diff --git a/compiler/rustc_codegen_gcc/src/builder.rs b/compiler/rustc_codegen_gcc/src/builder.rs
index fff2aa6df7c72..997213d43e8c0 100644
--- a/compiler/rustc_codegen_gcc/src/builder.rs
+++ b/compiler/rustc_codegen_gcc/src/builder.rs
@@ -1404,7 +1404,7 @@ impl<'a, 'gcc, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'gcc, 'tcx> {
         self.cx
     }
 
-    fn do_not_inline(&mut self, _llret: RValue<'gcc>) {
+    fn mark_callsite_cold(&mut self, _llret: RValue<'gcc>) {
         unimplemented!();
     }
 
diff --git a/compiler/rustc_codegen_llvm/src/builder.rs b/compiler/rustc_codegen_llvm/src/builder.rs
index 8c3054b23ff41..107300ed304f6 100644
--- a/compiler/rustc_codegen_llvm/src/builder.rs
+++ b/compiler/rustc_codegen_llvm/src/builder.rs
@@ -1201,8 +1201,8 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         unsafe { llvm::LLVMBuildZExt(self.llbuilder, val, dest_ty, UNNAMED) }
     }
 
-    fn do_not_inline(&mut self, llret: &'ll Value) {
-        llvm::Attribute::NoInline.apply_callsite(llvm::AttributePlace::Function, llret);
+    fn mark_callsite_cold(&mut self, llret: &'ll Value) {
+        llvm::Attribute::Cold.apply_callsite(llvm::AttributePlace::Function, llret);
     }
 }
 
diff --git a/compiler/rustc_codegen_ssa/src/mir/block.rs b/compiler/rustc_codegen_ssa/src/mir/block.rs
index e914e49326932..8cefd415e28b8 100644
--- a/compiler/rustc_codegen_ssa/src/mir/block.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/block.rs
@@ -160,11 +160,8 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
             let llret = bx.call(fn_ty, fn_ptr, &llargs, self.funclet(fx));
             bx.apply_attrs_callsite(&fn_abi, llret);
             if fx.mir[self.bb].is_cleanup {
-                // Cleanup is always the cold path. Don't inline
-                // drop glue. Also, when there is a deeply-nested
-                // struct, there are "symmetry" issues that cause
-                // exponential inlining - see issue #41696.
-                bx.do_not_inline(llret);
+                // Cleanup is always the cold path.
+                bx.mark_callsite_cold(llret);
             }
 
             if let Some((ret_dest, target)) = destination {
diff --git a/compiler/rustc_codegen_ssa/src/traits/builder.rs b/compiler/rustc_codegen_ssa/src/traits/builder.rs
index 158e658301eed..c1cdff3addadd 100644
--- a/compiler/rustc_codegen_ssa/src/traits/builder.rs
+++ b/compiler/rustc_codegen_ssa/src/traits/builder.rs
@@ -311,5 +311,5 @@ pub trait BuilderMethods<'a, 'tcx>:
     ) -> Self::Value;
     fn zext(&mut self, val: Self::Value, dest_ty: Self::Type) -> Self::Value;
 
-    fn do_not_inline(&mut self, llret: Self::Value);
+    fn mark_callsite_cold(&mut self, llret: Self::Value);
 }
diff --git a/src/test/codegen/unwind-landingpad-cold.rs b/src/test/codegen/unwind-landingpad-cold.rs
new file mode 100644
index 0000000000000..0bf2941374a66
--- /dev/null
+++ b/src/test/codegen/unwind-landingpad-cold.rs
@@ -0,0 +1,14 @@
+// compile-flags: -Cno-prepopulate-passes
+#![crate_type = "lib"]
+
+// This test checks that drop calls in unwind landing pads
+// get the `cold` attribute.
+
+// CHECK-LABEL: @check_cold
+// CHECK: call void {{.+}}drop_in_place{{.+}} [[ATTRIBUTES:#[0-9]+]]
+// CHECK: attributes [[ATTRIBUTES]] = { cold }
+#[no_mangle]
+pub fn check_cold(f: fn(), x: Box<u32>) {
+    // this may unwind
+    f();
+}
diff --git a/src/test/codegen/unwind-landingpad-inline.rs b/src/test/codegen/unwind-landingpad-inline.rs
new file mode 100644
index 0000000000000..d641c908ea99a
--- /dev/null
+++ b/src/test/codegen/unwind-landingpad-inline.rs
@@ -0,0 +1,22 @@
+// no-system-llvm: needs patch for Rust alloc/dealloc functions
+// compile-flags: -Copt-level=3
+#![crate_type = "lib"]
+
+// This test checks that we can inline drop_in_place in
+// unwind landing pads. Without this, the box pointers escape,
+// and LLVM will not optimize out the pointer comparison.
+// See https://github.com/rust-lang/rust/issues/46515
+
+// Everything should be optimized out.
+// CHECK-LABEL: @check_no_escape_in_landingpad
+// CHECK: start:
+// CHECK-NEXT: ret void
+#[no_mangle]
+pub fn check_no_escape_in_landingpad(f: fn()) {
+    let x = &*Box::new(0);
+    let y = &*Box::new(0);
+
+    if x as *const _ == y as *const _ {
+        f();
+    }
+}