diff --git a/tests/end-to-end/regression/5493.phpt b/tests/end-to-end/regression/5493.phpt
new file mode 100644
index 00000000000..8dd1d687b5f
--- /dev/null
+++ b/tests/end-to-end/regression/5493.phpt
@@ -0,0 +1,31 @@
+--TEST--
+https://github.com/sebastianbergmann/phpunit/issues/5493
+--XFAIL--
+https://github.com/sebastianbergmann/phpunit/issues/5493
+--FILE--
+<?php declare(strict_types=1);
+$_SERVER['argv'][] = '--do-not-cache-result';
+$_SERVER['argv'][] = '--no-configuration';
+$_SERVER['argv'][] = __DIR__ . '/5493';
+
+require_once __DIR__ . '/../../bootstrap.php';
+
+(new PHPUnit\TextUI\Application)->run($_SERVER['argv']);
+--EXPECTF--
+PHPUnit %s by Sebastian Bergmann and contributors.
+
+Runtime: %s
+
+F                                                                   1 / 1 (100%)
+
+Time: %s, Memory: %s
+
+There was 1 failure:
+
+1) PHPUnit\TestFixture\Issue5493\Issue5493Test::testOne
+Failed asserting that true is false.
+
+%sIssue5493Test.php:19
+
+FAILURES!
+Tests: 1, Assertions: 1, Failures: 1.
diff --git a/tests/end-to-end/regression/5493/Issue5493Test.php b/tests/end-to-end/regression/5493/Issue5493Test.php
new file mode 100644
index 00000000000..5be15f4d06f
--- /dev/null
+++ b/tests/end-to-end/regression/5493/Issue5493Test.php
@@ -0,0 +1,26 @@
+<?php declare(strict_types=1);
+/*
+ * This file is part of PHPUnit.
+ *
+ * (c) Sebastian Bergmann <sebastian@phpunit.de>
+ *
+ * For the full copyright and license information, please view the LICENSE
+ * file that was distributed with this source code.
+ */
+namespace PHPUnit\TestFixture\Issue5493;
+
+use PHPUnit\Framework\TestCase;
+
+final class Issue5493Test extends TestCase
+{
+    protected function setUp(): void
+    {
+        /** @noinspection PhpUnitAssertCanBeReplacedWithFailInspection */
+        $this->assertTrue(false);
+    }
+
+    public function testOne(): void
+    {
+        $this->assertTrue(true);
+    }
+}