diff --git a/build.rs b/build.rs
index 0ee39951c0723..5b709da55e1eb 100644
--- a/build.rs
+++ b/build.rs
@@ -14,7 +14,6 @@ const ALLOWED_CFGS: &'static [&'static str] = &[
     "freebsd13",
     "freebsd14",
     "freebsd15",
-    "libc_cfg_target_vendor",
     "libc_const_extern_fn",
     "libc_const_extern_fn_unstable",
     "libc_deny_warnings",
@@ -84,11 +83,6 @@ fn main() {
         set_cfg("libc_deny_warnings");
     }
 
-    // Rust >= 1.33 supports cfg(target_vendor).
-    if rustc_minor_ver >= 33 || rustc_dep_of_std {
-        set_cfg("libc_cfg_target_vendor");
-    }
-
     // Rust >= 1.40 supports #[non_exhaustive].
     if rustc_minor_ver >= 40 || rustc_dep_of_std {
         set_cfg("libc_non_exhaustive");
diff --git a/src/unix/mod.rs b/src/unix/mod.rs
index af5925197d2ab..b3cc7424cd0d4 100644
--- a/src/unix/mod.rs
+++ b/src/unix/mod.rs
@@ -642,21 +642,13 @@ extern "C" {
     pub fn getchar_unlocked() -> ::c_int;
     pub fn putchar_unlocked(c: ::c_int) -> ::c_int;
 
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(target_os = "netbsd", link_name = "__socket30")]
     #[cfg_attr(target_os = "illumos", link_name = "__xnet_socket")]
     #[cfg_attr(target_os = "solaris", link_name = "__xnet7_socket")]
     #[cfg_attr(target_os = "espidf", link_name = "lwip_socket")]
     pub fn socket(domain: ::c_int, ty: ::c_int, protocol: ::c_int) -> ::c_int;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(
         all(target_os = "macos", target_arch = "x86"),
         link_name = "connect$UNIX2003"
@@ -673,22 +665,14 @@ extern "C" {
     )]
     #[cfg_attr(target_os = "espidf", link_name = "lwip_listen")]
     pub fn listen(socket: ::c_int, backlog: ::c_int) -> ::c_int;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(
         all(target_os = "macos", target_arch = "x86"),
         link_name = "accept$UNIX2003"
     )]
     #[cfg_attr(target_os = "espidf", link_name = "lwip_accept")]
     pub fn accept(socket: ::c_int, address: *mut sockaddr, address_len: *mut socklen_t) -> ::c_int;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(
         all(target_os = "macos", target_arch = "x86"),
         link_name = "getpeername$UNIX2003"
@@ -699,11 +683,7 @@ extern "C" {
         address: *mut sockaddr,
         address_len: *mut socklen_t,
     ) -> ::c_int;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(
         all(target_os = "macos", target_arch = "x86"),
         link_name = "getsockname$UNIX2003"
@@ -736,11 +716,7 @@ extern "C" {
         protocol: ::c_int,
         socket_vector: *mut ::c_int,
     ) -> ::c_int;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(
         all(target_os = "macos", target_arch = "x86"),
         link_name = "sendto$UNIX2003"
@@ -1250,11 +1226,7 @@ extern "C" {
     pub fn dlsym(handle: *mut ::c_void, symbol: *const ::c_char) -> *mut ::c_void;
     pub fn dlclose(handle: *mut ::c_void) -> ::c_int;
 
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(
         any(target_os = "illumos", target_os = "solaris"),
         link_name = "__xnet_getaddrinfo"
@@ -1266,11 +1238,7 @@ extern "C" {
         hints: *const addrinfo,
         res: *mut *mut addrinfo,
     ) -> ::c_int;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(target_os = "espidf", link_name = "lwip_freeaddrinfo")]
     pub fn freeaddrinfo(res: *mut addrinfo);
     pub fn hstrerror(errcode: ::c_int) -> *const ::c_char;
diff --git a/src/unix/newlib/mod.rs b/src/unix/newlib/mod.rs
index e68da50aa3c0a..45d1b1a028fad 100644
--- a/src/unix/newlib/mod.rs
+++ b/src/unix/newlib/mod.rs
@@ -91,7 +91,7 @@ s! {
 
         #[cfg(not(any(
             target_os = "espidf",
-            all(libc_cfg_target_vendor, target_arch = "powerpc", target_vendor = "nintendo"))))]
+            all(target_arch = "powerpc", target_vendor = "nintendo"))))]
         pub ai_addr: *mut sockaddr,
 
         pub ai_next: *mut addrinfo,
@@ -843,11 +843,7 @@ extern "C" {
     pub fn rand() -> ::c_int;
     pub fn srand(seed: ::c_uint);
 
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(target_os = "espidf", link_name = "lwip_bind")]
     pub fn bind(fd: ::c_int, addr: *const sockaddr, len: socklen_t) -> ::c_int;
     pub fn clock_settime(clock_id: ::clockid_t, tp: *const ::timespec) -> ::c_int;
@@ -856,11 +852,7 @@ extern "C" {
     #[cfg_attr(target_os = "espidf", link_name = "lwip_close")]
     pub fn closesocket(sockfd: ::c_int) -> ::c_int;
     pub fn ioctl(fd: ::c_int, request: ::c_ulong, ...) -> ::c_int;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     #[cfg_attr(target_os = "espidf", link_name = "lwip_recvfrom")]
     pub fn recvfrom(
         fd: ::c_int,
@@ -870,11 +862,7 @@ extern "C" {
         addr: *mut sockaddr,
         addr_len: *mut socklen_t,
     ) -> isize;
-    #[cfg(not(all(
-        libc_cfg_target_vendor,
-        target_arch = "powerpc",
-        target_vendor = "nintendo"
-    )))]
+    #[cfg(not(all(target_arch = "powerpc", target_vendor = "nintendo")))]
     pub fn getnameinfo(
         sa: *const sockaddr,
         salen: socklen_t,