diff --git a/docs/commands.md b/docs/commands.md
index b4ac40f04..fbd365879 100644
--- a/docs/commands.md
+++ b/docs/commands.md
@@ -119,4 +119,4 @@ Upgrade your app's template files to the specified or latest npm version using [
 
 Using this command is a recommended way of upgrading relatively simple React Native apps with not too many native libraries linked. The more iOS and Android build files are modified, the higher chance for a conflicts. The command will guide you on how to continue upgrade process manually in case of failure.
 
-_Note: If you'd like to upgrade using this method from React Native version lower than 0.59.0, you may use a standalone version of this CLI: `npx @react-native-community/cli upgrade`._
+_Note: If you'd like to upgrade using this method from React Native version lower than 0.59.0, you may use a standalone version of this CLI: `npx @react-native-community/cli upgrade`._
\ No newline at end of file
diff --git a/packages/cli-platform-android/README.md b/packages/cli-platform-android/README.md
index b24fa44d9..d2b324b44 100644
--- a/packages/cli-platform-android/README.md
+++ b/packages/cli-platform-android/README.md
@@ -126,6 +126,9 @@ react-native build-android --extra-params "-x lint -x test"
 
 Installs passed binary instead of building a fresh one. This command is not compatible with `--tasks`.
 
+#### `--user` <number | string>
+
+Id of the User Profile you want to install the app on.
 ### `log-android`
 
 Usage:
diff --git a/packages/cli-platform-android/src/commands/runAndroid/__tests__/checkUsers.test.ts b/packages/cli-platform-android/src/commands/runAndroid/__tests__/checkUsers.test.ts
new file mode 100644
index 000000000..8c137de04
--- /dev/null
+++ b/packages/cli-platform-android/src/commands/runAndroid/__tests__/checkUsers.test.ts
@@ -0,0 +1,25 @@
+import execa from 'execa';
+import {checkUsers} from '../listAndroidUsers';
+
+// output of "adb -s ... shell pm users list" command
+const gradleOutput = `
+Users:
+        UserInfo{0:Homersimpsons:c13} running
+        UserInfo{10:Guest:404}
+`;
+
+jest.mock('execa', () => {
+  return {sync: jest.fn()};
+});
+
+describe('check android users', () => {
+  it('should correctly parse recieved users', () => {
+    (execa.sync as jest.Mock).mockReturnValueOnce({stdout: gradleOutput});
+    const users = checkUsers('device', 'adbPath');
+
+    expect(users).toStrictEqual([
+      {id: '0', name: 'Homersimpsons'},
+      {id: '10', name: 'Guest'},
+    ]);
+  });
+});
diff --git a/packages/cli-platform-android/src/commands/runAndroid/getTaskNames.ts b/packages/cli-platform-android/src/commands/runAndroid/getTaskNames.ts
index d994e2621..26b71dac4 100644
--- a/packages/cli-platform-android/src/commands/runAndroid/getTaskNames.ts
+++ b/packages/cli-platform-android/src/commands/runAndroid/getTaskNames.ts
@@ -10,10 +10,11 @@ export function getTaskNames(
   taskPrefix: 'assemble' | 'install' | 'bundle',
   sourceDir: string,
 ): Array<string> {
-  let appTasks = tasks || [taskPrefix + toPascalCase(mode)];
+  let appTasks =
+    tasks && tasks.length ? tasks : [taskPrefix + toPascalCase(mode)];
 
   // Check against build flavors for "install" task ("assemble" don't care about it so much and will build all)
-  if (!tasks && taskPrefix === 'install') {
+  if (!tasks?.length && taskPrefix === 'install') {
     const actionableInstallTasks = getGradleTasks('install', sourceDir);
     if (!actionableInstallTasks.find((t) => t.task.includes(appTasks[0]))) {
       const installTasksForMode = actionableInstallTasks.filter((t) =>
diff --git a/packages/cli-platform-android/src/commands/runAndroid/index.ts b/packages/cli-platform-android/src/commands/runAndroid/index.ts
index 68ba317b2..a269cb555 100644
--- a/packages/cli-platform-android/src/commands/runAndroid/index.ts
+++ b/packages/cli-platform-android/src/commands/runAndroid/index.ts
@@ -22,6 +22,7 @@ import path from 'path';
 import {build, runPackager, BuildFlags, options} from '../buildAndroid';
 import {promptForTaskSelection} from './listAndroidTasks';
 import {getTaskNames} from './getTaskNames';
+import {checkUsers, promptForUser} from './listAndroidUsers';
 
 export interface Flags extends BuildFlags {
   appId: string;
@@ -30,6 +31,7 @@ export interface Flags extends BuildFlags {
   deviceId?: string;
   listDevices?: boolean;
   binaryPath?: string;
+  user?: number | string;
 }
 
 export type AndroidProject = NonNullable<Config['project']['android']>;
@@ -121,6 +123,17 @@ async function buildAndRun(args: Flags, androidProject: AndroidProject) {
       );
     }
 
+    if (args.interactive) {
+      const users = checkUsers(device.deviceId as string, adbPath);
+      if (users && users.length > 1) {
+        const user = await promptForUser(users);
+
+        if (user) {
+          args.user = user.id;
+        }
+      }
+    }
+
     if (device.connected) {
       return runOnSpecificDevice(
         {...args, deviceId: device.deviceId},
@@ -167,14 +180,16 @@ function runOnSpecificDevice(
   // if coming from run-android command and we have selected task
   // from interactive mode we need to create appropriate build task
   // eg 'installRelease' -> 'assembleRelease'
-  const buildTask = selectedTask?.replace('install', 'assemble') ?? 'build';
+  const buildTask = selectedTask
+    ? [selectedTask.replace('install', 'assemble')]
+    : [];
 
   if (devices.length > 0 && deviceId) {
     if (devices.indexOf(deviceId) !== -1) {
       let gradleArgs = getTaskNames(
         androidProject.appName,
         args.mode || args.variant,
-        args.tasks ?? [buildTask],
+        args.tasks ?? buildTask,
         'install',
         androidProject.sourceDir,
       );
@@ -287,6 +302,11 @@ export default {
       description:
         'Path relative to project root where pre-built .apk binary lives.',
     },
+    {
+      name: '--user <number>',
+      description: 'Id of the User Profile you want to install the app on.',
+      parse: Number,
+    },
   ],
 };
 
diff --git a/packages/cli-platform-android/src/commands/runAndroid/listAndroidUsers.ts b/packages/cli-platform-android/src/commands/runAndroid/listAndroidUsers.ts
new file mode 100644
index 000000000..cb0b38321
--- /dev/null
+++ b/packages/cli-platform-android/src/commands/runAndroid/listAndroidUsers.ts
@@ -0,0 +1,57 @@
+import {logger} from '@react-native-community/cli-tools';
+import execa from 'execa';
+import prompts from 'prompts';
+
+type User = {
+  id: string;
+  name: string;
+};
+
+export function checkUsers(device: string, adbPath: string) {
+  try {
+    const adbArgs = ['-s', device, 'shell', 'pm', 'list', 'users'];
+
+    logger.debug(`Checking users on "${device}"...`);
+    const {stdout} = execa.sync(adbPath, adbArgs, {encoding: 'utf-8'});
+    const regex = new RegExp(
+      /^\s*UserInfo\{(?<userId>\d+):(?<userName>.*):(?<userFlags>[0-9a-f]*)}/,
+    );
+    const users: User[] = [];
+
+    const lines = stdout.split('\n');
+    for (const line of lines) {
+      const res = regex.exec(line);
+      if (res?.groups) {
+        users.push({id: res.groups.userId, name: res.groups.userName});
+      }
+    }
+
+    if (users.length > 1) {
+      logger.debug(
+        `Available users are:\n${users
+          .map((user) => `${user.name} - ${user.id}`)
+          .join('\n')}`,
+      );
+    }
+
+    return users;
+  } catch (error) {
+    logger.error('Failed to check users of device.', error as any);
+    return [];
+  }
+}
+
+export async function promptForUser(users: User[]) {
+  const {selectedUser}: {selectedUser: User} = await prompts({
+    type: 'select',
+    name: 'selectedUser',
+    message: 'Which profile would you like to launch your app into?',
+    choices: users.map((user: User) => ({
+      title: user.name,
+      value: user,
+    })),
+    min: 1,
+  });
+
+  return selectedUser;
+}
diff --git a/packages/cli-platform-android/src/commands/runAndroid/tryInstallAppOnDevice.ts b/packages/cli-platform-android/src/commands/runAndroid/tryInstallAppOnDevice.ts
index eeef15a7d..b0a387ae4 100644
--- a/packages/cli-platform-android/src/commands/runAndroid/tryInstallAppOnDevice.ts
+++ b/packages/cli-platform-android/src/commands/runAndroid/tryInstallAppOnDevice.ts
@@ -45,11 +45,13 @@ function tryInstallAppOnDevice(
       pathToApk = args.binaryPath;
     }
 
-    const adbArgs = ['-s', device, 'install', '-r', '-d', pathToApk];
+    const installArgs = ['-s', device, 'install', '-r', '-d'];
+    if (args.user !== undefined) {
+      installArgs.push('--user', `${args.user}`);
+    }
+    const adbArgs = [...installArgs, pathToApk];
     logger.info(`Installing the app on the device "${device}"...`);
-    logger.debug(
-      `Running command "cd android && adb -s ${device} install -r -d ${pathToApk}"`,
-    );
+    logger.debug(`Running command "cd android && adb ${adbArgs.join(' ')}"`);
     execa.sync(adbPath, adbArgs, {stdio: 'inherit'});
   } catch (error) {
     throw new CLIError(
@@ -82,7 +84,7 @@ function getInstallApkName(
     return apkName;
   }
 
-  throw new CLIError('Could not find the correct install APK file.');
+  throw new Error('Could not find the correct install APK file.');
 }
 
 export default tryInstallAppOnDevice;