diff --git a/core/emitter.js b/core/emitter.js
index 0f9ba4f06a..419fa6d453 100644
--- a/core/emitter.js
+++ b/core/emitter.js
@@ -1,17 +1,16 @@
 import EventEmitter from 'eventemitter3';
-import instances from './instances';
+// import instances from './instances';
 import logger from './logger';
 
 const debug = logger('quill:events');
 const EVENTS = ['selectionchange', 'mousedown', 'mouseup', 'click'];
+const EMITTERS = [];
+const supportsRootNode = 'getRootNode' in document;
 
 EVENTS.forEach(eventName => {
   document.addEventListener(eventName, (...args) => {
-    Array.from(document.querySelectorAll('.ql-container')).forEach(node => {
-      const quill = instances.get(node);
-      if (quill && quill.emitter) {
-        quill.emitter.handleDOM(...args);
-      }
+    EMITTERS.forEach(em => {
+      em.handleDOM(...args);
     });
   });
 });
@@ -20,6 +19,7 @@ class Emitter extends EventEmitter {
   constructor() {
     super();
     this.listeners = {};
+    EMITTERS.push(this);
     this.on('error', debug.error);
   }
 
@@ -29,8 +29,25 @@ class Emitter extends EventEmitter {
   }
 
   handleDOM(event, ...args) {
+    const target = event.composedPath ? event.composedPath()[0] : event.target;
+    const containsNode = (node, targetNode) => {
+      if (!supportsRootNode || targetNode.getRootNode() === document) {
+        return node.contains(targetNode);
+      }
+
+      while (!node.contains(targetNode)) {
+        const root = targetNode.getRootNode();
+        if (!root || !root.host) {
+          return false;
+        }
+        targetNode = root.host;
+      }
+
+      return true;
+    };
+
     (this.listeners[event.type] || []).forEach(({ node, handler }) => {
-      if (event.target === node || node.contains(event.target)) {
+      if (target === node || containsNode(node, target)) {
         handler(event, ...args);
       }
     });
diff --git a/core/selection.js b/core/selection.js
index b099fad6e4..b724db96b0 100644
--- a/core/selection.js
+++ b/core/selection.js
@@ -3,6 +3,7 @@ import cloneDeep from 'lodash.clonedeep';
 import isEqual from 'lodash.isequal';
 import Emitter from './emitter';
 import logger from './logger';
+import { ShadowSelection } from './shadow-selection-polyfill';
 
 const debug = logger('quill:selection');
 
@@ -20,6 +21,9 @@ class Selection {
     this.composing = false;
     this.mouseDown = false;
     this.root = this.scroll.domNode;
+    this.rootDocument = this.root.getRootNode
+      ? this.root.getRootNode()
+      : document;
     this.cursor = this.scroll.create('cursor', this);
     // savedRange is last non-null range
     this.savedRange = new Range(0, 0);
@@ -32,11 +36,23 @@ class Selection {
         setTimeout(this.update.bind(this, Emitter.sources.USER), 1);
       }
     });
-    this.emitter.on(Emitter.events.SCROLL_BEFORE_UPDATE, () => {
+    this.emitter.on(Emitter.events.SCROLL_BEFORE_UPDATE, (_, mutations) => {
       if (!this.hasFocus()) return;
       const native = this.getNativeRange();
       if (native == null) return;
+
+      // We might need to hack the offset on Safari, when we are dealing with the first character of a row.
+      // This likely happens because of a race condition between quill's update method being called before the
+      // selectionchange event being fired in the selection polyfill.
+      const hackOffset =
+        native.start.offset === 0 &&
+        native.start.offset === native.end.offset &&
+        this.rootDocument.getSelection() instanceof ShadowSelection &&
+        mutations.some(a => a.type === 'characterData' && a.oldValue === '')
+          ? 1
+          : 0;
       if (native.start.node === this.cursor.textNode) return; // cursor.restore() will handle
+      // TODO unclear if this has negative side effects
       this.emitter.once(Emitter.events.SCROLL_UPDATE, () => {
         try {
           if (
@@ -45,9 +61,9 @@ class Selection {
           ) {
             this.setNativeRange(
               native.start.node,
-              native.start.offset,
+              native.start.offset + hackOffset,
               native.end.node,
-              native.end.offset,
+              native.end.offset + hackOffset,
             );
           }
           this.update(Emitter.sources.SILENT);
@@ -184,7 +200,7 @@ class Selection {
   }
 
   getNativeRange() {
-    const selection = document.getSelection();
+    const selection = this.rootDocument.getSelection();
     if (selection == null || selection.rangeCount <= 0) return null;
     const nativeRange = selection.getRangeAt(0);
     if (nativeRange == null) return null;
@@ -202,8 +218,8 @@ class Selection {
 
   hasFocus() {
     return (
-      document.activeElement === this.root ||
-      contains(this.root, document.activeElement)
+      this.rootDocument.activeElement === this.root ||
+      contains(this.root, this.rootDocument.activeElement)
     );
   }
 
@@ -325,7 +341,7 @@ class Selection {
     ) {
       return;
     }
-    const selection = document.getSelection();
+    const selection = this.rootDocument.getSelection();
     if (selection == null) return;
     if (startNode != null) {
       if (!this.hasFocus()) this.root.focus();
@@ -416,6 +432,8 @@ class Selection {
   }
 }
 
+// TODO ShadowDom consider? https://github.com/ing-bank/lion/blob/master/packages/overlays/src/utils/deep-contains.js
+// TODO note that handleDOM has a contains impl as well..
 function contains(parent, descendant) {
   try {
     // Firefox inserts inaccessible nodes around video elements
diff --git a/core/shadow-selection-polyfill.js b/core/shadow-selection-polyfill.js
new file mode 100644
index 0000000000..260c70df38
--- /dev/null
+++ b/core/shadow-selection-polyfill.js
@@ -0,0 +1,103 @@
+// see https://github.com/GoogleChromeLabs/shadow-selection-polyfill/issues/11
+const SUPPORTS_SHADOW_SELECTION = typeof window.ShadowRoot.prototype.getSelection === 'function';
+const SUPPORTS_BEFORE_INPUT = window.InputEvent && typeof window.InputEvent.prototype.getTargetRanges === 'function';
+const IS_FIREFOX = window.navigator.userAgent.toLowerCase().indexOf('firefox') > -1;
+const IS_MSIE = !!(window.navigator.userAgent.match(/Trident/) && !window.navigator.userAgent.match(/MSIE/));
+const IS_EDGE = window.navigator.userAgent.match(/Edge/);
+
+let processing = false;
+export class ShadowSelection {
+  constructor() {
+    this._ranges = [];
+  }
+
+  get rangeCount() {
+    return this._ranges.length;
+  }
+
+  getRangeAt(index) {
+    return this._ranges[index];
+  }
+
+  addRange(range) {
+    this._ranges.push(range);
+    if (!processing) {
+      let windowSel = window.getSelection();
+      windowSel.removeAllRanges();
+      windowSel.addRange(range);
+    }
+  }
+
+  removeAllRanges() {
+    this._ranges = [];
+  }
+
+  // todo: implement remaining `Selection` methods and properties.
+}
+
+function getActiveElement() {
+  let active = document.activeElement;
+
+  /* eslint-disable no-constant-condition */
+  while (true) {
+    if (active && active.shadowRoot && active.shadowRoot.activeElement) {
+      active = active.shadowRoot.activeElement;
+    } else {
+      break;
+    }
+  }
+
+  return active;
+}
+
+if ((IS_FIREFOX || IS_MSIE || IS_EDGE) && !SUPPORTS_SHADOW_SELECTION) {
+  window.ShadowRoot.prototype.getSelection = function() {
+    return document.getSelection();
+  }
+}
+
+if (!IS_FIREFOX && !SUPPORTS_SHADOW_SELECTION && SUPPORTS_BEFORE_INPUT) {
+  let selection = new ShadowSelection();
+
+  window.ShadowRoot.prototype.getSelection = function() {
+    return selection;
+  }
+
+  window.addEventListener('selectionchange', () => {
+    if (!processing) {
+      processing = true;
+
+      const active = getActiveElement();
+
+      if (active && (active.getAttribute('contenteditable') === 'true')) {
+        document.execCommand('indent');
+      } else {
+        selection.removeAllRanges();
+      }
+
+      processing = false;
+    }
+  }, true);
+
+  window.addEventListener('beforeinput', (event) => {
+    if (processing) {
+      const ranges = event.getTargetRanges();
+      const range = ranges[0];
+
+      const newRange = new Range();
+
+      newRange.setStart(range.startContainer, range.startOffset);
+      newRange.setEnd(range.endContainer, range.endOffset);
+
+      selection.removeAllRanges();
+      selection.addRange(newRange);
+
+      event.preventDefault();
+      event.stopImmediatePropagation();
+    }
+  }, true);
+
+  window.addEventListener('selectstart', () => {
+    selection.removeAllRanges();
+  }, true);
+}
diff --git a/modules/clipboard.js b/modules/clipboard.js
index 8eadd406a6..fc5a81d088 100644
--- a/modules/clipboard.js
+++ b/modules/clipboard.js
@@ -155,7 +155,8 @@ class Clipboard extends Module {
     if (!html && files.length > 0) {
       this.quill.uploader.upload(range, files);
       return;
-    } else if (html && files.length > 0) {
+    }
+    if (html && files.length > 0) {
       const doc = new DOMParser().parseFromString(html, 'text/html');
       if (
         doc.body.childElementCount === 1 &&
diff --git a/modules/toolbar.js b/modules/toolbar.js
index a16923ec0a..e4d753adb9 100644
--- a/modules/toolbar.js
+++ b/modules/toolbar.js
@@ -4,6 +4,7 @@ import Quill from '../core/quill';
 import logger from '../core/logger';
 import Module from '../core/module';
 
+const supportsRootNode = 'getRootNode' in document;
 const debug = logger('quill:toolbar');
 
 class Toolbar extends Module {
@@ -15,7 +16,10 @@ class Toolbar extends Module {
       quill.container.parentNode.insertBefore(container, quill.container);
       this.container = container;
     } else if (typeof this.options.container === 'string') {
-      this.container = document.querySelector(this.options.container);
+      const rootDocument = supportsRootNode
+        ? quill.container.getRootNode()
+        : document;
+      this.container = rootDocument.querySelector(this.options.container);
     } else {
       this.container = this.options.container;
     }
diff --git a/package.json b/package.json
index 53492be397..1372397a99 100644
--- a/package.json
+++ b/package.json
@@ -140,6 +140,7 @@
     }
   },
   "eslintIgnore": [
+    "core/shadow-selection-polyfill.js",
     "dist/",
     "docs/",
     "node_modules/"
diff --git a/test/unit/core/selection.js b/test/unit/core/selection.js
index 164f5f8bed..a29eeacf31 100644
--- a/test/unit/core/selection.js
+++ b/test/unit/core/selection.js
@@ -41,6 +41,47 @@ describe('Selection', function() {
     });
   });
 
+  describe('shadow root', function() {
+    // Some browsers don't support shadow DOM
+    if (!document.head.attachShadow) {
+      return;
+    }
+
+    let container;
+    let root;
+
+    beforeEach(function() {
+      root = document.createElement('div');
+      root.attachShadow({ mode: 'open' });
+      root.shadowRoot.innerHTML = '<div></div>';
+
+      document.body.appendChild(root);
+
+      container = root.shadowRoot.firstChild;
+    });
+
+    afterEach(function() {
+      document.body.removeChild(root);
+    });
+
+    it('getRange()', function() {
+      const selection = this.initialize(Selection, '<p>0123</p>', container);
+      selection.setNativeRange(container.firstChild.firstChild, 1);
+      const [range] = selection.getRange();
+      expect(range.index).toEqual(1);
+      expect(range.length).toEqual(0);
+    });
+
+    it('setRange()', function() {
+      const selection = this.initialize(Selection, '', container);
+      const expected = new Range(0);
+      selection.setRange(expected);
+      const [range] = selection.getRange();
+      expect(range).toEqual(expected);
+      expect(selection.hasFocus()).toBe(true);
+    });
+  });
+
   describe('getRange()', function() {
     it('empty document', function() {
       const selection = this.initialize(Selection, '');
diff --git a/test/unit/modules/toolbar.js b/test/unit/modules/toolbar.js
index 7e04fc911d..e5d960886e 100644
--- a/test/unit/modules/toolbar.js
+++ b/test/unit/modules/toolbar.js
@@ -106,6 +106,38 @@ describe('Toolbar', function() {
     });
   });
 
+  describe('shadow dom', function() {
+    // Some browsers don't support shadow DOM
+    if (!document.head.attachShadow) {
+      return;
+    }
+
+    let container;
+    let editor;
+
+    beforeEach(function() {
+      container = document.createElement('div');
+      container.attachShadow({ mode: 'open' });
+      container.shadowRoot.innerHTML = `
+        <div class="editor"></div>
+        <div class="toolbar"></div>`;
+
+      editor = new Quill(container.shadowRoot.querySelector('.editor'), {
+        modules: {
+          toolbar: '.toolbar',
+        },
+      });
+    });
+
+    it('should initialise', function() {
+      const editorDiv = container.shadowRoot.querySelector('.editor');
+      const toolbarDiv = container.shadowRoot.querySelector('.toolbar');
+      expect(editorDiv.className).toBe('editor ql-container');
+      expect(toolbarDiv.className).toBe('toolbar ql-toolbar');
+      expect(editor.container).toBe(editorDiv);
+    });
+  });
+
   describe('active', function() {
     beforeEach(function() {
       const container = this.initialize(