diff --git a/CMakeLists.txt b/CMakeLists.txt
index e20f1352701..1b17d0e7c98 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -78,6 +78,10 @@ OPTION(WANT_VST_32	"Include 32-bit VST support" ON)
 OPTION(WANT_VST_64	"Include 64-bit VST support" ON)
 OPTION(WANT_WINMM	"Include WinMM MIDI support" OFF)
 OPTION(WANT_DEBUG_FPE	"Debug floating point exceptions" OFF)
+option(WANT_DEBUG_ASAN	"Enable AddressSanitizer" OFF)
+option(WANT_DEBUG_TSAN	"Enable ThreadSanitizer" OFF)
+option(WANT_DEBUG_MSAN	"Enable MemorySanitizer" OFF)
+option(WANT_DEBUG_UBSAN	"Enable UndefinedBehaviorSanitizer" OFF)
 OPTION(BUNDLE_QT_TRANSLATIONS	"Install Qt translation files for LMMS" OFF)
 
 
@@ -649,6 +653,31 @@ IF(CMAKE_CXX_COMPILER_ID MATCHES "GNU|Clang")
 	ENDIF(WIN32)
 ENDIF()
 
+# add enabled sanitizers
+function(add_sanitizer sanitizer supported_compilers want_flag status_flag)
+	if(${want_flag})
+		if(CMAKE_CXX_COMPILER_ID MATCHES "${supported_compilers}")
+			set("${status_flag}" "Enabled" PARENT_SCOPE)
+			string(REPLACE ";" " " additional_flags "${ARGN}")
+			# todo CMake 3.13: use add_compile_options/add_link_options instead
+			set(CMAKE_C_FLAGS_DEBUG "${CMAKE_C_FLAGS_DEBUG} -fsanitize=${sanitizer} ${additional_flags}" PARENT_SCOPE)
+			set(CMAKE_CXX_FLAGS_DEBUG "${CMAKE_CXX_FLAGS_DEBUG} -fsanitize=${sanitizer} ${additional_flags}" PARENT_SCOPE)
+		else()
+			set("${status_flag}" "Wanted but disabled due to unsupported compiler" PARENT_SCOPE)
+		endif()
+	else()
+		set("${status_flag}" "Disabled" PARENT_SCOPE)
+	endif()
+endfunction()
+
+add_sanitizer(address "GNU|Clang|MSVC" WANT_DEBUG_ASAN STATUS_DEBUG_ASAN)
+add_sanitizer(thread "GNU|Clang" WANT_DEBUG_TSAN STATUS_DEBUG_TSAN)
+add_sanitizer(memory "Clang" WANT_DEBUG_MSAN STATUS_DEBUG_MSAN -fno-omit-frame-pointer)
+# UBSan does not link with vptr enabled due to a problem with references from PeakControllerEffect
+# not being found by PeakController
+add_sanitizer(undefined "GNU|Clang" WANT_DEBUG_UBSAN STATUS_DEBUG_UBSAN -fno-sanitize=vptr)
+
+
 # use ccache
 include(CompileCache)
 
@@ -717,7 +746,6 @@ ADD_CUSTOM_TARGET(uninstall
 	COMMAND ${CMAKE_COMMAND} -DCMAKE_INSTALL_PREFIX="${CMAKE_INSTALL_PREFIX}" -P "${CMAKE_CURRENT_SOURCE_DIR}/cmake/uninstall.cmake"
 )
 
-
 #
 # display configuration information
 #
@@ -783,7 +811,11 @@ MESSAGE(
 MESSAGE(
 "Developer options\n"
 "-----------------------------------------\n"
-"* Debug FP exceptions         : ${STATUS_DEBUG_FPE}\n"
+"* Debug FP exceptions               : ${STATUS_DEBUG_FPE}\n"
+"* Debug using AddressSanitizer      : ${STATUS_DEBUG_ASAN}\n"
+"* Debug using ThreadSanitizer       : ${STATUS_DEBUG_TSAN}\n"
+"* Debug using MemorySanitizer       : ${STATUS_DEBUG_MSAN}\n"
+"* Debug using UBSanitizer           : ${STATUS_DEBUG_UBSAN}\n"
 )
 
 MESSAGE(
diff --git a/plugins/LadspaEffect/calf/CMakeLists.txt b/plugins/LadspaEffect/calf/CMakeLists.txt
index 90f50641738..0c9cd8fa96e 100644
--- a/plugins/LadspaEffect/calf/CMakeLists.txt
+++ b/plugins/LadspaEffect/calf/CMakeLists.txt
@@ -36,9 +36,9 @@ TARGET_COMPILE_DEFINITIONS(veal PRIVATE DISABLE_OSC=1)
 
 SET(INLINE_FLAGS "")
 IF("${CMAKE_CXX_COMPILER_ID}" STREQUAL "GNU")
-	SET(INLINE_FLAGS "-finline-functions-called-once -finline-limit=80")
+	SET(INLINE_FLAGS -finline-functions-called-once -finline-limit=80)
 ENDIF()
-SET_TARGET_PROPERTIES(veal PROPERTIES COMPILE_FLAGS "-fexceptions -O2 -finline-functions ${INLINE_FLAGS}")
+target_compile_options(veal PRIVATE -fexceptions -O2 -finline-functions ${INLINE_FLAGS})
 
 if(LMMS_BUILD_WIN32)
 	add_custom_command(
@@ -50,5 +50,5 @@ if(LMMS_BUILD_WIN32)
 	)
 endif()
 IF(NOT LMMS_BUILD_APPLE AND NOT LMMS_BUILD_OPENBSD)
-	SET_TARGET_PROPERTIES(veal PROPERTIES LINK_FLAGS "${LINK_FLAGS} -shared -Wl,-no-undefined")
+	target_link_libraries(veal PRIVATE -shared)
 ENDIF()
diff --git a/plugins/LadspaEffect/cmt/CMakeLists.txt b/plugins/LadspaEffect/cmt/CMakeLists.txt
index ded7b895898..75dba319d6c 100644
--- a/plugins/LadspaEffect/cmt/CMakeLists.txt
+++ b/plugins/LadspaEffect/cmt/CMakeLists.txt
@@ -5,7 +5,7 @@ ADD_LIBRARY(cmt MODULE ${SOURCES})
 INSTALL(TARGETS cmt LIBRARY DESTINATION "${PLUGIN_DIR}/ladspa")
 
 SET_TARGET_PROPERTIES(cmt PROPERTIES PREFIX "")
-SET_TARGET_PROPERTIES(cmt PROPERTIES COMPILE_FLAGS "-Wall -O3 -fno-strict-aliasing")
+target_compile_options(cmt PRIVATE -Wall -O3 -fno-strict-aliasing)
 
 if(LMMS_BUILD_WIN32)
 	add_custom_command(
@@ -18,10 +18,10 @@ if(LMMS_BUILD_WIN32)
 endif()
 
 if(NOT LMMS_BUILD_WIN32)
-	set_target_properties(cmt PROPERTIES COMPILE_FLAGS "${COMPILE_FLAGS} -fPIC")
+	target_compile_options(cmt PRIVATE -fPIC)
 endif()
 
 IF(NOT LMMS_BUILD_APPLE AND NOT LMMS_BUILD_OPENBSD)
-	SET_TARGET_PROPERTIES(cmt PROPERTIES LINK_FLAGS "${LINK_FLAGS} -shared -Wl,-no-undefined")
+	target_link_libraries(cmt PRIVATE -shared)
 ENDIF()