
-    long_description=long_description,
-    long_description_content_type="text/x-rst",
-    author="https://www.updateframework.com",
-    author_email="theupdateframework@googlegroups.com",
-    url="https://github.com/secure-systems-lab/securesystemslib",
-    keywords="cryptography, keys, signatures, rsa, ed25519, ecdsa",
-    classifiers=[
-        "Development Status :: 4 - Beta",
-        "Intended Audience :: Developers",
-        "License :: OSI Approved :: MIT License",
-        "Natural Language :: English",
-        "Operating System :: POSIX",
-        "Operating System :: POSIX :: Linux",
-        "Operating System :: MacOS :: MacOS X",
-        "Operating System :: Microsoft :: Windows",
-        "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.7",
-        "Programming Language :: Python :: 3.8",
-        "Programming Language :: Python :: 3.9",
-        "Programming Language :: Python :: 3.10",
-        "Programming Language :: Python :: Implementation :: CPython",
-        "Topic :: Security",
-        "Topic :: Software Development",
-    ],
-    project_urls={
-        "Source": "https://github.com/secure-systems-lab/securesystemslib",
-        "Issues": "https://github.com/secure-systems-lab/securesystemslib/issues",
-    },
-    python_requires="~=3.7",
-    extras_require={
-        "crypto": ["cryptography>=37.0.0"],
-        "pynacl": ["pynacl>1.2.0"],
-        "PySPX": ["PySPX==0.5.0"],
-    },
-    packages=find_packages(exclude=["tests", "debian"]),
-    scripts=[],
-)