experimental_condition_20231014_v4.141.obo

format-version: 1.2
data-version: 4.141
date: 14:10:2023 20:13
saved-by: jrsmith
auto-generated-by: --RGD OBO FILE GENERATOR -- build 2023-05-30 --
default-namespace: experimental_condition_ontology
ontology: xco

[Term]
id: XCO:0000000
name: experimental condition
def: "A state of being, an external or environmental factor or a treatment observed or administered prior to or concurrent with an investigative procedure such as an assessment of a morphological or physiological state or property in a single individual or sample or in a group of individuals or samples, especially a state, factor or treatment which has the potential to influence the outcome of such an assessment." [http://www.thefreedictionary.com/ "Multiple_Dictionaries", PMID:22654893]

[Term]
id: XCO:0000001
name: activity
def: "The state of being involved in some action, either physical or mental." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000000 ! experimental condition

[Term]
id: XCO:0000002
name: resting
def: "A state in which the organism is not exhibiting any physical exertion." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000059 ! physical activity

[Term]
id: XCO:0000003
name: resting on treadmill
def: "A state in which the organism is on an non-operating exercise machine in which there is an endless belt that moves when operational so that the organism can walk or run in place." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000002 ! resting

[Term]
id: XCO:0000004
name: walking on treadmill
def: "The action of ambulation on an exercise apparatus with an endless moving belt on which the organism can walk in place." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000007 ! walking

[Term]
id: XCO:0000005
name: running on treadmill
def: "The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000008 ! running

[Term]
id: XCO:0000006
name: swimming
def: "A condition in which the main influencing factor is the action of moving one's appendages to propel oneself through water." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000059 ! physical activity

[Term]
id: XCO:0000007
name: walking
def: "The act of ambulation, moving oneself forward on legs or on an exercise apparatus." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000059 ! physical activity

[Term]
id: XCO:0000008
name: running
def: "Condition in which the major influencing factor is the action of rapid movement of feet that propels the organism forward or is done on an exercise machine so that the organism performs the activity in place." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000059 ! physical activity

[Term]
id: XCO:0000009
name: controlled atmosphere composition
def: "An experimental condition in which the amount of one or more of the gases which make up the air surrounding an organism are controlled, or in which additional components are added to the air surrounding an organism, as part of the experiment on that organism." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, RGD:MS]
is_a: XCO:0000998 ! controlled breathing condition

[Term]
id: XCO:0000010
name: air oxygen content
def: "A condition in which the oxygen level of the air surrounding an organism or breathed by the organism is controlled as part of the experiment." [RGD:MS]
relationship: part_of XCO:0000009 ! controlled atmosphere composition

[Term]
id: XCO:0000011
name: air temperature
def: "The degree of heat or cold of the air surrounding an organism." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000111 ! temperature exposure

[Term]
id: XCO:0000012
name: air carbon dioxide content
def: "A condition in which the level of carbon dioxide in the air surrounding the organism or breathed by the organism is controlled as part of the experiment." [RGD:MS]
relationship: part_of XCO:0000009 ! controlled atmosphere composition

[Term]
id: XCO:0000013
name: diet
def: "The food and drink consumed by an organism day to day." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000000 ! experimental condition

[Term]
id: XCO:0000014
name: controlled content diet
def: "A regimen of solid food in which the amount of one or more elements of the diet are controlled." [RGD:MS]
is_a: XCO:0000019 ! solid diet

[Term]
id: XCO:0000015
name: controlled calorie content diet
def: "A regimen of solid food in which the number of calories consumed is controlled." [RGD:MS]
is_a: XCO:0000014 ! controlled content diet

[Term]
id: XCO:0000016
name: standard rat chow
is_a: XCO:0000069 ! standard diet

[Term]
id: XCO:0000017
name: nephrectomy
def: "Surgical removal of kidney." [RGD:MS]
is_a: XCO:0000026 ! surgical removal
created_by: mshimoyama
creation_date: 2011-11-02T02:06:00Z

[Term]
id: XCO:0000018
name: bilateral nephrectomy
def: "Surgical removal of both kidneys." [RGD:MS]
is_a: XCO:0000017 ! nephrectomy
created_by: mshimoyama
creation_date: 2011-11-02T02:07:13Z

[Term]
id: XCO:0000019
name: solid diet
def: "The solid food that is consumed by an organism." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000013 ! diet

[Term]
id: XCO:0000020
name: drink
def: "A liquid consumed by an organism." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000013 ! diet

[Term]
id: XCO:0000021
name: water
def: "The clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), specifically, as supplied for drinking, that is, to be brought into the mouth and swallowed to quench thirst, for nourishment, etc." [http://www.yourdictionary.com/drink "YourDictionary", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "drinking water" EXACT []
is_a: XCO:0000020 ! drink

[Term]
id: XCO:0000022
name: controlled sodium content diet
def: "A regimen of solid food in which the amount of sodium consumed is controlled." [RGD:MS]
is_a: XCO:0000014 ! controlled content diet

[Term]
id: XCO:0000023
name: controlled ethanol content drinking water
def: "A drink made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, for consumption by an organism in an experiment." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000070 ! alcoholic drink
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000325 ! ethanol

[Term]
id: XCO:0000024
name: controlled iron content diet
def: "A regimen of solid food in which the amount of iron consumed is controlled." [https://www.merriam-webster.com, ISBN-13:9780781733908]
synonym: "controlled Fe content diet" EXACT []
is_a: XCO:0000920 ! controlled mineral content diet

[Term]
id: XCO:0000025
name: controlled fat content diet
def: "A regimen of solid food in which the amount of fat consumed is controlled." [RGD:MS]
is_a: XCO:0000014 ! controlled content diet

[Term]
id: XCO:0000026
name: surgical removal
def: "The process of ablating or extracting all or part of an organ, gland or other body part from an organism as a medical or experimental procedure." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
is_a: XCO:0000165 ! surgical manipulation

[Term]
id: XCO:0000027
name: surgical implantation
def: "Any insertion of a tissue, material or device into the body using a procedure involving incision into the body." [Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000165 ! surgical manipulation

[Term]
id: XCO:0000028
name: caffeinated drink
def: "A drink containing caffeine, one of the methylxanthines soluble in water and alcohol and obtainable from coffee, tea, guarana and mate." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000020 ! drink

[Term]
id: XCO:0000029
name: controlled carbohydrate content diet
def: "A regimen of solid food in which the amount of carbohydrates consumed is controlled." [RGD:MS]
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000172 ! carbohydrate

[Term]
id: XCO:0000030
name: controlled protein content diet
def: "A regimen of solid food in which the amount of protein consumed is controlled." [RGD:MS]
is_a: XCO:0000014 ! controlled content diet

[Term]
id: XCO:0000031
name: controlled calcium content diet
def: "A regimen of solid food in which the amount of calcium consumed is controlled." [RGD:MS]
is_a: XCO:0000014 ! controlled content diet

[Term]
id: XCO:0000032
name: controlled potassium content diet
def: "A regimen of solid food in which the amount of potassium consumed is controlled." [RGD:MS]
is_a: XCO:0000014 ! controlled content diet

[Term]
id: XCO:0000033
name: housing condition
is_a: XCO:0000000 ! experimental condition

[Term]
id: XCO:0000034
name: individual housing
is_a: XCO:0000033 ! housing condition

[Term]
id: XCO:0000035
name: housing in pairs
is_a: XCO:0000033 ! housing condition

[Term]
id: XCO:0000036
name: housing with socially dominant partner
is_a: XCO:0000035 ! housing in pairs
is_a: XCO:0000490 ! ongoing social environment condition

[Term]
id: XCO:0000037
name: housing with socially subordinate partner
is_a: XCO:0000035 ! housing in pairs
is_a: XCO:0000490 ! ongoing social environment condition

[Term]
id: XCO:0000038
name: radiation exposure
def: "The condition of being subjected to any type of energy transmitted by waves through space or through some medium or to a stream of particles, such as electrons or alpha particles." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000000 ! experimental condition

[Term]
id: XCO:0000039
name: ionizing radiation exposure
def: "The condition of being subjected to transmitted energy composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Ionizing_radiation "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000045 ! electromagnetic radiation exposure

[Term]
id: XCO:0000040
name: gamma ray exposure
def: "The condition of being subjected to high frequency, high energy electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Gamma radiation is traditionally considered to have wavelengths less than 0.01 nm and are generally emitted by nuclei rather than by electrons." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Gamma_ray "Wikipedia", ISBN:978-1416049982]
synonym: "gamma radiation exposure" EXACT []
is_a: XCO:0000039 ! ionizing radiation exposure

[Term]
id: XCO:0000041
name: radon exposure
def: "The condition of being subjected to transmitted energy from the gaseous radioactive element radon, atomic number 86, resulting from decay of radium. Such radiation is composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule. alpha, beta, and gamma rays are released during the radioactive decay of radon." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Ionizing_radiation "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000039 ! ionizing radiation exposure

[Term]
id: XCO:0000042
name: ultraviolet ray exposure
def: "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, in the part of the electromagnetic spectrum with wavelengths between about 10 and 400 nm.  Ultraviolet radiation can be ionizing or non-ionizing depending on the wavelength." [http://en.wikipedia.org/wiki/Electromagnetic_Radiation "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "UV radiation exposure" EXACT []
is_a: XCO:0000045 ! electromagnetic radiation exposure

[Term]
id: XCO:0000043
name: X-ray exposure
def: "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between approximately 0.01 and 10 nm." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, http://en.wikipedia.org/wiki/Electromagnetic_Radiation "Wikipedia"]
synonym: "roentgen radiation exposure" EXACT []
synonym: "X-radiation exposure" EXACT []
is_a: XCO:0000039 ! ionizing radiation exposure

[Term]
id: XCO:0000044
name: non-ionizing radiation exposure
def: "The condition of being subjected to transmitted energy that does not carry enough energy per quantum to completely remove an electron from an atom or molecule. Such radiation has sufficient energy only for excitation, the movement of an electron to a higher energy state." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Non-ionizing_radiation "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000045 ! electromagnetic radiation exposure

[Term]
id: XCO:0000045
name: electromagnetic radiation exposure
def: "The condition of being subjected to energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Electromagnetic radiation includes, in order of decreasing wavelength, radio waves, microwaves, infrared, visible, and ultraviolet light, x-rays, gamma rays, and cosmic rays." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Electromagnetic_Radiation "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000038 ! radiation exposure

[Term]
id: XCO:0000046
name: infrared radiation exposure
def: "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths longer than those of visible light, i.e. from approximately 750 nm to 1 mm." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, http://en.wikipedia.org/wiki/Electromagnetic_Radiation "Wikipedia"]
synonym: "IR radiation exposure" EXACT []
is_a: XCO:0000044 ! non-ionizing radiation exposure
is_a: XCO:0000045 ! electromagnetic radiation exposure

[Term]
id: XCO:0000047
name: sensory stimulus
def: "An action or condition designed to cause the registration or perception of a stimulus and the voyage made by incoming nerve impulses from the sense organs to the nerve centers. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." [http://www.medterms.com "MedicineNet", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000000 ! experimental condition

[Term]
id: XCO:0000048
name: auditory stimulus
def: "Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of hearing. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "audible sound stimulus" EXACT []
is_a: XCO:0000047 ! sensory stimulus

[Term]
id: XCO:0000049
name: visual stimulus
def: "Any action or condition designed to cause the registration or perception of a stimulus by the optical sense organs. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000047 ! sensory stimulus

[Term]
id: XCO:0000050
name: olfactory stimulus
def: "Any action or condition designed to cause the registration or perception of a stimulus, by organs or receptors involved in the sense of smell. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000047 ! sensory stimulus

[Term]
id: XCO:0000051
name: taste stimulus
def: "Any action or condition designed to cause the registration or perception of a stimulus by the gustatory receptors in the tongue. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000047 ! sensory stimulus

[Term]
id: XCO:0000052
name: tactile stimulus
def: "Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of touch, that is, the physiological sense by which external objects or forces are perceived through contact with the body. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000047 ! sensory stimulus

[Term]
id: XCO:0000053
name: targeted heat exposure
def: "An activity or condition involving a high temperature directed toward a particular part of an organism's body." [Collins:Collins_Online_English_Dictionary]
synonym: "heat exposure, targeted" EXACT []
is_a: XCO:0000308 ! heat exposure

[Term]
id: XCO:0000054
name: targeted cold exposure
def: "An activity or condition involving a low temperature directed toward a particular part of an organism's body." [Collins:Collins_Online_English_Dictionary]
synonym: "cold exposure, targeted" EXACT []
is_a: XCO:0000306 ! cold exposure

[Term]
id: XCO:0000055
name: tactile electric shock exposure
def: "This is any condition in which the main influencing factor is the stimulation of nerves involved in the physiological sense by which external objects or forces are perceived through contact with the body via application of an electric current." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "foot shock" RELATED []
is_a: XCO:0000052 ! tactile stimulus

[Term]
id: XCO:0000056
name: naive control condition
def: "A baseline condition in which none of the experimental manipulations are performed." [RGD:MS]
synonym: "standard control condition" RELATED []
is_obsolete: true

[Term]
id: XCO:0000057
name: rebreathed air
def: "Breathing in again air which has been exhaled." [Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
relationship: part_of XCO:0000009 ! controlled atmosphere composition
created_by: mshimoyama
creation_date: 2009-12-17T01:47:13Z

[Term]
id: XCO:0000058
name: room temperature
def: "The temperature of the air surrounding an organism which is considered the most common level for the facility. For humans the temperature considered most comfortable for a room is between 18 and 27 degrees celsius." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000011 ! air temperature
created_by: mshimoyama
creation_date: 2009-12-17T01:49:34Z

[Term]
id: XCO:0000059
name: physical activity
def: "Action in which a part of the body or whole body is involved in movement." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000001 ! activity
created_by: mshimoyama
creation_date: 2009-12-17T01:50:15Z

[Term]
id: XCO:0000060
name: mental activity
def: "Being in a state of action within the mind often involving manipulation of words or numbers." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000001 ! activity
created_by: mshimoyama
creation_date: 2009-12-17T01:50:54Z

[Term]
id: XCO:0000061
name: serial subtraction exercise
def: "An activity in which a person starts with a number and deducts a specified number from that and then deducts the same number from the remainder of the first computation, without using a calculator or pencil and paper." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000060 ! mental activity
created_by: mshimoyama
creation_date: 2009-12-17T01:51:15Z

[Term]
id: XCO:0000062
name: cycling
def: "The action of riding on a stationary or moving vehicle with wheels that is propelled by the movement of a person's legs." [RGD:MS]
is_a: XCO:0000059 ! physical activity
created_by: mshimoyama
creation_date: 2009-12-17T01:51:51Z

[Term]
id: XCO:0000063
name: cycling, stationary
def: "The act of propelling the wheel or wheels of a fixed exercise machine through the action of one's legs." [RGD:MS]
is_a: XCO:0000062 ! cycling
created_by: mshimoyama
creation_date: 2009-12-17T01:52:04Z

[Term]
id: XCO:0000064
name: cycling, non-stationary
def: "The action of propelling a two wheeled vehicle by the movement of a person's legs." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000062 ! cycling
created_by: mshimoyama
creation_date: 2009-12-17T01:52:17Z

[Term]
id: XCO:0000065
name: hand dynamometer activity
def: "The action of squeezing an apparatus that measures the muscular contraction of the hand, used as a condition of exertion in experiments measuring other physiological functions." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000059 ! physical activity
created_by: mshimoyama
creation_date: 2009-12-17T01:52:57Z

[Term]
id: XCO:0000066
name: body position change
def: "Change in position or attitude of body as part of the experiment in which measurements are taken before, during and/or after the change." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000081 ! body position
created_by: mshimoyama
creation_date: 2009-12-17T01:53:24Z

[Term]
id: XCO:0000067
name: body position change, seated to standing
is_a: XCO:0000066 ! body position change
created_by: mshimoyama
creation_date: 2009-12-17T01:53:35Z

[Term]
id: XCO:0000068
name: body position change, supine to standing
is_a: XCO:0000066 ! body position change
created_by: mshimoyama
creation_date: 2009-12-17T01:53:58Z

[Term]
id: XCO:0000069
name: standard diet
is_a: XCO:0000019 ! solid diet
is_a: XCO:0000099 ! control condition
created_by: mshimoyama
creation_date: 2009-12-17T01:56:44Z

[Term]
id: XCO:0000070
name: alcoholic drink
def: "A drink containing ethanol, a transparent, colorless, volatile,flammable liquid, which is formed by microbial fermentation of carbohydrates." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "ethanol" RELATED []
is_a: XCO:0000020 ! drink
created_by: mshimoyama
creation_date: 2010-01-05T03:10:55Z

[Term]
id: XCO:0000071
name: beer
def: "An alcoholic drink brewed by fermenting malt with sugar and yeast and flavored with hops." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000070 ! alcoholic drink
created_by: mshimoyama
creation_date: 2010-01-05T03:11:11Z

[Term]
id: XCO:0000072
name: wine
def: "Alcoholic drink made by fermenting the juice of grapes." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000070 ! alcoholic drink
created_by: mshimoyama
creation_date: 2010-01-05T03:11:23Z

[Term]
id: XCO:0000073
name: liquor
def: "Alcoholic beverage produced by distillation." [Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000070 ! alcoholic drink
created_by: mshimoyama
creation_date: 2010-01-05T03:11:33Z

[Term]
id: XCO:0000074
name: controlled caffeine content drinking water
def: "A drink made up of water and a specified amount of caffeine consumed by an organism as part of an experiment. Caffeine is a xanthine alkaloid that acts primarily as a central nervous system and metabolic stimulant, and also as a mild vasoconstrictor, diuretic, and bronchodilator." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Caffeine "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000028 ! caffeinated drink
is_a: XCO:0000163 ! controlled content drinking water
created_by: mshimoyama
creation_date: 2010-01-05T03:15:30Z

[Term]
id: XCO:0000075
name: tea
is_a: XCO:0000028 ! caffeinated drink
created_by: mshimoyama
creation_date: 2010-01-05T03:15:42Z

[Term]
id: XCO:0000076
name: coffee
def: "A drink made of the decoction or infusion of the dried, roasted sees of Coffea arabica or Coffea canephora." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000028 ! caffeinated drink
created_by: mshimoyama
creation_date: 2010-01-05T03:15:55Z

[Term]
id: XCO:0000077
name: tobacco use
def: "The use of any product made for human consumption from Nicotiana tabacum." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000013 ! diet
created_by: mshimoyama
creation_date: 2010-01-05T03:17:37Z

[Term]
id: XCO:0000078
name: cigar smoking
def: "The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigar, a rolled cylinder of tobacco wrapped in tobacco leaves." [http://medical-dictionary.thefreedictionary.com "Multiple_Dictionaries"]
synonym: "Cigar Smoking NCI Thesaurus" RELATED [NCI:C19702]
is_a: XCO:0000077 ! tobacco use
created_by: mshimoyama
creation_date: 2010-01-05T03:17:52Z

[Term]
id: XCO:0000079
name: cigarette smoking
def: "The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigarette, a small roll of finely cut tobacco enclosed in a wrapper of thin paper." [http://medical-dictionary.thefreedictionary.com "Multiple_Dictionaries"]
synonym: "Cigarette Smoking_NCI Thesaurus" RELATED [NCI:C18270]
is_a: XCO:0000077 ! tobacco use
created_by: mshimoyama
creation_date: 2010-01-05T03:18:03Z

[Term]
id: XCO:0000080
name: tobacco chewing
def: "Mastication of a form of the prepared leaves of Nicotiana tabacum that is chewed." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000077 ! tobacco use
created_by: mshimoyama
creation_date: 2010-01-05T03:18:13Z

[Term]
id: XCO:0000081
name: body position
def: "The attitude or posture of the body." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "posture" RELATED []
is_a: XCO:0000000 ! experimental condition
created_by: mshimoyama
creation_date: 2010-03-04T09:05:26Z

[Term]
id: XCO:0000082
name: sitting position
def: "A position of rest in which the weight is largely supported by the buttocks, usually with the body vertical." [Encarta:Encarta_World_English_Dictionary]
synonym: "seated" RELATED []
is_a: XCO:0000081 ! body position
created_by: mshimoyama
creation_date: 2010-03-04T09:06:36Z

[Term]
id: XCO:0000083
name: standing position
def: "A position in which an organism is upright balanced on two legs for bipedal organisms or four legs for quadrapedal organisms." [RGD:MS]
is_a: XCO:0000081 ! body position
created_by: mshimoyama
creation_date: 2010-03-04T09:06:49Z

[Term]
id: XCO:0000084
name: supine position
def: "A position in which the organism is lying face up." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000081 ! body position
created_by: mshimoyama
creation_date: 2010-03-04T09:07:12Z

[Term]
id: XCO:0000085
name: stationary bicycle dynamometer
is_a: XCO:0000063 ! cycling, stationary
created_by: mshimoyama
creation_date: 2010-03-04T01:56:42Z

[Term]
id: XCO:0000086
name: exercise training program
def: "A fixed series of exercises or body movements repeated at intervals over a specified period of time as part of a program to improve strength, aerobic capacity or other elements of fitness." [RGD:MS]
is_a: XCO:0000059 ! physical activity
created_by: mshimoyama
creation_date: 2010-03-04T02:09:06Z

[Term]
id: XCO:0000087
name: specific pathogen-free condition
def: "A standard living condition with the absence of a resident pathogen, a biological agent that causes disease, especially a microorganism such as a bacterium, virus, or fungus." [https://www.dictionary.com, https://www.merriam-webster.com/]
is_a: XCO:0000099 ! control condition
created_by: mshimoyama
creation_date: 2010-06-29T03:35:43Z

[Term]
id: XCO:0000088
name: chemical
def: "Any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Collins:Collins_Online_English_Dictionary]
is_a: XCO:0000000 ! experimental condition
created_by: mshimoyama
creation_date: 2010-11-01T01:00:51Z

[Term]
id: XCO:0000089
name: neoplasm-inducing chemical
def: "Any condition in which the main influencing factor is a chemical, i.e., a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, which has the capacity to promote the formation of neoplasms, new and abnormal growths, specifically those in which cell multiplication is uncontrolled and progressive." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "cancer inducing agent" NARROW []
synonym: "carcinogen" NARROW []
synonym: "carcinogenic agent" NARROW []
synonym: "neoplasm inducing agent" EXACT []
is_a: XCO:0000259 ! disease-inducing chemical
created_by: mshimoyama
creation_date: 2010-11-01T01:01:08Z

[Term]
id: XCO:0000090
name: 7,12-dimethyltetraphene (DMBA)
def: "A tetraphene having methyl substituents at the 7- and 12- positions. It is a potent carcinogen and is present in tobacco smoke." []
synonym: "7,12-dimethylbenzo[a]anthracene" RELATED []
synonym: "7,12-DMBA" RELATED []
synonym: "9,10-Dimethyl-1,2-benzanthracene" RELATED []
synonym: "DMBA" RELATED []
xref: CHEBI:254496
xref: MESH:D015127
is_a: XCO:0000093 ! polycyclic arene
created_by: mshimoyama
creation_date: 2010-11-01T01:01:46Z

[Term]
id: XCO:0000091
name: steroid
def: "Any condition in which the main influencing factor is a naturally occurring compound or related synthetic analog with a molecular structure based on the cyclopenta[a]phenanthrene carbon skeleton, that is, a phenanthrene, to the a side of which a three-carbon fragment is fused.  According to the definition at the Chemical Entities of Biological Importance (ChEBI) database, 'By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred' which expands the class to include molecules based on but not containing the cannonical arrangement of four fused cycloalkane rings." [http://en.wikipedia.org/wiki/Steroid "Wikipedia", http://www.medilexicon.com/medicaldictionary.php?t=22261 "MediLexicon"]
xref: CHEBI:35341
is_a: XCO:0000342 ! chemical with specified structure
created_by: mshimoyama
creation_date: 2010-11-01T01:03:53Z

[Term]
id: XCO:0000092
name: 17 beta-estradiol
def: "The predominant circulating form of estrogen, the female sex hormone." [http://en.wikipedia.org/wiki/Estradiol "Wikipedia"]
synonym: "beta-estradiol" RELATED []
synonym: "CO47085" RELATED []
synonym: "E2" RELATED []
synonym: "estradiol" RELATED []
xref: CHEBI:16469
is_a: XCO:0000294 ! estrogen/estrogen analog
created_by: mshimoyama
creation_date: 2010-11-01T01:04:03Z

[Term]
id: XCO:0000093
name: polycyclic arene
def: "Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by alternating double and single bonds that may be represented graphically by multiple interlinking circular or triangular forms." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
synonym: "polycyclic aromatic hydrocarbon" RELATED []
xref: CHEBI:33848
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000278 ! polycyclic hydrocarbon
created_by: mshimoyama
creation_date: 2010-11-01T01:07:01Z

[Term]
id: XCO:0000094
name: ovariectomy
def: "The removal of one or both ovaries, the female gonads, from an organism." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "oophorectomy" RELATED []
is_a: XCO:0000026 ! surgical removal
created_by: mshimoyama
creation_date: 2010-11-02T01:28:36Z

[Term]
id: XCO:0000095
name: bilateral ovariectomy
def: "Surgical removal of both ovaries." [RGD:MS]
is_a: XCO:0000094 ! ovariectomy
created_by: mshimoyama
creation_date: 2010-11-02T01:29:19Z

[Term]
id: XCO:0000096
name: unilateral ovariectomy
def: "Surgical removal of a single ovary." [RGD:MS]
is_a: XCO:0000094 ! ovariectomy
created_by: mshimoyama
creation_date: 2010-11-02T01:29:34Z

[Term]
id: XCO:0000097
name: right ovariectomy
def: "Surgical removal of the right ovary." [RGD:MS]
is_a: XCO:0000096 ! unilateral ovariectomy
created_by: mshimoyama
creation_date: 2010-11-02T01:29:48Z

[Term]
id: XCO:0000098
name: left ovariectomy
def: "Surgical removal of the left ovary." [RGD:MS]
is_a: XCO:0000096 ! unilateral ovariectomy
created_by: mshimoyama
creation_date: 2010-11-02T01:30:01Z

[Term]
id: XCO:0000099
name: control condition
alt_id: XCO:0000056
alt_id: XCO:0000791
def: "This is a condition defined by a mostly uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison. It is a baseline condition in which none of the experimental manipulations are performed." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "naive control condition" EXACT []
synonym: "standard condition" EXACT []
synonym: "standard control condition" EXACT []
is_a: XCO:0000000 ! experimental condition
created_by: mshimoyama
creation_date: 2010-11-02T02:06:02Z

[Term]
id: XCO:0000100
name: sham surgical control condition
def: "A surgical treatment or procedure that is performed as a control and that is similar to but omits a key therapeutic element of the treatment or procedure under investigation." [Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
is_a: XCO:0000099 ! control condition
is_a: XCO:0000165 ! surgical manipulation
created_by: mshimoyama
creation_date: 2010-11-02T02:06:46Z

[Term]
id: XCO:0000101
name: vehicle control condition
def: "A treatment used as a control in which a saline or other solution is administered in the same manner as the experimental solution minus the key element of the experimental solution." [https://www.merriam-webster.com/, ISBN-13:9780781733908]
synonym: "vehicle control diet" RELATED []
xref: PMID:28928461
is_a: XCO:0000099 ! control condition
created_by: mshimoyama
creation_date: 2010-11-02T02:07:02Z

[Term]
id: XCO:0000102
name: fasting
def: "Abstaining from the consumption of food, often for a specified period of time." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000013 ! diet
created_by: mshimoyama
creation_date: 2010-11-08T09:37:31Z

[Term]
id: XCO:0000103
name: glucose solution
def: "A mixture in which molecules of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "dextrose solution" RELATED []
relationship: has_component XCO:0000275 ! glucose
created_by: mshimoyama
creation_date: 2010-11-08T09:40:03Z

[Term]
id: XCO:0000104
name: glucose solution, 2.8M
def: "A mixture in which 2.8 moles of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout a sufficient volume of another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level and the final volume is one liter." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000103 ! glucose solution
created_by: mshimoyama
creation_date: 2010-11-08T09:40:19Z

[Term]
id: XCO:0000105
name: pancreatectomy
def: "Surgical removal of part or all of the pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000026 ! surgical removal
created_by: mshimoyama
creation_date: 2010-11-10T02:19:58Z

[Term]
id: XCO:0000106
name: anesthetic/analgesic
def: "Condition in which the main influencing factor is a drug or agent used to reduce or eliminate pain or sensation." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000341 ! chemical with specified function
created_by: mshimoyama
creation_date: 2011-01-21T09:44:08Z

[Term]
id: XCO:0000107
name: pentobarbital
def: "Short to intermediate acting barbiturate used as a sedative and hypnotic." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: mshimoyama
creation_date: 2011-01-21T09:45:03Z

[Term]
id: XCO:0000108
name: pentobarbital, sodium
def: "Sodium salt of pentobarbital, a short to intermediate acting barbiturate used as a sedative and hypnotic." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000107 ! pentobarbital
created_by: mshimoyama
creation_date: 2011-01-21T09:46:40Z

[Term]
id: XCO:0000109
name: isoflurane
def: "Potent inhalational anesthetic." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: mshimoyama
creation_date: 2011-01-21T09:48:47Z

[Term]
id: XCO:0000110
name: prone position
def: "A position in which the organism is lying face down." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000081 ! body position
created_by: mshimoyama
creation_date: 2011-02-07T01:44:52Z

[Term]
id: XCO:0000111
name: temperature exposure
is_a: XCO:0000000 ! experimental condition
created_by: mshimoyama
creation_date: 2011-02-08T02:22:15Z

[Term]
id: XCO:0000112
name: unilateral nephrectomy
def: "Surgical removal of a single kidney." [RGD:MS]
is_a: XCO:0000017 ! nephrectomy
created_by: mshimoyama
creation_date: 2011-11-02T02:08:41Z

[Term]
id: XCO:0000113
name: right nephrectomy
def: "Surgical removal of the right kidney." [RGD:MS]
is_a: XCO:0000112 ! unilateral nephrectomy
created_by: mshimoyama
creation_date: 2011-11-02T02:11:31Z

[Term]
id: XCO:0000114
name: left nephrectomy
def: "Surgical removal of the left kidney." [RGD:MS]
is_a: XCO:0000112 ! unilateral nephrectomy
created_by: mshimoyama
creation_date: 2011-11-02T02:12:44Z

[Term]
id: XCO:0000115
name: perfusate
def: "Any fluid which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000340 ! solution
created_by: mshimoyama
creation_date: 2012-01-09T01:29:00Z

[Term]
id: XCO:0000116
name: Kreb's solution perfusate
def: "A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/1/k3753pis.Par.0001.File.tmp/k3753pis.pdf "Sigma-Aldrich", ISBN:978-1416049982]
synonym: "Krebs-Henseleit buffer perfusate" RELATED []
synonym: "Krebs-Henseleit solution perfusate" RELATED []
synonym: "Krebs-Ringer buffer perfusate" RELATED []
synonym: "Krebs-Ringer solution perfusate" RELATED []
is_a: XCO:0000115 ! perfusate
created_by: mshimoyama
creation_date: 2012-01-09T01:29:11Z

[Term]
id: XCO:0000117
name: saline solution perfusate
def: "A fluid containing a specified amount of a chemical salt, for example sodium chloride, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." [Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000115 ! perfusate
created_by: mshimoyama
creation_date: 2012-01-09T01:29:28Z

[Term]
id: XCO:0000118
name: perfusate suspended
def: "A condition in which a fluid which has been injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel, remains in but is no longer actively passed through the organ or tissue for a specified period of time." [Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000115 ! perfusate
created_by: mshimoyama
creation_date: 2012-01-09T01:29:47Z

[Term]
id: XCO:0000119
name: amino acid
def: "Any naturally occurring or synthetic organic compound containing an amino group, a carboxylic acid group and a side chain. An amino acid may be administered as a nutritional supplement or as a drug." [http://en.eikipedia.org/wiki/ "Wikipedia"]
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2012-02-16T12:55:34Z

[Term]
id: XCO:0000120
name: inhibitor
def: "A substance or compound which interferes with a chemical reaction or a molecular or physiological process or activity." [http://medical-dictionary.thefreedictionary.com/inhibitor "Multiple_Dictionaries", RGD:JRS]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-02-16T01:09:21Z

[Term]
id: XCO:0000121
name: NG-nitroarginine methyl ester
def: "A basic amino acid, commonly known as L-NAME, used as a non-selective inhibitor of nitric oxide synthase." [MESH:D019331]
synonym: "L-NAME" EXACT []
xref: CAS:51298-62-5
xref: chembl.compound:CHEMBL7890
xref: MESH:D019331
xref: pubchem.compound:39836
is_a: XCO:0000119 ! amino acid
is_a: XCO:0000523 ! enzyme inhibitor
created_by: JSmith
creation_date: 2012-02-16T01:15:20Z

[Term]
id: XCO:0000122
name: diuretic
def: "A chemical which tends to increase the excretion of urine." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-02-16T01:51:41Z

[Term]
id: XCO:0000123
name: sulfonamide
def: "A compound containing a sulfonamide functional group. A sulfonamide functional group contains sulfonyl connected to an amine group and has the general structure R-S(=O)2-NH2. Sulfonamide also refers to several classes of drugs which include antimicrobial 'sulfa drugs', anticonvulsants and the sulfonylureas and thiazide diuretics." [http://en.eikipedia.org/wiki/ "Wikipedia"]
xref: CHEBI:35358
is_a: XCO:0000342 ! chemical with specified structure
is_a: XCO:0000950 ! anticonvulsant
created_by: JSmith
creation_date: 2012-02-16T01:52:39Z

[Term]
id: XCO:0000124
name: furosemide
def: "A diuretic drug which inhibits Nkcc2, one of the Na-K symporters and reduces the reabsorption of sodium chloride. Furosemide is used experimentally for sodium depletion." [http://en.eikipedia.org/wiki/ "Wikipedia"]
synonym: "Frusemide" RELATED []
synonym: "Lasix" RELATED []
xref: CHEBI:47426
xref: pubchem.compound:3440
is_a: XCO:0000122 ! diuretic
is_a: XCO:0000123 ! sulfonamide
created_by: JSmith
creation_date: 2012-02-16T01:53:25Z

[Term]
id: XCO:0000125
name: hormone
def: "A chemical substance which in its endogenous state is produced by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-02-16T02:54:55Z

[Term]
id: XCO:0000126
name: angiotensin
def: "A peptide hormone which increases blood pressure by causing blood vessel constriction. Part of the renin-angiotensin system." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000141 ! vasoconstrictor
is_a: XCO:0000228 ! peptide hormone
created_by: JSmith
creation_date: 2012-02-16T03:00:38Z

[Term]
id: XCO:0000127
name: norepinephrine
def: "A catecholamine neurotransmitter and stress hormone with multiple physiological roles including affects on heart rate, blood pressure and vascular tone." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "noradrenaline" EXACT []
is_a: XCO:0000141 ! vasoconstrictor
is_a: XCO:0000144 ! neurotransmitter
is_a: XCO:0000230 ! monoamine hormone
created_by: JSmith
creation_date: 2012-02-16T03:01:05Z

[Term]
id: XCO:0000128
name: drink with chemical additive
is_obsolete: true
created_by: JSmith
creation_date: 2012-02-16T03:23:23Z

[Term]
id: XCO:0000129
name: water with NG-Nitroarginine Methyl Ester
def: "Drinking water with a specified concentration of NG-Nitroarginine Methyl Ester (L-NAME) added to it. L-NAME is used as a non-selective inhibitor of nitric oxide synthase." [PGA:Renal_protocol]
synonym: "water with L-NAME" EXACT []
is_obsolete: true
created_by: JSmith
creation_date: 2012-02-16T03:23:57Z

[Term]
id: XCO:0000130
name: ketamine
def: "An analgesic and anesthetic which functions as a noncompetitive NMDA receptor (NMDAR) antagonist, binding to the allosteric site of the NMDA receptor and effectively inhibiting its channel." [http://en.wikipedia.org/wiki/Ketamine "Wikipedia"]
xref: CHEBI:6121
xref: pubchem.compound:3821
is_a: XCO:0000947 ! NMDA receptor antagonist
created_by: JSmith
creation_date: 2012-03-15T07:33:06Z

[Term]
id: XCO:0000131
name: xylazine
def: "An alpha2-adrenergic receptor agonist used for sedation, anesthesia, muscle relaxation, and analgesia in animals." [http://en.wikipedia.org/wiki/Xylazine "Wikipedia"]
xref: CHEBI:165540
xref: chembl.compound:CHEMBL297362
xref: pubchem.compound:5707
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: JSmith
creation_date: 2012-03-15T07:34:39Z

[Term]
id: XCO:0000132
name: acepromazine
def: "A phenothiazine-derivative antipsychotic drug used in animals as a sedative and antiemetic and which can also cause peripheral vasodilation." [http://en.wikipedia.org/wiki/Acepromazine "Wikipedia"]
xref: CHEBI:44932
xref: pubchem.compound:6077
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: JSmith
creation_date: 2012-03-15T07:39:01Z

[Term]
id: XCO:0000133
name: antigen
def: "A condition in which the major influencing factor is a chemical compound to which the body can mount a specific localized or systemic immune reaction, e.g. a T cell or B cell response." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed, RGD:JRS]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-03-15T07:42:13Z

[Term]
id: XCO:0000134
name: methacholine
def: "A synthetic choline ester that acts as a non-selective muscarinic receptor agonist, that is, a chemical which when bound to the receptor produces a physiologic reaction typical of the naturally occurring ligand, in the parasympathetic nervous system." [http://en.wikipedia.org/wiki/Methacholine "Wikipedia"]
xref: CHEBI:6804
is_a: XCO:0000135 ! receptor agonist
created_by: JSmith
creation_date: 2012-03-15T07:45:00Z

[Term]
id: XCO:0000135
name: receptor agonist
def: "A drug or other chemical that can combine with a receptor to produce a physiologic reaction typical of a naturally occurring substance. A receptor is a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect in the cell." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000214 ! activator
created_by: JSmith
creation_date: 2012-03-15T07:46:38Z

[Term]
id: XCO:0000136
name: enzyme substrate
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-03-15T07:48:19Z

[Term]
id: XCO:0000137
name: FAPGG
def: "An oligopeptide substrate for continuous spectrophotometric assay of angiotensin converting enzyme (ACE) which hydrolyzes FAPGG to furylacryloylphenylalanine (FAP) and glycylglycine with a resulting decrease in absorbance at 340 nm." [http://www.sigmaaldrich.com/catalog/product/sigma/f7131?lang=en&region=US "Website", http://www.trinitybiotech.com/Product%20Documents/305-10-29%20EN.pdf "Website"]
synonym: "3-(2-FurylAcryloyl)-L-PHE-GLY-GLY" EXACT []
synonym: "FurylAcrylolPhenylalanylGlycylGlycine" EXACT []
xref: CAS:64566-61-6
xref: pubchem.compound:6438387
is_a: XCO:0000136 ! enzyme substrate
created_by: JSmith
creation_date: 2012-03-15T07:48:41Z

[Term]
id: XCO:0000138
name: methylene blue
def: "Methylene blue is monoamine oxidase inhibitor and nitric oxide synthase inhibitor, as well as a cationic dye used as a redox indicator." [RGD:SL]
synonym: "methylthioninium chloride" EXACT []
xref: CHEBI:6872
xref: pubchem.compound:6099
is_a: XCO:0000199 ! oxidation-reduction indicator
is_a: XCO:0000523 ! enzyme inhibitor
created_by: JSmith
creation_date: 2012-03-15T07:51:22Z

[Term]
id: XCO:0000139
name: vasoactive chemical
def: "A condition in which the main influencing factor is a molecule that directly or indirectly acts upon blood vessels to cause constriction or dilation." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-03-15T07:53:30Z

[Term]
id: XCO:0000140
name: vasodilator
def: "A condition in which the main influencing factor is a molecule that functions to dilate or increase the interior diameter of blood vessels." [Gale:Gale_Encyclopedia_of_Medicine]
is_a: XCO:0000139 ! vasoactive chemical
created_by: JSmith
creation_date: 2012-03-15T07:55:13Z

[Term]
id: XCO:0000141
name: vasoconstrictor
def: "A condition in which the main influencing factor is a molecule that acts to constrict or reduce the interior diameter of blood vessels." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "vasopressor" RELATED []
is_a: XCO:0000139 ! vasoactive chemical
created_by: JSmith
creation_date: 2012-03-15T07:56:15Z

[Term]
id: XCO:0000142
name: sodium nitroprusside
def: "The red-coloured inorganic salt with the formula Na2[Fe(CN)5NO]·2H2O used as a potent vasodilator." [http://en.wikipedia.org/wiki/Sodium_nitroprusside "Wikipedia"]
synonym: "disodium pentacyanonitrosylferrate(2-) dehydrate" EXACT []
synonym: "sodium nitroferricyanide" EXACT []
xref: CHEBI:29321
xref: pubchem.compound:11953891
xref: pubchem.compound:11963579
is_a: XCO:0000140 ! vasodilator
created_by: JSmith
creation_date: 2012-03-15T07:58:24Z

[Term]
id: XCO:0000143
name: acetylcholine
def: "An organic, polyatomic cation, formed as an ester of acetic acid and choline, that acts as a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms." [http://en.wikipedia.org/wiki/Acetylcholine "Wikipedia"]
xref: CHEBI:15355
xref: pubchem.compound:187
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000144 ! neurotransmitter
created_by: JSmith
creation_date: 2012-03-15T08:00:34Z

[Term]
id: XCO:0000144
name: neurotransmitter
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-03-15T08:01:41Z

[Term]
id: XCO:0000145
name: phenylephrine
def: "A selective alpha1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and as a vasoconstrictor." [http://en.wikipedia.org/wiki/Phenylephrine "Wikipedia"]
xref: CHEBI:8093
xref: pubchem.compound:6041
is_a: XCO:0000141 ! vasoconstrictor
is_a: XCO:0000673 ! alpha-adrenergic agonist
created_by: JSmith
creation_date: 2012-03-15T08:02:39Z

[Term]
id: XCO:0000146
name: controlled oxygen content Kreb's solution perfusate
def: "A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source in which a specified amount of the tasteless, odorless, colorless gas essential for aerobic respiration with atomic number 8 has been dissolved, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/1/k3753pis.Par.0001.File.tmp/k3753pis.pdf "Sigma-Aldrich", ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled oxygen content Krebs-Henseleit buffer perfusate" RELATED []
synonym: "controlled oxygen content Krebs-Henseleit solution perfusate" RELATED []
synonym: "controlled oxygen content Krebs-Ringer buffer perfusate" RELATED []
synonym: "controlled oxygen content Krebs-Ringer solution perfusate" RELATED []
is_a: XCO:0000116 ! Kreb's solution perfusate
created_by: JSmith
creation_date: 2012-03-21T02:07:15Z

[Term]
id: XCO:0000147
name: physiological salt solution perfusate
def: "A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood." [http://en.wikipedia.org/wiki/Saline_%28medicine%29#Normal "Wikipedia"]
synonym: "normal saline perfusate" RELATED []
synonym: "PSS" EXACT []
is_a: XCO:0000117 ! saline solution perfusate
created_by: JSmith
creation_date: 2012-03-21T02:18:12Z

[Term]
id: XCO:0000148
name: controlled oxygen content physiological salt solution perfusate
def: "A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of oxygen gas, the tasteless, odorless, colorless gas with atomic number 8 essential for aerobic respiration, dissolved in it." [http://en.wikipedia.org/wiki/Saline_%28medicine%29#Normal "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "oxygenated PSS" EXACT []
is_a: XCO:0000147 ! physiological salt solution perfusate
created_by: JSmith
creation_date: 2012-03-21T02:19:03Z

[Term]
id: XCO:0000149
name: ion/salt
def: "Any condition in which the main influencing factor is an atom or molecule that has gained or lost one or more electrons and thereby acquired a charge, or is any of a large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion)." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2012-03-23T07:25:49Z

[Term]
id: XCO:0000150
name: potassium ion
def: "A condition in which the main influencing factor is an atom of potassium, the chemical element with atomic number 19, that has lost one electron, forming a cation with a charge of +1. Potassium is the chief cation of intracellular fluid." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
comment: Not used for potassium salt in animal feed. For that application  XCO:0000032, "controlled potassium content diet" is used.
synonym: "K+ ion" EXACT []
xref: CHEBI:29103
is_a: XCO:0000149 ! ion/salt
created_by: JSmith
creation_date: 2012-03-23T07:31:29Z

[Term]
id: XCO:0000151
name: chemical time series
is_a: XCO:0000088 ! chemical
created_by: JSmith
creation_date: 2012-03-23T08:10:45Z

[Term]
id: XCO:0000152
name: drug dose time series
def: "The condition of exposing an organism, organ or tissue to a series of increasing or decreasing doses of a drug or other chemical from which a single measurement value is obtained." [RGD:JRS]
is_a: XCO:0000151 ! chemical time series
created_by: JSmith
creation_date: 2012-03-23T08:11:18Z

[Term]
id: XCO:0000153
name: sample resting period
def: "A predetermined and specified amount of time during which an experimental specimen sits undisturbed, for example to allow a chemical reaction to proceed." [RGD:JRS]
synonym: "sample room temperature incubation" NARROW []
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2012-03-26T10:46:30Z

[Term]
id: XCO:0000154
name: ion/salt solution
def: "This is any condition in which the main influencing factor is a homogeneous mixture of one or more ions, i.e. atoms or molecules that have gained or lost electron(s) and thereby acquired a charge, or one or more salts, i.e. members of the large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion), dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000340 ! solution
relationship: has_component XCO:0000149 ! ion/salt
created_by: JSmith
creation_date: 2012-03-26T04:34:54Z

[Term]
id: XCO:0000155
name: sodium chloride solution
def: "A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "saline solution" RELATED []
synonym: "salt solution" EXACT []
xref: CHEBI:26710
is_a: XCO:0000254 ! sodium ion solution
created_by: JSmith
creation_date: 2012-03-26T04:36:15Z

[Term]
id: XCO:0000156
name: 0.9% sodium chloride solution
def: "This is a condition in which the main influencing factor is a solution of sodium chloride (NaCl) and water in which the level of NaCl is maintained at a mass concentration of 9 grams per liter (0.9 grams per 100 mls of solution, or 0.9 % m/v). The osmolarity of normal saline is a close approximation to the osmolarity of NaCl in blood." [http://en.wikipedia.org/wiki/Saline_%28medicine%29 "Wikipedia"]
synonym: "0.9% Sodium Chloride Injection" RELATED []
synonym: "normal saline" EXACT []
xref: CHEBI:26710
is_a: XCO:0000020 ! drink
is_a: XCO:0000155 ! sodium chloride solution
created_by: JSmith
creation_date: 2012-03-26T04:56:10Z

[Term]
id: XCO:0000157
name: physical restraint
def: "The use of manual or mechanical means to limit some or all of an animal's normal movement for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation." [http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf "NIH"]
is_a: XCO:0000001 ! activity
created_by: JSmith
creation_date: 2012-06-07T12:30:41Z

[Term]
id: XCO:0000158
name: physical restraint in mechanical restrainer
def: "The use of mechanical means, i.e. a manufactured apparatus or machine, to limit some or all of an animal's normal movements." [http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf "NIH", RGD:JRS]
is_a: XCO:0000157 ! physical restraint
created_by: JSmith
creation_date: 2012-06-07T12:42:46Z

[Term]
id: XCO:0000159
name: physical restraint in tube type rodent restrainer
def: "The use of a tube type rodent restrainer, that is, a hollow cylinder usually made of a rigid clear material in a size that approximates the size of the animal and can be capped at one or both ends to prevent escape, to limit some or all of an animal's normal movements." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf "NIH"]
is_a: XCO:0000158 ! physical restraint in mechanical restrainer
created_by: JSmith
creation_date: 2012-06-07T12:43:33Z

[Term]
id: XCO:0000160
name: receptor antagonist
def: "A substance that binds to a receptor without eliciting a biological response, blocking binding of substances that could elicit such responses." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000120 ! inhibitor
created_by: JSmith
creation_date: 2012-07-03T03:15:44Z

[Term]
id: XCO:0000161
name: losartan
def: "Angiotensin receptor antagonist and vasodilator which consists of a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position. Losartan also has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position." []
xref: CHEBI:6541
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000536 ! angiotensin II receptor antagonist
created_by: JSmith
creation_date: 2012-07-09T10:53:01Z

[Term]
id: XCO:0000162
name: pentolinium
def: "Nicotinic acetylcholine receptor antagonist, ganglionic blocking agent and vasodilator which consists of a dication whose structure comprises a pentane backbone linking two 1-methylpyrrolidinium groups." []
xref: CHEBI:347401
xref: CHEBI:55326
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000160 ! receptor antagonist
created_by: JSmith
creation_date: 2012-07-09T10:58:54Z

[Term]
id: XCO:0000163
name: controlled content drinking water
def: "Drinking water in which the amount of one or more solutes are adjusted to a requirement." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
is_a: XCO:0000021 ! water
created_by: JSmith
creation_date: 2012-07-09T11:14:14Z

[Term]
id: XCO:0000164
name: controlled sodium content drinking water
def: "A drink made up of water and a specified amount of sodium, i.e. sodium ions, consumed by an organism as part of an experiment. A sodium ion is an atom of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000254 ! sodium ion solution
created_by: JSmith
creation_date: 2012-07-09T11:19:29Z

[Term]
id: XCO:0000165
name: surgical manipulation
def: "Any process involving manual and instrumental techniques for incision or excision of a part of an organism to investigate and/or treat a pathological condition." [http://en.wikipedia.org/wiki/Surgery "Wikipedia"]
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2012-07-11T01:38:55Z

[Term]
id: XCO:0000166
name: controlled in situ organ condition
def: "Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." [http://www.thefreedictionary.com/ "Multiple_Dictionaries", RGD:JRS, RGD:MRD]
is_a: XCO:0000165 ! surgical manipulation
created_by: JSmith
creation_date: 2012-07-11T02:55:03Z

[Term]
id: XCO:0000167
name: controlled in situ kidney condition
def: "Any experimental condition in which the internal or external environment of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, RGD:JRS]
is_a: XCO:0000166 ! controlled in situ organ condition
created_by: JSmith
creation_date: 2012-07-11T03:01:51Z

[Term]
id: XCO:0000168
name: controlled in situ renal perfusion pressure
def: "Condition in which the difference in pressure between the arteries and veins in the kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally regulated, for example by injecting or pumping a fluid into the kidney at a specified pressure or by regulating the blood flow through the kidney, without removal of the organ from the body." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000167 ! controlled in situ kidney condition
created_by: JSmith
creation_date: 2012-07-11T03:07:44Z

[Term]
id: XCO:0000169
name: labeled chemical
def: "Any chemical to which a tracer has been added such as the addition of a fluorescent tag or inclusion of a radioactive element during synthesis." [RGD:JRS]
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2012-07-11T03:39:04Z

[Term]
id: XCO:0000170
name: fluorescently labeled chemical
def: "Chemical to which a fluorescent tag has been added as a tracer." [RGD:JRS]
is_a: XCO:0000169 ! labeled chemical
created_by: JSmith
creation_date: 2012-07-11T03:51:55Z

[Term]
id: XCO:0000171
name: radioactively labeled chemical
def: "Chemical into which a radioactive element has been incorporated as a tracer." [RGD:JRS]
is_a: XCO:0000169 ! labeled chemical
created_by: JSmith
creation_date: 2012-07-11T03:53:33Z

[Term]
id: XCO:0000172
name: carbohydrate
def: "Any of a group of organic compounds that includes sugars, starches, celluloses, and gums and serves as a major energy source in the diet of animals." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
xref: CHEBI:16646
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2012-07-11T04:09:48Z

[Term]
id: XCO:0000173
name: polysaccharide
def: "A macromolecule consisting of large numbers of monosaccharide residues, that is, simple carbohydrate residues each consisting of a single basic sugar unit with the general formula Cn(H2O)n, linked glycosidically." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: CHEBI:18154
is_a: XCO:0000172 ! carbohydrate
created_by: JSmith
creation_date: 2012-07-11T04:13:15Z

[Term]
id: XCO:0000174
name: inulin
def: "A fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: CHEBI:15443
is_a: XCO:0000173 ! polysaccharide
created_by: JSmith
creation_date: 2012-07-11T04:15:22Z

[Term]
id: XCO:0000175
name: tritiated inulin
def: "Inulin, a fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration, into which the mass 3 radioactive isotope of hydrogen has been incorporated as a tracer." [Mosby:Mosbys_Medical_Dictionary--8th_Ed, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "3H-inulin" EXACT []
is_a: XCO:0000171 ! radioactively labeled chemical
is_a: XCO:0000174 ! inulin
created_by: JSmith
creation_date: 2012-07-11T04:18:17Z

[Term]
id: XCO:0000176
name: enzyme
def: "Any of numerous proteins or conjugated proteins produced by living organisms and functioning as specialized catalysts for biochemical reactions." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
is_a: XCO:0000193 ! peptide/protein
created_by: JSmith
creation_date: 2012-07-12T05:06:15Z

[Term]
id: XCO:0000177
name: thrombin
def: "An enzyme in blood formed from prothrombin that facilitates blood clotting by reacting with fibrinogen to form fibrin, as well as participating in additional steps in the coagulation pathway." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, http://en.wikipedia.org/wiki/Thrombin "Wikipedia"]
xref: EC:3.4.21.5
is_a: XCO:0000176 ! enzyme
created_by: JSmith
creation_date: 2012-07-12T05:13:12Z

[Term]
id: XCO:0000178
name: thapsigargin
def: "A non-competitive inhibitor of the sarco / endoplasmic reticulum Ca2+ ATPase (SERCA) class of enzymes. Acts as a non-phorbol-ester-type tumor promoter and acts as an inhibitor of calcium ATPase of endoplasmic reticulum, leading to an increase in cytoplasmic calcium ions." [http://en.wikipedia.org/wiki/Thapsigargin "Wikipedia", Mondofacto:Mondofacto_Online_Medical_Dictionary]
xref: CHEBI:9516
is_a: XCO:0000523 ! enzyme inhibitor
is_a: XCO:0000892 ! tumor promoter
created_by: JSmith
creation_date: 2012-07-12T05:24:18Z

[Term]
id: XCO:0000179
name: ionizing ultraviolet radiation exposure
def: "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 10 and 120 nm. Radiation (i.e. ultraviolet light) at this wavelength is considered  ionizing, that is, composed of photons that individually carry enough energy to liberate an electron from an atom or molecule without raising the bulk material to ionization temperature." [http://en.wikipedia.org/wiki/Electromagnetic_Radiation "Wikipedia", http://en.wikipedia.org/wiki/Ionizing_radiation "Wikipedia"]
synonym: "extreme ultraviolet ray exposure" RELATED []
synonym: "extreme UV ray exposure" RELATED []
synonym: "ionizing UV radiation exposure" EXACT []
is_a: XCO:0000039 ! ionizing radiation exposure
is_a: XCO:0000042 ! ultraviolet ray exposure
created_by: JSmith
creation_date: 2012-07-13T12:39:17Z

[Term]
id: XCO:0000180
name: non-ionizing ultraviolet radiation exposure
def: "The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 120 and 400 nm. Radiation (i.e. ultraviolet light) at this wavelength does not have sufficient energy to liberate electrons from atoms or molecules although it can induce photochemical reactions, or accelerate radical reactions." [http://en.wikipedia.org/wiki/Electromagnetic_Radiation "Wikipedia", http://en.wikipedia.org/wiki/Ultraviolet "Wikipedia"]
synonym: "near ultraviolet radiation exposure" NARROW []
synonym: "non-ionizing UV radiation exposure" EXACT []
is_a: XCO:0000042 ! ultraviolet ray exposure
is_a: XCO:0000044 ! non-ionizing radiation exposure
created_by: JSmith
creation_date: 2012-07-13T01:00:12Z

[Term]
id: XCO:0000181
name: controlled visible light condition
def: "Condition in which the presence or absence of visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is constrained." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2012-07-13T02:59:55Z

[Term]
id: XCO:0000182
name: controlled exposure to ambient light
def: "Condition in which the natural, usual or environmental level and/or time of exposure to visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is controlled." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
synonym: "diurnal condition" RELATED []
is_a: XCO:0000284 ! controlled visible light exposure
created_by: JSmith
creation_date: 2012-07-13T03:09:31Z

[Term]
id: XCO:0000183
name: controlled exposure to darkness
def: "Condition during which visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is removed." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
synonym: "nocturnal condition" RELATED []
is_a: XCO:0000181 ! controlled visible light condition
created_by: JSmith
creation_date: 2012-07-13T03:12:34Z

[Term]
id: XCO:0000184
name: calcium ion
def: "The divalent cation of calcium, the chemical element with symbol Ca and atomic number 20." [http://en.wikipedia.org/wiki/Calcium "Wikipedia"]
xref: CHEBI:29108
is_a: XCO:0000149 ! ion/salt
created_by: JSmith
creation_date: 2012-07-13T03:19:56Z

[Term]
id: XCO:0000185
name: calcium ion solution
def: "A solution of the divalent cation of calcium, the chemical element with symbol Ca and atomic number 20." [http://en.wikipedia.org/wiki/Calcium "Wikipedia"]
xref: CHEBI:29108
is_a: XCO:0000154 ! ion/salt solution
relationship: has_component XCO:0000184 ! calcium ion
created_by: JSmith
creation_date: 2012-07-13T03:25:32Z

[Term]
id: XCO:0000186
name: cytisine
def: "A toxic selective nicotinic cholinergic alkaloid from the seed of Laburnum anagyroides and other Leguminosae. Used in pharmacological studies of nicotinic cholinergic receptors in the brain." [Mondofacto:Mondofacto_Online_Medical_Dictionary]
synonym: "baptitoxine" RELATED []
synonym: "sophorine" RELATED []
xref: CAS:485-35-8
is_a: XCO:0000693 ! cholinergic agonist
created_by: JSmith
creation_date: 2012-07-30T08:40:00Z

[Term]
id: XCO:0000187
name: trimethaphan camsylate
def: "A drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia by acting as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor." [http://en.wikipedia.org/wiki/Trimethaphan_camsylate "Wikipedia"]
synonym: "Arfonad" RELATED []
synonym: "trimetaphan camsilate" EXACT []
xref: CAS:7187-66-8
xref: CHEBI:9729
is_a: XCO:0000630 ! cholinergic antagonist
created_by: JSmith
creation_date: 2012-07-30T08:54:30Z

[Term]
id: XCO:0000188
name: darodipine
def: "Calcium channel blocker." [http://en.wikipedia.org/wiki/Darodipine "Wikipedia"]
synonym: "PY 108-068" RELATED []
xref: CAS:72803-02-2
is_a: XCO:0000269 ! calcium channel inhibitor
created_by: JSmith
creation_date: 2012-07-30T09:01:57Z

[Term]
id: XCO:0000189
name: physical restraint on immobilization board
def: "Immobilization of a subject on a frame or platform by securing all four limbs to it, e.g. by taping them to mounts attached to the frame, thereby eliminating the subject's ability to move at will." [Fink:Encyclopedia_of_Stress]
is_a: XCO:0000158 ! physical restraint in mechanical restrainer
created_by: JSmith
creation_date: 2012-08-01T04:38:43Z

[Term]
id: XCO:0000190
name: angiotensin I
def: "The 10 amino acid cleavage product produced by the action of renin on angiotensinogen.  Ang I is apparently inactive unless further cleaved by angiotensin-converting enzyme (ACE) into Ang II." [PMID:18793332]
is_a: XCO:0000126 ! angiotensin
created_by: JSmith
creation_date: 2012-08-09T01:48:44Z

[Term]
id: XCO:0000191
name: angiotensin II
def: "The 8 amino acid cleavage product produced by the action of angiotensin-converting enzyme (ACE) on Ang I.  Ang II is considered to be the main effector of the renin-angiotensin system (RAS), has endocrine, autocrine/paracrine, and intracrine hormone activities in the body and acts as a powerful vasoconstrictor." [PMID:18793332]
xref: CHEBI:48432
is_a: XCO:0000126 ! angiotensin
created_by: JSmith
creation_date: 2012-08-09T01:58:29Z

[Term]
id: XCO:0000192
name: deoxycorticosterone acetate
def: "The acetate ester of 11-deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone." [http://en.wikipedia.org/wiki/11-Deoxycorticosterone "Wikipedia"]
synonym: "21-hydroxyprogesterone acetate" RELATED []
synonym: "desoxycorticosterone acetate" RELATED []
synonym: "DOCA" RELATED []
xref: CHEBI:16973
is_a: XCO:0000330 ! deoxycorticosterone
created_by: JSmith
creation_date: 2012-08-09T02:19:10Z

[Term]
id: XCO:0000193
name: peptide/protein
def: "Any natural or synthetic complex organic macromolecule composed of chain(s) of amino acids. A peptide can be contain as few as two amino acids; a protein can contain multiple chains composed of hundreds of amino acids." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "polypeptide" RELATED []
is_a: XCO:0000342 ! chemical with specified structure
created_by: jsmith
creation_date: 2012-08-27T04:50:37Z

[Term]
id: XCO:0000194
name: antibody
def: "An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that induced its synthesis and with molecules containing structures similar to that antigen.  An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
synonym: "immunoglobulin" RELATED []
is_a: XCO:0000193 ! peptide/protein
created_by: jsmith
creation_date: 2012-08-27T05:01:08Z

[Term]
id: XCO:0000195
name: myelin oligodendrocyte glycoprotein
def: "A membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is considered a primary target antigen involved in immune-mediated demyelination." [NCBI_Gene:4340]
synonym: "Mog" RELATED []
synonym: "RGD:3102" NARROW []
synonym: "rMog (recombinant Mog)" RELATED []
is_a: XCO:0000193 ! peptide/protein
created_by: jsmith
creation_date: 2012-08-27T05:05:03Z

[Term]
id: XCO:0000196
name: glybenclamide
def: "ATP-sensitive potassium channel inhibitor used as an anti-arrhythmia drug and a hypoglycemic/anti-diabetes drug. In the latter case, the drug causes beta cell membrane depolarization, which in turn results in opening of voltage-dependent calcium channels and subsequent insulin release." [http://en.wikipedia.org/wiki/Glibenclamide "Wikipedia"]
synonym: "glyburide" EXACT []
xref: CHEBI:5441
is_a: XCO:0000225 ! potassium channel inhibitor
created_by: JSmith
creation_date: 2012-09-10T11:39:12Z

[Term]
id: XCO:0000197
name: indicator
def: "Any substance that indicates the presence, absence, or concentration of another substance or the degree of reaction between substances by means of a characteristic change, especially in color." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-09-10T12:25:59Z

[Term]
id: XCO:0000198
name: pH indicator
def: "Any substance that indicates the concentration of hydrogen ions, that is the acidity level, of a solution by means of a characteristic change, especially in color." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
is_a: XCO:0000197 ! indicator
created_by: JSmith
creation_date: 2012-09-10T12:30:07Z

[Term]
id: XCO:0000199
name: oxidation-reduction indicator
def: "Any substance which indicates the oxidation status of another substance or of a reaction by means of a characteristic change, especially in color." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "redox indicator" EXACT []
is_a: XCO:0000197 ! indicator
created_by: JSmith
creation_date: 2012-09-10T12:34:38Z

[Term]
id: XCO:0000200
name: 4-methyl-2-oxopentanoic acid
def: "A monocarboxylic acid that serves as an intermediate in the metabolism of leucine and a substrate for NADPH-dependent dehydrogenases." [http://en.wikipedia.org/wiki/Alpha-Ketoisocaproic_acid "Wikipedia"]
synonym: "2-Oxoisocaproate" EXACT []
synonym: "4-methyl-2-oxovaleric acid" EXACT []
synonym: "alpha-ketoisocaproic acid" EXACT []
synonym: "alpha-KIC" RELATED []
synonym: "Ketoleucine" RELATED []
xref: CHEBI:48430
xref: pubchem.compound:70
is_a: XCO:0000136 ! enzyme substrate
created_by: JSmith
creation_date: 2012-09-10T12:50:31Z

[Term]
id: XCO:0000201
name: orchiectomy
def: "Surgical removal of one or both testes." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "orchidectomy" EXACT []
synonym: "testectomy" EXACT []
is_a: XCO:0000026 ! surgical removal
created_by: JSmith
creation_date: 2012-09-10T01:13:58Z

[Term]
id: XCO:0000202
name: unilateral orchiectomy
def: "Surgical removal of a single testis." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "unilateral orchidectomy" EXACT []
synonym: "unilateral testectomy" RELATED []
is_a: XCO:0000201 ! orchiectomy
created_by: JSmith
creation_date: 2012-09-10T01:18:15Z

[Term]
id: XCO:0000203
name: bilateral orchiectomy
def: "Surgical removal of both testes." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "bilateral orchidectomy" EXACT []
synonym: "bilateral testectomy" EXACT []
synonym: "castration" RELATED []
is_a: XCO:0000201 ! orchiectomy
created_by: JSmith
creation_date: 2012-09-10T01:20:16Z

[Term]
id: XCO:0000204
name: testosterone
def: "The principal androgenic, that is, male sex hormone. Responsible for regulation of gonadotropic secretion, spermatogenesis and control of other male characteristics." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000229 ! steroid hormone
created_by: JSmith
creation_date: 2012-09-10T01:41:13Z

[Term]
id: XCO:0000205
name: mutation inducing chemical
def: "An agent that causes or increases the frequency of permanent, heritable changes in the DNA sequence or chromosomal structure of a cell or organism." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "mutagen" EXACT []
synonym: "mutation inducing agent" RELATED []
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-09-11T04:39:32Z

[Term]
id: XCO:0000206
name: N-nitrosodiethylamine
def: "A component of tobacco smoke which has been shown to be mutagenic and carcinogenic in animal studies." [PMID:8910949]
synonym: "diethylnitrosamine" RELATED []
synonym: "NDEA" RELATED []
synonym: "N,N-diethylnitrosamine" RELATED []
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000205 ! mutation inducing chemical
created_by: JSmith
creation_date: 2012-09-11T05:01:10Z

[Term]
id: XCO:0000207
name: 3-methyl-4'-dimethylaminoazobenzene
def: "A condition in which the main influencing factor is 3-methyl-4'-dimethylaminoazobenzene (MDAB), an azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. MDAB is a potent liver carcinogen." [http://potency.berkeley.edu/chempages/3%27-METHYL-4-DIMETHYLAMINOAZOBENZENE.html "Website"]
synonym: "3'-Me-DAB" RELATED []
synonym: "3'-methyl-4-(dimethylamino)azobenzene" RELATED []
synonym: "4-Dimethylamino-3'-methylazobenzene" EXACT []
synonym: "MDAB" RELATED []
synonym: "methyldimethylaminoazobenzene" EXACT []
xref: CAS:55-80-1
xref: CHEBI:76329
xref: pubchem.compound:5934
is_a: XCO:0000089 ! neoplasm-inducing chemical
created_by: JSmith
creation_date: 2012-09-11T05:33:14Z

[Term]
id: XCO:0000208
name: 2-acetamidofluorene
def: "A condition in which the main influencing factor is 2-acetamidofluorene (2-AAF) an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. 2-AAF and a number of its metabolites are both carcinogenic and mutagenic." [http://en.wikipedia.org/wiki/Acetylaminofluorene "Wikipedia"]
synonym: "2-AAF" RELATED []
synonym: "2-acetylaminofluorene" RELATED []
xref: CHEBI:17356
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000205 ! mutation inducing chemical
created_by: JSmith
creation_date: 2012-09-13T06:33:44Z

[Term]
id: XCO:0000209
name: hepatectomy
is_a: XCO:0000026 ! surgical removal
created_by: JSmith
creation_date: 2012-09-13T06:34:26Z

[Term]
id: XCO:0000210
name: partial hepatectomy
def: "A condition involving the surgical excision of part of the liver, the large abdominal organ/gland which functions in the storage and filtration of blood, secretion of bile, and other processes. The partial liver removal may be minor (< 50%) or major (> 50%)." [ISBN-13:9780781733908, PMID:32156510]
synonym: "major hepatectomy" NARROW []
synonym: "minor hepatectomy" NARROW []
xref: PMID:32156510
is_a: XCO:0000209 ! hepatectomy
created_by: JSmith
creation_date: 2012-09-13T06:34:52Z

[Term]
id: XCO:0000211
name: controlled sucrose content diet
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000432 ! sucrose
created_by: JSmith
creation_date: 2012-09-13T06:36:13Z

[Term]
id: XCO:0000212
name: controlled copper content diet
def: "A regimen of solid food in which the amount of copper consumed is controlled." [https://www.merriam-webster.com, ISBN-13:9780781733908]
synonym: "controlled Cu content diet" EXACT []
is_a: XCO:0000920 ! controlled mineral content diet
created_by: JSmith
creation_date: 2012-09-13T06:36:56Z

[Term]
id: XCO:0000213
name: arginine
def: "Any condition in which the main influencing factor is arginine (L-arginine), an alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group." [CHEBI:29016, https://en.wikipedia.org/wiki/Arginine]
synonym: "2-amino-5-guanidinopentanoic acid" EXACT []
synonym: "ARG" EXACT []
synonym: "L-arginine" EXACT []
synonym: "R" EXACT []
xref: CHEBI:29016
xref: MESH:D001120
is_a: XCO:0000119 ! amino acid
created_by: JSmith
creation_date: 2012-09-13T06:45:59Z

[Term]
id: XCO:0000214
name: activator
def: "Any substance that makes another substance active or reactive, induces a chemical reaction, or combines with an enzyme to increase its catalytic activity." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-10-04T05:09:16Z

[Term]
id: XCO:0000215
name: controlled calcium ion content physiological salt solution perfusate
def: "A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of calcium ions, divalent cations of the metallic chemical element with atomic number 20, dissolved in it." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, http://en.wikipedia.org/wiki/Saline_%28medicine%29#Normal "Wikipedia"]
is_a: XCO:0000147 ! physiological salt solution perfusate
created_by: JSmith
creation_date: 2012-10-05T11:11:47Z

[Term]
id: XCO:0000216
name: ion channel activator
def: "Any chemical substance which increases the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "ion channel agonist" RELATED []
is_a: XCO:0000214 ! activator
created_by: JSmith
creation_date: 2012-10-04T05:16:39Z

[Term]
id: XCO:0000217
name: cation channel activator
def: "Any chemical substance which increases the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000216 ! ion channel activator
created_by: JSmith
creation_date: 2012-10-04T05:40:42Z

[Term]
id: XCO:0000218
name: 4-alpha-phorbol 12,13-didecanoate
def: "A phorbol ester analog that is an activator of TRPV4 (transient receptor potential cation channel, subfamily V, member 4) channels." [http://www.lclabs.com/PRODFILE/P-R/P-2170.php4 "Website"]
synonym: "4-alpha-PDD" EXACT []
xref: CHEBI:295732
xref: pubchem.compound:452544
is_a: XCO:0000217 ! cation channel activator
created_by: JSmith
creation_date: 2012-10-04T05:41:38Z

[Term]
id: XCO:0000219
name: dihydrocapsaicin
def: "A capsaicinoid which is an irritant and a selective TRPV1 (transient receptor potential cation channel, subfamily V, member 1) agonist." [http://datasheets.scbt.com/sc-202578.pdf "Website"]
synonym: "8-Methyl-N-vanillylnonanamide" EXACT []
synonym: "DHC" RELATED []
synonym: "N-(4-Hydroxy-3-methoxybenzyl)-8-methylnonanamide" EXACT []
xref: CHEBI:46932
is_a: XCO:0000217 ! cation channel activator
created_by: JSmith
creation_date: 2012-10-04T06:08:13Z

[Term]
id: XCO:0000220
name: anion channel agonist
def: "Any chemical substance which increases the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000216 ! ion channel activator
created_by: JSmith
creation_date: 2012-10-04T06:11:24Z

[Term]
id: XCO:0000221
name: ion channel inhibitor
def: "Any chemical substance which decreases or interferes with the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "ion channel antagonist" RELATED []
is_a: XCO:0000120 ! inhibitor
created_by: JSmith
creation_date: 2012-10-04T06:13:42Z

[Term]
id: XCO:0000222
name: cation channel inhibitor
def: "Any chemical substance which decreases or interferes with the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "cation channel antagonist" RELATED []
is_a: XCO:0000221 ! ion channel inhibitor
created_by: JSmith
creation_date: 2012-10-05T10:45:01Z

[Term]
id: XCO:0000223
name: anion channel inhibitor
def: "Any chemical substance which decreases or interferes with the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "anion channel antagonist" RELATED []
is_a: XCO:0000221 ! ion channel inhibitor
created_by: JSmith
creation_date: 2012-10-05T10:48:12Z

[Term]
id: XCO:0000224
name: ruthenium red
def: "An inorganic dye which also intereacts with many types of proteins including ion channels and enzymes." [http://en.wikipedia.org/wiki/Ruthenium_red "Wikipedia"]
synonym: "ammoniated ruthenium oxychloride" EXACT []
synonym: "RuR" RELATED []
xref: CHEBI:34956
is_a: XCO:0000222 ! cation channel inhibitor
created_by: JSmith
creation_date: 2012-10-05T11:03:00Z

[Term]
id: XCO:0000225
name: potassium channel inhibitor
def: "Any chemical substance which decreases or interferes with the activity of a potassium ion channel, that is, a complex of membrane-bound and membrane-spanning proteins that specifically allow diffusion of positively charged potassium ions across a cell membrane." [http://en.wikipedia.org/wiki/Potassium_channel "Wikipedia"]
is_a: XCO:0000222 ! cation channel inhibitor
created_by: JSmith
creation_date: 2012-10-05T11:29:50Z

[Term]
id: XCO:0000226
name: apamin
def: "An 18 amino acid peptide neurotoxin from bee venom which blocks small-conductance Ca2+-activated K+ channels." [http://en.wikipedia.org/wiki/Apamin "Wikipedia"]
synonym: "apamine" EXACT []
xref: pubchem.compound:16129677
xref: UniProtKB:P01500
is_a: XCO:0000225 ! potassium channel inhibitor
created_by: JSmith
creation_date: 2012-10-05T11:41:19Z

[Term]
id: XCO:0000227
name: charybdotoxin
def: "A 37 amino acid peptide neurotoxin from scorpion venom that is a blocker of large- and intermediate-conductance Ca2+-activated K+ channels." [http://en.wikipedia.org/wiki/Charybdotoxin "Wikipedia"]
synonym: "ChTX" RELATED []
synonym: "ChTx-a" RELATED []
synonym: "ChTX-Lq1" RELATED []
xref: UniProtKB:P13487
is_a: XCO:0000225 ! potassium channel inhibitor
created_by: JSmith
creation_date: 2012-10-05T11:53:12Z

[Term]
id: XCO:0000228
name: peptide hormone
def: "A molecular chain compound composed of two or more amino acids joined by peptide bonds that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000125 ! hormone
is_a: XCO:0000193 ! peptide/protein
created_by: JSmith
creation_date: 2012-10-15T04:30:11Z

[Term]
id: XCO:0000229
name: steroid hormone
def: "A condition in which the main influencing factor is a chemical substance the structure of which is based on the basic 17-carbon-atom ring system steroid nucleus but may or may not have the characteristic arrangement of four fused cycloalkane rings, and which is produced in its endogenous state by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue." [CHEBI:35341, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:26764
is_a: XCO:0000091 ! steroid
is_a: XCO:0000125 ! hormone
created_by: JSmith
creation_date: 2012-10-15T04:36:54Z

[Term]
id: XCO:0000230
name: monoamine hormone
def: "A chemical substance consisting of an amine compound which contains one amino group and was derived from an aromatic amino acid, that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000125 ! hormone
created_by: JSmith
creation_date: 2012-10-15T04:51:18Z

[Term]
id: XCO:0000231
name: anti-RT6.1 antibody
def: "Antibody directed against the RT6.1 cell surface alloantigen (also known as ART2, Pta.A2, and Ag-F1). RT6.1 is an allelic form of the RT6 antigen which is expressed on most peripheral T cells but not on thymocytes." [PMID:7559400]
synonym: "anti-ADP-ribosyltransferase 2 antibody" EXACT []
synonym: "anti-Art2.1 mAb" RELATED []
synonym: "Art2 antibody" EXACT []
synonym: "DS4.23 mAb" RELATED []
is_a: XCO:0000194 ! antibody
created_by: JSmith
creation_date: 2012-10-16T12:39:20Z

[Term]
id: XCO:0000232
name: nucleic acid
def: "A high-molecular-weight polymeric compound composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose or deoxyribose sugar, and a phosphate group." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2012-10-16T01:26:26Z

[Term]
id: XCO:0000233
name: ribonucleic acid
def: "A long, polymeric chain of alternating phosphate and ribose units with the bases adenine, guanine, cytosine, and uracil bonded to the ribose. Although RNA is usually single-stranded it can also exist as RNA:RNA or RNA:DNA double-stranded molecules." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
synonym: "RNA" EXACT []
is_a: XCO:0000232 ! nucleic acid
created_by: JSmith
creation_date: 2012-10-16T02:15:23Z

[Term]
id: XCO:0000234
name: deoxyribonucleic acid
def: "A long, polymeric chain of alternating phosphate and deoxyribose units with the bases adenine, guanine, cytosine, and thymine bonded to the deoxyribose. DNA can be single stranded or double stranded, that is, composed of either a single polymer or a pair of antiparallel polymers joined by hydrogen bonding between complementary bases." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
synonym: "DNA" EXACT []
is_a: XCO:0000232 ! nucleic acid
created_by: JSmith
creation_date: 2012-10-16T02:22:54Z

[Term]
id: XCO:0000235
name: Poly I:C
def: "Poly I:C is a synthetic analog of dsRNA, which is the ligand of choice for Toll-like receptor 3 (TLR3). Poly(I:C) is composed of a strand of poly(I) annealed to a strand of poly(C)." [http://www.invivogen.com/tlr3-ligands?gclid=CLDYv5u4wLICFahaMgod_H8AGg "Website"]
synonym: "polyinosine-polycytidylic acid" EXACT []
is_a: XCO:0000233 ! ribonucleic acid
created_by: JSmith
creation_date: 2012-10-16T02:34:34Z

[Term]
id: XCO:0000236
name: pathogen
def: "An biological agent that causes disease, especially a living microorganism such as a bacterium, virus, or fungus." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
is_a: XCO:0000258 ! disease-inducing agent
created_by: JSmith
creation_date: 2012-10-16T03:04:11Z

[Term]
id: XCO:0000237
name: viral pathogen
def: "A virus which has the potential to cause disease. A virus is one of a group of heterogeneous infective agents characterized by their lack of independent metabolism, their inability to replicate outside a host cell, their simple organization and their unique mode of replication. A virus consists of genetic material--either DNA or RNA--surrounded by a protein coat and, in some cases, by a membranous envelope." [Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "virus" EXACT []
is_a: XCO:0000236 ! pathogen
created_by: JSmith
creation_date: 2012-10-16T03:06:55Z

[Term]
id: XCO:0000238
name: Kilham rat virus
def: "A common parvovirus pathogen which causes largely asymptomatic infections in rats. KRV can be used to model environmental influences in the development of type 1 diabetes mellitus." [http://www.criver.com/SiteCollectionDocuments/rm_ld_r_Rat_Parvoviruses.pdf "Website", PMID:19720792]
synonym: "KRV" RELATED []
is_a: XCO:0000237 ! viral pathogen
created_by: JSmith
creation_date: 2012-10-16T03:20:45Z

[Term]
id: XCO:0000239
name: toxic substance
def: "A chemical or biological substance which is capable of causing illness, debilitation or death, to living organisms, tissues or cells." [Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
synonym: "poison" RELATED []
synonym: "toxic chemical" RELATED []
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2012-10-16T03:57:33Z

[Term]
id: XCO:0000240
name: toxin
def: "A protein or conjugated protein produced by some higher plants, certain animals, and pathogenic bacteria, that is highly poisonous for other living organisms." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000239 ! toxic substance
created_by: JSmith
creation_date: 2012-10-16T04:07:55Z

[Term]
id: XCO:0000241
name: streptozotocin
def: "A condition in which the main influencing factor is streptozotocin, a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. STZ can be used to treat pancreatic islet cell cancers and to model type 1 diabetes mellitus in animals via destruction of the insulin-producing beta cells of the islets of Langerhans." [http://en.wikipedia.org/wiki/Streptozotocin "Wikipedia"]
synonym: "streptozocin" EXACT []
synonym: "STZ" RELATED []
xref: CHEBI:9288
is_a: XCO:0000239 ! toxic substance
is_a: XCO:0000885 ! diabetes-inducing chemical
created_by: JSmith
creation_date: 2012-10-16T04:09:16Z

[Term]
id: XCO:0000242
name: alloxan
def: "A condition in which the main influencing factor is alloxan, an oxygenated pyrimidine derivative which is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling type 1 diabetes mellitus through destruction of the beta cells." [http://en.wikipedia.org/wiki/Alloxan "Wikipedia"]
synonym: "2,4,5,6-pyrimidinetetrone" EXACT []
synonym: "5-Oxobarbituric acid" EXACT []
synonym: "alloxane" EXACT []
synonym: "mesoxalylurea" EXACT []
xref: pubchem.compound:5781
is_a: XCO:0000239 ! toxic substance
is_a: XCO:0000885 ! diabetes-inducing chemical
created_by: JSmith
creation_date: 2012-10-16T04:29:35Z

[Term]
id: XCO:0000243
name: partial pancreatectomy
def: "Surgical removal of a portion of the pancreas, resulting in reduction but not elimination of the physiological functions of the pancreas." [Gale:Gale_Encyclopedia_of_Medicine]
synonym: "subtotal pancreatectomy" RELATED []
is_a: XCO:0000105 ! pancreatectomy
created_by: JSmith
creation_date: 2012-10-16T04:49:10Z

[Term]
id: XCO:0000244
name: controlled fructose content diet
def: "A solid diet in which the amount of fructose, the monosaccharide found in honey and many sweet fruits which chemically combines with glucose to form the disaccharide sucrose, is maintained at a specified level." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000428 ! fructose
created_by: JSmith
creation_date: 2012-10-16T05:00:17Z

[Term]
id: XCO:0000245
name: insulin
def: "A protein hormone formed from proinsulin in the beta cells of the pancreatic islets of Langerhans. The major fuel-regulating hormone, it is secreted into the blood in response to a rise in concentration of blood glucose or amino acids. Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000228 ! peptide hormone
created_by: JSmith
creation_date: 2012-10-16T05:04:48Z

[Term]
id: XCO:0000246
name: controlled cholesterol content diet
def: "A regimen of solid food in which the amount of cholesterol, a steroid alcohol found in animal fats and oils, is controlled." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
is_a: XCO:0000014 ! controlled content diet
created_by: JSmith
creation_date: 2012-11-30T15:42:17Z

[Term]
id: XCO:0000247
name: controlled olive oil content diet
def: "A regimen of solid food to which a specified amount of olive oil has been added." [RGD:JRS]
is_a: XCO:0000454 ! controlled oil content diet
created_by: JSmith
creation_date: 2012-11-30T15:44:29Z

[Term]
id: XCO:0000248
name: kidney transplant
def: "A surgical procedure in which one or both kidneys from a donor organism are implanted into a recipient organism." [Gale:Gale_Encyclopedia_of_Medicine]
synonym: "kidney transplantation" EXACT []
is_a: XCO:0000027 ! surgical implantation
created_by: JSmith
creation_date: 2012-11-30T15:46:26Z

[Term]
id: XCO:0000249
name: left kidney transplant
def: "A surgical procedure in which the left kidney from a donor organism is implanted into a recipient organism." [Gale:Gale_Encyclopedia_of_Medicine]
is_a: XCO:0000248 ! kidney transplant
created_by: JSmith
creation_date: 2012-11-30T15:51:17Z

[Term]
id: XCO:0000250
name: right kidney transplant
def: "A surgical procedure in which the right kidney from a donor organism is implanted into a recipient organism." [Gale:Gale_Encyclopedia_of_Medicine]
is_a: XCO:0000248 ! kidney transplant
created_by: JSmith
creation_date: 2012-11-30T15:53:04Z

[Term]
id: XCO:0000251
name: secretagogue
def: "Any agent that induces exocrine, endocrine, or paracrine secretion." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000214 ! activator
created_by: JSmith
creation_date: 2012-11-30T15:55:11Z

[Term]
id: XCO:0000252
name: tolbutamide
def: "A first generation potassium channel blocker and sulfonylurea oral hypoglycemic drug which stimulates the secretion of insulin by the pancreas." [http://en.wikipedia.org/wiki/Tolbutamide "Wikipedia"]
is_a: XCO:0000225 ! potassium channel inhibitor
is_a: XCO:0000251 ! secretagogue
is_a: XCO:0000407 ! hypoglycemic agent
created_by: JSmith
creation_date: 2012-11-30T15:56:41Z

[Term]
id: XCO:0000253
name: sodium ion
def: "A condition in which the main influencing factor is an atom of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
comment: Not used for sodium salt in animal feed. For that application  XCO:0000022, "controlled sodium content diet" is used.
synonym: "Na+ ion" EXACT []
xref: CHEBI:29101
is_a: XCO:0000149 ! ion/salt
created_by: JSmith
creation_date: 2013-02-28T13:11:25Z

[Term]
id: XCO:0000254
name: sodium ion solution
def: "A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "Na+ ion solution" EXACT []
xref: CHEBI:29101
is_a: XCO:0000154 ! ion/salt solution
relationship: has_component XCO:0000253 ! sodium ion
created_by: JSmith
creation_date: 2013-02-28T18:54:08Z

[Term]
id: XCO:0000255
name: anti-glomerular basement membrane antibody
def: "An immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with one or more components of the structure located between endothelial cells of renal capillaries and the visceral epithelial cells of the kidney glomerulus." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "anti-GBM antibody" RELATED []
synonym: "nephritogenic monoclonal antibody b35" RELATED []
is_a: XCO:0000194 ! antibody
created_by: JSmith
creation_date: 2013-03-01T11:49:57Z

[Term]
id: XCO:0000256
name: isoproterenol
def: "A drug which is structurally similar to epinephrine and that binds to beta-adrenergic receptors to produce a physiologic reaction similar to or the same as that of epinephrine." [http://en.wikipedia.org/wiki/Isoprenaline#Chemistry "Wikipedia"]
synonym: "isoprenaline" EXACT []
xref: CHEBI:64317
is_a: XCO:0000665 ! beta-adrenergic agonist
created_by: JSmith
creation_date: 2013-03-01T12:37:50Z

[Term]
id: XCO:0000257
name: controlled hydrogen ion content drinking water
def: "A drink made up of water containing a specified amount of hydrogen ions, the chemical element with atomic number 1 that have lost one electron forming a cation with a charge of +1, for consumption by an organism in an experiment. Adjusting the amount of hydrogen ions adjusts the acidity, i.e. the pH of the drinking water." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
synonym: "controlled acidity water" RELATED []
synonym: "controlled pH water" RELATED []
synonym: "water with adjusted pH" RELATED []
is_a: XCO:0000163 ! controlled content drinking water
created_by: JSmith
creation_date: 2013-03-01T16:10:48Z

[Term]
id: XCO:0000258
name: disease-inducing agent
def: "Any phenomenon, chemical or biologic substance, or organism that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs." [Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "disease inducing agent" EXACT []
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2013-03-01T16:24:26Z

[Term]
id: XCO:0000259
name: disease-inducing chemical
def: "A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "disease inducing chemical" EXACT []
is_a: XCO:0000258 ! disease-inducing agent
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2013-03-01T16:30:57Z

[Term]
id: XCO:0000260
name: peptide/protein antigen
def: "A condition in which the major influencing factor is a peptide or protein, that is, any of a group of complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, capable of inducing a specific localized and/or systemic immune response." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
synonym: "antigenic protein" EXACT []
is_a: XCO:0000133 ! antigen
is_a: XCO:0000193 ! peptide/protein
created_by: JSmith
creation_date: 2013-03-01T16:46:02Z

[Term]
id: XCO:0000261
name: arthritis inducing chemical
def: "A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones." [Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000259 ! disease-inducing chemical
is_a: XCO:0000349 ! arthritis-inducing agent
created_by: JSmith
creation_date: 2013-03-01T17:07:13Z

[Term]
id: XCO:0000262
name: collagen
def: "A condition in which the major influencing factor is any of a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility; composed of molecules of tropocollagen." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000260 ! peptide/protein antigen
is_a: XCO:0000261 ! arthritis inducing chemical
created_by: JSmith
creation_date: 2013-03-01T17:35:20Z

[Term]
id: XCO:0000263
name: pristane
def: "A condition in which the major influencing factor is an acyclic saturated hydrocarbon derived from phytane by loss of its C-16 terminal methyl group." []
synonym: "2,6,10,14-tetramethylpentadecane" EXACT []
xref: CHEBI:53181
xref: MESH:C009042
is_a: XCO:0000133 ! antigen
is_a: XCO:0000261 ! arthritis inducing chemical
created_by: JSmith
creation_date: 2013-03-01T17:39:39Z

[Term]
id: XCO:0000264
name: Freund's adjuvant
def: "A nonspecific stimulator of the immune response consisting of non-metabolizable oils used to make water-in-oil emulsions with specific antigens. The adjuvant increases the strength of the immune response." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, https://www.invivogen.com/ifa "InvivoGen", ISBN:978-1416049982]
is_a: XCO:0000133 ! antigen
created_by: JSmith
creation_date: 2013-03-01T18:05:06Z

[Term]
id: XCO:0000265
name: Freund's incomplete adjuvant
def: "IFA is used to make a water-in-oil antigen-containing emulsion that lacks the Mycobacteria found in Complete Freund&#8242;s Adjuvant so it minimizes the side-effects. It is routinely used for boosting immunizations subsequent to use of Freund's complete adjuvant." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, https://www.sigmaaldrich.com/catalog/product/sigma/f5506?lang=en&region=US "Sigma-Aldrich", ISBN:978-1416049982]
synonym: "FIA" RELATED []
synonym: "IFA" RELATED []
is_a: XCO:0000264 ! Freund's adjuvant
created_by: JSmith
creation_date: 2013-03-01T18:07:25Z

[Term]
id: XCO:0000266
name: Freund's complete adjuvant
def: "A water-in-oil emulsion incorporating antigen in the aqueous phase, and killed, dried mycobacteria, e.g., Mycobacterium butyricum in lightweight paraffin oil. A suspension is achieved with the aid of an emulsifying agent. The mixture induces both cell-mediated immunity (delayed hypersensitivity), and humoral antibody formation." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "CFA" RELATED []
synonym: "FCA" RELATED []
is_a: XCO:0000264 ! Freund's adjuvant
created_by: JSmith
creation_date: 2013-03-01T18:10:14Z

[Term]
id: XCO:0000267
name: peptidoglycan-polysaccharide
def: "A condition in which the major influencing factor is a polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "PG-PS" RELATED []
xref: CHEBI:8005
is_a: XCO:0000133 ! antigen
is_a: XCO:0000173 ! polysaccharide
is_a: XCO:0000261 ! arthritis inducing chemical
created_by: JSmith
creation_date: 2013-03-11T15:53:57Z

[Term]
id: XCO:0000268
name: balloon angioplasty
def: "A technique of mechanically widening narrowed or obstructed arteries by use of a soft catheter with an inflatable tip." [http://en.wikipedia.org/wiki/Balloon_angioplasty "Wikipedia"]
is_a: XCO:0000595 ! surgical manipulation of blood vessels
created_by: JSmith
creation_date: 2013-03-11T16:14:44Z

[Term]
id: XCO:0000269
name: calcium channel inhibitor
def: "Any chemical substance which decreases or interferes with the activity of a calcium channel, one or more membrane-bound globular proteins that display selective permeability to calcium ions, the chemical element with atomic number 20 that has lost two electrons forming a cation with a charge of +2, and allow diffusion of these ions across a cell membrane." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "calcium channel blocker" RELATED []
is_a: XCO:0000222 ! cation channel inhibitor
created_by: JSmith
creation_date: 2013-03-11T16:37:02Z

[Term]
id: XCO:0000270
name: captopril
def: "A sulfur-containing carboxylic acid with a pyrrolidine substituent at C-1, which decreases or interferes with the activity of angiotensin converting enzyme (ACE) inhibitor, used as an anti-hypertensive drug." [http://en.wikipedia.org/wiki/Captopril "Wikipedia"]
xref: CHEBI:3380
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
is_a: XCO:0000863 ! antihypertensive agent
created_by: JSmith
creation_date: 2013-03-11T16:51:57Z

[Term]
id: XCO:0000271
name: antioxidant
def: "A substance that opposes oxidation, a reaction in which the atoms in an element lose electrons, and/or inhibits reactions brought about by dioxygen or peroxides." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, CHEBI:22586]
synonym: "antioxydant" EXACT []
synonym: "antoxidant" EXACT []
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2013-03-12T11:01:04Z

[Term]
id: XCO:0000272
name: tempol
def: "A heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide." [http://en.wikipedia.org/wiki/4-Hydroxy-TEMPO "Wikipedia"]
synonym: "4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl" RELATED []
synonym: "4-Oxypiperidol" RELATED []
synonym: "HyTEMPO" RELATED []
synonym: "Nitroxyl-2" RELATED []
synonym: "Tanol" RELATED []
synonym: "TMPN" RELATED []
xref: pubchem.compound:137994
is_a: XCO:0000271 ! antioxidant
created_by: JSmith
creation_date: 2013-03-12T11:09:12Z

[Term]
id: XCO:0000273
name: carrageenan
def: "A family of linear, sulfated, high-molecular-weight polysaccharides made up of repeating galactose and 3,6-anhydrogalactose units with alternating alpha 1-3 and beta 1-4 glycosidic linkages." [http://en.wikipedia.org/wiki/Carrageenan "Wikipedia"]
xref: CHEBI:3435
is_a: XCO:0000173 ! polysaccharide
created_by: JSmith
creation_date: 2013-03-12T13:07:06Z

[Term]
id: XCO:0000274
name: monosaccharide
def: "Any simple carbohydrate consisting of a single basic sugar unit with the general formula Cn(H2O)n, with n ranging from 3 to 8." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000172 ! carbohydrate
created_by: JSmith
creation_date: 2013-03-12T13:10:01Z

[Term]
id: XCO:0000275
name: glucose
def: "A monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues. It is one of the three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
synonym: "dextrose" RELATED []
is_a: XCO:0000274 ! monosaccharide
created_by: JSmith
creation_date: 2013-03-12T13:28:39Z

[Term]
id: XCO:0000276
name: hydrocarbon
def: "Any of a large group of organic compounds whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2013-03-12T16:18:50Z

[Term]
id: XCO:0000277
name: cyclic hydrocarbon
def: "Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form a continuous or closed chain linked by bonds that may be represented graphically by one or more circular or triangular forms." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
is_a: XCO:0000276 ! hydrocarbon
created_by: JSmith
creation_date: 2013-03-12T17:18:43Z

[Term]
id: XCO:0000278
name: polycyclic hydrocarbon
def: "Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by bonds that may be represented graphically by multiple interlinking circular or triangular forms." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
is_a: XCO:0000277 ! cyclic hydrocarbon
created_by: JSmith
creation_date: 2013-03-12T17:20:06Z

[Term]
id: XCO:0000279
name: terpene
def: "Any of a large and diverse class of organic compounds which are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, which are derived biosynthetically from units of isoprene and which have the general molecular formula (CH2=C(CH3)CH=CH2)n where n is the number of linked isoprene units." [http://en.wikipedia.org/wiki/Terpene "Wikipedia"]
is_a: XCO:0000276 ! hydrocarbon
created_by: JSmith
creation_date: 2013-03-12T17:24:22Z

[Term]
id: XCO:0000280
name: squalene
def: "A triterpene, that is a terpine containing six isoprene units, consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration. Squalene is the biochemical precursor to steroids." [http://en.wikipedia.org/wiki/Squalene "Wikipedia"]
synonym: "Spinacene" RELATED []
synonym: "Supraene" RELATED []
xref: CHEBI:15440
xref: MESH:D013185
is_a: XCO:0000279 ! terpene
created_by: JSmith
creation_date: 2013-03-12T17:25:17Z

[Term]
id: XCO:0000281
name: type II collagen
def: "A condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye.  Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Collagen "Wikipedia", ISBN:978-1416049982]
synonym: "type 2 collagen" EXACT []
is_a: XCO:0000262 ! collagen
created_by: JSmith
creation_date: 2013-03-12T17:41:57Z

[Term]
id: XCO:0000282
name: anti-Thy1 antibody
def: "An immunoglobulin molecule having a specific amino acid sequence that gives it the ability to adhere to and interact only with Thy1, i.e. Thymocyte antigen 1, and molecules containing structures similar to that antigen.  Thy1, also known as CD90, is a 25-37 kDa, heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored, conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen and now known to be the smallest member of the immunoglobulin superfamily of proteins." [http://en.wikipedia.org/wiki/CD90 "Wikipedia", Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
synonym: "anti-CD90 antibody" EXACT []
is_a: XCO:0000194 ! antibody
created_by: JSmith
creation_date: 2013-03-12T18:06:13Z

[Term]
id: XCO:0000283
name: visible light stimulus
def: "Exposure to visible light in a manner, such as for a length of time or at a level, which would not be considered natural, usual or environmental and which is designed to elicit or evoke an action or response in a cell, an excitable tissue, or an organism." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
synonym: "light therapy" EXACT []
synonym: "phototherapy" EXACT []
is_a: XCO:0000049 ! visual stimulus
is_a: XCO:0000284 ! controlled visible light exposure
created_by: JSmith
creation_date: 2013-03-13T12:03:39Z

[Term]
id: XCO:0000284
name: controlled visible light exposure
def: "Condition during which a subject or sample is directly in the presence of or influenced by visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, at a constrained level and/or for a constrained period of time." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
is_a: XCO:0000045 ! electromagnetic radiation exposure
is_a: XCO:0000181 ! controlled visible light condition
created_by: JSmith
creation_date: 2013-03-13T12:12:45Z

[Term]
id: XCO:0000285
name: controlled NG-nitroarginine methyl ester content drinking water
def: "A drink made up of water and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, MESH:D019331]
synonym: "controlled L-NAME content drinking water" EXACT []
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000121 ! NG-nitroarginine methyl ester
created_by: JSmith
creation_date: 2013-03-13T14:48:31Z

[Term]
id: XCO:0000286
name: retinal S-antigen
def: "A condition in which the major influencing factor is a highly antigenic, soluble photoreceptor protein expressed in the retina and the pineal gland and involved in desensitization of the photoactivated transduction cascade." [NCBI_GeneID:6295]
synonym: "arrestin" BROAD []
synonym: "HSAg" RELATED []
synonym: "retinal soluble antigen" RELATED []
synonym: "SAG" RELATED []
synonym: "S-antigen" RELATED []
synonym: "S-antigen peptide" RELATED []
synonym: "S-arrestin" RELATED []
is_a: XCO:0000260 ! peptide/protein antigen
created_by: JSmith
creation_date: 2013-03-13T17:02:20Z

[Term]
id: XCO:0000287
name: interphotoreceptor retinoid-binding protein
def: "A condition in which the major influencing factor is a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors." [NCBI_GeneID:5949]
synonym: "interphotoreceptor retinol-binding protein" EXACT []
synonym: "IRBP" RELATED []
synonym: "Rbp3" RELATED []
synonym: "retinol binding protein 3, interstitial" EXACT []
is_a: XCO:0000260 ! peptide/protein antigen
created_by: JSmith
creation_date: 2013-03-13T17:19:56Z

[Term]
id: XCO:0000288
name: R16 peptide of interphotoreceptor retinoid-binding protein
def: "A condition in which the major influencing factor is a 15 amino acid peptide (aa 1177-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors." [NCBI_GeneID:5949]
synonym: "R16 peptide of IRBP" RELATED []
xref: PMID:10323205
relationship: part_of XCO:0000287 ! interphotoreceptor retinoid-binding protein
created_by: JSmith
creation_date: 2013-03-13T17:55:10Z

[Term]
id: XCO:0000289
name: R14 peptide of interphotoreceptor retinoid-binding protein
def: "A condition in which the major influencing factor is a 23 amino acid peptide (aa 1169-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors." [NCBI_GeneID:5949]
synonym: "R14 peptide of IRBP" RELATED []
xref: PMID:18203685
relationship: part_of XCO:0000287 ! interphotoreceptor retinoid-binding protein
created_by: JSmith
creation_date: 2013-03-13T17:56:51Z

[Term]
id: XCO:0000290
name: peripheral myelin protein 2
def: "A condition in which the major influencing factor is a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins." [UniProtKB:P02689]
synonym: "myelin P2 protein" EXACT []
synonym: "Pmp2" RELATED []
xref: RGD:1585218
is_a: XCO:0000260 ! peptide/protein antigen
relationship: part_of XCO:0000292 ! peripheral nerve myelin
created_by: JSmith
creation_date: 2013-03-13T18:21:29Z

[Term]
id: XCO:0000291
name: peripheral myelin protein 2 peptide 58-81
def: "A condition in which the major influencing factor is the peptide (KNTEISFKLGQEFEETTADNRKTK) representing residues 58 to 81 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins." [RGD:2306736, UniProtKB:P02689]
synonym: "P2 58-81" RELATED []
synonym: "P2 peptide 58-81" RELATED []
relationship: part_of XCO:0000290 ! peripheral myelin protein 2
created_by: JSmith
creation_date: 2013-03-13T18:44:21Z

[Term]
id: XCO:0000292
name: peripheral nerve myelin
def: "A condition in which the major influencing factor is peripheral nerve myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the axons of peripheral nerves, that is, nerves that are not part of either the brain or spinal cord of the organism." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "peripheral nervous system myelin" RELATED []
synonym: "PNM" RELATED []
synonym: "PNS myelin" RELATED []
is_a: XCO:0000352 ! myelin
created_by: JSmith
creation_date: 2013-03-13T19:18:05Z

[Term]
id: XCO:0000293
name: 99mTc-sestamibi
def: "A coordination complex of technetium-99m, a radioisotope of the chemical element technetium, atomic number 43, a gamma emitter having a half-life of approximately 6 hours, and methoxyisobutylisonitrile (MIBI), a lipophilic cation, used as an agent in nuclear medicine imaging." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Technetium_%2899mTc%29_sestamibi "Wikipedia", ISBN:978-1416049982]
synonym: "99mTc-hexakis-2-methoxy-2-methylpropyl isonitrile" RELATED []
synonym: "Cardiolite" RELATED []
synonym: "MIBI" RELATED []
xref: CHEBI:33371
is_a: XCO:0000171 ! radioactively labeled chemical
created_by: JSmith
creation_date: 2013-03-13T20:07:09Z

[Term]
id: XCO:0000294
name: estrogen/estrogen analog
def: "Any of the  naturally-occuring, primary female sex hormones or  related synthetic molecules with the capacity to perform the same function(s), i.e. to bind to  estrogen receptors and stimulate or control the development and maintenance of female sex characteristics." [http://en.wikipedia.org/wiki/Estrogen "Wikipedia"]
synonym: "Not4Curation" RELATED []
xref: CHEBI:50114
is_a: XCO:0000229 ! steroid hormone
created_by: JSmith
creation_date: 2013-05-07T15:32:52Z

[Term]
id: XCO:0000295
name: diethylstilbestrol
def: "A synthetic estrogen analog with chemical formula C18H20O2.  The structure is similar to that of estrogen but lacks the complete four ring structure. As a drug it is used to treat prostatic and sometimes breast carcinomas. It is an epigenetic carcinogen." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Diethylstilbestrol "Wikipedia", ISBN:978-1416049982]
synonym: "DES" RELATED []
xref: CHEBI:41922
is_a: XCO:0000294 ! estrogen/estrogen analog
is_a: XCO:0000435 ! antineoplastic agent
created_by: JSmith
creation_date: 2013-05-07T16:01:13Z

[Term]
id: XCO:0000296
name: running on inclined treadmill
def: "The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, Encarta:Encarta_World_English_Dictionary]
synonym: "running on sloped treadmill" EXACT []
is_a: XCO:0000005 ! running on treadmill
created_by: JSmith
creation_date: 2013-06-07T16:08:44Z

[Term]
id: XCO:0000297
name: fluid deprivation
def: "Condition in which liquids for drinking (bringing a liquid into the mouth and swallowing it to quench thirst, for nourishment, etc.), such as water, are withheld for a specified period of time." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, http://www.yourdictionary.com/drink "YourDictionary"]
synonym: "water deprivation" NARROW []
is_a: XCO:0000013 ! diet
created_by: JSmith
creation_date: 2013-06-11T09:50:38Z

[Term]
id: XCO:0000298
name: controlled saccharin content drinking water
def: "Water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O) supplied as a drink, that is, as a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., in which the amount of saccharin, a cyclic imine of 2-sulfobenzoic acid which is 500 times sweeter than sugar and used as a nonnutritive sweetener, is adjusted to a requirement." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
is_a: XCO:0000163 ! controlled content drinking water
created_by: JSmith
creation_date: 2013-06-11T10:05:25Z

[Term]
id: XCO:0000299
name: controlled ethanol content drinking water with no other optional drink source
def: "Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied as the only available drink option for consumption by an organism in an experiment." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
is_a: XCO:0000023 ! controlled ethanol content drinking water
created_by: JSmith
creation_date: 2013-06-11T10:06:43Z

[Term]
id: XCO:0000300
name: controlled ethanol content drinking water with water as an optional drink source
def: "Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied along with additive-free water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), as an additional drink option for consumption by an organism in an experiment." [http://www.thefreedictionary.com/ "Multiple_Dictionaries"]
is_a: XCO:0000023 ! controlled ethanol content drinking water
created_by: JSmith
creation_date: 2013-06-11T10:07:22Z

[Term]
id: XCO:0000301
name: lithium ion solution
def: "A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:49713
is_a: XCO:0000154 ! ion/salt solution
relationship: has_component XCO:0000313 ! lithium ion
created_by: JSmith
creation_date: 2013-06-11T10:08:36Z

[Term]
id: XCO:0000302
name: lithium chloride solution
def: "A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:48607
is_a: XCO:0000301 ! lithium ion solution
created_by: JSmith
creation_date: 2013-06-11T10:09:05Z

[Term]
id: XCO:0000303
name: adrenalectomy
def: "The surgical excision of one or both of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "suprarenalectomy" EXACT []
is_a: XCO:0000026 ! surgical removal
created_by: JSmith
creation_date: 2013-06-20T17:37:01Z

[Term]
id: XCO:0000304
name: bilateral adrenalectomy
def: "The surgical excision of both adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "bilateral suprarenalectomy" EXACT []
is_a: XCO:0000303 ! adrenalectomy
created_by: JSmith
creation_date: 2013-06-20T17:49:29Z

[Term]
id: XCO:0000305
name: unilateral adrenalectomy
def: "The surgical excision of only one of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "unilateral suprarenalectomy" EXACT []
is_a: XCO:0000303 ! adrenalectomy
created_by: JSmith
creation_date: 2013-06-20T17:50:15Z

[Term]
id: XCO:0000306
name: cold exposure
def: "An activity or condition which involves subjecting all or part of an organism to a relatively low, i.e., lower than considered normal, temperature." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
is_a: XCO:0000111 ! temperature exposure
created_by: JSmith
creation_date: 2013-06-21T16:31:04Z

[Term]
id: XCO:0000307
name: cold ambient air exposure
def: "An activity or condition in which the air surrounding or encircling the organism has a relatively low, or lower than considered normal, temperature, i.e., air in which the molecules possess a lower than normal amount of random kinetic energy." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
synonym: "cold exposure, ambient air" EXACT []
synonym: "cold stress" RELATED []
is_a: XCO:0000011 ! air temperature
is_a: XCO:0000306 ! cold exposure
created_by: JSmith
creation_date: 2013-06-21T16:52:48Z

[Term]
id: XCO:0000308
name: heat exposure
def: "An activity or condition which involves subjecting all or part of an organism to a relatively high, or higher than considered normal, temperature, that is, possessing a higher than normal level of random kinetic energy of atoms, molecules, or ions." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
is_a: XCO:0000111 ! temperature exposure
created_by: JSmith
creation_date: 2013-06-21T17:12:21Z

[Term]
id: XCO:0000309
name: heated ambient air exposure
def: "An activity or condition in which the air surrounding or encircling the organism has a relatively high, or higher than considered normal, temperature, i.e., air in which the molecules possess a higher than normal amount of random kinetic energy." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
synonym: "heat exposure, ambient air" EXACT []
synonym: "hot ambient air exposure" RELATED []
synonym: "warm ambient air exposure" RELATED []
is_a: XCO:0000011 ! air temperature
is_a: XCO:0000308 ! heat exposure
created_by: JSmith
creation_date: 2013-06-21T17:21:42Z

[Term]
id: XCO:0000310
name: guanethidine
def: "An antihypertensive agent that acts by selectively inhibiting transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. It does not appear to act at the level of the adrenergic receptors." [http://www.drugbank.ca/drugs/DB01170#pharmacology "Website"]
xref: CHEBI:5557
xref: MESH:D006145
is_a: XCO:0000120 ! inhibitor
created_by: JSmith
creation_date: 2013-06-21T18:45:16Z

[Term]
id: XCO:0000311
name: potassium ion solution
def: "A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "K+ ion solution" EXACT []
xref: CHEBI:29103
is_a: XCO:0000154 ! ion/salt solution
relationship: has_component XCO:0000150 ! potassium ion
created_by: JSmith
creation_date: 2013-06-25T14:02:51Z

[Term]
id: XCO:0000312
name: potassium chloride solution
def: "A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "KCl solution" EXACT []
xref: CHEBI:32588
is_a: XCO:0000311 ! potassium ion solution
created_by: JSmith
creation_date: 2013-06-25T14:06:24Z

[Term]
id: XCO:0000313
name: lithium ion
def: "A condition in which the main influencing factor is an atom of lithium, the chemical element with atomic number 3, that has lost one electron, forming a cation with a charge of +1." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "Li+ ion" EXACT []
xref: CHEBI:49713
is_a: XCO:0000149 ! ion/salt
created_by: JSmith
creation_date: 2013-06-25T14:24:21Z

[Term]
id: XCO:0000314
name: buffer
def: "Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base." []
xref: CHEBI:35225
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2013-06-25T14:52:26Z

[Term]
id: XCO:0000315
name: buffer solution
def: "A homogeneous mixture of molecules, atoms and/or ions,  one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:35225
is_a: XCO:0000314 ! buffer
is_a: XCO:0000340 ! solution
created_by: JSmith
creation_date: 2013-06-25T14:58:18Z

[Term]
id: XCO:0000316
name: calcium-free buffer solution
def: "A homogeneous mixture which does not contain calcium, the chemical element with atomic number 20, but does contain molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:35225
is_a: XCO:0000315 ! buffer solution
created_by: JSmith
creation_date: 2013-06-25T15:06:57Z

[Term]
id: XCO:0000317
name: buffered calcium ion solution
def: "A homogeneous mixture of calcium, the chemical element with atomic number 20, with other molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "calcium-containing buffer solution" EXACT []
xref: CHEBI:29108
xref: CHEBI:35225
is_a: XCO:0000185 ! calcium ion solution
is_a: XCO:0000315 ! buffer solution
created_by: JSmith
creation_date: 2013-06-25T15:13:18Z

[Term]
id: XCO:0000318
name: surgical construction
def: "A process in which manual and instrumental techniques are used to assemble or combine parts or substances, especially in order to create something new." [Cambridge:Cambridge_Online_Dictionary_of_American_English, Collins:Collins_Online_English_Dictionary, http://en.wikipedia.org/wiki/Surgery "Wikipedia"]
is_a: XCO:0000165 ! surgical manipulation
created_by: JSmith
creation_date: 2013-06-25T16:06:11Z

[Term]
id: XCO:0000319
name: artificial aortocaval fistula
def: "A surgically created passageway between the abdominal aorta and inferior vena cava." [ISBN-13:978-0781733908]
synonym: "ACF" RELATED []
xref: PMID:2142618
is_a: XCO:0000595 ! surgical manipulation of blood vessels
created_by: JSmith
creation_date: 2013-06-25T16:08:47Z

[Term]
id: XCO:0000320
name: hexamethonium
def: "Either of two compounds (C12H30Br2N2 or C12H30Cl2N2) used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself." [http://en.wikipedia.org/wiki/Hexamethonium "Wikipedia", Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
xref: chembl.compound:CHEMBL105608
xref: pubchem.compound:3604
is_a: XCO:0000160 ! receptor antagonist
created_by: JSmith
creation_date: 2013-06-25T17:12:45Z

[Term]
id: XCO:0000321
name: hexamethonium bromide
def: "The compound C12H30Br2N2, consisting of a hexamethonium cation and dibromide anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself." [http://en.wikipedia.org/wiki/Hexamethonium "Wikipedia", Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
synonym: "hexamethonium dibromide" RELATED []
xref: chembl.compound:CHEMBL105608
xref: pubchem.compound:5938
is_a: XCO:0000320 ! hexamethonium
created_by: JSmith
creation_date: 2013-06-25T17:17:10Z

[Term]
id: XCO:0000322
name: hexamethonium chloride
def: "The compound C12H30Cl2N2, consisting of a hexamethonium cation and dichloride anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself." [http://en.wikipedia.org/wiki/Hexamethonium "Wikipedia", Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
synonym: "hexamethonium dichloride" RELATED []
xref: chembl.compound:CHEMBL105608
xref: pubchem.compound:93550
is_a: XCO:0000320 ! hexamethonium
created_by: JSmith
creation_date: 2013-06-25T17:19:38Z

[Term]
id: XCO:0000323
name: alcohol
def: "Any condition in which the main influencing factor is an alcohol, a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." []
xref: CHEBI:30879
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2013-08-07T16:27:07Z

[Term]
id: XCO:0000324
name: primary alcohol
def: "Any condition in which the main influencing factor is a primary alcohol, a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." []
xref: CHEBI:15734
is_a: XCO:0000323 ! alcohol
created_by: JSmith
creation_date: 2013-08-07T16:35:17Z

[Term]
id: XCO:0000325
name: ethanol
def: "Any condition in which the main influencing factor is ethanol, a primary alcohol with chemical formula CH3-CH2-OH, that is ethane in which one of the hydrogens is substituted by a hydroxy group." []
synonym: "ethyl alcohol" EXACT []
synonym: "EtOH" RELATED []
xref: CHEBI:16236
is_a: XCO:0000324 ! primary alcohol
created_by: JSmith
creation_date: 2013-08-07T16:39:26Z

[Term]
id: XCO:0000326
name: controlled ethanol content saline
def: "Any condition in which the main influencing factor is ethanol, the colorless, volatile, flammable liquid, CH3CH2OH, produced by yeast fermentation of carbohydrates or synthesized by hydration of ethylene, suspended in a saline solution, a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Webster:Random_House_Kernerman_Websters_College_Dictionary_2010]
synonym: "ethanol in 0.9 % saline" NARROW []
synonym: "ethanol in 0.9 % saline solution" NARROW []
synonym: "ethanol in saline" EXACT []
relationship: has_component XCO:0000325 ! ethanol
created_by: JSmith
creation_date: 2013-08-07T16:45:26Z

[Term]
id: XCO:0000327
name: controlled quinine content drinking water
def: "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of quinine, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Quinine is a bitter alkaloid of cinchona that has antimalarial, analgesic, antipyretic, mild oxytocic, cardiac depressant, and sclerosing properties, and that decreases the excitability of the motor end plate." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://www.yourdictionary.com/drink "YourDictionary", ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000163 ! controlled content drinking water
created_by: JSmith
creation_date: 2013-08-07T17:05:17Z

[Term]
id: XCO:0000328
name: controlled deoxycorticosterone content drinking water
def: "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/11-Deoxycorticosterone "Wikipedia", http://www.yourdictionary.com/drink "YourDictionary", ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled DOC content drinking water" RELATED []
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000330 ! deoxycorticosterone
created_by: jsmith
creation_date: 2013-08-22T12:58:04Z

[Term]
id: XCO:0000329
name: controlled deoxycorticosterone content saline drink
def: "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of sodium chloride (i.e. atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1) dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/11-Deoxycorticosterone "Wikipedia", http://www.yourdictionary.com/drink "YourDictionary", ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled deoxycorticosterone and sodium content drinking water" RELATED []
synonym: "controlled DOC and sodium chloride content drinking water" RELATED []
synonym: "controlled DOC content saline drink" RELATED []
xref: CHEBI:16973
is_a: XCO:0000164 ! controlled sodium content drinking water
is_a: XCO:0000328 ! controlled deoxycorticosterone content drinking water
created_by: jsmith
creation_date: 2013-08-22T13:00:11Z

[Term]
id: XCO:0000330
name: deoxycorticosterone
def: "Any condition in which the main influencing factor is deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone, or a derivative of that hormone." [http://en.wikipedia.org/wiki/11-Deoxycorticosterone "Wikipedia"]
synonym: "DOC" RELATED []
is_a: XCO:0000229 ! steroid hormone
created_by: jsmith
creation_date: 2013-08-22T14:38:17Z

[Term]
id: XCO:0000331
name: RU28362
def: "Any condition in which the main influencing factor is RU28362, a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor." [http://en.wikipedia.org/wiki/RU28362 "Wikipedia", http://www.nursa.org/molecule.cfm?molType=ligand&molId=1123 "Website"]
synonym: "11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one" EXACT []
xref: pubchem.compound:123790
is_a: XCO:0000135 ! receptor agonist
created_by: jsmith
creation_date: 2013-08-22T14:49:55Z

[Term]
id: XCO:0000332
name: controlled RU28362 content drinking water
def: "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of RU28362, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor." [http://en.wikipedia.org/wiki/RU28362 "Wikipedia", http://www.nursa.org/molecule.cfm?molType=ligand&molId=1123 "Website", http://www.thefreedictionary.com/ "Multiple_Dictionaries", ISBN:978-1416049982]
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000331 ! RU28362
created_by: jsmith
creation_date: 2013-08-22T15:03:35Z

[Term]
id: XCO:0000333
name: controlled RU28362 content saline drink
def: "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of RU28362, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor." [http://en.wikipedia.org/wiki/RU28362 "Wikipedia", http://www.nursa.org/molecule.cfm?molType=ligand&molId=1123 "Website", http://www.thefreedictionary.com/ "Multiple_Dictionaries", ISBN:978-1416049982]
synonym: "controlled RU28362 and sodium chloride content drinking water" RELATED []
is_a: XCO:0000164 ! controlled sodium content drinking water
is_a: XCO:0000332 ! controlled RU28362 content drinking water
created_by: jsmith
creation_date: 2013-08-22T15:06:01Z

[Term]
id: XCO:0000334
name: left adrenalectomy
def: "The surgical excision of only the adrenal gland on the left side of the body. The left adrenal gland is generally the larger of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, http://en.wikipedia.org/wiki/Adrenal_gland "Wikipedia"]
comment: Note that "left" in this context refers to the perspective of the organism, not that of the observer. (Wikipedia:  Anatomical_terms_of_location).
synonym: "left suprarenalectomy" EXACT []
synonym: "left unilateral adrenalectomy" EXACT []
synonym: "left unilateral suprarenalectomy" EXACT []
is_a: XCO:0000305 ! unilateral adrenalectomy
created_by: jsmith
creation_date: 2013-08-22T15:48:28Z

[Term]
id: XCO:0000335
name: right adrenalectomy
def: "The surgical excision of only the adrenal gland on the right side of the body. The right adrenal gland is generally the smaller of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, http://en.wikipedia.org/wiki/Adrenal_gland "Wikipedia"]
comment: Note that "right" in this context refers to the perspective of the organism, not that of the observer. (Wikipedia:  Anatomical_terms_of_location).
synonym: "right suprarenalectomy" EXACT []
synonym: "right unilateral adrenalectomy" EXACT []
synonym: "right unilateral suprarenalectomy" EXACT []
is_a: XCO:0000305 ! unilateral adrenalectomy
created_by: jsmith
creation_date: 2013-08-22T15:50:50Z

[Term]
id: XCO:0000336
name: adrenergic antagonist
def: "Any condition in which the main influencing factor is an agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists, substances that have an affinity for and stimulate physiologic activity at adrenergic receptors. Adrenergic receptors are a class of G protein-coupled receptors that are targets of catecholamines, especially norepinephrine and epinephrine." [CHEBI:37887, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Adrenergic_receptors "Wikipedia", ISBN:978-1416049982]
synonym: "adrenergic receptor antagonist" EXACT []
is_a: XCO:0000160 ! receptor antagonist
created_by: jsmith
creation_date: 2013-08-22T16:22:29Z

[Term]
id: XCO:0000337
name: air-jet exposure
def: "A condition in which an air jet, i.e. a rapid stream of air (the colorless, odorless, tasteless mixture of gases, mainly nitrogen, oxygen and lesser gases, plus water vapor and particulates, that surrounds the earth) forced under pressure through a small opening or nozzle, is directed toward the body or a part of the body of an organism." [American_Heritage:The_American_Heritage_Science_Dictionary_2005]
synonym: "air-jet stress" RELATED []
synonym: "forced air exposure" RELATED []
is_a: XCO:0000052 ! tactile stimulus
created_by: jsmith
creation_date: 2013-08-22T17:01:21Z

[Term]
id: XCO:0000338
name: chemical nanoparticle
def: "Any condition in which the main influencing factor is a particle, i.e. a body whose internal motion and structure, if any, are irrelevant in a specific problem, with a size between 1 and 100 nanometers composed of any substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, American_Heritage:The_American_Heritage_Science_Dictionary_2005, Collins:Collins_Online_English_Dictionary, http://en.wikipedia.org/wiki/Nanoparticle "Wikipedia"]
synonym: "ultrafine chemical particle" EXACT []
is_a: XCO:0000342 ! chemical with specified structure
created_by: jsmith
creation_date: 2013-08-23T12:19:49Z

[Term]
id: XCO:0000339
name: titanium dioxide nanoparticles
def: "Any condition in which the main influencing factor is a particle, i.e. a body whose internal motion and structure, if any, are irrelevant in a specific problem, with a size between 1 and 100 nanometers composed of titanium dioxide. Titanium dioxide is a white insoluble powder that is the naturally occurring oxide of titanium, chemical formula TiO2, i.e. composed of one atom of titanium, the strong, low-density, highly corrosion-resistant metallic element with atomic number 22, and two atoms of oxygen, the highly reactive chemical element with atomic number 8 that is essential for plant and animal respiration and is required for nearly all combustion." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, http://en.wikipedia.org/wiki/Nanoparticle "Wikipedia", http://en.wikipedia.org/wiki/Titanium_dioxide "Wikipedia"]
synonym: "titania nanoparticles" EXACT []
synonym: "titanium(IV) oxide nanoparticles" EXACT []
synonym: "ultrafine TiO2 powder" RELATED []
synonym: "ultrafine titanium dioxide powder" RELATED []
xref: CHEBI:51050
is_a: XCO:0000338 ! chemical nanoparticle
created_by: jsmith
creation_date: 2013-08-23T15:14:06Z

[Term]
id: XCO:0000340
name: solution
def: "Any condition in which the main influencing factor is a homogeneous mixture of molecules, atoms and/or ions dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000000 ! experimental condition
created_by: jsmith
creation_date: 2013-08-23T15:45:06Z

[Term]
id: XCO:0000341
name: chemical with specified function
def: "Any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules and which has the capacity to perform a particular role or initiate or participate in a particular activity or process." [American_Heritage:The_American_Heritage_Science_Dictionary_2005, Collins:Collins_Online_English_Dictionary, Mosby:Mosbys_Dental_Dictionary--2nd_Ed]
synonym: "chemical with specified role" EXACT []
xref: CHEBI:50906
is_a: XCO:0000088 ! chemical
created_by: JSmith
creation_date: 2013-09-03T16:26:49Z

[Term]
id: XCO:0000342
name: chemical with specified structure
def: "Any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, where that molecular composition explicitly contains one or more particular parts or groups that are held or put together in a particular way." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, American_Heritage:The_American_Heritage_Science_Dictionary_2005, Collins:Collins_Online_English_Dictionary]
xref: CHEBI:24431
is_a: XCO:0000088 ! chemical
created_by: JSmith
creation_date: 2013-09-03T16:30:12Z

[Term]
id: XCO:0000343
name: nitrosourea
def: "Any condition in which the main influencing factor is a chemical having a nitroso (R-N=O) and a urea moiety.  A urea moiety consists of  two -NH2 groups joined by a carbonyl (C=O) group." [http://en.wikipedia.org/wiki/Nitrosourea "Wikipedia"]
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2013-09-04T13:12:02Z

[Term]
id: XCO:0000344
name: N-propyl-N-nitrosourea
def: "Any condition in which the main influencing factor is a chemical with three major moieties, a propyl group (a linear three-carbon alkyl substituent with chemical formula -C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." [http://en.wikipedia.org/wiki/Nitrosourea "Wikipedia", http://en.wikipedia.org/wiki/Propyl "Wikipedia", pubchem.compound:13157]
synonym: "1-nitroso-1-propylurea" EXACT []
synonym: "1-propyl-1-nitrosourea" RELATED []
synonym: "PNU" RELATED []
synonym: "propylnitrosourea" EXACT []
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000205 ! mutation inducing chemical
is_a: XCO:0000343 ! nitrosourea
created_by: JSmith
creation_date: 2013-09-04T13:25:28Z

[Term]
id: XCO:0000345
name: N-ethyl-N-nitrosourea
def: "Any condition in which the main influencing factor is a chemical with three major moieties, an ethyl group (a two-carbon alkyl substituent with chemical formula -C2H5), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." [http://en.wikipedia.org/wiki/Ethyl_group "Wikipedia", http://en.wikipedia.org/wiki/Nitrosourea "Wikipedia"]
synonym: "1-ethyl-1-nitrosourea" RELATED []
synonym: "ENU" RELATED []
synonym: "ethylnitrosourea" EXACT []
synonym: "N-ethyl-N-nitroso carbamide" EXACT []
xref: CHEBI:23995
xref: pubchem.compound:12967
is_a: XCO:0000205 ! mutation inducing chemical
is_a: XCO:0000343 ! nitrosourea
created_by: JSmith
creation_date: 2013-09-04T13:34:43Z

[Term]
id: XCO:0000346
name: N-methyl-N-nitrosourea
def: "Any condition in which the main influencing factor is a chemical with three major moieties, a methyl group (a one-carbon alkyl substituent with chemical formula -CH3), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." [http://en.wikipedia.org/wiki/Methyl_group "Wikipedia", http://en.wikipedia.org/wiki/N-Methyl-N-nitrosourea "Wikipedia", http://en.wikipedia.org/wiki/Nitrosourea "Wikipedia"]
synonym: "1-methyl-1-nitrosourea" RELATED []
synonym: "methylnitrosourea" EXACT []
synonym: "MNU" RELATED []
synonym: "N-methyl-N-nitrosocarbamide" EXACT []
xref: CHEBI:50102
xref: pubchem.compound:12967
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000205 ! mutation inducing chemical
is_a: XCO:0000343 ! nitrosourea
created_by: JSmith
creation_date: 2013-09-20T16:27:41Z

[Term]
id: XCO:0000347
name: blood vessel occlusion
def: "A surgical manipulation causing blockage of a blood vessel, any one of the network of muscular tubes that carry blood through the body." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000595 ! surgical manipulation of blood vessels
created_by: JSmith
creation_date: 2013-11-11T10:32:17Z

[Term]
id: XCO:0000348
name: middle cerebral artery occlusion
def: "A surgical manipulation causing blockage of the middle cerebral artery (MCA), one of the three major paired arteries that supply blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it branches and projects into the lateral cerebral cortex." [http://en.wikipedia.org/wiki/Middle_Cerebral_Artery "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "MCA occlusion" RELATED []
is_a: XCO:0000347 ! blood vessel occlusion
created_by: JSmith
creation_date: 2013-11-11T10:46:10Z

[Term]
id: XCO:0000349
name: arthritis-inducing agent
def: "Any phenomenon, chemical or biologic substance, or organism that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones." [Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000258 ! disease-inducing agent
created_by: JSmith
creation_date: 2013-11-11T12:01:59Z

[Term]
id: XCO:0000350
name: streptococcal cell wall
def: "A biologic agent consisting of a more or less purified preparation of cell walls from streptococcus bacteria. Streptococcus is a genus of spherical Gram-positive bacteria belonging to the phylum Firmicutes and the lactic acid bacteria group. The cell wall is the rigid structure that lies just outside of and is joined to the plasma membrane of plant cells and most prokaryotic cells, which protects the cell and maintains its shape." [Collins:Collins_Online_English_Dictionary, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Streptococcus "Wikipedia", ISBN:978-1416049982]
synonym: "SCW" RELATED []
is_a: XCO:0000349 ! arthritis-inducing agent
created_by: JSmith
creation_date: 2013-11-11T12:03:50Z

[Term]
id: XCO:0000351
name: 4-nitroquinoline N-oxide
alt_id: XCO:0000366
def: "A condition in which the major influencing factor is 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair." [http://en.wikipedia.org/wiki/4-Nitroquinoline_1-oxide "Wikipedia", http://en.wikipedia.org/wiki/Quinoline "Wikipedia"]
synonym: "4-Nitroquinoline 1-oxide" EXACT []
synonym: "4NQO" RELATED []
xref: CHEBI:16907
xref: MESH:D015112
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000205 ! mutation inducing chemical
created_by: JSmith
creation_date: 2013-11-11T13:00:15Z

[Term]
id: XCO:0000352
name: myelin
def: "A condition in which the major influencing factor is myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000133 ! antigen
created_by: JSmith
creation_date: 2013-11-11T13:10:37Z

[Term]
id: XCO:0000353
name: central nervous system myelin
def: "A condition in which the major influencing factor is the lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers of the central nervous system, i.e., the brain and spinal cord." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "CNS myelin" RELATED []
is_a: XCO:0000352 ! myelin
created_by: JSmith
creation_date: 2013-11-11T13:26:36Z

[Term]
id: XCO:0000354
name: N-methyl-N'-nitro-N-nitrosoguanidine
def: "A guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties." [http://en.wikipedia.org/wiki/Methylnitronitrosoguanidine "Wikipedia", MESH:D008769]
synonym: "1-methyl-3-nitro-1-nitrosoguanidine" EXACT []
synonym: "methylnitronitrosoguanidine" EXACT []
synonym: "MNNG" RELATED []
xref: CHEBI:21759
xref: pubchem.compound:9562060
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000205 ! mutation inducing chemical
created_by: JSmith
creation_date: 2013-11-11T14:50:46Z

[Term]
id: XCO:0000355
name: controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water
def: "A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). MNNG is a guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Methylnitronitrosoguanidine "Wikipedia", http://www.yourdictionary.com/drink "YourDictionary", ISBN:978-1416049982, MESH:D008769]
synonym: "controlled 1-methyl-3-nitro-1-nitrosoguanidine content drinking water" EXACT []
synonym: "controlled methylnitronitrosoguanidine content drinking water" EXACT []
synonym: "controlled MNNG content drinking water" RELATED []
xref: CHEBI:21759
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000354 ! N-methyl-N'-nitro-N-nitrosoguanidine
created_by: JSmith
creation_date: 2013-11-11T15:17:46Z

[Term]
id: XCO:0000356
name: spinal cord homogenate
def: "A condition in which the major contributing factor is a preparation of spinal cord which has been rendered uniform in structure and/or composition throughout, for example by grinding the tissue until it has been reduced to particles which are evenly distributed thoughout a fluid.  Spinal cord is the long, flexible, nearly cylindric structure of nerve tissue that extends from the medulla oblongata down through the vertebral canal and from which the spinal nerves branch off to various parts of the body." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000133 ! antigen
created_by: JSmith
creation_date: 2013-11-11T15:35:41Z

[Term]
id: XCO:0000357
name: walking on inclined treadmill
def: "The action of ambulation on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, Encarta:Encarta_World_English_Dictionary]
synonym: "walking on sloped treadmill" EXACT []
is_a: XCO:0000004 ! walking on treadmill
created_by: JSmith
creation_date: 2013-11-11T15:50:46Z

[Term]
id: XCO:0000358
name: diagnostic agent
def: "A substance administered specifically to aid diagnosis of a disease or condition." [CHEBI:33295, Webster:Random_House_Kernerman_Websters_College_Dictionary_2010]
synonym: "diagnostic aid" RELATED []
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2013-11-11T16:04:05Z

[Term]
id: XCO:0000359
name: sodium p-aminohippurate
def: "A condition in which the main influencing factor is an organic sodium salt that is the monosodium salt of p-aminohippuric acid, an amide derivative of the amino acid glycine and para-aminobenzoic acid. Sodium p-aminohippurate is used as a diagnostic agent in the measurement of renal plasma flow." [CHEBI:104011, CHEBI:31204, http://en.wikipedia.org/wiki/Aminohippuric_acid "Wikipedia"]
synonym: "PAH" RELATED []
synonym: "sodium para-aminohippurate" EXACT []
is_a: XCO:0000358 ! diagnostic agent
created_by: JSmith
creation_date: 2013-11-11T16:10:30Z

[Term]
id: XCO:0000360
name: arterial catheter implantation
def: "The insertion of a tubular, flexible surgical instrument into an artery to withdraw or introduce fluid. An artery is a vessel in which blood flows away from the heart." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000027 ! surgical implantation
is_a: XCO:0000595 ! surgical manipulation of blood vessels
created_by: JSmith
creation_date: 2013-12-20T12:41:32Z

[Term]
id: XCO:0000361
name: left L3-L5 ventral root avulsion
def: "The forcible surgical separation from the spine of the motor root of a left side spinal nerve between the #3 and #5 lumbar vertebrae." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Gale:Gale_Encyclopedia_of_Medicine_2008]
is_a: XCO:0000401 ! nerve root avulsion
created_by: JSmith
creation_date: 2013-12-20T13:05:25Z

[Term]
id: XCO:0000362
name: physical restraint in plastic bag
def: "The use of a pouch made from a very thin flexible plastic (any of various organic compounds produced by polymerization, capable of being molded, extruded, cast into various shapes and films) to limit some or all of an animal's normal movements." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, Collins:Collins_Online_English_Dictionary, http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf "NIH"]
is_a: XCO:0000158 ! physical restraint in mechanical restrainer
created_by: JSmith
creation_date: 2013-12-20T13:13:08Z

[Term]
id: XCO:0000363
name: eukaryotic pathogen
def: "A condition in which the main influencing factor is a single-celled or multicellular organism that has the capacity to cause disease, and the cell(s) of which individually have a true nucleus, that is, one  that is bounded by a nuclear membrane, contains one or more chromosomes, and divides by mitosis." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
is_a: XCO:0000236 ! pathogen
created_by: JSmith
creation_date: 2013-12-20T13:28:29Z

[Term]
id: XCO:0000364
name: Toxoplasma gondii
def: "A condition  in which the main influencing factor is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
is_a: XCO:0000363 ! eukaryotic pathogen
created_by: JSmith
creation_date: 2013-12-20T13:29:36Z

[Term]
id: XCO:0000365
name: Toxoplasma gondii cysts
def: "A condition in which the main influencing factor is Toxoplasma gondii cysts. Toxoplasma gondii is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis. Cyst refers to the larval stage in the life cycle during which individual organisms are enveloped in a protective wall." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000364 ! Toxoplasma gondii
created_by: JSmith
creation_date: 2013-12-20T13:30:01Z

[Term]
id: XCO:0000367
name: sham surgical device implantation
def: "A surgery in which a device is inserted which lacks the chemical or drug that in the experimental samples it would dispense." [PMID:15687265]
is_a: XCO:0000027 ! surgical implantation
is_a: XCO:0000100 ! sham surgical control condition
created_by: JSmith
creation_date: 2013-12-20T14:06:20Z

[Term]
id: XCO:0000368
name: autoimmune disease-inducing chemical
def: "Any condition in which the main influencing factor is a chemical that causes an anti-self reaction by the immune system of the treated individual." [RGD:JRS]
is_a: XCO:0000259 ! disease-inducing chemical
created_by: JSmith
creation_date: 2013-12-20T14:29:13Z

[Term]
id: XCO:0000369
name: aurothiopropanol sulfonate
def: "An antirheumatic of slow action that, in certain susceptible individuals, causes a gold-induced, Th2-dependent autoimmunity." [PMID:15128826]
synonym: "allochrysine" RELATED []
synonym: "Atps" RELATED []
synonym: "aurotioprol" RELATED []
is_a: XCO:0000368 ! autoimmune disease-inducing chemical
created_by: JSmith
creation_date: 2013-12-20T14:29:49Z

[Term]
id: XCO:0000370
name: Trichinella spiralis
def: "A condition in which the main influencing factor is any form of  Trichinella spiralis, a nematode parasite that occurs in animals such as rodents, pigs, bears, and in humans. The organism, which matures in the intestines, producing larvae that travel through the blood and lymphatic systems to the muscles where they encyst, is responsible for the disease trichinosis." [http://en.wikipedia.org/wiki/Trichinella_spiralis "Wikipedia"]
is_a: XCO:0000363 ! eukaryotic pathogen
created_by: JSmith
creation_date: 2014-01-09T13:19:52Z

[Term]
id: XCO:0000371
name: Trichinella spiralis larvae
def: "A condition in which the main influencing factor is the infective larvae of the nematode parasite Trichinella spiralis." [http://en.wikipedia.org/wiki/Trichinella_spiralis "Wikipedia"]
is_a: XCO:0000370 ! Trichinella spiralis
created_by: JSmith
creation_date: 2014-01-09T13:27:57Z

[Term]
id: XCO:0000372
name: dexamethasone
def: "A condition in which the main influencing factor is dexamethasone, a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities." [http://en.wikipedia.org/wiki/Dexamethasone "Wikipedia", http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682792.html "Website", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000091 ! steroid
is_a: XCO:0000505 ! anti-inflammatory agent
is_a: XCO:0000636 ! immunosuppressive agent
created_by: JSmith
creation_date: 2014-01-09T13:51:38Z

[Term]
id: XCO:0000373
name: surgical denervation
def: "The resection or complete surgical removal of a nerve, any of the cordlike structures that convey impulses between the central nervous system and one or more parts of the body, and that each consist of an outer connective tissue sheath surrounding a bundle of conductive fibers." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Dental_Dictionary--2nd_Ed]
xref: MESH:D003714
is_a: XCO:0000026 ! surgical removal
created_by: JSmith
creation_date: 2014-01-09T14:52:48Z

[Term]
id: XCO:0000374
name: axotomy
def: "Surgical transection or severing of an axon, the process of a neuron capable of conducting action potentials or self-propagating nerve impulses away from the cell body." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: MESH:D019771
is_a: XCO:0000373 ! surgical denervation
created_by: JSmith
creation_date: 2014-01-09T14:56:20Z

[Term]
id: XCO:0000375
name: sciatic nerve axotomy
def: "Surgical transection or severing of one or more axons of the sciatic nerve, the large sensory and motor nerve that in humans arises from the sacral plexus and passes through the greater sciatic foramen to midthigh where it divides into the common peroneal and tibial nerves." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: MA:0001172
xref: MESH:D019771
is_a: XCO:0000374 ! axotomy
created_by: JSmith
creation_date: 2014-01-09T14:57:23Z

[Term]
id: XCO:0000376
name: saphenous nerve axotomy
def: "Surgical transection or severing of one or more axons of the saphenous nerve, a sensory nerve that is a terminal branch of the femoral nerve, in humans extending from the femoral triangle to the foot, becoming subcutaneous on the medial side of the knee." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, Farlex:Farlex_Partner_Medical_Dictionary_2012, ISBN:978-1416049982]
xref: MA:0002761
xref: MESH:D019771
is_a: XCO:0000374 ! axotomy
created_by: JSmith
creation_date: 2014-01-09T14:57:26Z

[Term]
id: XCO:0000377
name: vitamin
def: "A condition in which the main influencing factor is any of a group of unrelated organic substances occurring in many foods in small amounts and necessary in trace amounts for the normal metabolic functioning of the body." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2014-01-09T17:12:36Z

[Term]
id: XCO:0000378
name: vitamin E
def: "A condition in which the main influencing factor is any of a group of at least eight related fat-soluble compounds with similar biological antioxidant activity, particularly alpha-tocopherol but also including other isomers of tocopherol and the related compounds tocotrienol and tocomonoenol." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://www.cyberlipid.org/vite/vite0001.htm "Website", ISBN:978-1416049982]
xref: CHEBI:33234
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000377 ! vitamin
created_by: JSmith
creation_date: 2014-01-09T17:14:02Z

[Term]
id: XCO:0000379
name: alpha-tocopherol
def: "A condition in which the main influencing factor is the most active form of vitamin E, a 6-hydroxychroman derivative (chromene) with methyl groups in position 2,5,7, and 8 and a phytyl side chain attached at carbon 2. May be described chemically as 2R-(4'R,8'R)-5,7,8-trimethyltocol, with the term tocol indicating the 2-ring structure (benzopyran-6-ol) basic to all vitamin E compounds." [http://www.cyberlipid.org/vite/vite0001.htm "Website"]
synonym: "a-tocopherol" RELATED []
xref: CHEBI:22470
relationship: part_of XCO:0000378 ! vitamin E
created_by: JSmith
creation_date: 2014-01-09T17:15:15Z

[Term]
id: XCO:0000380
name: phytyl side chain of alpha-tocopherol
def: "A condition in which the main influencing factor is a hydrophobic 13 carbon saturated chain with methyl side groups at the 4', 8' and 12' positions. In its native form, the molecule is attached to the 2-carbon of the benzopyran-6-ol double ring structure of alpha-tocopherol." [http://www.cyberlipid.org/vite/vite0001.htm "Website"]
synonym: "alpha-tocopherol phytyl side chain" RELATED []
is_a: XCO:0000276 ! hydrocarbon
relationship: part_of XCO:0000379 ! alpha-tocopherol
created_by: JSmith
creation_date: 2014-01-09T17:16:43Z

[Term]
id: XCO:0000381
name: progesterone
def: "Condition in which the main influencing factor is the steroid hormone progesterone, the principal pro-gestational hormone liberated by the corpus luteum, adrenal cortex, and placenta, whose function is to prepare the uterus for the reception and development of the fertilized oocyte by inducing transformation of the endometrium from the proliferative to the secretory stage." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000229 ! steroid hormone
created_by: JSmith
creation_date: 2014-01-09T17:37:07Z

[Term]
id: XCO:0000382
name: controlled captopril content drinking water
def: "A drink made up of water and a specified amount of captopril consumed by an organism as part of an experiment. Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Captopril "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000270 ! captopril
created_by: JSmith
creation_date: 2014-01-09T18:05:23Z

[Term]
id: XCO:0000383
name: controlled losartan content drinking water
def: "A drink made up of water and a specified amount of losartan consumed by an organism as part of an experiment. Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) receptor antagonist, reducing the end organ responses to angiotensin II." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Losartan "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000161 ! losartan
created_by: JSmith
creation_date: 2014-01-09T18:07:00Z

[Term]
id: XCO:0000384
name: controlled tempol content drinking water
def: "A drink made up of water and a specified amount of tempol consumed by an organism as part of an experiment. Tempol (4-Hydroxy-TEMPO) is a heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/TEMPOL "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000272 ! tempol
created_by: JSmith
creation_date: 2014-01-09T18:07:59Z

[Term]
id: XCO:0000385
name: glomerulonephritis-inducing agent
def: "Any substance, such as a chemical, a mix of chemicals or a pathogen, which has the capacity to cause the development of the symptoms of glomerulonephritis, kidney inflammation characterized by inflammation of the capillary loops in the renal glomeruli." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
is_a: XCO:0000258 ! disease-inducing agent
created_by: JSmith
creation_date: 2014-01-10T15:46:03Z

[Term]
id: XCO:0000386
name: collagenase-solubilized glomerular basement membrane
def: "A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Segen:Segens_Medical_Dictionary_2012]
synonym: "collagenase-solubilized GBM" RELATED []
is_a: XCO:0000385 ! glomerulonephritis-inducing agent
created_by: JSmith
creation_date: 2014-01-10T15:47:24Z

[Term]
id: XCO:0000387
name: collagenase-solubilized rat glomerular basement membrane
def: "A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli from rats (i.e., members of the species Rattus norvegicus) via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Segen:Segens_Medical_Dictionary_2012]
synonym: "collagenase-solubilized rat GBM" RELATED []
is_a: XCO:0000386 ! collagenase-solubilized glomerular basement membrane
created_by: JSmith
creation_date: 2014-01-10T15:48:30Z

[Term]
id: XCO:0000388
name: acetaminophen
def: "Condition in which the main influencing factor is acetaminophen, an analgesic and antipyretic with effects similar to aspirin but only weakly antiinflammatory." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "APAP" RELATED []
synonym: "N-acetyl-p-aminophenol" EXACT []
synonym: "para-acetylaminophenol" EXACT []
synonym: "paracetamol" EXACT []
xref: CHEBI:46195
xref: MESH:D000082
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: JSmith
creation_date: 2014-01-21T16:34:04Z

[Term]
id: XCO:0000389
name: controlled cigarette smoke content
def: "A condition in which the air surrounding an organism or breathed by the organism contains a controlled amount of cigarette smoke, the combined gases and particulates given off when tobacco in the form of a cigarette burns or smolders. A cigarette is a cylinder of cut blonde or black tobacco ensheathed in a tube of paper, with or without an incorporated filter to decrease inhaled tars." [McGraw-Hill:McGraw-Hill_Concise_Dictionary_of_Modern_Medicine]
synonym: "exposure to atmospheric cigarette smoke" RELATED []
relationship: part_of XCO:0000009 ! controlled atmosphere composition
created_by: JSmith
creation_date: 2014-01-21T16:58:06Z

[Term]
id: XCO:0000390
name: antimetabolite
def: "A condition in which the main influencing factor is a substance which competes with or replaces a metabolite (a chemical that is part of the normal metabolism of a cell or body), and so prevents or reduces its normal utilization or activity. Antimetabolites are often structurally similar to the metabolite for which they substitute." [http://en.wikipedia.org/wiki/Antimetabolite "Wikipedia"]
xref: CHEBI:35221
xref: MESH:D000963
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2014-02-07T15:47:34Z

[Term]
id: XCO:0000391
name: 5-bromo-2'-deoxyuridine
def: "A condition in which the main influencing factor is 5-bromo-2'-deoxyuridine (BrdU), a synthetic nucleoside analog and antimetabolite of thymidine. Because BrdU substitutes for thymidine in DNA during replication its incorporation can be used as a marker of cell division." [http://en.wikipedia.org/wiki/Bromodeoxyuridine "Wikipedia"]
synonym: "BrdU" RELATED []
synonym: "bromodeoxyuridine" RELATED []
xref: CHEBI:472552
xref: MESH:D001973
is_a: XCO:0000390 ! antimetabolite
is_a: XCO:0000392 ! nucleoside/nucleotide
is_a: XCO:0000435 ! antineoplastic agent
created_by: JSmith
creation_date: 2014-02-07T15:58:44Z

[Term]
id: XCO:0000392
name: nucleoside/nucleotide
def: "A condition in which the main influencing factor is any of various compounds consisting of a purine or pyrimidine base and a sugar, usually ribose or deoxyribose, with (nucleotide) or without (nucleoside) one or more phosphate groups." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, http://en.wikipedia.org/wiki/Nucleotide "Wikipedia"]
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2014-02-07T16:00:28Z

[Term]
id: XCO:0000393
name: 1,2-dimethylhydrazine
def: "A condition in which the main influencing factor is 1,2-dimethylhydrazine, DNA alkylating agent that is a potent carcinogen; used to induce colon tumours in experimental animals." [http://en.wikipedia.org/wiki/1\,2-dimethylhydrazine "Wikipedia", Mondofacto:Mondofacto_Online_Medical_Dictionary]
synonym: "Hydrazomethane" RELATED []
synonym: "N,N'-dimethylhydrazine" EXACT []
synonym: "SDMH" RELATED []
synonym: "symmetrical dimethylhydrazine" RELATED []
xref: CHEBI:73755
xref: MESH:D019813
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000205 ! mutation inducing chemical
created_by: JSmith
creation_date: 2014-02-07T16:46:23Z

[Term]
id: XCO:0000394
name: controlled bile acid content diet
def: "A regimen of solid food to which a specified amount of bile acid has been added. Bile acids are steroid acids derived from cholesterol in the liver (primary) or produced from primary bile acids by intestinal bacteria (secondary)." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000014 ! controlled content diet
created_by: JSmith
creation_date: 2014-02-07T16:57:51Z

[Term]
id: XCO:0000395
name: controlled 4-nitroquinoline N-oxide content drinking water
def: "A drink made up of water and a specified amount of 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair." [http://en.wikipedia.org/wiki/4-Nitroquinoline_1-oxide "Wikipedia"]
synonym: "controlled 4-Nitroquinoline 1-oxide drinking water" EXACT []
synonym: "controlled 4NQO drinking water" RELATED []
xref: CHEBI:16907
xref: MESH:D015112
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000351 ! 4-nitroquinoline N-oxide
created_by: JSmith
creation_date: 2014-02-07T17:03:31Z

[Term]
id: XCO:0000396
name: phenolic/phenol derivative
def: "Any organic aromatic compound consisting of at least one phenolic group, that is, a group having one or more hydroxy groups attached to a benzene or other arene ring." []
xref: CHEBI:33853
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2014-02-27T13:23:28Z

[Term]
id: XCO:0000397
name: bisphenol A
def: "A synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor." [http://en.wikipedia.org/wiki/Bisphenol_A "Wikipedia"]
synonym: "BPA" RELATED []
xref: CHEBI:33216
is_a: XCO:0000396 ! phenolic/phenol derivative
created_by: JSmith
creation_date: 2014-02-27T13:28:43Z

[Term]
id: XCO:0000398
name: cisplatin
def: "A condition in which the main influencing factor is cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion. Cisplatin is mutagenic and serves as an anti-cancer drug through its ability to bind to and crosslink DNA, interfering with cell division, triggering DNA repair mechanisms and, in turn, activating apoptosis." [CHEBI:27899, http://en.wikipedia.org/wiki/Cisplatin]
xref: CHEBI:27899
is_a: XCO:0000205 ! mutation inducing chemical
is_a: XCO:0000399 ! complex ion
is_a: XCO:0000435 ! antineoplastic agent
created_by: JSmith
creation_date: 2014-02-27T15:53:25Z

[Term]
id: XCO:0000399
name: complex ion
def: "A metal ion surrounded by, and forming coordinate covalent bonds with, a set of ligands comprised of any combination of other molecules or ions able to donate an electron pair." [http://chemwiki.ucdavis.edu/Inorganic_Chemistry/Coordination_Chemistry/Complex_Ion_Equilibria/Complex-Ion_Equilibria "Website", http://www.chemguide.co.uk/inorganic/complexions/whatis.html#top "Website"]
is_a: XCO:0000149 ! ion/salt
created_by: JSmith
creation_date: 2014-02-27T15:55:56Z

[Term]
id: XCO:0000400
name: surgical avulsion
def: "A surgical manipulation in which one tissue, organ or body part is forcibly torn away from the whole, or in which an attached or anchored tissue is torn away from another tissue or body part." [Mosby:Mosbys_Medical_Dictionary--8th_Ed, Segen:Segens_Medical_Dictionary_2012]
is_a: XCO:0000026 ! surgical removal
created_by: JSmith
creation_date: 2014-02-27T17:28:06Z

[Term]
id: XCO:0000401
name: nerve root avulsion
def: "The surgical tearing apart of the nerve root, the part of a nerve adjacent to the center to which it is connected, from that center, for example, surgical separation of one or both of two bundles of nerve fibers (the posterior and anterior roots) from the spinal cord by tearing rather than cutting." [Farlex:Farlex_Partner_Medical_Dictionary_2012, Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000373 ! surgical denervation
is_a: XCO:0000400 ! surgical avulsion
created_by: JSmith
creation_date: 2014-02-27T17:29:08Z

[Term]
id: XCO:0000402
name: habituation to experimental apparatus
def: "A condition in which an experimental subject is exposed to an experimental apparatus in order to habituate the individual to the apparatus. Habituation is the gradual decrease in behavioral responses to a particular stimulus or environment after repeated exposures have proven to be of no consequence." [http://en.wikipedia.org/wiki/Habituation "Wikipedia", Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2014-02-28T11:38:55Z

[Term]
id: XCO:0000403
name: controlled cisplatin content diet
def: "A solid diet in which the amount of cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion, is maintained at a specified level." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: CHEBI:27899
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000398 ! cisplatin
created_by: JSmith
creation_date: 2014-02-28T12:22:58Z

[Term]
id: XCO:0000404
name: controlled bisphenol A content diet
def: "A solid diet in which the amount of bisphenol A is maintained at a specified level. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor." [http://en.wikipedia.org/wiki/Bisphenol_A "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled BPA content diet" RELATED []
xref: CHEBI:33216
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000397 ! bisphenol A
created_by: JSmith
creation_date: 2014-02-28T12:23:03Z

[Term]
id: XCO:0000405
name: controlled cisplatin content drinking water
def: "A drink made up of water and a specified amount of cisplatin consumed by an organism as part of an experiment. Cisplatin is a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Cisplatin "Wikipedia", ISBN:978-1416049982]
xref: CHEBI:27899
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000398 ! cisplatin
created_by: JSmith
creation_date: 2014-02-28T12:48:11Z

[Term]
id: XCO:0000406
name: controlled bisphenol A content drinking water
def: "A drink made up of water and a specified amount of bisphenol A consumed by an organism as part of an experiment. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Bisphenol_A "Wikipedia", ISBN:978-1416049982]
synonym: "controlled BPA content drinking water" RELATED []
xref: CHEBI:33216
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000397 ! bisphenol A
created_by: JSmith
creation_date: 2014-02-28T12:48:15Z

[Term]
id: XCO:0000407
name: hypoglycemic agent
def: "A condition in which the main influencing factor is a substance which has the ability to lower the level of glucose, particularly blood glucose, in an organism." []
synonym: "antidiabetic agent" RELATED []
synonym: "antidiabetic  drug" RELATED []
synonym: "antihyperglycemic agent" EXACT []
xref: CHEBI:35526
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2014-02-28T17:14:36Z

[Term]
id: XCO:0000408
name: metformin
def: "A condition in which the main influencing factor is metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis)." [http://en.wikipedia.org/wiki/Metformin "Wikipedia"]
synonym: "Glucophage" NARROW []
xref: CHEBI:6801
is_a: XCO:0000407 ! hypoglycemic agent
created_by: JSmith
creation_date: 2014-02-28T17:17:09Z

[Term]
id: XCO:0000409
name: controlled metformin content drinking water
def: "A drink made up of water and a specified amount of metformin consumed by an organism as part of an experiment. Metformin is an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis)." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Metformin "Wikipedia", ISBN:978-1416049982]
xref: CHEBI:6801
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000408 ! metformin
created_by: JSmith
creation_date: 2014-02-28T17:27:21Z

[Term]
id: XCO:0000410
name: controlled metformin content diet
def: "A solid diet in which the amount of metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis), is maintained at a specified level." [http://en.wikipedia.org/wiki/Metformin "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: CHEBI:6801
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000408 ! metformin
created_by: JSmith
creation_date: 2014-02-28T17:29:02Z

[Term]
id: XCO:0000411
name: reproduction condition
def: "Any experimental condition that is specifically related to the reproduction of the organism, that is, to the cellular, genetic, behavioral and temporal processes by which an organism produces offspring similar to itself so that the species is perpetuated." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2014-03-04T12:21:41Z

[Term]
id: XCO:0000412
name: gestation
def: "The state of a female and/or her offspring, and the processes which occur, during the period from conception to birth or termination of the pregnancy." [Farlex:Farlex_Partner_Medical_Dictionary_2012]
synonym: "pregnancy" RELATED []
is_a: XCO:0000411 ! reproduction condition
created_by: JSmith
creation_date: 2014-03-04T12:29:54Z

[Term]
id: XCO:0000413
name: birth
def: "The emergence and separation of offspring from the body of the mother." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
synonym: "parturition" RELATED []
is_a: XCO:0000411 ! reproduction condition
created_by: JSmith
creation_date: 2014-03-04T12:36:04Z

[Term]
id: XCO:0000414
name: lactation
def: "The process of synthesis and secretion of milk from the mammary glands in the nourishment of offspring." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "breast feeding" RELATED []
synonym: "milk production" RELATED []
is_a: XCO:0000411 ! reproduction condition
created_by: JSmith
creation_date: 2014-03-04T12:38:40Z

[Term]
id: XCO:0000415
name: maternal milk
def: "The nutrient fluid produced by the mammary gland of a female mammal for the nourishment of her young and consumed by her offspring or a fosterling of the same species." [Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "breast milk" RELATED []
synonym: "mother's milk" RELATED []
is_a: XCO:0000416 ! milk
created_by: JSmith
creation_date: 2014-03-04T12:44:39Z

[Term]
id: XCO:0000416
name: milk
def: "A nutrient fluid containing proteins, fats, lactose, and various vitamins and minerals produced by the mammary gland of a female mammal." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
is_a: XCO:0000020 ! drink
created_by: JSmith
creation_date: 2014-03-04T12:54:50Z

[Term]
id: XCO:0000417
name: controlled phytoestrogen content diet
def: "A solid diet in which the amount of one or more phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants, is maintained at a specified level." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: CHEBI:76989
is_a: XCO:0000014 ! controlled content diet
created_by: JSmith
creation_date: 2014-03-04T13:32:02Z

[Term]
id: XCO:0000418
name: phytoestrogen-free diet
def: "A solid diet which specifically contains no phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: CHEBI:76989
is_a: XCO:0000419 ! soy-free diet
created_by: JSmith
creation_date: 2014-03-04T13:35:13Z

[Term]
id: XCO:0000419
name: soy-free diet
def: "A solid diet specifically containing no soy, that is, no derivative of soybeans, the bean of the leguminous plant, Glycine max, which contains little starch but is rich in protein and phytoestrogens." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000417 ! controlled phytoestrogen content diet
created_by: JSmith
creation_date: 2014-03-04T13:38:15Z

[Term]
id: XCO:0000420
name: controlled in utero environment
def: "A condition in which the environment of the offspring within the uterus is controlled during any or all of the period between fertilization and parturition." [Farlex:Farlex_Partner_Medical_Dictionary_2012]
synonym: "controlled gestational environment" RELATED []
is_a: XCO:0000421 ! in utero condition
created_by: JSmith
creation_date: 2014-03-04T13:53:44Z

[Term]
id: XCO:0000421
name: in utero condition
def: "Any condition which occurs while an organism is still within the uterus of its mother during the gestation period." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2014-03-04T15:25:32Z

[Term]
id: XCO:0000422
name: quinone
def: "Any condition in which the main influencing factor is a quinone, a member of a class of compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds." []
xref: CHEBI:36141
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2014-03-04T17:35:52Z

[Term]
id: XCO:0000423
name: thymoquinone
def: "A condition in which the main influencing factor is thymoquinone, an antioxidant phytochemical compound found in the plant Nigella sativa. Thymoquinone has the chemical formula C10H12O2 and is a 1,4-benzoquinone substituted at the 2 and 5 position with a methyl and an isopropyl group (2-Isopropyl-5-methyl- or 5-Isopropyl-2-methyl-)." [http://en.wikipedia.org/wiki/Thymoquinone "Wikipedia"]
synonym: "2-isopropyl-5-methylbenzoquinone" EXACT []
synonym: "2-methyl-5-isopropyl-p-benzoquinone" EXACT []
synonym: "2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione" EXACT []
synonym: "dihydrothymoquinone" EXACT []
xref: CHEBI:113532
xref: MESH:C003466
xref: pubchem.compound:10281
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000422 ! quinone
created_by: JSmith
creation_date: 2014-03-04T17:36:38Z

[Term]
id: XCO:0000424
name: benfotiamine
def: "A condition in which the main influencing factor is benfotiamine, a synthetic thioester S-acyl derivative and analogue of thiamine (vitamin B1); used as an antioxidant dietary supplement." [http://en.wikipedia.org/wiki/Benfotiamine "Wikipedia"]
synonym: "S-benzoylthiamine O-monophosphate" EXACT []
xref: CHEBI:41039
is_a: XCO:0000271 ! antioxidant
created_by: JSmith
creation_date: 2014-03-04T17:48:57Z

[Term]
id: XCO:0000425
name: lactotransferrin
def: "A condition in which the main influencing factor is lactotransferrin, a multifunctional protein of the transferrin family which is a major iron-binding protein in milk and body secretions, and has antimicrobial activity." [http://en.wikipedia.org/wiki/Lactoferrin "Wikipedia", RGD:1313477]
synonym: "lactoferrin" EXACT []
synonym: "LTF" RELATED []
is_a: XCO:0000193 ! peptide/protein
created_by: JSmith
creation_date: 2014-03-05T09:50:27Z

[Term]
id: XCO:0000426
name: 1H-pyrazole
def: "A condition in which the main influencing factor is 1H-pyrazole, an antioxidant, heterocyclic organic compound with the formula C3H3N2H which is a 5-membered ring of three carbon atoms and two adjacent nitrogen centers, i.e., with nitrogens at positions 1 and 2 of the ring." [http://en.wikipedia.org/wiki/Pyrazole "Wikipedia"]
synonym: "1,2-diazole" RELATED []
xref: CHEBI:17241
is_a: XCO:0000271 ! antioxidant
created_by: JSmith
creation_date: 2014-03-05T09:52:40Z

[Term]
id: XCO:0000427
name: lycopene
def: "A condition in which the main influencing factor is lycopene, a bright red polyunsaturated carotenoid hydrocarbon (i.e. a carotene) with the formula C40H56. Lycopene is a tetraterpene assembled from eight isoprene units and has antioxidant activity." [http://en.wikipedia.org/wiki/Lycopene "Wikipedia"]
xref: CHEBI:15948
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000279 ! terpene
created_by: JSmith
creation_date: 2014-03-05T09:54:44Z

[Term]
id: XCO:0000428
name: fructose
def: "A condition in which the main influencing factor is fructose, a monosaccharide isomer of glucose which, although it is a 6-carbon sugar (hexose), generally exists as a 5-member hemiketal ring. Fructose is one of three dietary monosaccharides that are absorbed directly into the bloodstream during digestion, is covalently bound to glucose to form the sucrose molecule, and is found naturally in honey and many sweet fruits." [http://en.wikipedia.org/wiki/Fructose "Wikipedia"]
xref: CHEBI:15824
xref: CHEBI:28757
is_a: XCO:0000274 ! monosaccharide
created_by: JSmith
creation_date: 2014-03-05T10:26:45Z

[Term]
id: XCO:0000429
name: controlled fructose content drinking water
def: "A drink made up of water and a specified amount of fructose consumed by an organism as part of an experiment. Fructose is one of three dietary monosaccharides that are absorbed directly into the bloodstream during digestion, is covalently bound to glucose to form the sucrose molecule, and is found naturally in honey and many sweet fruits." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Fructose "Wikipedia", ISBN:978-1416049982]
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000428 ! fructose
created_by: JSmith
creation_date: 2014-03-05T10:27:59Z

[Term]
id: XCO:0000430
name: silymarin
def: "A condition in which the main influencing factor is silymarin, a strongly antioxidant mixture of flavonolignans extracted from the milk thistle plant (Silybum marianum). The components or silymarin are capable of scavenging both free radicals and reactive oxygen species (ROS)." [PMID:24145092]
is_a: XCO:0000271 ! antioxidant
created_by: JSmith
creation_date: 2014-03-05T10:39:11Z

[Term]
id: XCO:0000431
name: disaccharide
def: "Any condition in which the main influencing factor is a disaccharide, a member of the class of sugars that yield two monosaccharide molecules upon hydrolysis." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000172 ! carbohydrate
created_by: JSmith
creation_date: 2014-03-07T10:28:37Z

[Term]
id: XCO:0000432
name: sucrose
def: "Any condition in which the main influencing factor is sucrose, a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:17992
is_a: XCO:0000431 ! disaccharide
created_by: JSmith
creation_date: 2014-03-07T10:31:32Z

[Term]
id: XCO:0000433
name: controlled sucrose content drinking water
def: "A drink made up of water and a specified amount of sucrose consumed by an organism as part of an experiment. Sucrose is a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:17992
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000432 ! sucrose
created_by: JSmith
creation_date: 2014-03-07T10:33:57Z

[Term]
id: XCO:0000434
name: octylphenol
def: "Condition in which the main influencing factor is octylphenol, a phenolic ring with an 8-carbon side chain." []
xref: CHEBI:34432
is_a: XCO:0000239 ! toxic substance
is_a: XCO:0000396 ! phenolic/phenol derivative
created_by: JSmith
creation_date: 2014-03-07T13:09:25Z

[Term]
id: XCO:0000435
name: antineoplastic agent
def: "A condition in which the main influencing factor is any chemical that inhibits or prevents the proliferation of neoplasms." []
synonym: "anticancer agent" RELATED []
synonym: "cancer chemotherapy agent" RELATED []
xref: CHEBI:35610
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2014-03-12T13:30:22Z

[Term]
id: XCO:0000436
name: controlled N-propyl-N-nitrosourea content diet
def: "A solid diet in which the amount of N-propyl-N-nitrosourea (PNU) is maintained at a specified level. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." [http://en.wikipedia.org/wiki/Nitrosourea "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed, pubchem.compound:13157]
synonym: "controlled 1-nitroso-1-propylurea content diet" EXACT []
synonym: "controlled 1-propyl-1-nitrosourea content diet" RELATED []
synonym: "controlled PNU content diet" RELATED []
synonym: "controlled propylnitrosourea content diet" EXACT []
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000344 ! N-propyl-N-nitrosourea
created_by: JSMITH
creation_date: 2014-04-17T12:42:14Z

[Term]
id: XCO:0000437
name: controlled N-propyl-N-nitrosourea content drinking water
def: "A drink made up of water and a specified amount of N-propyl-N-nitrosourea (PNU) consumed by an organism as part of an experiment. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group)." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Nitrosourea "Wikipedia", ISBN:978-1416049982, pubchem.compound:13157]
synonym: "controlled 1-nitroso-1-propylurea content drinking water" EXACT []
synonym: "controlled 1-propyl-1-nitrosourea content drinking water" RELATED []
synonym: "controlled PNU content drinking water" RELATED []
synonym: "controlled propylnitrosourea content drinking water" EXACT []
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000344 ! N-propyl-N-nitrosourea
created_by: JSMITH
creation_date: 2014-04-17T12:42:20Z

[Term]
id: XCO:0000438
name: candesartan
def: "A condition in which the main influencing factor is candesartan, the angiotensin II receptor 1 (AT1) antagonist which exhibits antihypertensive effects in animal models." [http://en.wikipedia.org/wiki/Candesartan "Wikipedia"]
synonym: "2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester" EXACT []
synonym: "TCV-116" EXACT []
xref: CHEBI:3348
xref: MESH:C081643
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000536 ! angiotensin II receptor antagonist
is_a: XCO:0000863 ! antihypertensive agent
created_by: JSMITH
creation_date: 2014-04-17T13:11:54Z

[Term]
id: XCO:0000439
name: controlled 3-methyl-4'-dimethylaminoazobenzene content drinking water
def: "A drink made up of water and a specified amount of 3-methyl-4'-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, consumed by an organism as part of an experiment." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://potency.berkeley.edu/chempages/3%27-METHYL-4-DIMETHYLAMINOAZOBENZENE.html "Website", ISBN:978-1416049982]
synonym: "controlled 3'-Me-DAB content drinking water" RELATED []
synonym: "controlled 3'-methyl-4-(dimethylamino)azobenzene content drinking water" RELATED []
synonym: "controlled 4-Dimethylamino-3'-methylazobenzene content drinking water" EXACT []
synonym: "controlled MDAB content drinking water" RELATED []
synonym: "controlled methyldimethylaminoazobenzene content drinking water" EXACT []
xref: CHEBI:76329
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000207 ! 3-methyl-4'-dimethylaminoazobenzene
created_by: JSMITH
creation_date: 2014-04-17T15:49:17Z

[Term]
id: XCO:0000440
name: controlled 3-methyl-4'-dimethylaminoazobenzene content diet
def: "A solid diet in which the amount of 3'-methyl-4-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, is maintained at a specified level." [http://potency.berkeley.edu/chempages/3%27-METHYL-4-DIMETHYLAMINOAZOBENZENE.html "Website", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled 3'-Me-DAB content diet" RELATED []
synonym: "controlled 3'-methyl-4-(dimethylamino)azobenzene content diet" EXACT []
synonym: "controlled 4-Dimethylamino-3'-methylazobenzene content diet" EXACT []
synonym: "controlled MDAB content diet" RELATED []
synonym: "controlled methyldimethylaminoazobenzene content diet" EXACT []
xref: CHEBI:76329
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000207 ! 3-methyl-4'-dimethylaminoazobenzene
created_by: JSMITH
creation_date: 2014-04-17T15:49:21Z

[Term]
id: XCO:0000441
name: controlled 2-acetamidofluorene content drinking water
def: "A drink made up of water and a specified amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, consumed by an organism as part of an experiment." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Acetylaminofluorene "Wikipedia", ISBN:978-1416049982]
synonym: "controlled 2-AAF content drinking water" RELATED []
synonym: "controlled 2-acetylaminofluorene content drinking water" RELATED []
xref: CHEBI:17356
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000208 ! 2-acetamidofluorene
created_by: JSMITH
creation_date: 2014-04-17T16:31:36Z

[Term]
id: XCO:0000442
name: controlled 2-acetamidofluorene content diet
def: "A solid diet in which the amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, is maintained at a specified level." [http://en.wikipedia.org/wiki/Acetylaminofluorene "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled 2-AAF content diet" RELATED []
synonym: "controlled 2-acetylaminofluorene content diet" RELATED []
xref: CHEBI:17356
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000208 ! 2-acetamidofluorene
created_by: JSMITH
creation_date: 2014-04-17T16:31:40Z

[Term]
id: XCO:0000443
name: controlled dexamethasone content diet
def: "A solid diet in which the amount of dexamethasone (DEX) is maintained at a specified level. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities." [http://en.wikipedia.org/wiki/Dexamethasone "Wikipedia", http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682792.html "Website", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled DEX content diet" RELATED []
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0000372 ! dexamethasone
created_by: JSmith
creation_date: 2014-04-24T13:35:39Z

[Term]
id: XCO:0000444
name: controlled dexamethasone content drinking water
def: "A drink made up of water and a specified amount of dexamethasone (DEX) consumed by an organism as part of an experiment. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://en.wikipedia.org/wiki/Dexamethasone "Wikipedia", http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682792.html "Website", ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled DEX content drinking water" RELATED []
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000372 ! dexamethasone
created_by: JSmith
creation_date: 2014-04-24T13:35:46Z

[Term]
id: XCO:0000445
name: phosphate buffered saline
def: "A relatively standardized solution of sodium chloride to which one or more phosphate salts have been added to maintain a neutral pH. PBS is isotonic, that is, the ionic strength of PBS is close to that inside living cells." [http://en.wikipedia.org/wiki/Phosphate_buffered_saline "Wikipedia"]
synonym: "PBS" RELATED []
synonym: "phosphate-buffer sodium chloride solution" RELATED []
xref: CHEBI:26020
xref: CHEBI:26710
xref: CHEBI:35225
is_a: XCO:0000155 ! sodium chloride solution
is_a: XCO:0000315 ! buffer solution
created_by: JSmith
creation_date: 2014-04-24T14:08:08Z

[Term]
id: XCO:0000446
name: estrus cycle
def: "One of the two types of reproductive cycles. Specifically, the correlated phenomena of the endocrine and reproductive systems of a female (especially, non-primate) mammal resulting in regularly occurring periods during which the female is sexually active and receptive, estrus, separated by periods in which there is no sexual receptivity." [Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "estral  cycle" RELATED []
synonym: "estrous cycle" EXACT []
is_a: XCO:0000411 ! reproduction condition
created_by: JSmith
creation_date: 2014-05-15T18:09:42Z

[Term]
id: XCO:0000447
name: estrus
def: "A regularly recurrent state of sexual excitability during which the female of non-primate mammalian species will accept the male and is capable of conceiving." [Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "estrous" RELATED []
synonym: "heat" RELATED []
synonym: "oestrus" EXACT []
relationship: part_of XCO:0000446 ! estrus cycle
created_by: JSmith
creation_date: 2014-05-15T18:16:20Z

[Term]
id: XCO:0000448
name: metestrus
def: "The period of regression and sexual inactivity in females of non-primate mammalian species between estrus and diestrus." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
synonym: "metestrous" RELATED []
relationship: part_of XCO:0000446 ! estrus cycle
created_by: JSmith
creation_date: 2014-05-15T18:25:00Z

[Term]
id: XCO:0000449
name: diestrus
def: "A period of sexual quiescence that intervenes between two periods of estrus in females of non-primate mammalian species between. In general during diestrus blood levels of estrogens are minimal, progesterone levels are high and the physiological state in the uterus is most conducive for implantation and growth of the developing fetus." [Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "diestrous" RELATED []
relationship: part_of XCO:0000446 ! estrus cycle
created_by: JSmith
creation_date: 2014-05-15T18:29:26Z

[Term]
id: XCO:0000450
name: proestrus
def: "A preparatory period immediately preceding estrus and characterized by growth of graafian follicles, increased estrogenic activity, and alteration of uterine and vaginal mucosa." [Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed]
synonym: "proestrous" RELATED []
relationship: part_of XCO:0000446 ! estrus cycle
created_by: JSmith
creation_date: 2014-05-15T18:33:04Z

[Term]
id: XCO:0000451
name: Herpes simplex virus type 1
def: "A condition in which the main influencing factor is a neurotropic virus that is a member of the Herpesviridae family and that, once the infection becomes chronic, has the ability to cycle through recurring outbreak periods followed by periods of latency or dormancy in which the virus is inactive but still present in infected nerve cells. HSV1 causes primarily mouth, throat, face, eye, and central nervous system infections." [http://en.wikipedia.org/wiki/Herpes_simplex_virus "Wikipedia"]
synonym: "Herpes simplex virus 1" RELATED []
synonym: "HSV-1" RELATED []
is_a: XCO:0000237 ! viral pathogen
created_by: JSmith
creation_date: 2014-05-15T19:05:50Z

[Term]
id: XCO:0000452
name: controlled casein content diet
def: "A solid diet in which the amount of casein is maintained at a specified level. Casein, a phosphoprotein, is the principle protein component of milk." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled caseinogen content diet" RELATED []
is_a: XCO:0000014 ! controlled content diet
created_by: JSmith
creation_date: 2014-06-12T17:25:24Z

[Term]
id: XCO:0000453
name: controlled butter content diet
def: "This is a solid diet in which the amount of butter is maintained at a specified level. Butter is a soft yellowish or whitish emulsion of milk fat, water and air, churned from milk or cream and processed for use in cooking and as a food." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000014 ! controlled content diet
created_by: JSmith
creation_date: 2014-06-12T17:27:00Z

[Term]
id: XCO:0000454
name: controlled oil content diet
def: "A solid diet in which the amount of a specified oil is maintained at a specified level. An oil is any unctuous, combustible substance that is liquid, or easily liquefiable, on warming, and is soluble in ether but not in water. Oils may be animal, vegetable, or mineral in origin." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000014 ! controlled content diet
created_by: JSmith
creation_date: 2014-06-12T17:27:48Z

[Term]
id: XCO:0000455
name: controlled corn oil content diet
def: "A solid diet in which the amount of corn oil is maintained at a specified level. Corn oil is a refined fixed, that is, nonvolatile, oil obtained from corn, the embryo of Zea mays plant. It is sometimes promoted as a good source of polyunsaturated fatty acids." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000454 ! controlled oil content diet
created_by: JSmith
creation_date: 2014-06-12T17:28:44Z

[Term]
id: XCO:0000456
name: retinyl palmitate
def: "Any condition in which the primary influencing agent is retinyl palmitate, the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2." [http://en.wikipedia.org/wiki/Retinyl_palmitate "Wikipedia"]
synonym: "retinol palmitate" RELATED []
is_a: XCO:0000271 ! antioxidant
created_by: JSmith
creation_date: 2014-06-12T17:56:00Z

[Term]
id: XCO:0000457
name: controlled retinoid content diet
def: "A solid diet in which the amount of any retinoid is maintained at a specified level. Retinoids comprise retinal, retinol and any structurally similar natural derivative or synthetic compound, with or without vitamin A activity." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled vitamin A content diet" EXACT []
is_a: XCO:0000690 ! controlled vitamin content diet
created_by: JSmith
creation_date: 2014-06-12T17:57:57Z

[Term]
id: XCO:0000458
name: controlled retinyl palmitate content diet
def: "A solid diet in which the amount of retinyl palmitate is maintained at a specified level. Retinyl palmitate is the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2." [http://en.wikipedia.org/wiki/Retinyl_palmitate "Wikipedia", Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "controlled retinol palmitate content diet" RELATED []
is_a: XCO:0000457 ! controlled retinoid content diet
relationship: has_component XCO:0000456 ! retinyl palmitate
created_by: JSmith
creation_date: 2014-06-12T17:59:02Z

[Term]
id: XCO:0000459
name: controlled light/dark cycle
def: "A recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000284 ! controlled visible light exposure
created_by: JSmith
creation_date: 2014-06-17T16:30:05Z

[Term]
id: XCO:0000460
name: subcutaneous interscapular air pouch
def: "Induction and/or maintenance of a hollow cavity beneath the skin between the scapulae (the flat triangular bones at the top or back of the shoulder), by injection or other introduction of a specified volume of air. Experimental air pouches are often used to encapsulate foreign cells or other substances." [PMID:17277140, PMID:7019400, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
is_a: XCO:0000165 ! surgical manipulation
created_by: JSmith
creation_date: 2014-06-17T17:19:15Z

[Term]
id: XCO:0000461
name: restricted feeding
def: "A dietary regimen in which access to food is limited, e.g. to a specified number of hours per day or to a specified part of the light-dark cycle, with or without restrictions in the amount or type of food available when feeding is allowed." [PMID:24739093]
synonym: "time-restricted feeding" RELATED []
synonym: "TRF" RELATED []
is_a: XCO:0000013 ! diet
created_by: JSmith
creation_date: 2014-06-23T16:24:46Z

[Term]
id: XCO:0000462
name: light phase of controlled light/dark cycle
def: "The portion of a controlled light/dark cycle in which the subject is exposed to ambient light (that is, during which the room is lit). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000459 ! controlled light/dark cycle
created_by: JSmith
creation_date: 2014-08-26T13:10:29Z

[Term]
id: XCO:0000463
name: dark phase of controlled light/dark cycle
def: "The portion of a controlled light/dark cycle in which the subject is not being exposed to ambient light (that is, during which the room is darkened). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000459 ! controlled light/dark cycle
created_by: JSmith
creation_date: 2014-08-26T13:12:48Z

[Term]
id: XCO:0000464
name: controlled ex vivo organ condition
def: "Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." [Farlex:Farlex_Partner_Medical_Dictionary_2012, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000000 ! experimental condition
created_by: JSmith
creation_date: 2015-01-13T12:48:26Z

[Term]
id: XCO:0000465
name: controlled ex vivo artery condition
def: "Any experimental condition in which the internal or external environment of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." [Farlex:Farlex_Partner_Medical_Dictionary_2012, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000464 ! controlled ex vivo organ condition
created_by: JSmith
creation_date: 2015-01-13T12:59:22Z

[Term]
id: XCO:0000466
name: controlled ex vivo artery perfusion pressure
def: "A condition in which the pressure, or force per area, exerted by a perfusate against the walls of an artery after removal from the body but while the tissue is still viable, is regulated or maintained at a specified level." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, Farlex:Farlex_Partner_Medical_Dictionary_2012, ISBN:978-1416049982]
synonym: "controlled ex vivo artery intraluminal  pressure" EXACT []
is_a: XCO:0000465 ! controlled ex vivo artery condition
created_by: JSmith
creation_date: 2015-01-13T13:16:48Z

[Term]
id: XCO:0000467
name: retinoid
def: "Condition in which the main influencing factor is a retinoid, any of a group of compounds containing 20 carbon atoms and structurally related to retinal, retinol, and other substances, some of which exhibit vitamin A activity." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
xref: CHEBI:26537
is_a: XCO:0000342 ! chemical with specified structure
created_by: JSmith
creation_date: 2015-03-06T18:09:40Z

[Term]
id: XCO:0000468
name: vitamin A
def: "Condition in which the main influencing factor is vitamin A, a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids. Vitamin A is involved in immune function, vision, reproduction, and cellular communication." [http://en.wikipedia.org/wiki/Vitamin_A "Wikipedia", https://ods.od.nih.gov/factsheets/VitaminA-Consumer/]
xref: CHEBI:12777
is_a: XCO:0000377 ! vitamin
is_a: XCO:0000467 ! retinoid
created_by: JSmith
creation_date: 2015-03-06T18:11:00Z

[Term]
id: XCO:0000469
name: isotretinoin
def: "Condition in which the main influencing factor is isotretinoin, a synthetic first generation retinoid compound used for the treatment of severe cases of acne and other skin diseases." [http://en.wikipedia.org/wiki/Retinoid "Wikipedia"]
synonym: "13-cis-retinoic acid" EXACT []
synonym: "13cRA" EXACT []
synonym: "Accutane" EXACT []
synonym: "Roaccutane" RELATED []
xref: CHEBI:6067
is_a: XCO:0000467 ! retinoid
created_by: JSmith
creation_date: 2015-03-06T18:13:57Z

[Term]
id: XCO:0000470
name: flavonoid
def: "Condition in which the main influencing factor is a flavonoid, any of a class of plant secondary metabolites that have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a heterocyclic ring (C)." [http://en.wikipedia.org/wiki/Flavonoid "Wikipedia"]
synonym: "bioflavonoid" RELATED []
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2015-03-06T18:16:29Z

[Term]
id: XCO:0000471
name: quercetin
def: "Condition in which the main influencing factor is quercetin, a pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is a yellow flavonoid pigment found in oak bark, the juice of lemons, asparagus, and other fruits and vegetables and is used to reduce abnormal capillary fragility." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "meletin" RELATED []
xref: CHEBI:16243
is_a: XCO:0000470 ! flavonoid
created_by: JSmith
creation_date: 2015-03-06T18:17:55Z

[Term]
id: XCO:0000472
name: chrysin
def: "Condition in which the main influencing factor is chrysin, a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7." []
synonym: "5,7-dihydroxyflavone" RELATED []
xref: CHEBI:75095
is_a: XCO:0000470 ! flavonoid
created_by: JSmith
creation_date: 2015-03-06T18:19:02Z

[Term]
id: XCO:0000473
name: naringenin
def: "Condition in which the main influencing factor is naringenin, a trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 6 and 4'.  Naringenin is the predominant flavanone in grapefruit and has demonstrated inhibitory activity against the CYP1A2 cytochrome P450 isoform." [http://en.wikipedia.org/wiki/Naringenin "Wikipedia"]
xref: CHEBI:50202
is_a: XCO:0000470 ! flavonoid
created_by: JSmith
creation_date: 2015-03-06T18:20:06Z

[Term]
id: XCO:0000474
name: alendronate
def: "Condition in which the main influencing factor is alendronate (the anionic form of alendronic acid), a bisphosphonate drug used for osteoporosis and several other bone diseases, because it inhibits osteoclast-mediated bone-resorption." [http://en.wikipedia.org/wiki/Alendronic_acid "Wikipedia"]
synonym: "alendronic acid" RELATED []
synonym: "Binosto" EXACT []
synonym: "Fosamax" EXACT []
synonym: "sodium alendronate" EXACT []
xref: CHEBI:2567
xref: CHEBI:50647
is_a: XCO:0000120 ! inhibitor
created_by: JSmith
creation_date: 2015-03-06T18:29:05Z

[Term]
id: XCO:0000475
name: bacterial pathogen
def: "Any condition in which the primary influencing agent is a bacterial pathogen,  a disease-causing unicellular prokaryotic microorganism that commonly multiplies by cell division, lacks a nucleus or membrane-bound organelles, and generally has a cell wall." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "pathogenic bacteria" RELATED []
is_a: XCO:0000236 ! pathogen
created_by: JSmith
creation_date: 2015-04-29T14:14:39Z

[Term]
id: XCO:0000476
name: Streptococcus pneumoniae
def: "A condition in which the primary influencing factor is Streptococcus pneumoniae, a species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers." [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae "Wikipedia"]
xref: NCBITaxon:1313
is_a: XCO:0000475 ! bacterial pathogen
created_by: JSmith
creation_date: 2015-04-30T13:35:44Z

[Term]
id: XCO:0000477
name: Streptococcus pneumoniae D39
def: "A condition in which the primary influencing factor is Streptococcus pneumoniae D39, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers." [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae "Wikipedia"]
synonym: "Streptococcus pneumoniae strain D39" EXACT []
xref: NCBITaxon:373153
is_a: XCO:0000476 ! Streptococcus pneumoniae
created_by: JSmith
creation_date: 2015-04-30T13:36:39Z

[Term]
id: XCO:0000478
name: Streptococcus pneumoniae TIGR4
def: "A condition in which the primary influencing factor is Streptococcus pneumoniae TIGR4, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers." [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae "Wikipedia"]
synonym: "Streptococcus pneumoniae strain TIGR4" EXACT []
xref: NCBITaxon:170187
is_a: XCO:0000476 ! Streptococcus pneumoniae
created_by: JSmith
creation_date: 2015-04-30T13:38:57Z

[Term]
id: XCO:0000479
name: Haemophilus influenzae
def: "A condition in which the primary influencing factor is Haemophilus influenzae, a Gram-negative, coccobacillary, facultatively anaerobic bacterium which is considered an opportunistic pathogen, i.e. one that can colonize a host without causing disease unless there are extenuating circumstances which result in susceptibility on the part of the host." [http://en.wikipedia.org/wiki/Haemophilus_influenzae "Wikipedia"]
xref: NCBITaxon:727
is_a: XCO:0000743 ! Haemophilus
created_by: JSmith
creation_date: 2015-04-30T13:41:32Z

[Term]
id: XCO:0000480
name: nontypeable Haemophilus influenzae
def: "A condition in which the primary influencing factor is one or more nontypeable strain(s) of Haemophilus influenzae (NTHi). NTHi refers to any unencapsulated strain of the Gram-negative, coccobacillary, facultatively anaerobic bacterium species Haemophilus influenza. Such bacteria lack the capsular antigens used to serotype strains and therefore cannot be classified by serology. NTHi strains are the important pathogens in chronic and recurrent otitis media in children." [http://en.wikipedia.org/wiki/Haemophilus_influenzae "Wikipedia", PMID:15968074]
synonym: "NTHi" RELATED []
is_a: XCO:0000479 ! Haemophilus influenzae
created_by: JSmith
creation_date: 2015-04-30T13:42:32Z

[Term]
id: XCO:0000481
name: Haemophilus influenzae 86-028NP
def: "A condition in which the primary influencing factor is the 86-028NP strain of Haemophilus influenzae. 86-028NP is a pathogenic, nontypeable H. influenzae strain isolated from the nasopharynx of a child with chronic otitis media." [http://en.wikipedia.org/wiki/Haemophilus_influenzae "Wikipedia", PMID:15968074]
synonym: "86028NP" RELATED []
synonym: "Haemophilus influenzae strain 86-028NP" EXACT []
synonym: "NTHi 86-028NP" RELATED []
xref: NCBITaxon:281310
is_a: XCO:0000480 ! nontypeable Haemophilus influenzae
created_by: JSmith
creation_date: 2015-04-30T13:48:27Z

[Term]
id: XCO:0000482
name: antimicrobial agent
def: "A substance that kills or slows the growth of one or more microorganisms, including bacteria, viruses, fungi and protozoans." []
synonym: "antibiotic" RELATED []
xref: CHEBI:33281
is_a: XCO:0000341 ! chemical with specified function
created_by: JSmith
creation_date: 2015-04-30T14:25:42Z

[Term]
id: XCO:0000483
name: antibacterial agent
def: "A substance that kills or slows the growth of bacteria, unicellular prokaryotic microorganisms that commonly multiply by cell division, lack a nucleus or membrane-bound organelles, and generally have a cell wall." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
xref: CHEBI:33282
is_a: XCO:0000482 ! antimicrobial agent
created_by: JSmith
creation_date: 2015-04-30T14:31:11Z

[Term]
id: XCO:0000484
name: ceftriaxone
def: "A third-generation cephalosporin antibacterial agent with broad-spectrum activity against both Gram-positive and Gram-negative bacteria." [http://en.wikipedia.org/wiki/Ceftriaxone "Wikipedia"]
xref: CHEBI:29007
is_a: XCO:0000483 ! antibacterial agent
created_by: JSmith
creation_date: 2015-04-30T14:44:33Z

[Term]
id: XCO:0000485
name: Haemophilus influenzae 86-028NP H2 mutant
def: "A condition in which the primary influencing factor is the H2 mutant of the 86-028NP strain of Haemophilus influenzae." [RGD:JRS]
synonym: "86H2" RELATED []
synonym: "Haemophilus influenzae mutant strain 86-028NP-H2" EXACT []
synonym: "NTHi 86-028NP H2 mutant" RELATED []
xref: NCBITaxon:281310
is_a: XCO:0000481 ! Haemophilus influenzae 86-028NP
created_by: JSmith
creation_date: 2015-05-14T17:54:23Z

[Term]
id: XCO:0000486
name: Haemophilus influenzae 86-028NP C5 mutant
def: "A condition in which the primary influencing factor is the C5 mutant of the 86-028NP strain of Haemophilus influenzae." [RGD:JRS]
synonym: "86C5" RELATED []
synonym: "Haemophilus influenzae mutant strain 86-028NP-C5" EXACT []
synonym: "NTHi 86-028NP C5 mutant" RELATED []
xref: NCBITaxon:281310
is_a: XCO:0000481 ! Haemophilus influenzae 86-028NP
created_by: JSmith
creation_date: 2015-05-14T17:58:28Z

[Term]
id: XCO:0000487
name: Streptococcus pneumoniae TIGR4 LuxS mutant
def: "A condition in which the primary influencing factor is the LuxS mutant of Streptococcus pneumoniae TIGR4." [RGD:JRS]
synonym: "Streptococcus pneumoniae mutant strain TIGR4luxS" EXACT []
synonym: "TIGR4luxS" RELATED []
xref: NCBITaxon:170187
is_a: XCO:0000478 ! Streptococcus pneumoniae TIGR4
created_by: JSmith
creation_date: 2015-05-14T17:59:26Z

[Term]
id: XCO:0000488
name: social environment condition
def: "Any condition related to or affecting the external interactions and relationships of a single organism, between single organisms, or within or between groups of organisms." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
synonym: "social context condition" RELATED []
is_a: XCO:0000000 ! experimental condition
created_by: jesmith
creation_date: 2015-12-07T15:12:14Z

[Term]
id: XCO:0000489
name: temporary social environment condition
def: "Any condition in which the social environment of an organism is set or changed for a specified and/or limited period of time." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
is_a: XCO:0000488 ! social environment condition
created_by: jesmith
creation_date: 2015-12-07T15:40:22Z

[Term]
id: XCO:0000490
name: ongoing social environment condition
def: "Any condition in which the social environment of an organism is set or changed for an extended period of time or on a continual basis." [Collins:Collins_Online_English_Dictionary]
is_a: XCO:0000488 ! social environment condition
created_by: jesmith
creation_date: 2015-12-07T15:56:22Z

[Term]
id: XCO:0000491
name: controlled exposure to an organism of the same species
def: "An experimental condition in which a test subject is placed in social contact with an organism from the same species. A species is a fundamental category of taxonomic classification, ranking below a genus and consisting of related organisms capable of interbreeding." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007]
is_a: XCO:0000489 ! temporary social environment condition
created_by: jesmith
creation_date: 2015-12-07T15:59:02Z

[Term]
id: XCO:0000492
name: controlled exposure to a juvenile of the same species
def: "This is an experimental condition in which a test subject is placed in social contact with a juvenile (young, not yet mature, not fully grown and/or not fully developed) organism from the same species." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, https://www.merriam-webster.com]
synonym: "controlled exposure to an adolescent of the same species" EXACT []
is_a: XCO:0000491 ! controlled exposure to an organism of the same species
created_by: jesmith
creation_date: 2015-12-07T16:11:18Z

[Term]
id: XCO:0000493
name: controlled exposure to an adult of the same species
def: "An experimental condition in which a test subject is placed in social contact with an adult  (an organism that is fully developed and has reached physical and/or sexual maturity) from the same species." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed]
is_a: XCO:0000491 ! controlled exposure to an organism of the same species
created_by: jesmith
creation_date: 2015-12-07T16:18:25Z

[Term]
id: XCO:0000494
name: postmenopause
def: "The physiological period after the natural cessation of estrus or menstruation cycles in an aging female mammal." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, http://www.medicaldictionaryweb.com/Postmenopause-definition/ "Website", ISBN:978-1416049982]
synonym: "postmenopausal" RELATED []
synonym: "post-productive period" RELATED []
is_a: XCO:0000411 ! reproduction condition
created_by: jesmith
creation_date: 2016-02-01T11:00:34Z

[Term]
id: XCO:0000495
name: neurotoxic substance
def: "A condition in which the main influencing factor is any substance that is poisonous or destructive to nerve cells or tissue, or that can be metabolized into a substance that is destructive to nerve cells or tissue." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
comment: Note that, although commonly used to refer to any neurotoxic substance, the term "neurotoxin" is technically restricted to naturally occurring proteins or peptides which are neurotoxic.
synonym: "neurotoxin" NARROW []
is_a: XCO:0000239 ! toxic substance
created_by: jesmith
creation_date: 2016-04-25T13:04:37Z

[Term]
id: XCO:0000496
name: neurotoxin
def: "A condition in which the main influencing factor is a peptide, a protein or a conjugated protein produced by some higher plants, animals, and pathogenic bacteria, that is poisonous or destructive to nerve cells or tissue." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000240 ! toxin
is_a: XCO:0000495 ! neurotoxic substance
created_by: jesmith
creation_date: 2016-04-25T13:25:58Z

[Term]
id: XCO:0000497
name: Parkinson disease inducing chemical
def: "A condition in which the main influencing factor is a synthetic or naturally derived compound that causes loss of dopaminergic neurons and induces Parkinson-like symptoms (parkinsonism) in animal models and/or Parkinson disease in humans." [PMID:22108613]
synonym: "Parkinson's disease inducing chemical" EXACT []
synonym: "parkinsonism-inducing chemical" RELATED []
xref: MESH:D010300
is_a: XCO:0000259 ! disease-inducing chemical
created_by: jesmith
creation_date: 2016-04-25T13:44:48Z

[Term]
id: XCO:0000498
name: oxidopamine
def: "A condition in which the main influencing factor is oxidopamine, a neurotoxic organic compound used to induce degeneration of dopaminergic neurons in animal models." [PMID:22108613]
synonym: "6-hydoxydopamine" RELATED []
synonym: "6-OHDA" RELATED []
xref: CHEBI:78741
is_a: XCO:0000495 ! neurotoxic substance
is_a: XCO:0000497 ! Parkinson disease inducing chemical
created_by: jesmith
creation_date: 2016-04-25T15:27:15Z

[Term]
id: XCO:0000499
name: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
def: "A condition in which the main influencing factor is1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the precursor to the toxic metabolite MPP+ (1-methyl-4-phenylpyridinium cation) which promotes degeneration of dopaminergic neurons." [PMID:22108613]
synonym: "MPTP" RELATED []
xref: CHEBI:17963
is_a: XCO:0000495 ! neurotoxic substance
is_a: XCO:0000497 ! Parkinson disease inducing chemical
created_by: jesmith
creation_date: 2016-04-25T15:31:31Z

[Term]
id: XCO:0000500
name: paraquat
def: "A condition in which the main influencing factor is paraquat, a herbicidal organic cation used to model Parkinson's disease in mice." [PMID:22108613]
xref: CHEBI:34905
is_a: XCO:0000495 ! neurotoxic substance
is_a: XCO:0000497 ! Parkinson disease inducing chemical
created_by: jesmith
creation_date: 2016-04-25T15:35:55Z

[Term]
id: XCO:0000501
name: rotenone
def: "A condition in which the main influencing factor is rotenone, an insecticide and piscicide extracted from Leguminosa plants. Rotenone can be used to induce degeneration of dopaminergic neurons in animal models." [PMID:22108613]
xref: CHEBI:28201
is_a: XCO:0000496 ! neurotoxin
is_a: XCO:0000497 ! Parkinson disease inducing chemical
created_by: jesmith
creation_date: 2016-04-25T15:41:51Z

[Term]
id: XCO:0000502
name: body part position change
def: "A condition characterized by an alteration in the placement, arrangement or orientation of any part of the body of an organism such as an organ or extremity." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--5th_Ed, https://en.wiktionary.org/wiki/body_part "Wiktionary"]
is_a: XCO:0000066 ! body position change
created_by: jesmith
creation_date: 2017-02-22T18:31:25Z

[Term]
id: XCO:0000503
name: head position change
def: "A condition characterized by an alteration in the placement, arrangement or orientation of the head of an organism." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--5th_Ed, https://en.wiktionary.org/wiki/body_part "Wiktionary"]
synonym: "change in position of the head" EXACT []
is_a: XCO:0000502 ! body part position change
created_by: jesmith
creation_date: 2017-02-22T18:33:23Z

[Term]
id: XCO:0000504
name: coronal plane rotational acceleration of the head
def: "A condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at an increasing velocity." [PMID:27188340]
synonym: "coronal plane angular acceleration of the head" RELATED []
is_a: XCO:0000503 ! head position change
created_by: jesmith
creation_date: 2017-02-22T18:34:51Z

[Term]
id: XCO:0000505
name: anti-inflammatory agent
def: "A condition in which the main influencing factor is a chemical which counteracts or suppresses inflammation." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "antiinflammatory agent" EXACT []
xref: CHEBI:67079
is_a: XCO:0000341 ! chemical with specified function
created_by: jesmith
creation_date: 2017-02-22T18:36:33Z

[Term]
id: XCO:0000506
name: non-steroidal anti-inflammatory drug
def: "A condition in which the main influencing factor is a chemical which counteracts or suppresses inflammation but which is not a steroid." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "NSAID" RELATED []
xref: CHEBI:35475
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: jesmith
creation_date: 2017-02-22T18:40:46Z

[Term]
id: XCO:0000507
name: carprofen
def: "Condition in which the main influencing factor is a non-steroidal anti-inflammatory drug with chemical formula C15H12ClNO2, used as a veterinary analgesic." [https://en.wikipedia.org/wiki/Carprofen "Wikipedia"]
xref: CHEBI:364453
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000506 ! non-steroidal anti-inflammatory drug
created_by: jesmith
creation_date: 2017-02-22T18:45:59Z

[Term]
id: XCO:0000508
name: audible tone stimulus
def: "An auditory stimulus consisting of a sound which is at a frequency and level to be perceptible to the ear, especially the human ear." [Farlex:Farlex_Partner_Medical_Dictionary_2012, Mosby:Mosbys_Medical_Dictionary--8th_Ed]
is_a: XCO:0000048 ! auditory stimulus
created_by: jesmith
creation_date: 2017-02-22T18:56:06Z

[Term]
id: XCO:0000509
name: ultrasonic stimulus
def: "An auditory stimulus consisting of sound waves which are beyond the upper limit of perception by the human ear." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000048 ! auditory stimulus
created_by: jesmith
creation_date: 2017-02-22T19:03:06Z

[Term]
id: XCO:0000510
name: coronal plane rotational velocity of the head
def: "An experimental condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at a relatively constant velocity." [PMID:27188340]
synonym: "coronal plane angular velocity of the head" RELATED []
is_a: XCO:0000503 ! head position change
created_by: jesmith
creation_date: 2017-04-21T13:27:10Z

[Term]
id: XCO:0000511
name: ester
def: "Any condition in which the main influencing factor is a substance is a chemical compound derived from the linkage of an organic or inorganic acid and an alcohol, phenol, heteroarenol, or enol with the loss of water (H2O) formed from one hydrogen derived from an acidic hydroxy group of the acid and an -OH (hydroxy) group of the alcohol." [https://en.wikipedia.org/wiki/Ester "Wikipedia"]
xref: CHEBI:35701
is_a: XCO:0000342 ! chemical with specified structure
created_by: jesmith
creation_date: 2017-07-18T12:56:04Z

[Term]
id: XCO:0000512
name: teratogen
def: "Any condition in which the main influencing factor is a substance with adverse or toxic effects on an embryo or fetus resulting in birth defects, specifically, altered development, growth retardation, functional defect and/or embryo death." [https://en.wikipedia.org/wiki/Teratology "Wikipedia"]
synonym: "teratogenic agent" EXACT []
xref: CHEBI:50905
is_a: XCO:0000259 ! disease-inducing chemical
created_by: jesmith
creation_date: 2017-07-18T12:58:04Z

[Term]
id: XCO:0000513
name: dibutyl phthalate
def: "A condition in which the main influencing factor is dibutyl phthalate (DBP), the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. DBP has been used as a plasticizer and as an antiparasitic drug used to treat infestation of parasites on the surface of the body, and is suspected of being an endocrine disruptor and teratogen." [https://en.wikipedia.org/wiki/Dibutyl_phthalate "Wikipedia"]
synonym: "DBP" RELATED []
synonym: "di-n-butyl phthalate" EXACT []
xref: CHEBI:34687
is_a: XCO:0000511 ! ester
is_a: XCO:0000512 ! teratogen
created_by: jesmith
creation_date: 2017-07-18T13:00:07Z

[Term]
id: XCO:0000514
name: metoprolol
def: "A condition in which the main influencing factor is metoprolol, a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches." [https://en.wikipedia.org/wiki/Metoprolol "Wikipedia", MESH:D008790]
xref: MESH:D008790
is_a: XCO:0000336 ! adrenergic antagonist
is_a: XCO:0000396 ! phenolic/phenol derivative
created_by: jesmith
creation_date: 2017-07-18T13:05:03Z

[Term]
id: XCO:0000515
name: metoprolol tartrate
def: "A condition in which the main influencing factor is metoprolol tartrate, an immediate-release formulation of metoprolol.  Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches." [https://en.wikipedia.org/wiki/Metoprolol "Wikipedia", MESH:D008790]
is_a: XCO:0000514 ! metoprolol
created_by: jesmith
creation_date: 2017-07-18T13:06:13Z

[Term]
id: XCO:0000516
name: metoprolol succinate
def: "A condition in which the main influencing factor is metoprolol succinate, an extended-release formulation of metoprolol.  Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches." [https://en.wikipedia.org/wiki/Metoprolol "Wikipedia", MESH:D008790]
is_a: XCO:0000514 ! metoprolol
created_by: jesmith
creation_date: 2017-07-18T13:06:16Z

[Term]
id: XCO:0000517
name: anti-transforming growth factor beta antibody
def: "A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with any or all of the transforming growth factor beta cytokines." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "1D11 monoclonal antibody" NARROW []
synonym: "anti-TGFbeta antibody" RELATED []
is_a: XCO:0000194 ! antibody
created_by: jesmith
creation_date: 2017-07-18T13:10:24Z

[Term]
id: XCO:0000518
name: anti-Shiga toxin 1 beta antibody
def: "A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed, PMID:26904753, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "anti-Shigatoxin 1B antibody" RELATED []
is_a: XCO:0000194 ! antibody
created_by: jesmith
creation_date: 2017-07-18T13:12:49Z

[Term]
id: XCO:0000519
name: anti-Shiga toxin 1 beta monoclonal antibody 13C4
def: "A condition in which the main influencing factor is an immunoglobulin molecule having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1. This monoclonal antibody has been used as an IgG1 isotype control." [Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed, PMID:14675041, PMID:26904753, Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed]
synonym: "anti-Shigatoxin 1B monoclonal antibody 13C4" RELATED []
is_a: XCO:0000518 ! anti-Shiga toxin 1 beta antibody
created_by: jesmith
creation_date: 2017-07-18T13:14:54Z

[Term]
id: XCO:0000520
name: neuromodulation
def: "Any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body." [https://en.wikipedia.org/wiki/Neuromodulation_(medicine) "Wikipedia"]
is_a: XCO:0000000 ! experimental condition
created_by: jesmith
creation_date: 2017-07-18T13:25:13Z

[Term]
id: XCO:0000521
name: direct electrical nerve stimulation
def: "Any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to a specific nerve or nerves, for example through the use of microelectrodes or an implanted device." [https://en.wikipedia.org/wiki/Neurostimulation "Wikipedia"]
synonym: "direct electrical nerve stimulus" RELATED []
is_a: XCO:0000520 ! neuromodulation
created_by: jesmith
creation_date: 2017-07-18T13:25:52Z

[Term]
id: XCO:0000522
name: common peroneal nerve direct electrical stimulation
def: "A condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly the common peroneal nerve(s), for example through the use of microelectrodes or an implanted device. The common peroneal nerve is one of the terminal divisions of the sciatic nerve, diverging from the tibial nerve at the upper end of the popliteal fossa, then coursing with the biceps tendon along the lateral portion of the popliteal space to wind around the neck of the fibula, where it divides into the superficial and deep peroneal nerves." [Farlex:Farlex_Partner_Medical_Dictionary_2012, https://en.wikipedia.org/wiki/Common_peroneal_nerve "Wikipedia", https://en.wikipedia.org/wiki/Neurostimulation "Wikipedia"]
synonym: "direct electrical stimulus of the common peroneal nerve" RELATED []
is_a: XCO:0000521 ! direct electrical nerve stimulation
created_by: jesmith
creation_date: 2017-07-18T13:27:01Z

[Term]
id: XCO:0000523
name: enzyme inhibitor
def: "Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of an enzyme, a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
is_a: XCO:0000120 ! inhibitor
created_by: jesmith
creation_date: 2017-07-18T13:31:10Z

[Term]
id: XCO:0000524
name: angiotensin converting enzyme inhibitor
def: "Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of angiotensin converting enzyme (ACE). ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. ACE inhibitors are used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, https://en.wikipedia.org/wiki/ACE_inhibitor "Wikipedia", ISBN:978-1416049982]
synonym: "ACE inhibitor" RELATED []
is_a: XCO:0000523 ! enzyme inhibitor
is_a: XCO:0000863 ! antihypertensive agent
created_by: jesmith
creation_date: 2017-07-18T13:32:02Z

[Term]
id: XCO:0000525
name: benazepril
def: "A condition in which the main influencing factor is benazepril, a benzazepine in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety of benazeprilat has been converted to the corresponding ethyl ester. Removal of the ester by the liver converts the prodrug back to its active form, benazeprilat.  Benazepril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, https://en.wikipedia.org/wiki/Benazepril "Wikipedia", ISBN:978-1416049982]
xref: CHEBI:3011
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: jesmith
creation_date: 2017-07-18T13:34:04Z

[Term]
id: XCO:0000526
name: swimming with water weights
def: "A condition in which the main influencing factor is the action of moving one's appendages to propel oneself through water while carrying weights (for example, aquatic dumbbells, ankle cuffs, or weighted belt) to increase resistance and/or decrease buoyancy thereby increasing the difficulty of the action." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--5th_Ed, Encarta:Encarta_World_English_Dictionary]
is_a: XCO:0000059 ! physical activity
created_by: jesmith
creation_date: 2017-07-18T13:50:19Z

[Term]
id: XCO:0000527
name: genetic manipulation
def: "A condition in which the genotype or the gene expression of an organism or a cell has been modified." [Farlex:Farlex_Partner_Medical_Dictionary_2009]
is_a: XCO:0000000 ! experimental condition
created_by: jesmith
creation_date: 2017-08-11T16:51:14Z

[Term]
id: XCO:0000528
name: gene transfer
def: "A condition in which copies of an exogenous gene have been  (transiently or stably) inserted into a living cell or organism in order to induce synthesis of that gene's product." [Webster:Random_House_Kernerman_Websters_College_Dictionary_2010]
synonym: "horizontal gene transfer" RELATED []
is_a: XCO:0000527 ! genetic manipulation
created_by: jesmith
creation_date: 2017-08-11T16:57:10Z

[Term]
id: XCO:0000529
name: gene transfer using adenovirus vector
def: "A condition in which gene transfer has been performed using an adenovirus as the carrier of the genetic material. An adenovirus is any of a group of medium-sized (90-100 nm) non-enveloped icosahedral viruses of the family Adenoviridae which are characterized by a nucleocapsid surrounding a double-stranded DNA genome." [Segen:Segens_Medical_Dictionary_2012]
synonym: "adenoviral gene transfer" EXACT []
synonym: "adenovirus transfer" EXACT []
is_a: XCO:0000528 ! gene transfer
created_by: jesmith
creation_date: 2017-08-11T16:58:54Z

[Term]
id: XCO:0000530
name: gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector
def: "A condition in which the mouse angiotensin I converting enzyme 2 (Ace2) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [RGD:12879447, Webster:Random_House_Kernerman_Websters_College_Dictionary_2010]
synonym: "Ad-Ace2" RELATED []
synonym: "adenoviral transfer of the murine Ace2 gene" EXACT []
synonym: "transfer of recombinant adenovirus containing the murine Ace2 gene" EXACT []
xref: MGI:1917258
xref: RGD:1550521
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: jesmith
creation_date: 2017-08-11T17:15:29Z

[Term]
id: XCO:0000531
name: gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector
def: "A condition in which the enhanced green fluorescent protein (EGFP) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [RGD:12879447, Webster:Random_House_Kernerman_Websters_College_Dictionary_2010]
synonym: "Ad-EGFP" RELATED []
synonym: "adenoviral transfer of the EGFP gene" EXACT []
synonym: "transfer of recombinant adenovirus containing the EGFP gene" EXACT []
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: jesmith
creation_date: 2017-08-11T17:17:27Z

[Term]
id: XCO:0000532
name: protein synthesis inhibitor
def: "Any condition in which the main influencing factor is a substance which disrupts one or more of the processes that lead directly to the generation of new proteins, that is, that inhibits the process of translation of mRNAs into proteins." [https://en.wikipedia.org/wiki/Protein_synthesis_inhibitor "Wikipedia"]
is_a: XCO:0000120 ! inhibitor
created_by: jesmith
creation_date: 2017-08-11T17:21:03Z

[Term]
id: XCO:0000533
name: puromycin
def: "Condition in which the main influencing factor is puromycin, an aminonucleoside antibiotic derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome." [https://en.wikipedia.org/wiki/Puromycin "Wikipedia"]
xref: CHEBI:17939
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000482 ! antimicrobial agent
is_a: XCO:0000532 ! protein synthesis inhibitor
created_by: jesmith
creation_date: 2017-08-11T17:21:54Z

[Term]
id: XCO:0000534
name: sunitinib
def: "A condition in which the main influencing factor is sunitinib, an antineoplastic agent which acts as a receptor tyrosine kinase inhibitor and an antagonist for multiple platelet-derived growth factor and vascular endothelial growth factor receptors. Sunitinib is used as a chemotherapy agent in the treatment of renal cell carcinoma and gastrointestinal stromal tumor." [https://en.wikipedia.org/wiki/Sunitinib "Wikipedia"]
synonym: "sunitinibum" RELATED []
synonym: "Sutent" RELATED []
xref: CHEBI:38940
is_a: XCO:0000160 ! receptor antagonist
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000970 ! protein kinase inhibitor
created_by: jesmith
creation_date: 2017-08-11T17:28:23Z

[Term]
id: XCO:0000535
name: lisinopril
def: "A condition in which the main influencing factor is lisinopril, an antihypertensive competitive inhibitor of angiotensin-converting enzyme (ACE)." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed, ISBN:978-1416049982]
synonym: "Prinivil" RELATED []
synonym: "Qbrelis" RELATED []
synonym: "Zestril" RELATED []
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: jrsmith
creation_date: 2018-05-11T10:54:07Z

[Term]
id: XCO:0000536
name: angiotensin II receptor antagonist
def: "Any condition in which the main influencing factor is an agent that blocks one or more angiotensin II receptors." [https://en.wikipedia.org/wiki/Angiotensin_II_receptor_blocker "Wikipedia"]
synonym: "angiotensin II receptor blocker" EXACT []
synonym: "ARB" RELATED []
synonym: "sartan" RELATED []
is_a: XCO:0000160 ! receptor antagonist
created_by: jrsmith
creation_date: 2018-05-14T18:01:31Z

[Term]
id: XCO:0000537
name: olmesartan medoxomil
def: "An experimental condition in which the main influencing factor is olmesartan medoxomil, an angiotensin II receptor blocker which is used as an antihypertensive agent." [https://en.wikipedia.org/wiki/Olmesartan "Wikipedia"]
synonym: "CS-866" RELATED []
is_a: XCO:0000536 ! angiotensin II receptor antagonist
is_a: XCO:0000863 ! antihypertensive agent
created_by: jrsmith
creation_date: 2018-05-14T18:27:28Z

[Term]
id: XCO:0000538
name: temocapril
def: "An experimental condition in which the main influencing factor is temocapril, an angiotensin-I converting enzyme (ACE) inhibitor consisting of a dipeptide prodrug with a thiazepine ring." [https://en.wikipedia.org/wiki/Temocapril "Wikipedia"]
synonym: "Acecol" RELATED []
synonym: "alpha-((2S,6R)-6-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl)acetic acid.HCl" EXACT []
synonym: "CS-622" RELATED []
synonym: "CS622" RELATED []
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: jrsmith
creation_date: 2018-05-14T18:34:03Z

[Term]
id: XCO:0000539
name: doxorubicin
def: "An experimental condition in which the main influencing factor is doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix." [drugbank:DB00997, https://en.wikipedia.org/wiki/Doxorubicin "Wikipedia"]
synonym: "ADR" EXACT []
synonym: "Adriablastine" EXACT []
synonym: "adriamycin" EXACT []
synonym: "DXR" EXACT []
xref: CHEBI:28748
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000482 ! antimicrobial agent
created_by: jrsmith
creation_date: 2018-05-15T15:54:18Z

[Term]
id: XCO:0000540
name: delapril
def: "An experimental condition in which the main influencing factor is delapril, an antihypertensive prodrug that, when converted to its active metabolites 5-hydroxy delapril diacid and delapril diacid, acts as an angiotensin-converting enzyme (ACE) inhibitor." [https://en.wikipedia.org/wiki/Delapril "Wikipedia"]
xref: CHEBI:135735
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: jrsmith
creation_date: 2018-05-15T15:58:32Z

[Term]
id: XCO:0000541
name: bosentan
def: "An experimental condition in which the main influencing factor is bosentan, a competitive antagonist of endothelin-1 that blocks the binding of endothelin to both the endothelin-A (ET-A) and endothelin-B (ET-B)receptors. Bosentan is used in the treatment of pulmonary arterial hypertension." [https://en.wikipedia.org/wiki/Bosentan "Wikipedia", https://phassociation.org/patients/treatments/bosentan/ "Website"]
synonym: "bosentanum" RELATED []
synonym: "Tracleer" RELATED []
is_a: XCO:0000730 ! endothelin receptor antagonist
created_by: jrsmith
creation_date: 2018-05-15T16:06:25Z

[Term]
id: XCO:0000542
name: enalapril
def: "An experimental condition in which the main influencing factor is enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE)." [https://en.wikipedia.org/wiki/Enalapril "Wikipedia"]
synonym: "Enacard" RELATED []
synonym: "Renitec" RELATED []
synonym: "Vasotec" RELATED []
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: jrsmith
creation_date: 2018-05-15T16:09:53Z

[Term]
id: XCO:0000543
name: vitamin D
def: "A condition in which the main influencing factor is one or more closely related forms (vitamers) of vitamin D, a group of fat-soluble secosteroid vitamins (when ingested from dietary sources) and/or hormones (when produced by the skin in response to ultraviolet radiation). Vitamin D is involved in intestinal absorption of calcium, magnesium and phosphate, and in calcium homeostasis and metabolism." [https://en.wikipedia.org/wiki/Vitamin_D "Wikipedia"]
is_a: XCO:0000377 ! vitamin
created_by: jrsmith
creation_date: 2018-05-15T16:17:43Z

[Term]
id: XCO:0000544
name: vitamin D2
def: "An experimental condition in which the main influencing factor is vitamin D2, a type of vitamin D found in food and used as a dietary supplement. The D2 vitamer has been found to be less efficiently absorbed in the human intestine and/or less biologically active than the D3 vitamer." [https://en.wikipedia.org/wiki/Ergocalciferol "Wikipedia", PMID:22552031]
synonym: "Calcidol" RELATED []
synonym: "calciferol" EXACT []
synonym: "Drisdol" RELATED []
synonym: "ergocalciferol" EXACT []
is_a: XCO:0000543 ! vitamin D
created_by: jrsmith
creation_date: 2018-05-15T16:22:22Z

[Term]
id: XCO:0000545
name: vitamin D3
def: "An experimental condition in which the main influencing factor is vitamin D3, a form of vitamin D which is naturally synthesized in the skin of animals by the action of ultraviolet B (UVB) radiation on 7-dehydrocholesterol. Vitamin D3 is also found in some foods and can be used as a dietary supplement.  The D3 vitamer has been found to be more efficiently absorbed in the human intestine and/or more biologically active than the D2 vitamer." [https://en.wikipedia.org/wiki/Cholecalciferol "Wikipedia", PMID:22552031]
synonym: "cholecalciferol" EXACT []
synonym: "colecalciferol" EXACT []
is_a: XCO:0000543 ! vitamin D
created_by: jrsmith
creation_date: 2018-05-15T16:35:39Z

[Term]
id: XCO:0000546
name: vitamin analog
def: "A condition in which the main influencing factor is a compound with structural and/or functional similarity to a vitamin and can therefore be substituted for the analogous vitamin." [https://en.wikipedia.org/wiki/Analog "Wikipedia"]
synonym: "vitamin analogue" EXACT []
is_a: XCO:0000377 ! vitamin
created_by: jrsmith
creation_date: 2018-05-15T16:41:42Z

[Term]
id: XCO:0000547
name: paricalcitol
def: "An experimental condition in which the main influencing factor is paricalcitol, an analog of vitamin D2 used for the prevention and treatment of secondary hyperparathyroidism." [https://en.wikipedia.org/wiki/Paricalcitol "Wikipedia"]
synonym: "19-nor-1,25-(OH)2-vitamin D2" EXACT []
synonym: "Zemplar" RELATED []
is_a: XCO:0000546 ! vitamin analog
created_by: jrsmith
creation_date: 2018-05-15T16:44:29Z

[Term]
id: XCO:0000548
name: ramipril
def: "An experimental condition in which the main influencing factor is ramipril, a prodrug that is metabolized in the liver to ramiprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE)." [drugbank:DB00178, MESH:D017257]
synonym: "Altace" EXACT []
synonym: "Tritace" EXACT []
xref: CHEBI:8774
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: jrsmith
creation_date: 2018-05-15T16:51:40Z

[Term]
id: XCO:0000549
name: left anterior descending coronary artery occlusion
def: "A surgical manipulation causing blockage of the left anterior descending coronary artery, the artery supplying blood to approximately half of the left ventricle of the heart including the anterolateral myocardium, apex, and interventricular septum." [https://en.wikipedia.org/wiki/Anterior_interventricular_branch_of_left_coronary_artery "Wikipedia"]
synonym: "LAD blockage" RELATED []
synonym: "LAD occlusion" RELATED []
synonym: "left coronary artery ligation" EXACT []
synonym: "widow maker occlusion" RELATED []
is_a: XCO:0000347 ! blood vessel occlusion
created_by: jrsmith
creation_date: 2018-05-15T16:57:52Z

[Term]
id: XCO:0000550
name: reserpine
def: "An experimental condition in which the main influencing factor is reserpine, an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2. Reserpine has been used as both an antihypertensive drug and an antipsychotic drug." [drugbank:DB00206, https://en.wikipedia.org/wiki/Reserpine "Wikipedia", PMID:7905859]
synonym: "methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate" EXACT []
synonym: "Serpasil" EXACT []
xref: CHEBI:28487
xref: MESH:D012110
is_a: XCO:0000120 ! inhibitor
is_a: XCO:0000863 ! antihypertensive agent
created_by: jrsmith
creation_date: 2018-05-15T17:19:06Z

[Term]
id: XCO:0000551
name: hydralazine
def: "An experimental condition in which the main influencing factor is hydralazine, a vasodilator that appears to have multiple, direct effects on smooth muscles of the arterial vessels, thereby reducing systemic vascular resistance and arterial pressure." [drugbank:DB01275, http://cvpharmacology.com/vasodilator/direct "Website"]
is_a: XCO:0000140 ! vasodilator
created_by: jrsmith
creation_date: 2018-05-15T17:22:47Z

[Term]
id: XCO:0000552
name: controlled hydralazine content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydralazine in which the amount of hydralazine consumed is maintained at a specified level." [https://www.merriam-webster.com/, MESH:D006830]
xref: CHEBI:5775
xref: PMID:3611778
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000551 ! hydralazine
created_by: jrsmith
creation_date: 2018-05-15T17:24:24Z

[Term]
id: XCO:0000553
name: everolimus
def: "An experimental condition in which the main influencing factor is everolimus, a mammalian target of rapamycin (mTOR) inhibitor which is selective for the mTORC1 protein complex, with little or no effect on mTORC2.  Everolimus is used as an antineoplastic and immunosuppressive agent." [https://en.wikipedia.org/wiki/Everolimus "Wikipedia"]
xref: CHEBI:68478
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000523 ! enzyme inhibitor
created_by: jrsmith
creation_date: 2018-05-31T13:41:07Z

[Term]
id: XCO:0000554
name: controlled phosphorus content diet
def: "A regimen of solid food in which the amount of phosphorus consumed is controlled." []
is_a: XCO:0000014 ! controlled content diet
created_by: sjwang
creation_date: 2018-11-14T15:58:10Z

[Term]
id: XCO:0000555
name: controlled lisinopril content drinking water
def: "A drink made up of water and a specified amount of lisinopril consumed by an organism as part of an experiment." []
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000535 ! lisinopril
created_by: sjwang
creation_date: 2018-11-14T16:04:27Z

[Term]
id: XCO:0000556
name: amino monosaccharide
def: "Any amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group." []
xref: CHEBI:60926
is_a: XCO:0000274 ! monosaccharide
created_by: sjwang
creation_date: 2018-11-16T10:50:55Z

[Term]
id: XCO:0000557
name: glucosamine
def: "Glucosamine, commonly used as a treatment for osteoarthritis, is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis." [drugbank:DB01296]
synonym: "2-amino-2-deoxyglucose" EXACT []
is_a: XCO:0000556 ! amino monosaccharide
created_by: sjwang
creation_date: 2018-11-16T10:55:31Z

[Term]
id: XCO:0000558
name: taxifolin
def: "Taxifolin is a flavanonol and a non-steroidal anti-inflammatory agent." [https://en.wikipedia.org/wiki/Taxifolin]
synonym: "catechin hydrate" EXACT []
synonym: "DHQ" EXACT []
synonym: "dihydroquercetin" EXACT []
synonym: "Distylin" EXACT []
synonym: "Taxifoliol" EXACT []
xref: CHEBI:38747
is_a: XCO:0000470 ! flavonoid
is_a: XCO:0000506 ! non-steroidal anti-inflammatory drug
created_by: sjwang
creation_date: 2018-11-16T11:03:16Z

[Term]
id: XCO:0000559
name: melatonin
def: "A biogenic amine that is found in animals and plants. In mammals, melatonin is a hormone produced by the pineal gland. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of sleep, mood, and reproduction. Melatonin is also an effective antioxidant." [https://druginfo.nlm.nih.gov/drugportal/name/melatonin "Drug Information Portal", https://meshb.nlm.nih.gov/record/ui?ui=D008550 "MESH"]
xref: CHEBI:16796
is_a: XCO:0000125 ! hormone
is_a: XCO:0000271 ! antioxidant
created_by: sjwang
creation_date: 2018-11-19T14:33:05Z

[Term]
id: XCO:0000560
name: controlled melatonin content diet
def: "A solid diet in which the amount of melatonin is maintained at a specified level." []
is_a: XCO:0000559 ! melatonin
created_by: sjwang
creation_date: 2018-11-19T14:48:04Z

[Term]
id: XCO:0000561
name: antidepressant
def: "Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions." []
is_a: XCO:0000341 ! chemical with specified function
created_by: sjwang
creation_date: 2018-11-21T09:51:04Z

[Term]
id: XCO:0000562
name: salidroside
def: "A glucoside of tyrosol found in the plant Rhodiola rosea. It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant." [https://druginfo.nlm.nih.gov/drugportal/name/salidroside "Drug Information Portal"]
synonym: "Rhodioloside" EXACT []
is_a: XCO:0000561 ! antidepressant
created_by: sjwang
creation_date: 2018-11-21T09:53:27Z

[Term]
id: XCO:0000563
name: Omacor
def: "OMACOR is a prescription medicine for adults called a lipid-regulating medicine. It is a mix of docosahexaenoic acid [DHA] (~ 50%) + eicosapentaenoic acid [EPA] (~40%) ethylesters." [https://www.nlm.nih.gov/medlineplus/ "Medline Plus"]
synonym: "Lovaza" EXACT []
synonym: "Omega-3-Acid Ethyl Esters (eicosapentaenoic acid and docosahexaenoic acid)" EXACT []
synonym: "Omytrg" EXACT []
is_a: XCO:0000511 ! ester
is_a: XCO:0000680 ! antilipemic agent
created_by: sjwang
creation_date: 2018-11-27T13:04:58Z

[Term]
id: XCO:0000564
name: meclofenamate
def: "A member of the anthranilic acid derivatives class of NSAID drug used for joint, muscular pain, arthritis and dysmenorrhea." [https://en.wikipedia.org/wiki/Meclofenamic_acid "Wikipedia"]
is_a: XCO:0000506 ! non-steroidal anti-inflammatory drug
created_by: sjwang
creation_date: 2018-11-27T14:31:01Z

[Term]
id: XCO:0000565
name: ipragliflozin
def: "A pharmaceutical drug for treatment of type 2 diabetes. Ipragliflozin reduces blood glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2." [https://en.wikipedia.org/wiki/Ipragliflozin "Wikipedia"]
is_a: XCO:0000407 ! hypoglycemic agent
created_by: sjwang
creation_date: 2018-11-30T14:59:25Z

[Term]
id: XCO:0000566
name: controlled ipragliflozin content diet
def: "A solid diet in which the amount of ipragliflozin, an oral antidiabetic drug, is maintained at a specified level." []
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000565 ! ipragliflozin
created_by: sjwang
creation_date: 2018-11-30T15:02:35Z

[Term]
id: XCO:0000567
name: adrenomedulin
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000228 ! peptide hormone
created_by: sjwang
creation_date: 2018-12-05T14:02:20Z

[Term]
id: XCO:0000568
name: hydralazine hydrochloride
def: "A vasodilator and an antioxidant. It relaxes arteries and inhibits membrane-bound enzymes that form reactive oxygen species, such as superoxides." []
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000551 ! hydralazine
created_by: sjwang
creation_date: 2018-12-05T14:06:11Z

[Term]
id: XCO:0000569
name: controlled hydralazine hydrochloride content drinking water
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000568 ! hydralazine hydrochloride
created_by: sjwang
creation_date: 2018-12-05T14:21:28Z

[Term]
id: XCO:0000570
name: tolvaptan
def: "A selective and competitive arginine vasopressin receptor 2 antagonist." []
is_a: XCO:0000160 ! receptor antagonist
created_by: sjwang
creation_date: 2018-12-05T14:25:32Z

[Term]
id: XCO:0000571
name: controlled tolvaptan content diet
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000570 ! tolvaptan
created_by: sjwang
creation_date: 2018-12-05T14:27:59Z

[Term]
id: XCO:0000572
name: vancomycin
def: "A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile." []
xref: CHEBI:28001
is_a: XCO:0000483 ! antibacterial agent
created_by: sjwang
creation_date: 2018-12-05T14:37:41Z

[Term]
id: XCO:0000573
name: null
is_obsolete: true
created_by: sjwang
creation_date: 2018-12-05T14:41:59Z

[Term]
id: XCO:0000574
name: controlled vancomycin content drinking water
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000572 ! vancomycin
created_by: sjwang
creation_date: 2018-12-05T14:42:50Z

[Term]
id: XCO:0000575
name: meropenem
def: "Meropenem is a broad-spectrum antibiotic used to treat a variety of bacterial infections." [https://en.wikipedia.org/wiki/Meropenem "Wikipedia"]
synonym: "3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid" EXACT []
synonym: "Merrem" EXACT []
synonym: "Merrem Novaplus" EXACT []
synonym: "Penem" EXACT []
synonym: "Ronem" EXACT []
synonym: "SM 7338" EXACT []
xref: CHEBI:43968
xref: MESH:D000077731
is_a: XCO:0000483 ! antibacterial agent
created_by: sjwang
creation_date: 2018-12-05T15:07:54Z

[Term]
id: XCO:0000576
name: controlled meropenem content drinking water
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000575 ! meropenem
created_by: sjwang
creation_date: 2018-12-05T15:12:42Z

[Term]
id: XCO:0000577
name: proton pump inhibitor
def: "Proton pump inhibitors (PPIs) reduce the production of acid by blocking H+/K+ ATPase in the wall of the stomach." []
synonym: "Synonym: PPI" EXACT []
is_a: XCO:0000523 ! enzyme inhibitor
created_by: sjwang
creation_date: 2018-12-05T15:17:00Z

[Term]
id: XCO:0000578
name: omeprazole
def: "A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome." []
is_a: XCO:0000577 ! proton pump inhibitor
created_by: sjwang
creation_date: 2018-12-05T15:19:50Z

[Term]
id: XCO:0000579
name: controlled in situ gastrointestinal condition
def: "Any experimental condition in which the internal or external environment of the gastrointestinal system is altered." [https://www.merriam-webster.com/, ISBN-13:9780781733908]
is_a: XCO:0000166 ! controlled in situ organ condition
created_by: sjwang
creation_date: 2018-12-05T15:24:01Z

[Term]
id: XCO:0000580
name: forced feeding
def: "The administration of food or drugs by force, especially to an animal, typically through a tube leading down the throat to the stomach." []
is_a: XCO:0000013 ! diet
created_by: sjwang
creation_date: 2018-12-05T15:43:29Z

[Term]
id: XCO:0000581
name: oral gavage
def: "Introduction of material, foods or drugs into the stomach by a tube via the oral cavity." []
is_a: XCO:0000580 ! forced feeding
created_by: sjwang
creation_date: 2018-12-05T15:45:21Z

[Term]
id: XCO:0000582
name: controlled content oral gavage
def: "Oral gavage in which the amount of one or more solutes are adjusted to a requirement." []
is_a: XCO:0000581 ! oral gavage
created_by: sjwang
creation_date: 2018-12-05T15:49:29Z

[Term]
id: XCO:0000583
name: controlled omeprazole content  oral gavage
def: "An oral gavage solution made up of solvent and a specified amount of omeprazole." []
is_a: XCO:0000578 ! omeprazole
is_a: XCO:0000582 ! controlled content oral gavage
created_by: sjwang
creation_date: 2018-12-05T15:51:33Z

[Term]
id: XCO:0000584
name: controlled cecal material content oral gavage
def: "An oral gavage delivery made up of a specified amount of harvested cecal material." []
is_a: XCO:0000582 ! controlled content oral gavage
created_by: sjwang
creation_date: 2018-12-05T15:55:37Z

[Term]
id: XCO:0000585
name: scrambled control oligodeoxynucleotide
def: "A control oligonucleotide with a non-specific scrambled sequence." []
synonym: "scrambled control ODN" RELATED []
synonym: "SCR ODN" RELATED []
is_a: XCO:0000234 ! deoxyribonucleic acid
created_by: sjwang
creation_date: 2018-12-06T15:58:27Z

[Term]
id: XCO:0000586
name: Gnai2 antisense oligonucleotide
synonym: "G&#945;i2 ODN" RELATED []
synonym: "G&#945;i2 oligodeoxynucleotide" RELATED []
synonym: "Gnai2 antisense oligodeoxynucleotide" RELATED []
synonym: "Gnai2 AS-ODN" RELATED []
synonym: "Gnai2 ODN" EXACT []
is_a: XCO:0000234 ! deoxyribonucleic acid
created_by: sjwang
creation_date: 2018-12-06T16:40:39Z

[Term]
id: XCO:0000587
name: intracerebroventricular cannula implantation
def: "Stereotaxic implant with a stainless steel cannula into a cerebral ventricle, which can be connected via silastic tubing to a miniosmotic pump for chronic infusion." [PMID:25312437]
synonym: "i.c.v. cannula implantation" RELATED []
is_a: XCO:0000027 ! surgical implantation
created_by: sjwang
creation_date: 2018-12-06T16:45:37Z

[Term]
id: XCO:0000588
name: perindopril
def: "Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE." [drugbank:DB00790]
synonym: "Aceon" EXACT []
synonym: "Coversum" EXACT []
synonym: "Coversyl" EXACT []
synonym: "ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate" EXACT []
xref: CHEBI:8024
xref: MESH:D020913
xref: PMID:12376396
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: sjwang
creation_date: 2018-12-07T15:47:47Z

[Term]
id: XCO:0000589
name: Moexipril
def: "A condition in which the main influencing factor is Moexipril, a non-sulfhydryl-containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor Moexiprilat and a vasodilatory antihypertensive drug." []
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: sjwang
creation_date: 2018-12-07T16:00:47Z

[Term]
id: XCO:0000590
name: icatibant
def: "A synthetic decapeptide that is a bradykinin receptor antagonist used for the treatment of hereditary angioedema." []
is_a: XCO:0000160 ! receptor antagonist
created_by: sjwang
creation_date: 2018-12-07T16:19:30Z

[Term]
id: XCO:0000591
name: quinapril
def: "A prodrug that is metabolized to quinaprilat (quinapril diacid), a competitive inhibitor of angiotensin-converting enzyme (ACE)." []
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: sjwang
creation_date: 2018-12-07T16:22:09Z

[Term]
id: XCO:0000592
name: cilazapril
def: "A prodrug that is hydrolyzed to its main metabolite cilazaprilat, an inhibitor of angiotensin-converting enzyme (ACE)." []
synonym: "Dynorm" EXACT []
synonym: "Inhibace" EXACT []
synonym: "Vascace" EXACT []
is_a: XCO:0000524 ! angiotensin converting enzyme inhibitor
created_by: sjwang
creation_date: 2018-12-20T15:23:56Z

[Term]
id: XCO:0000593
name: puromycin aminonucleoside
def: "The aminonucleoside portion of the antibiotic puromycin. NOTE: This molecule does not induce apoptosis and does not inhibit protein synthesis." []
synonym: "3'-Amino-3'-deoxy-N6,N6-dimethyladenosine" EXACT []
is_a: XCO:0000392 ! nucleoside/nucleotide
created_by: sjwang
creation_date: 2018-12-27T10:28:04Z

[Term]
id: XCO:0000594
name: saralasin
def: "A condition in which the main influencing factor is saralasin, a partial angiotensin II receptor agonist and antihypertensive agent." []
synonym: "Sar-Arg-Val-Tyr-Val-His-Pro-Ala" EXACT []
xref: CHEBI:135894
is_a: XCO:0000536 ! angiotensin II receptor antagonist
is_a: XCO:0000863 ! antihypertensive agent
created_by: sjwang
creation_date: 2018-12-27T13:23:15Z

[Term]
id: XCO:0000595
name: surgical manipulation of blood vessels
is_a: XCO:0000165 ! surgical manipulation
created_by: sjwang
creation_date: 2018-12-27T14:59:42Z

[Term]
id: XCO:0000596
name: blood vessel constriction
def: "This is any condition in which the main influencing factor is surgical narrowing of the lumen of a blood vessel. This lumen narrowing could be accomplished by circumferential suturing, use of a manipulatable sleeve, or some other method." []
is_a: XCO:0000595 ! surgical manipulation of blood vessels
created_by: sjwang
creation_date: 2018-12-27T15:05:18Z

[Term]
id: XCO:0000597
name: abdominal aortic constriction
def: "This is any condition in which the main influencing factor is surgical narrowing of the lumen of the abdominal aorta. The abdominal aorta consists of the suprarenal abdominal aorta and the infrarenal aorta." [PMID:28060255]
synonym: "AAC" EXACT []
synonym: "abdominal aorta constriction" EXACT []
is_a: XCO:0000596 ! blood vessel constriction
created_by: sjwang
creation_date: 2018-12-27T15:08:06Z

[Term]
id: XCO:0000598
name: thoracic aortic constriction
def: "This is any condition in which the main influencing factor is surgical narrowing of the lumen of the thoracic aorta. The thoracic aorta consists of the ascending aorta, the aortic arch, and the descending thoracic aorta." [https://en.wikipedia.org/wiki/Aorta]
synonym: "TAC" NARROW []
synonym: "thoracic aorta constriction" EXACT []
synonym: "transverse aortic constriction" NARROW []
is_a: XCO:0000596 ! blood vessel constriction
created_by: sjwang
creation_date: 2018-12-27T15:10:16Z

[Term]
id: XCO:0000599
name: aldosterone
def: "A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure." [CHEBI:27584]
synonym: "11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al" EXACT []
xref: MESH:D000450
xref: PMID:8770880
is_a: XCO:0000229 ! steroid hormone
created_by: sjwang
creation_date: 2018-12-27T15:39:58Z

[Term]
id: XCO:0000600
name: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
def: "A polychlorinated dibenzodioxine that has formula C12H4Cl4O2." []
xref: CHEBI:28119
is_a: XCO:0000135 ! receptor agonist
created_by: sjwang
creation_date: 2019-01-21T12:54:07Z

[Term]
id: XCO:0000601
name: gene transfer of the rat natriuretic peptide B gene using an adenovirus vector
def: "A condition in which the rat natriuretic peptide B gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." []
synonym: "gene transfer of adenovirus-NPPB" EXACT []
synonym: "gene transfer of the rat BNP gene using an adenovirus vector" EXACT []
synonym: "gene transfer of the rat Nppb gene using an adenovirus vector" EXACT []
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: sjwang
creation_date: 2019-01-22T13:43:52Z

[Term]
id: XCO:0000602
name: rosiglitazone
def: "A peroxisome proliferator-activated receptor gamma agonist; reduces lipid availability, improves insulin action & glucoregulation" [https://druginfo.nlm.nih.gov/drugportal/name/rosiglitazone "Drug Information Portal"]
xref: CHEBI:50122
is_a: XCO:0000135 ! receptor agonist
is_a: XCO:0000407 ! hypoglycemic agent
created_by: sjwang
creation_date: 2019-01-22T13:55:58Z

[Term]
id: XCO:0000603
name: hesperetin
def: "Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges." [drugbank:DB01094]
xref: CHEBI:28230
xref: MESH:C013015
is_a: XCO:0000470 ! flavonoid
created_by: sjwang
creation_date: 2019-01-22T14:38:41Z

[Term]
id: XCO:0000604
name: Aprotinin
def: "Any condition in which the main influencing factor is Aprotinin, also known as bovine pancreatic trypsin inhibitor (BPTI), a proteinase inhibitor used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery." [drugbank:DB06692]
synonym: "C284H432N84O79S7" EXACT []
synonym: "Trasylol" EXACT []
is_a: XCO:0000748 ! protease inhibitor
created_by: sjwang
creation_date: 2019-02-15T16:27:32Z

[Term]
id: XCO:0000605
name: aflatoxin B1
def: "An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11." [CHEBI:2504]
is_a: XCO:0000240 ! toxin
created_by: sjwang
creation_date: 2019-02-26T11:26:05Z

[Term]
id: XCO:0000606
name: AMG-8718
def: "AMG-8718 is the inhibitor of &#946;-site amyloid precursor protein cleaving enzyme (BACE1)." [PMID:25363711]
is_a: XCO:0000523 ! enzyme inhibitor
created_by: sjwang
creation_date: 2019-03-18T16:27:59Z

[Term]
id: XCO:0000607
name: acetic acid
def: "Product of the oxidation of ethanol and of the destructive distillation of wood. Acetic acid is used locally, occasionally internally, as a counterirritant and also as a reagent." [CHEBI:15366, Stedman:Stedmans_Medical_Dictionary_26th_ed]
is_a: XCO:0000088 ! chemical
created_by: sjwang
creation_date: 2019-03-19T17:06:26Z

[Term]
id: XCO:0000608
name: Allyl isothiocyanate
def: "An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi." [CHEBI:73224]
synonym: "MO" RELATED []
synonym: "mustard oil" RELATED []
xref: CHEBI:73224
xref: pubchem.compound:5971
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000482 ! antimicrobial agent
created_by: sjwang
creation_date: 2019-03-27T15:27:46Z

[Term]
id: XCO:0000609
name: 4-methyl-2-(piperidin-1-yl) quinoline
def: "A potent and selective blocker of TRPC4 channels." [PMID:24388923]
synonym: "ML-204" EXACT []
xref: pubchem.compound:230710
is_a: XCO:0000222 ! cation channel inhibitor
created_by: sjwang
creation_date: 2019-03-27T15:43:10Z

[Term]
id: XCO:0000610
name: morphine
def: "A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy)." [CHEBI:17303]
xref: CHEBI:17303
xref: pubchem.compound:5288826
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: sjwang
creation_date: 2019-03-27T15:52:55Z

[Term]
id: XCO:0000611
name: nifedipine
def: "Nifedipine is a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure." [MESH:D009543]
xref: CHEBI:7565
xref: pubchem.compound:4485
is_a: XCO:0000269 ! calcium channel inhibitor
created_by: sjwang
creation_date: 2019-04-22T16:41:50Z

[Term]
id: XCO:0000612
name: Endothelin-1
def: "Endothelin-1 is a 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production." [PMID:7609754]
xref: CHEBI:80240
xref: pubchem.compound:16212950
is_a: XCO:0000193 ! peptide/protein
created_by: sjwang
creation_date: 2019-05-08T14:50:29Z

[Term]
id: XCO:0000613
name: Adenosine triphosphate
def: "Adenosine Triphosphate (ATP) is an adenine nucleotide comprised of three phosphate groups esterified to the sugar moiety, found in all living cells. Adenosine triphosphate is involved in energy production for metabolic processes and RNA synthesis. In addition, this substance acts as a neurotransmitter. In cancer studies, adenosine triphosphate is synthesized to examine its use to decrease weight loss and improve muscle strength." [https://ncit.nci.nih.gov/ncitbrowser/ "NIH Thesaurus"]
xref: CHEBI:15422
xref: pubchem.compound:5957
is_a: XCO:0000392 ! nucleoside/nucleotide
created_by: sjwang
creation_date: 2019-05-08T15:10:50Z

[Term]
id: XCO:0000614
name: rolipram
def: "A phosphodiesterase 4 inhibitor with antidepressant properties." [https://www.ncbi.nlm.nih.gov/mesh/68020889 "MESH"]
xref: CHEBI:104872
is_a: XCO:0000523 ! enzyme inhibitor
created_by: sjwang
creation_date: 2019-05-22T13:50:17Z

[Term]
id: XCO:0000615
name: embolism injection of middle cerebral artery
def: "This is a condition in which the main influencing factor is an injection of a coagulated blood clot to the middle cerebral artery to induce an embolic stroke in an experimental subject." []
is_a: XCO:0000347 ! blood vessel occlusion
created_by: sjwang
creation_date: 2019-05-22T14:06:17Z

[Term]
id: XCO:0000616
name: verapamil
def: "Verapamil is a calcium channel blocker that is a class IV anti-arrhythmia agent." [https://www.ncbi.nlm.nih.gov/mesh?Db=mesh&Cmd=DetailsSearch&Term=%22Verapamil%22%5BMeSH+Terms%5D "MESH"]
xref: CHEBI:9948
xref: pubchem.compound:2520
is_a: XCO:0000269 ! calcium channel inhibitor
created_by: sjwang
creation_date: 2019-05-23T14:15:07Z

[Term]
id: XCO:0000617
name: quinidine
def: "Quinidine sulfate is an optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission." [https://www.ncbi.nlm.nih.gov/mesh/68011802 "MESH"]
xref: CHEBI:28593
xref: MESH:68011802
xref: pubchem.compound:5953
is_a: XCO:0000618 ! sodium channel inhibitor
created_by: sjwang
creation_date: 2019-05-23T14:24:09Z

[Term]
id: XCO:0000618
name: sodium channel inhibitor
def: "A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity." [drugbank.category:DBCAT000600]
synonym: "Sodium Channel Blockers" EXACT []
is_a: XCO:0000222 ! cation channel inhibitor
created_by: sjwang
creation_date: 2019-05-23T14:37:49Z

[Term]
id: XCO:0000619
name: digoxin
def: "A cardenolide glycoside that is digitoxin &#946;-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small." []
xref: CHEBI:4551
xref: pubchem.compound:2724385
is_a: XCO:0000139 ! vasoactive chemical
created_by: sjwang
creation_date: 2019-05-23T14:45:00Z

[Term]
id: XCO:0000620
name: vinblastine
def: "Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis." [https://ncit-stage.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C930&ns=ncit "NCI Thesaurus"]
xref: CHEBI:1322
xref: pubchem.compound:13342
is_a: XCO:0000435 ! antineoplastic agent
created_by: sjwang
creation_date: 2019-05-23T15:08:50Z

[Term]
id: XCO:0000621
name: tritiated verapamil
def: "Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker" []
synonym: "[Nmethyl- 3H]verapamil hydrochloride" EXACT []
is_a: XCO:0000171 ! radioactively labeled chemical
is_a: XCO:0000616 ! verapamil
created_by: sjwang
creation_date: 2019-05-23T15:20:09Z

[Term]
id: XCO:0000622
name: tritiated quinidine
synonym: "p-3H]quinidine" EXACT []
is_a: XCO:0000171 ! radioactively labeled chemical
is_a: XCO:0000617 ! quinidine
created_by: sjwang
creation_date: 2019-05-23T15:28:31Z

[Term]
id: XCO:0000623
name: tritiated digoxin
synonym: "Digoxin, [3H(G)]-" EXACT []
is_a: XCO:0000171 ! radioactively labeled chemical
is_a: XCO:0000619 ! digoxin
created_by: sjwang
creation_date: 2019-05-23T15:34:38Z

[Term]
id: XCO:0000624
name: thiobutabarbital
def: "A short-acting barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is still used in veterinary medicine for induction in surgical anaesthesia." [https://en.wikipedia.org/wiki/Thiobutabarbital "Wikipedia"]
synonym: "Brevinarcon" RELATED []
synonym: "Inactin" RELATED []
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000950 ! anticonvulsant
created_by: sjwang
creation_date: 2019-07-17T10:08:35Z

[Term]
id: XCO:0000625
name: urethane
def: "Antineoplastic agent that is also used as a veterinary anesthetic." []
xref: CHEBI:17967
xref: MESH:D014520
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000435 ! antineoplastic agent
created_by: sjwang
creation_date: 2019-07-17T10:12:04Z

[Term]
id: XCO:0000626
name: removal of maxillary molar crown
def: "Surgical removal of a maxillary molar crown at the gingival line." []
is_a: XCO:0000026 ! surgical removal
created_by: sjwang
creation_date: 2019-07-17T10:22:31Z

[Term]
id: XCO:0000627
name: spironolactone
def: "Any condition in which the main influencing factor isspironolactone, a potassium-sparing diuretic that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone is indicated to treat a number of conditions including heart failure, edema, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome." [drugbank:DB00421]
synonym: "DB00421" EXACT []
xref: CHEBI:9241
is_a: XCO:0000122 ! diuretic
is_a: XCO:0000838 ! mineralocorticoid receptor antagonist
created_by: sjwang
creation_date: 2019-07-24T14:33:14Z

[Term]
id: XCO:0000628
name: Atorvastatin
def: "Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels." []
synonym: "Lipitor" RELATED []
xref: CHEBI:39548
is_a: XCO:0000523 ! enzyme inhibitor
created_by: sjwang
creation_date: 2019-07-24T15:29:21Z

[Term]
id: XCO:0000629
name: carbenoxolone
def: "An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity." []
xref: MESH:D002229
xref: pubchem.compound:636403
is_a: XCO:0000279 ! terpene
created_by: sjwang
creation_date: 2019-07-24T16:11:51Z

[Term]
id: XCO:0000630
name: cholinergic antagonist
def: "Agents that bind to cholinoceptors (muscarinic or nicotinic) and prevent the effects of acetylcholine (ACh) and other cholinergic agonists." []
is_a: XCO:0000160 ! receptor antagonist
created_by: sjwang
creation_date: 2019-07-30T14:47:58Z

[Term]
id: XCO:0000631
name: atropine
def: "A naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters." [drugbank:DB00572]
xref: CHEBI:16684
is_a: XCO:0000630 ! cholinergic antagonist
created_by: sjwang
creation_date: 2019-07-30T14:53:02Z

[Term]
id: XCO:0000632
name: saxagliptin
def: "A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes. It belongs to the biological class EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor ." [CHEBI:71272]
synonym: "3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate" EXACT []
synonym: "BMS 477118" EXACT []
synonym: "Onglyza" EXACT []
xref: CHEBI:71272
xref: MESH:C502994
is_a: XCO:0000407 ! hypoglycemic agent
is_a: XCO:0000523 ! enzyme inhibitor
created_by: sjwang
creation_date: 2019-07-30T14:58:42Z

[Term]
id: XCO:0000633
name: hydrocortisone
def: "Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone. It is produced in many animals mainly by the zona fasciculata of the adrenal cortex within the adrenal gland." [https://en.wikipedia.org/wiki/Cortisol "wikipedia"]
synonym: "cortisol" RELATED []
is_a: XCO:0000229 ! steroid hormone
created_by: sjwang
creation_date: 2019-07-30T16:03:10Z

[Term]
id: XCO:0000634
name: antidiuretic
def: "An antidiuretic is a substance that helps to control fluid balance in an animal's body by reducing urination, opposing diuresis. Its effects are opposite that of a diuretic." []
is_a: XCO:0000341 ! chemical with specified function
created_by: sjwang
creation_date: 2019-07-30T16:16:56Z

[Term]
id: XCO:0000635
name: polyfructosan
def: "A naturally occurring sugar polymer that acts as an energy storage molecule in plants. It is an inulin analogue and highly soluble in water ." [https://en.wikipedia.org/wiki/Sinistrin "Wikipedia"]
synonym: "Inutest" EXACT []
synonym: "Polyfructosan-S" EXACT []
synonym: "Sinistrin" EXACT []
is_a: XCO:0000174 ! inulin
created_by: sjwang
creation_date: 2019-07-30T16:18:43Z

[Term]
id: XCO:0000636
name: immunosuppressive agent
def: "An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response." [CHEBI:35705]
xref: CHEBI:35705
is_a: XCO:0000341 ! chemical with specified function
created_by: sjwang
creation_date: 2019-08-01T12:47:37Z

[Term]
id: XCO:0000637
name: cyclosporine A
def: "A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle." [CHEBI:4031]
synonym: "cyclosporine" RELATED []
xref: CHEBI:4031
is_a: XCO:0000636 ! immunosuppressive agent
created_by: sjwang
creation_date: 2019-08-01T12:50:36Z

[Term]
id: XCO:0000638
name: Capsazepine
def: "A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist." [CHEBI:70773]
xref: CHEBI:70773
is_a: XCO:0000160 ! receptor antagonist
created_by: sjwang
creation_date: 2019-08-01T12:59:35Z

[Term]
id: XCO:0000639
name: V1-Cal
def: "Peptides developed according to the calcineurin A-interacting site on the C-terminus of Trpv1 was were synthesized as 1 polypeptide with transactivator of transcription (TAT)47&#8208;57 carrier in the following order: N&#8208;terminus–TAT47&#8208;57–spacer (Gly&#8208;Gly)–cargo–C terminus." [PMID:27671317]
is_a: XCO:0000193 ! peptide/protein
created_by: sjwang
creation_date: 2019-08-01T14:16:00Z

[Term]
id: XCO:0000640
name: controlled in situ myocardial condition
def: "Any experimental condition in which the internal or external environment of the myocardial system is altered." [https://www.merriam-webster.com/, ISBN-13:9780781733908]
is_a: XCO:0000166 ! controlled in situ organ condition
created_by: sjwang
creation_date: 2019-08-01T14:40:57Z

[Term]
id: XCO:0000641
name: Myocardial reperfusion
def: "Any experimental condition in which the flow of blood to the heart is restored after a period of blood vessel occlusion occurred naturally or experimentally." []
is_a: XCO:0000640 ! controlled in situ myocardial condition
created_by: sjwang
creation_date: 2019-08-01T14:50:02Z

[Term]
id: XCO:0000642
name: monocrotaline
def: "Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment." [https://www.ncbi.nlm.nih.gov/mesh/68016686 "MESH"]
synonym: "https://www.ncbi.nlm.nih.gov/mesh/68016686" RELATED []
synonym: "MCT" RELATED []
xref: CHEBI:6980
xref: pubchem.compound:9415
is_a: XCO:0000239 ! toxic substance
created_by: sjwang
creation_date: 2019-08-01T17:00:38Z

[Term]
id: XCO:0000643
name: controlled exposure to a foster mother of a different strain within the same species.
is_a: XCO:0000491 ! controlled exposure to an organism of the same species
created_by: sjwang
creation_date: 2019-10-03T15:41:29Z

[Term]
id: XCO:0000644
name: anti-T cell receptor antibody
def: "A monoclonal antibody that appears to be specific for a constant determinant of the rat alpha/beta heterodimeric T cell receptor." []
synonym: "R73" EXACT []
is_a: XCO:0000194 ! antibody
created_by: sjwang
creation_date: 2019-11-05T10:21:40Z

[Term]
id: XCO:0000645
name: propofol
def: "A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group." []
xref: CHEBI:44915
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: sjwang
creation_date: 2019-11-27T12:37:25Z

[Term]
id: XCO:0000646
name: Azoxymethane
def: "Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention." []
synonym: "ML-MFCD00126912" EXACT []
xref: CAS:25843-45-2
xref: pubchem.compound:329770827
is_a: XCO:0000089 ! neoplasm-inducing chemical
created_by: sjwang
creation_date: 2019-12-04T15:04:39Z

[Term]
id: XCO:0000647
name: darusentan
def: "A selective endothelin ETA receptor antagonist. It is being evaluated as a treatment for congestive heart failure and hypertension." [drugbank:DB04883]
is_a: XCO:0000730 ! endothelin receptor antagonist
created_by: slaulede
creation_date: 2019-12-09T18:27:43Z

[Term]
id: XCO:0000648
name: clodronic acid
def: "An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases." [CHEBI:110423]
synonym: "(dichloromethanediyl)bis(phosphonic acid)" EXACT []
synonym: "clodronate" EXACT []
is_a: XCO:0000435 ! antineoplastic agent
created_by: slaulede
creation_date: 2019-12-10T17:07:59Z

[Term]
id: XCO:0000649
name: trans-4-hydroxy-L-proline
def: "An optically active form of 4-hydroxyproline having L-trans-configuration." []
xref: CHEBI:18095
is_a: XCO:0000259 ! disease-inducing chemical
created_by: sjwang
creation_date: 2019-12-12T13:16:31Z

[Term]
id: XCO:0000650
name: controlled cilazapril content drinking water
def: "A drink made up of water and a specified amount of cilazapril consumed by an organism as part of an experiment. Cilazapril is a prodrug that is hydrolyzed to its main metabolite cilazaprilat, an inhibitor of angiotensin-converting enzyme (ACE)." []
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000592 ! cilazapril
created_by: slaulede
creation_date: 2019-12-16T15:56:17Z

[Term]
id: XCO:0000651
name: E4177
def: "A condition in which the main influencing factor is E4177, an agent that blocks one or more angiotensin II receptors." []
synonym: "4'-((2-cyclopropyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid" EXACT []
synonym: "E-4177" EXACT []
is_a: XCO:0000536 ! angiotensin II receptor antagonist
created_by: slaulede
creation_date: 2019-12-16T16:34:05Z

[Term]
id: XCO:0000652
name: controlled E4177 content drinking water
def: "A drink made up of water and a specified amount of E4177 consumed by an organism as part of an experiment. E4177 is an agent that blocks one or more angiotensin II receptors." []
synonym: "controlled 4'-((2-cyclopropyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid content drinking water" EXACT []
synonym: "controlled E-4177 content drinking water" EXACT []
is_a: XCO:0000651 ! E4177
created_by: slaulede
creation_date: 2019-12-16T16:39:42Z

[Term]
id: XCO:0000653
name: ionotropic glutamate receptor antagonist
def: "Any condition in which the main influencing factor is an agent that blocks the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." []
is_a: XCO:0000160 ! receptor antagonist
created_by: slaulede
creation_date: 2019-12-16T17:38:36Z

[Term]
id: XCO:0000654
name: kynurenate
def: "Kynurenate is a product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Kynurenate is an endogenous antagonist of the ionotropic glutamate receptors." []
is_a: XCO:0000653 ! ionotropic glutamate receptor antagonist
created_by: slaulede
creation_date: 2019-12-16T17:41:34Z

[Term]
id: XCO:0000655
name: prion
def: "An abnormal form of prion protein that in mammals includes pathogenic forms which arise sporadically, as a result of genetic mutation, or by transmission (as by ingestion of infected tissue) and which upon accumulation in the brain cause a prion disease (such as bovine spongiform encephalopathy or Creutzfeldt-Jakob disease." [https://www.merriam-webster.com/dictionary/prion "merriam-webster"]
synonym: "proteinacious infectious particle" EXACT []
is_a: XCO:0000236 ! pathogen
created_by: slaulede
creation_date: 2019-12-19T11:45:30Z

[Term]
id: XCO:0000656
name: ganciclovir
def: "An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections" []
is_a: XCO:0000657 ! antiviral agent
created_by: sjwang
creation_date: 2020-01-28T10:22:22Z

[Term]
id: XCO:0000657
name: antiviral agent
def: "A substance that kills or slows the growth of a virus." []
is_a: XCO:0000482 ! antimicrobial agent
created_by: sjwang
creation_date: 2020-01-28T10:24:15Z

[Term]
id: XCO:0000658
name: nisoldipine
alt_id: MESH:D015737
def: "A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris." [CHEBI:7577]
synonym: "rac-methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate" EXACT []
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000269 ! calcium channel inhibitor
created_by: slaulede
creation_date: 2020-01-28T16:25:54Z

[Term]
id: XCO:0000659
name: controlled nisoldipine content diet
def: "A regimen of solid food in which the amount of nisoldipine consumed is maintained at a specified level." []
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000658 ! nisoldipine
created_by: slaulede
creation_date: 2020-01-28T16:42:16Z

[Term]
id: XCO:0000660
name: controlled nisoldipine content drinking water
def: "A drink made up of water and a specified amount of nisoldipine in which the amount of nisoldipine consumed is maintained at a specified level." []
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000658 ! nisoldipine
created_by: slaulede
creation_date: 2020-01-28T16:53:19Z

[Term]
id: XCO:0000661
name: one-kidney, one-clip occlusion
def: "A surgical manipulation causing blood vessel blockage by the clipping of one renal artery and surgical removal of the contralateral kidney." [https://www.hindawi.com/journals/bmri/2015/528757/tab1/]
synonym: "1k1c" EXACT []
is_a: XCO:0000596 ! blood vessel constriction
created_by: slaulede
creation_date: 2020-01-31T09:44:27Z

[Term]
id: XCO:0000662
name: two-kidney, one-clip occlusion
def: "A surgical manipulation causing blood vessel blockage by the clipping of one renal artery." [https://www.hindawi.com/journals/bmri/2015/528757/tab1/]
synonym: "2K1C" EXACT []
is_a: XCO:0000596 ! blood vessel constriction
created_by: slaulede
creation_date: 2020-01-31T09:55:35Z

[Term]
id: XCO:0000663
name: two-kidney, two-clip occlusion
def: "A surgical manipulation causing blood vessel blockage by the dissection and clipping of both renal arteries." [https://www.hindawi.com/journals/bmri/2015/528757/tab1/]
synonym: "2K2C" EXACT []
is_a: XCO:0000596 ! blood vessel constriction
created_by: slaulede
creation_date: 2020-01-31T10:08:45Z

[Term]
id: XCO:0000664
name: adrenergic receptor agonist
def: "An agent that selectively binds to and activates adrenergic receptors." [CHEBI:37886]
synonym: "adrenergic agonists" EXACT []
synonym: "adrenoceptor agonists" EXACT []
synonym: "adrenomimetic" EXACT []
synonym: "adrenomimetics" EXACT []
is_a: XCO:0000135 ! receptor agonist
created_by: slaulede
creation_date: 2020-02-11T14:23:32Z

[Term]
id: XCO:0000665
name: beta-adrenergic agonist
alt_id: CHEBI:35522
def: "A substance that selectively binds to and activates beta-adrenergic receptors." [CHEBI:35522]
synonym: "beta-adrenergic agonists" EXACT []
synonym: "beta-adrenergic receptor agonist" EXACT []
synonym: "beta-adrenergic receptor agonists" EXACT []
synonym: "beta-adrenoceptor agonists" EXACT []
is_a: XCO:0000664 ! adrenergic receptor agonist
created_by: slaulede
creation_date: 2020-02-11T14:28:45Z

[Term]
id: XCO:0000666
name: bronchodilator agent
def: "Any condition in which the main influencing factor is a substance that causes an increase in the expansion of a bronchus or bronchial tubes." []
synonym: "bronchodilator" EXACT []
synonym: "bronchodilator agents" EXACT []
synonym: "broncholytic agent" EXACT []
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2020-02-11T14:48:25Z

[Term]
id: XCO:0000667
name: clenbuterol
alt_id: CHEBI:174690
alt_id: MESH:D002976
def: "A beta-adrenergic receptor agonist that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group." [CHEBI:174690]
synonym: "1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol" EXACT []
is_a: XCO:0000665 ! beta-adrenergic agonist
is_a: XCO:0000666 ! bronchodilator agent
created_by: slaulede
creation_date: 2020-02-11T14:51:50Z

[Term]
id: XCO:0000668
name: arterial catheter implantation and controlled hemorrhage
def: "The insertion of a tubular, flexible surgical instrument into an artery to withdraw a substantial, yet controlled, amount of blood." []
synonym: "arterial catheter implantation and bleeding" EXACT []
synonym: "arterial catheter implantation and hemorrhaging" EXACT []
is_a: XCO:0000360 ! arterial catheter implantation
created_by: slaulede
creation_date: 2020-02-11T16:01:15Z

[Term]
id: XCO:0000669
name: diazoxide
alt_id: CHEBI:4495
def: "Any condition in which the main influencing factor is diazoxide, a benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies." [CHEBI:4495]
synonym: "Proglycem" EXACT []
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000618 ! sodium channel inhibitor
created_by: slaulede
creation_date: 2020-03-05T14:07:13Z

[Term]
id: XCO:0000670
name: Pair-fed diet
def: "A technique in which the amount of food provided to a control group of animals is matched to that consumed by the experimental group, so as to determine the extent to which the effect of a treatment on body weight or body composition occurred independently of changes of energy intake." [PMID:20620991]
is_a: XCO:0000461 ! restricted feeding
created_by: slaulede
creation_date: 2020-03-05T14:46:27Z

[Term]
id: XCO:0000671
name: doxycycline
alt_id: CHEBI:50845
def: "A tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis." [CHEBI:50845]
synonym: "Doryx" EXACT []
synonym: "Doxyhexal" EXACT []
synonym: "Doxylin" EXACT []
is_a: XCO:0000483 ! antibacterial agent
is_a: XCO:0000672 ! tetracyclines
relationship: part_of XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2020-03-05T15:49:21Z

[Term]
id: XCO:0000672
name: tetracyclines
alt_id: CHEBI:26895
alt_id: MESH:D013754
def: "A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups." [CHEBI:26895]
is_a: XCO:0000342 ! chemical with specified structure
created_by: slaulede
creation_date: 2020-03-05T16:13:01Z

[Term]
id: XCO:0000673
name: alpha-adrenergic agonist
alt_id: CHEBI:35569
def: "An agent that selectively binds to and activates alpha-adrenergic receptors." [CHEBI:35569]
synonym: "alpha-adrenergic agonists" EXACT []
synonym: "alpha-adrenergic receptor agonist" EXACT []
synonym: "alpha-adrenoceptor agonists" EXACT []
is_a: XCO:0000664 ! adrenergic receptor agonist
created_by: slaulede
creation_date: 2020-03-05T16:49:13Z

[Term]
id: XCO:0000674
name: clonidine
alt_id: CHEBI:46631
alt_id: MESH:D003000
def: "An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION" [MESH:D003000]
synonym: "Catapres" EXACT []
synonym: "Kapvay" EXACT []
synonym: "Nexiclon" EXACT []
is_a: XCO:0000673 ! alpha-adrenergic agonist
created_by: slaulede
creation_date: 2020-03-05T16:56:21Z

[Term]
id: XCO:0000675
name: gene transfer using retrovirus vector
def: "A condition in which gene transfer has been performed using a retrovirus as the carrier of the genetic material. A retrovirus is any of a family (Retroviridae) of single-stranded RNA viruses that produce reverse transcriptase by means of which DNA is produced using their RNA as a template and incorporated into the genome of infected cells." [https://www.merriam-webster.com/dictionary/retrovirus]
synonym: "retroviral gene transfer" EXACT []
synonym: "retrovirus transfer" EXACT []
is_a: XCO:0000528 ! gene transfer
created_by: slaulede
creation_date: 2020-03-06T11:39:41Z

[Term]
id: XCO:0000676
name: gene transfer of the rat erb-b2 receptor tyrosine kinase 2 gene using a retrovirus vector
def: "A condition in which the rat erb-b2 receptor tyrosine kinase 2 gene (Erbb2) gene has been (transiently or stably) transferred into a cell or organism using a retrovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [PMID:1913683]
synonym: "pJR-neu" RELATED []
synonym: "retroviral transfer of the rat Erbb2 gene" EXACT []
synonym: "transfer of recombinant retrovirus containing the rat Erbb2 gene" EXACT []
is_a: XCO:0000675 ! gene transfer using retrovirus vector
created_by: slaulede
creation_date: 2020-03-06T12:01:39Z

[Term]
id: XCO:0000677
name: controlled enalapril content drinking water
def: "A drink made up of water and a specified amount of enalapril consumed by an organism as part of an experiment. Enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE)." [American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed, https://en.wikipedia.org/wiki/Enalapril "Wikipedia"]
synonym: "controlled Enacard content drinking water" EXACT []
synonym: "controlled Renitec content drinking water" EXACT []
synonym: "controlled Vasotec content drinking water" EXACT []
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000542 ! enalapril
created_by: slaulede
creation_date: 2020-03-06T13:46:09Z

[Term]
id: XCO:0000678
name: gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector
def: "A condition in which the rat MER proto-oncogene, tyrosine kinase gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [PMID:11592982, Webster:Random_House_Kernerman_Websters_College_Dictionary_2010]
synonym: "adenoviral transfer of the rat Mertk gene" EXACT []
synonym: "Ad-Mertk" RELATED []
synonym: "transfer of recombinant adenovirus containing the rat Mertk gene" EXACT []
xref: PMID:11592982
xref: RGD:69283
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: slaulede
creation_date: 2020-03-13T14:57:43Z

[Term]
id: XCO:0000679
name: fenofibrate
alt_id: CHEBI:5001
alt_id: MESH:D011345
def: "A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring. Used as a lipid -lowering drug." [CHEBI:5001]
is_a: XCO:0000511 ! ester
is_a: XCO:0000680 ! antilipemic agent
created_by: slaulede
creation_date: 2020-04-20T13:16:09Z

[Term]
id: XCO:0000680
name: antilipemic agent
alt_id: CHEBI:35679
def: "A substance used to treat hyperlipidemia (an excess of lipids in the blood)." [CHEBI:35679]
synonym: "antilipemic drug" EXACT []
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2020-04-20T13:26:24Z

[Term]
id: XCO:0000681
name: Medica 16
def: "An &#945;,&#969;-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties." [CHEBI:149582]
synonym: "3,3,14,14-Tetramethylhexadecanedioic acid" EXACT []
synonym: "Medic-16" EXACT []
xref: CAS:87272-20-6
xref: CHEBI:149582
is_a: XCO:0000135 ! receptor agonist
is_a: XCO:0000523 ! enzyme inhibitor
is_a: XCO:0000680 ! antilipemic agent
created_by: slaulede
creation_date: 2020-04-24T12:47:27Z

[Term]
id: XCO:0000682
name: Benfluorex
def: "A benzoate ester that has formula C19H20F3NO2. Functionally, it is an anorectic and hypolipidemic agent." [CHEBI:93826, https://en.wikipedia.org/wiki/Benfluorex "Wikipedia"]
synonym: "benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester" EXACT []
synonym: "Mediator" EXACT []
is_a: XCO:0000511 ! ester
is_a: XCO:0000680 ! antilipemic agent
created_by: slaulede
creation_date: 2020-04-27T18:51:37Z

[Term]
id: XCO:0000683
name: cholestyramine
def: "A bile acid-binding anticholesteremic drug that helps decrease the risk for strokes and heart attacks." [https://www.webmd.com/drugs/2/drug-49/questran-light-oral/details "webmd"]
synonym: "Cholestyramine resin" EXACT []
synonym: "Prevalite" EXACT []
synonym: "Questran" EXACT []
is_a: XCO:0000680 ! antilipemic agent
created_by: slaulede
creation_date: 2020-04-30T12:29:58Z

[Term]
id: XCO:0000684
name: nateglinide
def: "A condition in which the main influencing factor is nateglinide, an N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus." [CHEBI:31897]
synonym: "N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine" EXACT []
xref: CHEBI:31897
is_a: XCO:0000407 ! hypoglycemic agent
created_by: slaulede
creation_date: 2020-04-30T14:19:39Z

[Term]
id: XCO:0000685
name: fat emulsion
def: "A liquid composed of two immiscible substances, typically some form of fat and water. In parenteral nutrition, a fat emulsion may contain phospholipids, triglycerides and essential fatty acids." [https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fat-emulsion]
synonym: "lipid emulsion" EXACT []
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2020-04-30T14:52:23Z

[Term]
id: XCO:0000686
name: Intralipid 20
def: "A sterile, non&#8209;pyrogenic fat emulsion intended as a source of calories and essential fatty acids for use in a pharmacy admixture program. It is made up of 20% Soybean Oil, 1.2% Egg Yolk, Phospholipids, 2.25% Glycerin, and Water for Injection. In addition, sodium hydroxide has been added to adjust the pH so that the final product pH is 6 to 8.9." [https://www.fresenius-kabi.com/en-ca/products/lipid-emulsions]
synonym: "emulsion 68890-65-3" EXACT []
synonym: "Intralipid" EXACT []
synonym: "Intralipid 20%" EXACT []
synonym: "Intralipos" EXACT []
xref: PMID:12419950
is_a: XCO:0000685 ! fat emulsion
created_by: slaulede
creation_date: 2020-04-30T15:09:24Z

[Term]
id: XCO:0000687
name: cenicriviroc
def: "An experimental drug candidate for the treatment of HIV infection and in combination with Tropifexor for non-alcoholic steatohepatitis. It is an inhibitor of CCR2 and CCR5 receptors." [https://en.wikipedia.org/wiki/Cenicriviroc "Wikipedia"]
synonym: "CVC" EXACT []
synonym: "TAK 652" EXACT []
synonym: "TBR 652" EXACT []
synonym: "TBR-652" EXACT []
synonym: "TBR652" EXACT []
xref: MESH:C506967
is_a: XCO:0000160 ! receptor antagonist
is_a: XCO:0000657 ! antiviral agent
created_by: slaulede
creation_date: 2020-05-01T16:51:23Z

[Term]
id: XCO:0000688
name: myelin basic protein
def: "Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Myelin basic protein may constitute as much as one-third of all protein in myelin." [https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/myelin-basic-protein "ScienceDirect"]
synonym: "Golli-MBP" EXACT []
synonym: "MBP" EXACT []
synonym: "MBP S" EXACT []
synonym: "Mbps" EXACT []
synonym: "myelin A1 protein" EXACT []
synonym: "myelin basic protein S" EXACT []
synonym: "myelin membrane encephalitogenic protein" EXACT []
xref: RGD:736262
is_a: XCO:0000260 ! peptide/protein antigen
is_a: XCO:0000292 ! peripheral nerve myelin
created_by: slaulede
creation_date: 2020-05-11T16:03:19Z

[Term]
id: XCO:0000689
name: vitamin C
def: "Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. Humans, unlike most animals, are unable to synthesize vitamin C endogenously, so it is an essential dietary component." [https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/ "NIH"]
synonym: "L-ascorbic acid" EXACT []
synonym: "Sodium Ascorbate" EXACT []
xref: CHEBI:21241
xref: MESH:D001205
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000377 ! vitamin
created_by: slaulede
creation_date: 2020-05-11T17:25:22Z

[Term]
id: XCO:0000690
name: controlled vitamin content diet
def: "A solid diet in which the amount of any vitamin is maintained at a specified level. Vitamins are organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body." [MESH:D014815]
xref: CHEBI:33229
xref: MESH:D014815
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000377 ! vitamin
created_by: slaulede
creation_date: 2020-05-11T17:39:15Z

[Term]
id: XCO:0000691
name: controlled vitamin C content diet
def: "A solid diet in which the amount of vitamin C is maintained at a specified level. Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement." [https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/ "NIH"]
synonym: "controlled ascorbate content diet" EXACT []
synonym: "controlled ascorbic acid content diet" EXACT []
is_a: XCO:0000689 ! vitamin C
is_a: XCO:0000690 ! controlled vitamin content diet
created_by: slaulede
creation_date: 2020-05-11T17:49:21Z

[Term]
id: XCO:0000692
name: carbachol
def: "An ammonium salt that has formula C6H15N2O2. It is a slowly hydrolyzed cholinergic agonist that acts at both muscarinic receptors and nicotinic receptors." []
synonym: "carbamylcholine" EXACT []
synonym: "carbastat" EXACT []
synonym: "carboptic" EXACT []
synonym: "Isopto Carbachol" EXACT []
synonym: "Miostat" EXACT []
xref: CHEBI:3385
xref: MESH:D002217
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000693 ! cholinergic agonist
created_by: slaulede
creation_date: 2020-05-12T16:35:15Z

[Term]
id: XCO:0000693
name: cholinergic agonist
def: "An agent that selectively binds to and activates cholinergic receptors." [CHEBI:38324]
synonym: "acetylcholine receptor agonist" EXACT []
synonym: "cholinomimetic" EXACT []
xref: CHEBI:38324
xref: MESH:D018679
is_a: XCO:0000135 ! receptor agonist
created_by: slaulede
creation_date: 2020-05-12T16:44:51Z

[Term]
id: XCO:0000694
name: enzyme activator
def: "Any substance that combines with an enzyme to increase its catalytic activity. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism" [https://en.wikipedia.org/wiki/Enzyme_activator "Wikipedia", Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed]
is_a: XCO:0000214 ! activator
created_by: slaulede
creation_date: 2020-05-15T09:27:57Z

[Term]
id: XCO:0000695
name: soluble guanylate cyclase activator
def: "An effector that binds to and activates soluble guanylate cyclase (EC 4.6.1.2). It increases the activity of the enzyme only when the heme iron is oxidized (Fe3+) or the heme group is missing." [CHEBI:76022, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/enzyme-activator "ScienceDirect"]
synonym: "sGC activator" EXACT []
xref: CHEBI:76022
is_a: XCO:0000694 ! enzyme activator
created_by: slaulede
creation_date: 2020-05-15T09:38:35Z

[Term]
id: XCO:0000696
name: soluble guanylate cyclase stimulator
def: "An allosteric enzyme activator that increases guanylate cyclase activity only when the heme iron is in its reduced state (Fe2+)." [CHEBI:76022, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/enzyme-activator "ScienceDirect"]
synonym: "sGC stimulator" EXACT []
xref: CHEBI:76022
is_a: XCO:0000694 ! enzyme activator
created_by: slaulede
creation_date: 2020-05-15T09:53:41Z

[Term]
id: XCO:0000697
name: GSK2181236A
def: "This chemical belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase." [PMID:22783192]
synonym: "1-(6-{2-[({3-methyl-4 -[(trifluoromethyl)oxy]-4-biphenylyl}methyl)oxy] phenyl}-2-pyridinyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid" EXACT []
xref: PMID:22783192
is_a: XCO:0000695 ! soluble guanylate cyclase activator
created_by: slaulede
creation_date: 2020-05-15T10:01:48Z

[Term]
id: XCO:0000698
name: BAY60-4552
def: "This chemical belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase." [PMID:22783192]
synonym: "Nelociguat" EXACT []
xref: PMID:22783192
is_a: XCO:0000696 ! soluble guanylate cyclase stimulator
created_by: slaulede
creation_date: 2020-05-15T10:36:38Z

[Term]
id: XCO:0000699
name: controlled GSK2181236A content diet
def: "A regimen of solid food in which the amount of GSK2181236A consumed is controlled." [PMID:22783192]
synonym: "controlled 1-(6-{2-[({3-methyl-4 -[(trifluoromethyl)oxy]-4-biphenylyl}methyl)oxy] phenyl}-2-pyridinyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid content diet" EXACT []
xref: PMID:22783192
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000697 ! GSK2181236A
created_by: slaulede
creation_date: 2020-05-15T11:12:27Z

[Term]
id: XCO:0000700
name: controlled BAY60-4552 content diet
def: "A regimen of solid food in which the amount of BAY60-4552 consumed is controlled." [PMID:22783192]
synonym: "Nelociguat" EXACT []
xref: PMID:22783192
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000698 ! BAY60-4552
created_by: slaulede
creation_date: 2020-05-15T11:16:58Z

[Term]
id: XCO:0000702
name: thiazoles
alt_id: MESH:D013844
def: "An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom." [CHEBI:48901]
xref: MESH:D013844
is_a: XCO:0000342 ! chemical with specified structure
created_by: slaulede
creation_date: 2020-05-21T14:51:33Z

[Term]
id: XCO:0000703
name: 2,4,5 trimethylthiazoline
def: "A constituent of fox urine and feces that may be an innately aversive odor to rodents." [https://en.wikipedia.org/wiki/Trimethylthiazoline "Wikipedia"]
synonym: "2,4,5-Trimethyl-4,5-dihydro-1,3-thiazole" EXACT []
synonym: "fox odor" EXACT []
synonym: "TMT" EXACT []
xref: MESH:C451263
is_a: XCO:0000702 ! thiazoles
created_by: slaulede
creation_date: 2020-05-21T15:14:18Z

[Term]
id: XCO:0000704
name: carotid artery occlusion
def: "A surgical manipulation causing blockage of one or both of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries." [Mosby:Mosbys_Medical_Dictionary--8th_Ed]
synonym: "common carotid artery occlusion" NARROW []
synonym: "permanent carotid artery occlusion" NARROW []
synonym: "UCAO" NARROW []
synonym: "unilateral carotid artery occlusion" NARROW []
is_a: XCO:0000347 ! blood vessel occlusion
created_by: slaulede
creation_date: 2020-05-21T15:46:29Z

[Term]
id: XCO:0000705
name: organic radical
def: "Neutral organic radicals are subvalent molecules, i.e., they have unpaired electrons, and, as such, they are typically highly reactive, transient species with short lifetimes that tend to dimerize, disproportionate, or react with oxygen." [https://www.sciencedirect.com/topics/chemistry/organic-radical "ScienceDirect"]
is_a: XCO:0000342 ! chemical with specified structure
created_by: slaulede
creation_date: 2020-05-22T12:37:56Z

[Term]
id: XCO:0000706
name: lithium phthalocyanine
def: "Physicochemically lithium phthalocyanine is very stable; its response to pO2 does not change with conditions and environments (e.g., pH, temperature, redox conditions) likely to occur in viable biological systems. It is an organic radical compound that forms metallic-organic, paramagnetic crystallites that appear very useful for in vitro and in vivo electron paramagnetic resonance oximetry." [PMID:8390665]
synonym: "LiPc" EXACT []
is_a: XCO:0000705 ! organic radical
created_by: slaulede
creation_date: 2020-05-22T12:53:58Z

[Term]
id: XCO:0000707
name: carvedilol
def: "Carvedilol is a beta-blocker that works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. It is used to treat heart failure, high blood pressure, and heart attack patients." [https://medlineplus.gov/druginfo/meds/a697042.html]
synonym: "1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol" EXACT []
synonym: "Coreg" EXACT []
synonym: "Coropres" EXACT []
synonym: "Dilatrend" EXACT []
synonym: "Eucardic" EXACT []
synonym: "Kredex" EXACT []
synonym: "Querto" EXACT []
xref: CHEBI:3441
xref: MESH:D000077261
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000336 ! adrenergic antagonist
created_by: slaulede
creation_date: 2020-05-28T16:40:29Z

[Term]
id: XCO:0000708
name: controlled carvedilol content diet
def: "A regimen of solid food in which the amount of carvedilol consumed is controlled." [PMID:17551266]
synonym: "controlled Coreg content diet" EXACT []
synonym: "controlled Querto content diet" EXACT []
xref: PMID:17551266
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000707 ! carvedilol
created_by: slaulede
creation_date: 2020-05-28T16:52:10Z

[Term]
id: XCO:0000709
name: cancer cells
def: "A condition in which cells from one organism are used to cause cancer in another organism by injection of, or other means of transferring, live cells from the donor organism to the host organism. Cancer is a disease characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." [DOID:162]
synonym: "carcinoma cells" NARROW []
synonym: "malignant neoplasm cells" EXACT []
synonym: "malignant tumor cells" EXACT []
synonym: "primary cancer cells" NARROW []
synonym: "sarcoma cells" NARROW []
synonym: "tumor cells" BROAD []
is_a: XCO:0000258 ! disease-inducing agent
created_by: slaulede
creation_date: 2020-06-05T10:25:14Z

[Term]
id: XCO:0000710
name: DHD/K12/TRb cells
def: "A condition in which the main influencing factor is a rat colonic carcinoma cell line used to study biochemical correlates of metastasis." [ECACC:90062901]
synonym: "DHD/K12 cells" EXACT []
synonym: "DHD K12/TRb cells" EXACT []
synonym: "DHD-K12 TRb cells" EXACT []
synonym: "TRb cells" EXACT []
xref: ECACC:90062901
xref: PMID:19850492
is_a: XCO:0000709 ! cancer cells
created_by: slaulede
creation_date: 2020-06-05T10:56:45Z

[Term]
id: XCO:0000711
name: taurolidine
def: "An antimicrobial that is also being studied as a treatment for cancer. It is derived from the endogenous amino acid taurine." [https://en.wikipedia.org/wiki/Taurolidine "Wikipedia"]
synonym: "tauroflex" EXACT []
synonym: "taurolin" EXACT []
synonym: "tauroline" EXACT []
xref: CHEBI:135173
xref: MESH:C012566
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000483 ! antibacterial agent
created_by: slaulede
creation_date: 2020-06-05T11:10:11Z

[Term]
id: XCO:0000712
name: vasopressin receptor agonist
def: "Any drug which binds to vasopressin receptors and triggers a response." [CHEBI:59727]
synonym: "antidiuretic hormone agonist" EXACT []
synonym: "arginine vasopressin receptor agonist" EXACT []
synonym: "argipressin receptor agonist" EXACT []
xref: CHEBI:59727
is_a: XCO:0000135 ! receptor agonist
created_by: slaulede
creation_date: 2020-06-05T13:31:12Z

[Term]
id: XCO:0000713
name: desmopressin
def: "A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. Its action is mediated by the vasopressin receptor V2. It has prolonged antidiuretic activity, but little pressor effects." [CHEBI:4450, MESH:D003894]
synonym: "1-Desamino-8-arginine Vasopressin" EXACT []
synonym: "Adiuretin" EXACT []
synonym: "dDAVP" EXACT []
synonym: "Deamino Arginine Vasopressin" EXACT []
synonym: "Desmogalen" EXACT []
xref: CHEBI:4450
xref: MESH:D003894
is_a: XCO:0000228 ! peptide hormone
is_a: XCO:0000712 ! vasopressin receptor agonist
created_by: slaulede
creation_date: 2020-06-05T13:42:43Z

[Term]
id: XCO:0000714
name: SB-239063
def: "A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively. It is a mitogen-activated protein kinase inhibitor." [CHEBI:90681]
synonym: "EC 2.7.11.24 inhibitor" EXACT []
synonym: "trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole" EXACT []
synonym: "trans-4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl]cyclohexan-1-ol" EXACT []
xref: CHEBI:90681
xref: MESH:C406525
is_a: XCO:0000715 ! mitogen-activated protein kinase inhibitor
created_by: slaulede
creation_date: 2020-06-08T14:10:13Z

[Term]
id: XCO:0000715
name: mitogen-activated protein kinase inhibitor
def: "Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a mitogen-activated protein kinase." [Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed]
synonym: "EC 2.7.11.24 inhibitor" EXACT []
synonym: "MAPK inhibitor" RELATED []
is_a: XCO:0000970 ! protein kinase inhibitor
created_by: slaulede
creation_date: 2020-06-08T14:19:35Z

[Term]
id: XCO:0000716
name: controlled SB-239063 content diet
def: "A regimen of solid food in which the amount of SB-239063 consumed is controlled." []
synonym: "controlled EC 2.7.11.24 inhibitor content diet" BROAD []
xref: PMID:14561850
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000714 ! SB-239063
created_by: slaulede
creation_date: 2020-06-08T14:38:59Z

[Term]
id: XCO:0000717
name: MRI contrast agent
def: "MRI contrast agents are an indispensable part of magnetic resonance imaging. Contrast agents are used to improve the visibility of internal body structures in magnetic resonance imaging (MRI)." [https://en.wikipedia.org/wiki/MRI_contrast_agent "Wikipedia", https://radiopaedia.org/articles/mri-contrast-agents?lang=us]
xref: CHEBI:37335
is_a: XCO:0000358 ! diagnostic agent
created_by: slaulede
creation_date: 2020-06-08T14:55:27Z

[Term]
id: XCO:0000718
name: gadolinium-based contrast agents
def: "Gadolinium-Based Contrast Agents (GBCA) are intravenous drugs used in diagnostic imaging procedures to enhance the quality of magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA)." [https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/information-gadolinium-based-contrast-agents "FDA"]
synonym: "GBCA" EXACT []
is_a: XCO:0000717 ! MRI contrast agent
created_by: slaulede
creation_date: 2020-06-08T15:03:11Z

[Term]
id: XCO:0000719
name: gadopentetate dimeglumine
def: "A gadolinium coordination entity that has formula C28H54GdN5O20." [CHEBI:31797]
synonym: "gadolinium (bis{2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl}amino)acetate--1-deoxy-1-(methylamino)-D-glucitol (1:2)" EXACT []
synonym: "Gd-DTPA" EXACT []
synonym: "Magnevist" EXACT []
xref: CHEBI:31797
is_a: XCO:0000718 ! gadolinium-based contrast agents
created_by: slaulede
creation_date: 2020-06-08T15:14:36Z

[Term]
id: XCO:0000720
name: laser photocoagulation
def: "A condition involving eye surgery using a laser to shrink or destroy abnormal structures in the retina, or to intentionally cause scarring." [https://medlineplus.gov/ency/article/007664.htm "MedlinePlus"]
synonym: "laser coagulation" EXACT []
synonym: "laser eye surgery" EXACT []
synonym: "photocoagulation" EXACT []
is_a: XCO:0000165 ! surgical manipulation
is_a: XCO:0000804 ! laser therapy
created_by: slaulede
creation_date: 2020-06-08T17:19:58Z

[Term]
id: XCO:0000721
name: eprosartan
def: "A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure." [CHEBI:4814]
synonym: "Eprozar" EXACT []
synonym: "Teveten" EXACT []
xref: CHEBI:4814
is_a: XCO:0000536 ! angiotensin II receptor antagonist
is_a: XCO:0000863 ! antihypertensive agent
created_by: slaulede
creation_date: 2020-06-11T17:41:02Z

[Term]
id: XCO:0000722
name: solid food deprivation
def: "Condition in which solid food is withheld for a specified period of time, while nourishment through liquids is provided." [https://www.merriam-webster.com/, PMID:23955305]
xref: PMID:23955305
is_a: XCO:0000461 ! restricted feeding
created_by: slaulede
creation_date: 2020-06-12T17:33:11Z

[Term]
id: XCO:0000723
name: butanol
def: "A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes." [CHEBI:28885]
synonym: "1-butanol" EXACT []
synonym: "1-butyl alcohol" EXACT []
synonym: "butan-1-ol" EXACT []
synonym: "n-butanol" EXACT []
xref: CHEBI:28885
is_a: XCO:0000324 ! primary alcohol
created_by: slaulede
creation_date: 2020-06-15T15:35:54Z

[Term]
id: XCO:0000724
name: Carbon-14 butanol
def: "A primary alcohol that is butanol in which one or several of the carbon (C12) atoms is replaced by radioactive Carbon-14." [CHEBI:28885, https://arcinova.com/services/isotope-labelling]
synonym: "C-14 butanol" EXACT []
synonym: "C14 butanol" EXACT []
synonym: "radiocarbon butanol" EXACT []
xref: CHEBI:28885
xref: https://arcinova.com/services/isotope-labelling
is_a: XCO:0000171 ! radioactively labeled chemical
is_a: XCO:0000723 ! butanol
created_by: slaulede
creation_date: 2020-06-15T16:30:42Z

[Term]
id: XCO:0000725
name: cyclodextrin (CD)-clathrated hesperetin
def: "Hesperetin is the aglycone of hesperidin - clathration by CD enhances hesperetin solubility." [PMID:19966469]
xref: PMID:19966469
is_a: XCO:0000603 ! hesperetin
created_by: slaulede
creation_date: 2020-06-23T14:43:30Z

[Term]
id: XCO:0000726
name: hesperidin
def: "A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage." [CHEBI:28775]
synonym: "Hesperetin 7-O-Rutinoside" EXACT []
synonym: "Hesperidin 2S" EXACT []
xref: CHEBI:28775
xref: MESH:D006569
xref: PMID:19966469
is_a: XCO:0000603 ! hesperetin
created_by: slaulede
creation_date: 2020-06-23T14:57:51Z

[Term]
id: XCO:0000727
name: splenectomy
def: "Surgical removal of part or all of the spleen, the highly vascular lymphoid organ which serves to store blood, disintegrate old blood cells, filter foreign substances from the blood, and produce lymphocytes." [American_Heritage:The_American_Heritage_Medical_Dictionary_2007, Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed]
synonym: "spleen removal" EXACT []
is_a: XCO:0000026 ! surgical removal
created_by: slaulede
creation_date: 2020-06-25T12:48:31Z

[Term]
id: XCO:0000728
name: partial splenectomy
def: "Surgical removal of a portion of the spleen, resulting in reduction but not elimination of the physiological functions of the spleen." [Gale:Gale_Encyclopedia_of_Medicine]
synonym: "PS" EXACT []
is_a: XCO:0000727 ! splenectomy
created_by: slaulede
creation_date: 2020-06-25T12:58:14Z

[Term]
id: XCO:0000729
name: enrasentan
def: "Enrasentan is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor." [https://drugs.ncats.io/drug/QG16H8A6ZH]
synonym: "(1S,2R,3S)-3-(2-(2-HYDROXYETHOXY)-4-METHOXYPHENYL)-1-(3,4-(METHYLENEDIOXY)PHENYL)-5-PROPOXY-2-INDANCARBOXYLIC ACID" EXACT []
synonym: "SB-217242" EXACT []
is_a: XCO:0000730 ! endothelin receptor antagonist
created_by: slaulede
creation_date: 2020-07-27T15:38:14Z

[Term]
id: XCO:0000730
name: endothelin receptor antagonist
def: "Any condition in which the main influencing factor is an agent that blocks one or more endothelin receptors." [XCO:0000536]
synonym: "endothelin receptor blocker" EXACT []
xref: CHEBI:51451
is_a: XCO:0000160 ! receptor antagonist
created_by: slaulede
creation_date: 2020-07-27T15:48:37Z

[Term]
id: XCO:0000731
name: controlled enrasentan content diet
def: "A regimen of solid food in which the amount of enrasentan consumed is controlled." [RGD:36174026]
synonym: "controlled SB-217242 content diet" EXACT []
xref: RGD:36174026
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000729 ! enrasentan
created_by: slaulede
creation_date: 2020-07-27T16:09:03Z

[Term]
id: XCO:0000732
name: CC531 cells
def: "A condition in which the main influencing factor is CC531, a rat colonic adenocarcinoma cell line used to study metastasis." []
synonym: "CC-531" EXACT []
xref: PMID:8225852
xref: RRID:CVCL_0206
is_a: XCO:0000709 ! cancer cells
created_by: slaulede
creation_date: 2020-08-18T16:56:25Z

[Term]
id: XCO:0000733
name: sanguinarine
def: "A benzophenanthridine alkaloid derived from Sanguinaria canadensis and poppy Fumaria species, shown to exhibit anti-microbial, anti-tumoral, and anti-inflammatory activities." [CHEBI:17183, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sanguinarine, PMID:21849887]
synonym: "13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridinium" EXACT []
synonym: "pseudochelerythrine" EXACT []
xref: CHEBI:17183
xref: MESH:C005705
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000482 ! antimicrobial agent
created_by: slaulede
creation_date: 2020-09-04T16:56:22Z

[Term]
id: XCO:0000734
name: chemerin-9
def: "A potent chemokine-like receptor 1 (CMKLR1) agonist that corresponds to C-terminal of full length human Chemerin (RARRES2), amino acids 149 - 157. Activates Gi/o signaling pathways in vitro; inhibits cAMP production and promotes phospholipase C production, Ca2+ mobilization, and smooth muscle contraction." [https://www.rndsystems.com/products/chemerin-9-human_7116, PMID:29906243, RGD:1320450]
synonym: "(149)YFPGQFAFS(157)" EXACT []
synonym: "YFPGQFAFS" EXACT []
xref: PMID:29906243
is_a: XCO:0000120 ! inhibitor
is_a: XCO:0000482 ! antimicrobial agent
created_by: slaulede
creation_date: 2020-09-04T17:26:44Z

[Term]
id: XCO:0000735
name: paclitaxel
def: "A tetracyclic diterpenoid which is a mitotic inhibitor used in cancer chemotherapy." [CHEBI:45863]
synonym: "Taxol" EXACT []
xref: CHEBI:45863
xref: MESH:D017239
is_a: XCO:0000435 ! antineoplastic agent
created_by: slaulede
creation_date: 2020-09-08T14:14:00Z

[Term]
id: XCO:0000736
name: diphtheria toxin
def: "An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that can cause a localized infection of mucous membranes or skin (diphtheria), myocarditis, polyneuritis, and other systemic toxic effects." [DOID:11405, MESH:D004165]
synonym: "DT" EXACT []
xref: DOID:11405
xref: MESH:D004165
is_a: XCO:0000240 ! toxin
created_by: slaulede
creation_date: 2020-09-08T17:35:42Z

[Term]
id: XCO:0000737
name: endotoxin
def: "A component of bacterial cells, an endotoxin can be a part of the outer membrane of gram-negative bacteria (lipopolysacharride) or a part or the \"spore\" of gram-positive bacteria (delta endotoxin)." [https://www.horseshoecrab.org/med/endotoxin.html, PMID:11468393]
is_a: XCO:0000239 ! toxic substance
created_by: slaulede
creation_date: 2020-09-14T17:54:49Z

[Term]
id: XCO:0000738
name: lipopolysaccharide
def: "This most common type of endotoxin is found in the outer membrane of gram-negative bacteria. Lipopolysaccharide consists of the lipid A portion containing fatty acids and disaccharide phosphates, core polysaccharides, and the O-antigen (repetitive glycan polymer)." [https://www.horseshoecrab.org/med/endotoxin.html, PMID:8119492]
synonym: "endotoxin" BROAD []
synonym: "LPS" EXACT []
is_a: XCO:0000737 ! endotoxin
created_by: slaulede
creation_date: 2020-09-14T18:06:38Z

[Term]
id: XCO:0000739
name: housing in trios
def: "Subjects maintained in groups of three during specified time period." [https://www.merriam-webster.com/, PMID:16197708]
is_a: XCO:0000033 ! housing condition
created_by: slaulede
creation_date: 2020-09-15T14:52:57Z

[Term]
id: XCO:0000740
name: housing with pathogen-infected subject
def: "A condition in which subjects are maintained in housing groups in which at least one subject had a pathogenic infection during the time period leading up to the specified housing period." [https://www.merriam-webster.com/, PMID:16197708]
is_a: XCO:0000033 ! housing condition
created_by: slaulede
creation_date: 2020-09-15T15:27:06Z

[Term]
id: XCO:0000741
name: housing with bacterial pathogen-infected subject
def: "A condition in which subjects are maintained in housing groups in which at least one subject had a bacterial pathogenic infection during the time period leading up to the specified housing period." [https://www.merriam-webster.com/, PMID:16197708]
is_a: XCO:0000475 ! bacterial pathogen
is_a: XCO:0000740 ! housing with pathogen-infected subject
created_by: slaulede
creation_date: 2020-09-15T15:31:42Z

[Term]
id: XCO:0000742
name: housing with Haemophilus-infected subject
def: "A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus infection during the time period leading up to the specified housing period. Haemophilus is a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." [https://www.merriam-webster.com/, PMID:16197708]
is_a: XCO:0000743 ! Haemophilus
is_a: XCO:0000747 ! housing with Pasteurellaceae-infected subject
created_by: slaulede
creation_date: 2020-09-15T15:38:24Z

[Term]
id: XCO:0000743
name: Haemophilus
def: "A condition in which the primary influencing factor is a species of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." [https://en.wikipedia.org/wiki/Haemophilus, https://www.merriam-webster.com/, PMID:16197708]
is_a: XCO:0000475 ! bacterial pathogen
created_by: slaulede
creation_date: 2020-09-15T15:47:23Z

[Term]
id: XCO:0000744
name: housing with Haemophilus H21-infected subject
def: "A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H21 infection during the time period leading up to the specified housing period. Haemophilus H21 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." [https://www.merriam-webster.com/, PMID:16197708]
is_a: XCO:0000742 ! housing with Haemophilus-infected subject
created_by: slaulede
creation_date: 2020-09-15T16:42:53Z

[Term]
id: XCO:0000745
name: housing with Haemophilus H35-infected subject
def: "A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H35 infection during the time period leading up to the specified housing period. Haemophilus H35 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic." [https://www.merriam-webster.com/, PMID:16197708]
is_a: XCO:0000742 ! housing with Haemophilus-infected subject
created_by: slaulede
creation_date: 2020-09-15T16:46:22Z

[Term]
id: XCO:0000746
name: housing with Pasteurella pneumotropica-infected subject
def: "A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurella pneumotropica infection during the time period leading up to the specified housing period. Pasteurella pneumotropica is a strain of Pasteurella, a genus Gram-negative, coccobacilli bacteria, some of which are pathogenic." [https://www.uptodate.com/contents/pasteurella-infections, PMID:16197708]
is_a: XCO:0000747 ! housing with Pasteurellaceae-infected subject
created_by: slaulede
creation_date: 2020-09-15T17:00:42Z

[Term]
id: XCO:0000747
name: housing with Pasteurellaceae-infected subject
def: "A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurellaceae infection during the time period leading up to the specified housing period. Pasteurellaceae is a large family of Gram-negative bacteria including the genera Pasteurella and Haemophilus, some of which are pathogenic." [https://en.wikipedia.org/wiki/Pasteurellaceae, PMID:16197708]
is_a: XCO:0000741 ! housing with bacterial pathogen-infected subject
created_by: slaulede
creation_date: 2020-09-15T17:15:32Z

[Term]
id: XCO:0000748
name: protease inhibitor
def: "Any condition in which the main influencing factor is a substance which decreases or interferes with the activity of a protease, any of numerous enzymes that hydrolyze proteins." [ISBN-13:978-0877798071, ISBN-13:978-1416062578]
synonym: "peptidase inhibitor" RELATED []
synonym: "proteinase inhibitor" EXACT []
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2020-09-22T15:03:07Z

[Term]
id: XCO:0000749
name: phosphoramidon
def: "Any condition in which the main influencing factor is phosphoramidon, a potent inhibitor of thermolysin and other metallo-endopeptidases, isolated from the cultures of Streptomyces tanashiensis." [CHEBI:45353, https://www.sigmaaldrich.com/catalog/product/sigma/r7385?lang=en&region=US]
xref: CHEBI:45353
xref: MESH:C008890
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000748 ! protease inhibitor
created_by: slaulede
creation_date: 2020-09-22T15:31:08Z

[Term]
id: XCO:0000750
name: diclofenac
def: "A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. It is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt." [CHEBI:47381, MESH:D004008]
xref: CHEBI:47381
xref: MESH:D004008
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000506 ! non-steroidal anti-inflammatory drug
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2020-09-25T10:32:53Z

[Term]
id: XCO:0000751
name: unilateral carotid artery occlusion
def: "A surgical manipulation causing blockage of one of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries." [ISBN-13:978-0323049375, PMID:29486300]
synonym: "UCAO" EXACT []
xref: PMID:29486300
is_a: XCO:0000704 ! carotid artery occlusion
created_by: slaulede
creation_date: 2020-09-25T13:30:19Z

[Term]
id: XCO:0000752
name: right carotid artery occlusion
def: "A surgical manipulation causing blockage of the right common carotid artery, or a branch (internal or external) of the right common carotid artery." [ISBN-13:978-0323049375, PMID:29486300]
is_a: XCO:0000751 ! unilateral carotid artery occlusion
created_by: slaulede
creation_date: 2020-09-25T13:54:07Z

[Term]
id: XCO:0000753
name: left carotid artery occlusion
def: "A surgical manipulation causing blockage of the left common carotid artery, or a branch (internal or external) of the left common carotid artery." [ISBN-13:978-0323049375, PMID:31482584]
is_a: XCO:0000751 ! unilateral carotid artery occlusion
created_by: slaulede
creation_date: 2020-09-25T14:00:57Z

[Term]
id: XCO:0000754
name: bilateral carotid artery occlusion
def: "A surgical manipulation causing blockage of both of the common carotid arteries, or left and right branches (internal or external) of the common carotid arteries." [ISBN-13:978-0323049375, PMID:32937001]
synonym: "BCCAo" NARROW []
synonym: "bilateral common carotid artery occlusion" NARROW []
is_a: XCO:0000704 ! carotid artery occlusion
created_by: slaulede
creation_date: 2020-09-25T14:09:32Z

[Term]
id: XCO:0000755
name: dimethyl sulfoxide
def: "Any condition in which the main influencing factor is dimethyl sulfoxide, a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation." [CHEBI:28262, MESH:D004121]
synonym: "DMSO" EXACT []
xref: CHEBI:28262
xref: MESH:D004121
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: slaulede
creation_date: 2020-09-25T14:25:59Z

[Term]
id: XCO:0000756
name: Kolliphor HS 15
def: "This non-ionic surfactant and emulsifier is a potential therapeutic agent because of its effectiveness for reversing multidrug resistance in vitro and its low toxicity in vivo." [https://www.sigmaaldrich.com/catalog/papers/1988130, PMID:1988130]
synonym: "Macrogol (15)-hydroxystearate" EXACT []
synonym: "Polyethylene glycol (15)-hydroxystearate" EXACT []
synonym: "Polyoxyethylated 12-hydroxystearic acid" EXACT []
synonym: "Solutol" EXACT []
synonym: "Solutol HS 15" EXACT []
xref: CHEBI:9194
is_a: XCO:0000511 ! ester
is_a: XCO:0000757 ! surfactant
relationship: has_component XCO:0000926 ! polyethylene glycol
created_by: slaulede
creation_date: 2020-09-25T14:43:25Z

[Term]
id: XCO:0000757
name: surfactant
def: "A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapor and/or at other interfaces." [CHEBI:35195, https://www.merriam-webster.com/dictionary/surfactant]
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2020-09-25T15:01:23Z

[Term]
id: XCO:0000758
name: retinoic acid
def: "Condition in which the main influencing factor is retinoic acid, a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). Retinoic acid is derived from retinol (vitamin A) and plays important roles in cell growth, differentiation, and organogenesis." [CHEBI:26536, PMID:22439772]
xref: CHEBI:26536
xref: PMID:22439772
is_a: XCO:0000468 ! vitamin A
created_by: slaulede
creation_date: 2020-10-05T16:57:15Z

[Term]
id: XCO:0000760
name: 26 kDa Schistosoma mansoni antigen
def: "A condition in which the major influencing factor is a soluble Schistosoma mansoni protein expressed by the schistosomulum and target of cytotoxic IgE antibodies." [PMID:1719096, PMID:6698106]
is_a: XCO:0000260 ! peptide/protein antigen
created_by: slaulede
creation_date: 2020-10-13T18:01:28Z

[Term]
id: XCO:0000761
name: biologic
def: "Any condition in which the main influencing factor is a biologic (product of, or component of, a living organism) introduced externally or internally to a subject to effect a change in phenotype of the subject, usually in treatment of a medical condition." [https://www.fda.gov/about-fda/center-biologics-evaluation-and-research-cber/what-are-biologics-questions-and-answers, https://www.merriam-webster.com/]
synonym: "biological product" EXACT []
is_a: XCO:0000000 ! experimental condition
created_by: slaulede
creation_date: 2020-10-15T17:39:53Z

[Term]
id: XCO:0000762
name: rat anti-Ab2 T cells
def: "Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies." [PMID:1719096, PMID:2494262]
xref: PMID:1719096
xref: PMID:2494262
is_a: XCO:0000763 ! T cells
created_by: slaulede
creation_date: 2020-10-15T17:53:02Z

[Term]
id: XCO:0000763
name: T cells
def: "Any condition in which the main influencing factor is an injection of T cells (T lymphocytes). T cells are integral to the functioning of the immune system and are at the core of adaptive immunity, the system that tailors the body's immune response to specific pathogens" [CL:0000084, https://www.medicinenet.com/script/main/art.asp?articlekey=11300]
is_a: XCO:0000761 ! biologic
created_by: slaulede
creation_date: 2020-10-15T18:06:48Z

[Term]
id: XCO:0000764
name: rat anti-Ab2 T cell line
def: "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies." [https://www.merriam-webster.com/, PMID:1719096, PMID:2494262]
xref: PMID:1719096
xref: PMID:2494262
is_a: XCO:0000762 ! rat anti-Ab2 T cells
created_by: slaulede
creation_date: 2020-10-16T15:00:38Z

[Term]
id: XCO:0000765
name: rat anti-26 kDa T cells
def: "Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni ." [https://www.merriam-webster.com/, PMID:1719096]
is_a: XCO:0000763 ! T cells
created_by: slaulede
creation_date: 2020-10-16T16:53:18Z

[Term]
id: XCO:0000766
name: rat anti-26 kDa T cell line
def: "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni." [https://www.merriam-webster.com/, PMID:1719096]
is_a: XCO:0000765 ! rat anti-26 kDa T cells
created_by: slaulede
creation_date: 2020-10-16T16:59:07Z

[Term]
id: XCO:0000767
name: Schistosoma mansoni
def: "A condition in which the main influencing factor is Schistosoma mansoni, a trematode parasite that lives in certain types of freshwater snails. The infectious form of the parasite, known as cercariae, emerge from the snail into the water. Humans can become infected when skin comes in contact with contaminated freshwater." [https://www.cdc.gov/parasites/schistosomiasis/index.html, PMID:1719096]
is_a: XCO:0000363 ! eukaryotic pathogen
created_by: slaulede
creation_date: 2020-10-16T17:29:53Z

[Term]
id: XCO:0000768
name: Schistosoma mansoni cercariae
def: "A condition in which the main influencing factor is the infective cercariae (larvae) of the trematode parasite Schistosoma mansoni." [https://www.britannica.com/science/cercaria, PMID:1719096]
is_a: XCO:0000767 ! Schistosoma mansoni
created_by: slaulede
creation_date: 2020-10-16T17:50:16Z

[Term]
id: XCO:0000769
name: antiserum
def: "Blood serum that contains antibodies against an infective agent (such as a bacteria or virus) or toxic substance (such as snake venom) and may be used to prevent or treat infection or poisoning." [https://www.biologyonline.com/dictionary/antiserum, https://www.merriam-webster.com/]
is_a: XCO:0000761 ! biologic
created_by: slaulede
creation_date: 2020-10-19T13:58:56Z

[Term]
id: XCO:0000770
name: rat anti-Ab2 antiserum
def: "Any condition in which the main influencing factor is serum prepared from rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies." [https://www.merriam-webster.com/, PMID:1719096]
xref: PMID:1719096
is_a: XCO:0000769 ! antiserum
created_by: slaulede
creation_date: 2020-10-19T14:05:35Z

[Term]
id: XCO:0000771
name: rat anti-26 kDa antiserum
def: "Any condition in which the main influencing factor is serum prepared from rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni." [https://www.merriam-webster.com/, PMID:1719096]
xref: PMID:1719096
is_a: XCO:0000769 ! antiserum
created_by: slaulede
creation_date: 2020-10-19T14:09:02Z

[Term]
id: XCO:0000772
name: controlled cocoa butter content diet
def: "A solid diet in which the amount of cocoa butter is maintained at a specified level. Cocoa butter is a pale vegetable fat with a low melting point obtained from cacao beans." [https://www.healthline.com/health/beauty-skin-care/cocoa-butter-benefits, https://www.merriam-webster.com/]
is_a: XCO:0000014 ! controlled content diet
created_by: slaulede
creation_date: 2020-10-19T15:39:19Z

[Term]
id: XCO:0000773
name: controlled soybean oil content diet
def: "A solid diet in which the amount of soybean oil is maintained at a specified level. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols." [https://www.merriam-webster.com/, https://www.webmd.com/vitamins/ai/ingredientmono-196/soybean-oil]
is_a: XCO:0000454 ! controlled oil content diet
created_by: slaulede
creation_date: 2020-10-19T17:46:26Z

[Term]
id: XCO:0000774
name: oil
def: "Any condition in which the main influencing factor is any of numerous unctuous combustible substances that are liquid or can be liquefied easily on warming, are soluble in ether but not in water, and leave a greasy stain on paper or cloth." [https://www.britannica.com/science/oil-chemical-compound, https://www.merriam-webster.com/, ISBN:978-1-4684-6878-6]
is_a: XCO:0000342 ! chemical with specified structure
created_by: slaulede
creation_date: 2020-10-19T18:03:59Z

[Term]
id: XCO:0000775
name: soybean oil
def: "Any condition in which the main influencing factor is soybean oil. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols." [https://www.merriam-webster.com/, https://www.webmd.com/vitamins/ai/ingredientmono-196/soybean-oil]
is_a: XCO:0000774 ! oil
created_by: slaulede
creation_date: 2020-10-19T18:21:13Z

[Term]
id: XCO:0000776
name: fatty acid
def: "Any condition in which the main influencing factor is any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax." [CHEBI:35366, https://www.merriam-webster.com/]
xref: CHEBI:35366
is_a: XCO:0000342 ! chemical with specified structure
created_by: slaulede
creation_date: 2020-10-19T18:27:54Z

[Term]
id: XCO:0000777
name: lipoic acid
def: "This is any condition in which the main influencing factor is alpha-lipoic acid, a heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position." [CHEBI:16494, MESH:D008063]
synonym: "&#945;-lipoic acid" EXACT []
synonym: "alpha-lipoic acid" EXACT []
synonym: "LA" EXACT []
synonym: "Thioctic Acid" EXACT []
xref: CHEBI:16494
xref: MESH:D008063
xref: PMID:30208622
is_a: XCO:0000776 ! fatty acid
created_by: slaulede
creation_date: 2020-10-19T18:33:37Z

[Term]
id: XCO:0000778
name: spiroplatin
def: "A condition in which the main influencing factor is spiroplatin, a metal drug and analog of the second generation for cisplatin, developed for the treatment of cancer. Spiroplatin induces DNA cross-linking, thereby inhibiting DNA replication and the synthesis of RNA and protein. Initial clinical trials of spiroplatin showed that it could cause less nausea and vomiting than cisplatin, but development was discontinued due to weak anti-tumor effects and toxicity at high dosages." [https://drugs.ncats.io/drug/H2V318W7LE, MESH:C040757]
synonym: "aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum (II)" EXACT []
synonym: "NSC-311056" EXACT []
synonym: "TNO-6" EXACT []
xref: MESH:C040757
is_a: XCO:0000399 ! complex ion
is_a: XCO:0000435 ! antineoplastic agent
created_by: slaulede
creation_date: 2020-10-20T14:53:27Z

[Term]
id: XCO:0000779
name: rat IgM immunocytoma cells
def: "A condition in which the main influencing factor is rat IgM-secreting immunocytoma cells. The transplantable tumor cells are used in various studies including antibody secretion studies and antitumoral drug studies." [DOID:0050747, PMID:6683993]
synonym: "rat IgM lymphoplasmacytic lymphoma cells" EXACT []
xref: PMID:6683993
is_a: XCO:0000709 ! cancer cells
created_by: slaulede
creation_date: 2020-10-22T13:12:29Z

[Term]
id: XCO:0000780
name: liposomes
def: "An experimental condition in which the main influencing factor is liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances." [https://www.merriam-webster.com/, https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposome]
xref: PMID:6744286
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2020-10-27T16:40:20Z

[Term]
id: XCO:0000781
name: positively charged liposomes
def: "An experimental condition in which the main influencing factor is positively charged liposomes, artificial positively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances." [https://www.merriam-webster.com/, https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposome, PMID:6744286]
synonym: "lip+" EXACT []
xref: PMID:6744286
is_a: XCO:0000780 ! liposomes
created_by: slaulede
creation_date: 2020-10-27T16:48:40Z

[Term]
id: XCO:0000782
name: negatively charged liposomes
def: "An experimental condition in which the main influencing factor is negatively charged liposomes, artificial negatively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances." [https://www.merriam-webster.com/, https:www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposome, PMID:6744286]
synonym: "lip-" EXACT []
xref: PMID:6744286
is_a: XCO:0000780 ! liposomes
created_by: slaulede
creation_date: 2020-10-27T16:52:12Z

[Term]
id: XCO:0000783
name: cytokine
def: "Any condition in which the main influencing factor is a cytokine, a small secreted protein that has a specific effect on the interactions and communications between cells. Cytokine is a general name for other signaling molecules, including lymphokines, monokines, and chemokines." [ISBN-13:978-1608316922, PMID:17426506]
synonym: "chemokine" NARROW []
synonym: "lymphokine" NARROW []
synonym: "monokine" NARROW []
is_a: XCO:0000193 ! peptide/protein
created_by: slaulede
creation_date: 2020-10-30T13:38:35Z

[Term]
id: XCO:0000784
name: interleukin-2
def: "Any condition in which the main influencing factor is interleukin-2, a cytokine made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system." [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/interleukin-2, ISBN-13:978-1608316922]
synonym: "IL-2" EXACT []
synonym: "IL2" EXACT []
synonym: "interleukin 2" EXACT []
xref: MESH:D007376
is_a: XCO:0000783 ! cytokine
created_by: slaulede
creation_date: 2020-10-30T13:52:50Z

[Term]
id: XCO:0000785
name: PROb cells
def: "A condition in which the main influencing factor is a rat cell line derived from a colonic adenocarcinoma induced by 1,2- dimethylhydrazine in BDIX rats." [PMID:6358055, PMID:9833767]
xref: PMID:6358055
xref: PMID:9833767
is_a: XCO:0000709 ! cancer cells
created_by: slaulede
creation_date: 2020-10-30T14:41:50Z

[Term]
id: XCO:0000786
name: PRObR1 cells
def: "A rat cell line (PROb 5-FU-resistant subline) derived from colonic adenocarcinoma PROb cells. The R1 cell line was established from PROb cells by in vivo and in vitro adaptation to 5-fluorouracil (5-FU), an anticancer drug." [PMID:9399677, PMID:9833767]
xref: PMID:9399677
xref: PMID:9833767
is_a: XCO:0000785 ! PROb cells
created_by: slaulede
creation_date: 2020-10-30T14:51:26Z

[Term]
id: XCO:0000787
name: sodium butyrate
def: "Any condition in which the main influencing factor is sodium butyrate, an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid (a short-chain fatty acid) by a sodium ion." [CHEBI:64103, MESH:D002087]
synonym: "sodium butanoate" EXACT []
xref: CHEBI:64103
xref: MESH:D002087
is_a: XCO:0000776 ! fatty acid
created_by: slaulede
creation_date: 2020-10-30T14:59:55Z

[Term]
id: XCO:0000788
name: S4MH cells
def: "A condition in which the main influencing factor is a rat rhabdomyosarcoma cell line used to study metastasis." [ISBN-13:978-0781733908, PMID:18028954]
xref: PMID:18028954
is_a: XCO:0000709 ! cancer cells
created_by: slaulede
creation_date: 2020-11-12T16:13:47Z

[Term]
id: XCO:0000789
name: methylcellulose
def: "Methylcellulose is a methylester of cellulose and it is used as an emulsifying and suspending agent in cosmetics, pharmaceuticals and the chemical industry. It is used therapeutically as a bulk laxative." [CHEBI:53448, MESH:D008747]
synonym: "Citrucel" EXACT []
synonym: "MC" EXACT []
synonym: "methyl cellulose" EXACT []
is_a: XCO:0000511 ! ester
created_by: slaulede
creation_date: 2020-11-16T14:59:35Z

[Term]
id: XCO:0000790
name: controlled sodium chloride content drinking water
def: "A drink made up of water and a specified amount of sodium chloride dissolved in a sufficient quantity of water." [https://www.merriam-webster.com/]
synonym: "controlled NaCl content drinking water" EXACT []
is_a: XCO:0000164 ! controlled sodium content drinking water
created_by: slaulede
creation_date: 2020-11-19T14:53:13Z

[Term]
id: XCO:0000791
name: standard condition
def: "A condition defined by a mostly uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison." [https://www.dictionary.com, https://www.merriam-webster.com/]
is_obsolete: true
created_by: slaulede
creation_date: 2020-11-30T14:00:43Z

[Term]
id: XCO:0000792
name: emodin
def: "A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs." [CHEBI:42223]
xref: CHEBI:42223
xref: MESH:D004642
xref: PMID:31983185
is_a: XCO:0000120 ! inhibitor
is_a: XCO:0000435 ! antineoplastic agent
created_by: slaulede
creation_date: 2020-11-30T18:03:20Z

[Term]
id: XCO:0000793
name: BTB14431
def: "This is an in-silico screening analog of emodin (XCO:0000792)." [PMID:31983185]
synonym: "BTB 14431" EXACT []
xref: PMID:31983185
is_a: XCO:0000435 ! antineoplastic agent
created_by: slaulede
creation_date: 2020-11-30T18:19:37Z

[Term]
id: XCO:0000794
name: gene transfer of the lin-28 homolog B gene using an adenovirus vector
def: "A condition in which the lin-28 homolog B gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [ISBN-13:978-0781733908, PMID:24279313]
synonym: "Ad/Lin28B" RELATED []
synonym: "adenoviral transfer of the Lin28B gene" EXACT []
synonym: "gene transfer of the Lin28B gene using an adenovirus vector" EXACT []
synonym: "transfer of recombinant adenovirus containing the Lin28B gene" EXACT []
xref: PMID:27384999
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: slaulede
creation_date: 2020-12-01T17:05:51Z

[Term]
id: XCO:0000795
name: controlled sodium chloride content diet
def: "A regimen of solid food in which the amount of sodium chloride consumed is controlled." [https://www.merriam-webster.com/]
synonym: "controlled NaCl content diet" EXACT []
is_a: XCO:0000022 ! controlled sodium content diet
created_by: slaulede
creation_date: 2020-12-18T17:49:31Z

[Term]
id: XCO:0000796
name: U46619
def: "A prostaglandin endoperoxide analogue (11,9 epoxymethano-prostaglandin H2) that is a selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor. It is a stable thromboxane A2 mimetic and a vasoconstrictor." [http://www.apexbt.com, https://www.sigmaaldrich.com]
synonym: "9,11-Dideoxy-9&#945;,11&#945;-methanoepoxyprostaglandin F 2&#945;" EXACT []
synonym: "U 46619" EXACT []
xref: CAS:56985-40-1
xref: PMID:22508433
is_a: XCO:0000135 ! receptor agonist
created_by: slaulede
creation_date: 2021-01-04T16:46:45Z

[Term]
id: XCO:0000797
name: Y-27632
def: "A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It is a cell-permeable, reversible inhibitor of Rho-associated protein kinase (ROCK) enzyme." [CHEBI:75393, https://www.sigmaaldrich.com]
synonym: "Rho-associated protein kinase Inhibitor" EXACT []
synonym: "ROCK Inhibitor" EXACT []
synonym: "Y 27632" EXACT []
synonym: "Y27632" EXACT []
xref: CAS:146986-50-7
xref: MESH:C108830
xref: PMID:22508433
is_a: XCO:0000970 ! protein kinase inhibitor
created_by: slaulede
creation_date: 2021-01-04T16:52:50Z

[Term]
id: XCO:0000798
name: nociceptin
def: "Generated from the gene PNOC, which produces a preproprotein, which in subsequently processed to form multiple protein products. Nociceptin a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity." [https://www.ncbi.nlm.nih.gov/gene/5368]
synonym: "NOP" EXACT []
synonym: "OFQ" EXACT []
synonym: "orphanin FQ" EXACT []
xref: PMID:17875345
is_a: XCO:0000228 ! peptide hormone
created_by: slaulede
creation_date: 2021-02-08T16:43:57Z

[Term]
id: XCO:0000799
name: ether
def: "A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes." [https://www.merriam-webster.com/, MESH:D004986]
synonym: "(C2H5)2O" EXACT []
synonym: "C4H10O" EXACT []
synonym: "CH3CH2OCH2CH3" EXACT []
synonym: "Diethyl ether" EXACT []
xref: CHEBI:25698
xref: D004986
is_a: XCO:0000106 ! anesthetic/analgesic
created_by: slaulede
creation_date: 2021-02-08T16:54:25Z

[Term]
id: XCO:0000800
name: iron oxide nanoparticles
def: "Any condition in which the main influencing factor is a particle with a size between 1 and 100 nanometers composed of iron oxide (Fe3O4). It contains both Fe2+ and Fe3+ ions and is sometimes formulated as FeO &#8729; Fe2O3. It exhibits permanent magnetism and is ferrimagnetic." [https://en.wikipedia.org/wiki/Iron(II\,III)_oxide, https://pubchem.ncbi.nlm.nih.gov/compound/Iron_II_III_oxide]
synonym: "Fe3O4 nanoparticles" EXACT []
synonym: "Iron(II,III)oxide nanoparticles" EXACT []
synonym: "magnetic nanoparticles" EXACT []
synonym: "MNPs" EXACT []
xref: PMID:22661893
is_a: XCO:0000338 ! chemical nanoparticle
created_by: slaulede
creation_date: 2021-02-09T12:06:12Z

[Term]
id: XCO:0000801
name: controlled gliadin content diet
def: "A regimen of solid food in which the amount of gliadin consumed is controlled. Gliadins are a group of proteins called alpha, beta, gamma and omega according to their relative electrophoretic mobility in gels. They are the major component of wheat gluten and made up of single-chain polypeptides with an average molecular weight of 25–100 kDa linked by intramolecular disulfide bonds." [https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gliadin]
xref: PMID:19327106
is_a: XCO:0000030 ! controlled protein content diet
created_by: slaulede
creation_date: 2021-02-09T12:53:16Z

[Term]
id: XCO:0000802
name: GSK1016790A
def: "It is a tertiary carboxamide and cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel." [CHEBI:140524]
synonym: "C28H32Cl2N4O6S2" EXACT []
xref: CAS:942206-85-1
xref: PMID:29875065
xref: pubchem.compound:23630211
is_a: XCO:0000217 ! cation channel activator
created_by: slaulede
creation_date: 2021-02-09T15:22:33Z

[Term]
id: XCO:0000803
name: subthreshold laser therapy
def: "Subthreshold therapy is photocoagulation that does not produce clinical or histologic evidence of retinal damage. Therapeutic benefit is thought to be derived by inducing thermal stress on RPE cells. The goal of the subthreshold therapy is to maintain the temperature rise below the threshold of irreversible thermal damage. The main types are micropulse, selective retinal therapy (SRT), and continuous wave laser with EndPoint Management (algorithm/protocol)." [https://eyewiki.aao.org/Sub-threshold_Laser#\:~\:text=Selective%20Retinal%20Therapy%20%28SRT%29%20Selective%20Retinal%20Therapy%20is\,using%20laser%20pulse%20durations%20of%20microseconds%20or%20nanoseconds., PMID:27841848]
xref: PMID:31402999
is_a: XCO:0000720 ! laser photocoagulation
created_by: slaulede
creation_date: 2021-02-11T13:52:41Z

[Term]
id: XCO:0000804
name: laser therapy
def: "Any biomedical use of lasers for purposes designed to improve the state of the subject. Light from a laser is tuned to specific wavelengths and is a beam of coherent electromagnetic radiation usually in the ultraviolet, visible, or infrared regions of the spectrum." [https://www.healthline.com/health/laser-therapy, https://www.merriam-webster.com/]
xref: MESH:D053685
xref: PMID:31402999
is_a: XCO:0000045 ! electromagnetic radiation exposure
created_by: slaulede
creation_date: 2021-02-11T14:10:41Z

[Term]
id: XCO:0000805
name: nondamaging retinal laser therapy
def: "Nondamaging retinal laser therapy (NRT) is a retinal treatment with a lack of tissue damage. Lack of tissue damage allows high-density treatment patterns to increase therapeutic response and periodic retreatments for chronic macular diseases. It is similar to SRT (selective RPE therapy), but using lower energy to avoid killing retinal pigmented epithelial cells." [PMID:27159441]
synonym: "NRT" EXACT []
xref: PMID:31402999
is_a: XCO:0000803 ! subthreshold laser therapy
created_by: slaulede
creation_date: 2021-02-11T15:38:45Z

[Term]
id: XCO:0000806
name: selective retinal therapy
def: "Selective retinal therapy (SRT) is a subthreshold laser therapy used to treat retinal disorders while preventing severe damage to the retina. In SRT RPE (retinal pigment epithelium) cells are selectively damaged without affecting the photoreceptors or choroid by using laser pulse durations of microseconds or nanoseconds" [https://eyewiki.aao.org/Sub-threshold_Laser#\:~\:text=Selective%20Retinal%20Therapy%20%28SRT%29%20Selective%20Retinal%20Therapy%20is\,using%20laser%20pulse%20durations%20of%20microseconds%20or%20nanoseconds., PMID:27841848]
synonym: "selective RPE therapy" EXACT []
synonym: "SRT" EXACT []
xref: PMID:31402999
is_a: XCO:0000803 ! subthreshold laser therapy
created_by: slaulede
creation_date: 2021-02-11T17:14:59Z

[Term]
id: XCO:0000807
name: tetrahydrocurcumin
def: "A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. It is is a major herbal antioxidant and anti-inflammatory agent" [CHEBI:67263, PMID:22212488]
synonym: "Sabiwhite" EXACT []
synonym: "tetrahydrodiferuloylmethane" EXACT []
xref: CHEBI:67263
xref: PMID:22212488
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: slaulede
creation_date: 2021-02-16T16:28:33Z

[Term]
id: XCO:0000808
name: DL-&#945;-aminoadipate
def: "Any condition in which the main influencing factor is DL-&#945;-aminoadipate. This excitatory amino acid analogue is an intermediate in the principal biosynthetic pathway of lysine. It is a also an inhibitor of glutamine synthetase." [MESH:D015074]
synonym: "AAA" EXACT []
synonym: "dl-&#945;AA" EXACT []
synonym: "DL-&#945;-AAA" EXACT []
xref: CHEBI:37024
xref: MESH:D015074
xref: PMID:28615682
is_a: XCO:0000240 ! toxin
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2021-02-16T17:08:36Z

[Term]
id: XCO:0000809
name: 2-methyl-6-(phenylethynyl)pyridine
def: "Any condition in which the main influencing factor is 2-methyl-6-(phenylethynyl)pyridine, a methylpyridine that consists of 2-methylpyridine bearing an additional phenylethynyl group at position 6. It is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. It functions as an excitatory amino acid antagonist and an anxiolytic agent." [CHEBI:64159, MESH:C121465]
synonym: "2-methyl-6-(phenylethynyl)pyridine" EXACT []
synonym: "MPEP" EXACT []
xref: PMID:28615682
is_a: XCO:0000160 ! receptor antagonist
created_by: slaulede
creation_date: 2021-02-16T17:41:28Z

[Term]
id: XCO:0000810
name: 2-Chloro-5-hydroxyphenylglycine
def: "Any condition in which the main influencing factor is 2-Chloro-5-hydroxyphenylglycine, a metabotropic glutamate receptor 5 agonist." [PMID:28615682]
synonym: "(R,S)-2-chloro- 5-hydroxyphenylglycine" EXACT []
synonym: "CHPG" EXACT []
xref: MESH:C107349
xref: PMID:28615682
is_a: XCO:0000135 ! receptor agonist
created_by: slaulede
creation_date: 2021-02-16T18:30:58Z

[Term]
id: XCO:0000811
name: A23187
def: "Any condition in which the main influencing factor is A23187, an ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes." [MESH:D000001]
synonym: "A-23187" EXACT []
synonym: "calcimycin" EXACT []
xref: CHEBI:3305
xref: MESH:D000001
xref: PMID:22508433
is_a: XCO:0000140 ! vasodilator
created_by: slaulede
creation_date: 2021-02-22T13:09:46Z

[Term]
id: XCO:0000812
name: controlled hemorrhage
def: "The drawing of blood (by venipuncture or artery puncture) for transfusion, apheresis, diagnostic testing, or experimental procedures." [https://www.merriam-webster.com/, ISBN-13:978-0702033896]
synonym: "phlebotomy" NARROW []
xref: PMID:17998886
is_a: XCO:0000595 ! surgical manipulation of blood vessels
created_by: slaulede
creation_date: 2021-02-23T15:25:59Z

[Term]
id: XCO:0000813
name: total body irradiation
def: "Total body irradiation (TBI) is a form of radiotherapy (typically X-rays or gamma rays) used primarily as part of the preparative regimen for hematopoietic stem cell (or bone marrow) transplantation." [https://en.wikipedia.org/wiki/Total_body_irradiation, https://www.merriam-webster.com/]
synonym: "TBI" EXACT []
xref: ISBN-13:978-0323240987
xref: PMID:30575429
is_a: XCO:0000043 ! X-ray exposure
created_by: slaulede
creation_date: 2021-03-02T14:21:45Z

[Term]
id: XCO:0000814
name: partial body irradiation
def: "Partial body irradiation (PBI) is a form of radiotherapy used to target certain organs or to study the effects of sublethal doses of radiation." [PMID:22929471, PMID:27147332]
synonym: "PBI" EXACT []
xref: PMID:22929471
xref: PMID:27147332
is_a: XCO:0000043 ! X-ray exposure
created_by: slaulede
creation_date: 2021-03-02T14:31:47Z

[Term]
id: XCO:0000815
name: leg-out partial body irradiation
def: "This is a condition/model system that features partial body irradiation (PBI) delivering a high dose of radiation to most of the body, and a small fraction of that dose to one leg of the subject. It allows the study of multi-organ radiation injury while sparing the bone marrow from a lethal dose." [PMID:27682899, PMID:30575429]
synonym: "leg-out PBI" EXACT []
xref: PMID:27682899
xref: PMID:30575429
is_a: XCO:0000814 ! partial body irradiation
created_by: slaulede
creation_date: 2021-03-02T15:00:18Z

[Term]
id: XCO:0000816
name: partial-body irradiation with 5% bone marrow sparing
def: "Partial-body irradiation with 5% bone marrow sparing (tibiae, ankles, feet) is used to define acute radiation-induced GI-ARS, H-ARS, and acute kidney injury (AKI) as well as the delayed effects of acute radiation exposure (DEARE) characterized by prolonged GI, lung, and heart injury and chronic kidney injury (CKI). This condition/model system allows analysis of concomitant multi-organ sequelae." [PMID:22929471, PMID:30575429]
synonym: "PBI/BM5" EXACT []
xref: PMID:22929471
xref: PMID:30575429
is_a: XCO:0000814 ! partial body irradiation
created_by: slaulede
creation_date: 2021-03-02T15:35:19Z

[Term]
id: XCO:0000817
name: whole thorax lung irradiation
def: "Whole thorax lung irradiation is a type of partial body irradiation used to target the lungs. In experimental animals it is used to study the lung morbidities caused by radiation exposure." [PMID:30575429]
synonym: "WTLI" EXACT []
xref: PMID:30575429
xref: PMID:33009295
is_a: XCO:0000814 ! partial body irradiation
created_by: slaulede
creation_date: 2021-03-02T15:55:53Z

[Term]
id: XCO:0000818
name: gene transfer using plasmid vector
def: "A condition in which gene transfer has been performed using a plasmid as the carrier of the genetic material. A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell's chromosomal DNA. Plasmids naturally exist in bacterial cells, and they also occur in some eukaryotes. Plasmids that are used experimentally as molecular tools are called vectors." [https://www.merriam-webster.com/, https://www.nature.com/scitable/definition/plasmid-plasmids-28/]
synonym: "plasmid gene transfer" EXACT []
xref: PMID:21993171
is_a: XCO:0000528 ! gene transfer
created_by: slaulede
creation_date: 2021-03-04T18:11:03Z

[Term]
id: XCO:0000819
name: gene transfer using plasmid vector pVAX2
def: "A condition in which gene transfer has been performed using the plasmid pVAX2 as the carrier of the genetic material. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines." [https://www.thermofisher.com/order/catalog/product/V26020#/V26020, PMID:19440225]
xref: PMID:19440225
is_a: XCO:0000818 ! gene transfer using plasmid vector
created_by: slaulede
creation_date: 2021-03-04T18:29:17Z

[Term]
id: XCO:0000820
name: gene transfer using empty plasmid vector pVAX2
def: "A control condition in which gene transfer has been performed using an empty plasmid pVAX2. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines." [https://www.thermofisher.com/order/catalog/product/V26020#/V26020, PMID:21993171]
synonym: "gene transfer using only the backbone of plasmid vector pVAX2" EXACT []
xref: PMID:19440225
xref: PMID:21993171
is_a: XCO:0000819 ! gene transfer using plasmid vector pVAX2
created_by: slaulede
creation_date: 2021-03-08T13:54:50Z

[Term]
id: XCO:0000821
name: gene transfer of the rat GDNF gene using the plasmid vector pVAX2
def: "A condition in which the rat GDNF gene has been (transiently or stably) transferred into a cell or organism using the plasmid vector pVAX2 in order to induce synthesis of that gene's product in the recipient cell or organism." [https://www.thermofisher.com/order/catalog/product/V26020#/V26020, PMID:21993171]
xref: PMID:19440225
xref: PMID:21993171
is_a: XCO:0000819 ! gene transfer using plasmid vector pVAX2
created_by: slaulede
creation_date: 2021-03-08T14:07:05Z

[Term]
id: XCO:0000822
name: JTE-607
def: "JTE-607 is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3). JTE-607 reduces the production of proinflammatory cytokines in models of acute injury, septic shock and endotoxemia." [https://www.sigmaaldrich.com/catalog/product/sigma/sml2833?lang=en&region=US, https://www.tocris.com/products/jte-607-dihydrochloride_5185?gclid=Cj0KCQiA1pyCBhCtARIsAHaY_5d7izfKf8E3Lgu7fCItYrJRNFR8iSoRV7HWnsqZOjNwTGeTa9Pcu-4aAthgEALw_wcB]
synonym: "JTE 607" EXACT []
synonym: "JTE 607 dihydrochloride" EXACT []
xref: PMID:10493164
is_a: XCO:0000120 ! inhibitor
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: slaulede
creation_date: 2021-03-09T12:06:36Z

[Term]
id: XCO:0000823
name: peanut oil
def: "Any condition in which the main influencing factor is peanut oil, a colorless to yellow fatty nondrying oil that is obtained from peanuts and is used chiefly as a salad oil, in margarine, in soap, and as a vehicle in pharmaceutical preparations and cosmetics." [https://www.merriam-webster.com]
synonym: "arachis oil" EXACT []
synonym: "groundnut oil" EXACT []
xref: PMID:24388923
is_a: XCO:0000774 ! oil
created_by: slaulede
creation_date: 2021-03-25T15:05:12Z

[Term]
id: XCO:0000824
name: pertussis toxin
def: "Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is one of the most complex bacterial toxins known, composed of six subunits with an A protomer responsible for biologic activities and a B pentamer directing binding and entry of the A subunit into the cytoplasm." [https://en.wikipedia.org/wiki/Pertussis_toxin, https://www.sciencedirect.com/topics/medicine-and-dentistry/pertussis-toxin]
synonym: "B. pertussis toxin" EXACT []
synonym: "Bordetella pertussis toxin" EXACT []
synonym: "PT" EXACT []
xref: PMID:1702803
is_a: XCO:0000240 ! toxin
created_by: slaulede
creation_date: 2021-04-01T16:00:00Z

[Term]
id: XCO:0000825
name: cyclophosphamide
def: "An experimental condition in which the main influencing factor is cyclophosphamide (CP), an antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma." [https://en.wikipedia.org/wiki/Cyclophosphamide, MESH:D003520]
synonym: "CP" EXACT []
synonym: "cytophosphane" EXACT []
xref: CHEBI:4027
xref: MESH:D003520
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000636 ! immunosuppressive agent
created_by: slaulede
creation_date: 2021-04-01T16:35:28Z

[Term]
id: XCO:0000826
name: rat anti-Hu-MBP T cell line
def: "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with human myelin basic protein." [PMID:1702803]
synonym: "rat anti-Hu-BP T cell line" EXACT []
xref: PMID:1702803
is_a: XCO:0000763 ! T cells
created_by: slaulede
creation_date: 2021-04-01T17:07:53Z

[Term]
id: XCO:0000827
name: rat anti-Hu-S102-129 T cell line
def: "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with synthetic human myelin basic protein peptide 102-129." [PMID:1702803]
xref: PMID:1702803
is_a: XCO:0000763 ! T cells
created_by: slaulede
creation_date: 2021-04-01T17:27:28Z

[Term]
id: XCO:0000828
name: human myelin basic protein
def: "Any condition in which the main influencing factor is human myelin basic protein, a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Human myelin basic protein is purified from human tissue or extracted from cultured cells containing cloned copies of the human myelin basic protein gene." [PMID:1702803]
synonym: "Hu-BP" EXACT []
synonym: "human MBP" EXACT []
xref: PMID:1702803
is_a: XCO:0000688 ! myelin basic protein
created_by: slaulede
creation_date: 2021-04-01T17:46:52Z

[Term]
id: XCO:0000829
name: corn oil
def: "Corn oil is a refined fixed, that is, nonvolatile, oil obtained from from the germ of corn kernels. It has high polyunsaturated lipid content and is used as a delivery vehicle for lipophilic substances." [https://www.merriam-webster.com, ISBN-13:978-1608316922]
synonym: "maize oil" EXACT []
xref: PMID:26514922
is_a: XCO:0000774 ! oil
created_by: slaulede
creation_date: 2021-04-08T17:10:21Z

[Term]
id: XCO:0000830
name: artificial cerebrospinal fluid
def: "Any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF), a buffer solution prepared with a composition representative of cerebrospinal fluid. It is used experimentally for rat brain microdialysis experiments, the culture of hippocampal tissue slices, or irrigation treatment of brain trauma lesions to supply oxygen, maintain osmolarity, and to buffer pH at biological levels." [https://biochemazone.com/product/artificial-cerebrospinal-solution-bz178/, https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid]
synonym: "aCSF" EXACT []
synonym: "cerebrospinal fluid simulation fluid" EXACT []
xref: PMID:22356885
is_a: XCO:0000154 ! ion/salt solution
created_by: slaulede
creation_date: 2021-04-23T17:15:50Z

[Term]
id: XCO:0000831
name: 2% dimethyl sulfoxide in artificial cerebrospinal fluid
def: "Any condition in which the main influencing factor is a 2% solution (v/v) of dimethyl sulfoxide in artificial cerebrospinal fluid, a buffer solution prepared with a composition representative of cerebrospinal fluid. Dimethyl sulfoxide is a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent." [CHEBI:28262, https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid, MESH:D004121]
synonym: "2% DMSO in aCSF" EXACT []
xref: PMID:22356885
relationship: has_component XCO:0000755 ! dimethyl sulfoxide
relationship: has_component XCO:0000830 ! artificial cerebrospinal fluid
created_by: slaulede
creation_date: 2021-04-23T17:27:15Z

[Term]
id: XCO:0000832
name: lensotomy
def: "Any process involving manual and instrumental techniques for incision of a lens in the eye of an organism to investigate and/or treat a pathological condition." [https://en.wikipedia.org/wiki/List_of_surgical_procedures, PMID:16631043]
synonym: "intentional incision of an ocular lens" EXACT []
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2021-04-30T17:36:25Z

[Term]
id: XCO:0000833
name: lacidipine
def: "Any condition in which the main influencing factor is lacidipine, a lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension." [https://go.drugbank.com/drugs/DB09236, https://www.sigmaaldrich.com/catalog/product/sigma/sml0946?lang=en&region=US&utm_medium=cpc&utm_source=bing&utm_term=lacidipine&utm_campaign=Backlog%20Product-Focused%20Ads%20Phase%202%20(Bing%20ebizpfs)%20(new_c)&utm_content=sigma/sml0946]
synonym: "Lacipil" EXACT []
synonym: "Motens" EXACT []
xref: CHEBI:135737
xref: MESH:C060285
xref: PMID:10023637
is_a: XCO:0000140 ! vasodilator
is_a: XCO:0000269 ! calcium channel inhibitor
is_a: XCO:0000511 ! ester
created_by: slaulede
creation_date: 2021-05-10T13:22:23Z

[Term]
id: XCO:0000834
name: formaldehyde
def: "Any condition in which the main influencing factor is formaldehyde, an aldehyde resulting from the formal oxidation of methanol. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative." [CHEBI:16842, MESH:D005557]
synonym: "formalin" EXACT []
synonym: "Methanal" EXACT []
synonym: "Methylene oxide" EXACT []
synonym: "Oxomethane" EXACT []
xref: CHEBI:16842
xref: PMID:21184763
is_a: XCO:0000239 ! toxic substance
created_by: slaulede
creation_date: 2021-05-17T14:00:31Z

[Term]
id: XCO:0000835
name: BT4C cells
def: "A condition in which the main influencing factor is a rat malignant glioma cell line." [https://web.expasy.org/cellosaurus/CVCL_5712, PMID:23079672]
synonym: "BT4c" EXACT []
xref: CVCL_5712
xref: PMID:23079672
is_a: XCO:0000709 ! cancer cells
created_by: slaulede
creation_date: 2021-05-18T13:29:46Z

[Term]
id: XCO:0000836
name: gene transfer of the HSV-tk gene using an adenovirus vector
def: "A condition in which the herpes simplex virus thymidine kinase (HSV-tk) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [PMID:23079672]
synonym: "gene transfer of the herpes simplex virus thymidine kinase gene using an adenovirus vector" EXACT []
synonym: "gene transfer of the Herpes Simplex Virus type 1 thymidine kinase gene using an adenovirus vector" EXACT []
synonym: "gene transfer using AdHSV-tk" EXACT []
xref: PMID:23079672
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: slaulede
creation_date: 2021-05-18T13:40:36Z

[Term]
id: XCO:0000837
name: gene transfer of the 15-LO-1 gene using an adenovirus vector
def: "A condition in which the 15-Lipoxygenase-1 (15-LO-1) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [PMID:23079672]
synonym: "gene transfer of the 15-Lipoxygenase-1 gene using an adenovirus vector" EXACT []
synonym: "gene transfer using Ad15-LO-1" EXACT []
xref: PMID:23079672
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: slaulede
creation_date: 2021-05-18T13:57:02Z

[Term]
id: XCO:0000838
name: mineralocorticoid receptor antagonist
def: "Any condition in which the main influencing factor is an agent that blocks the mineralocorticoid (primarily aldosterone) receptor (NR3C2), which regulates water and electrolyte metabolism." [https://en.wikipedia.org/wiki/Aldosterone, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mineralocorticoids]
synonym: "aldosterone receptor antagonist" EXACT []
synonym: "MR antagonist" EXACT []
xref: PMID:32088716
is_a: XCO:0000160 ! receptor antagonist
created_by: slaulede
creation_date: 2021-05-21T11:58:21Z

[Term]
id: XCO:0000839
name: finerenone
def: "Any condition in which the main influencing factor is finerenone, a nonsteroidal mineralocorticoid receptor antagonist." [https://en.wikipedia.org/wiki/Finerenone, https://www.medchemexpress.com/finerenone.html]
synonym: "BAY 94-8862" EXACT []
synonym: "DB16165" EXACT []
synonym: "FIN" EXACT []
xref: PMID:32088716
is_a: XCO:0000838 ! mineralocorticoid receptor antagonist
created_by: slaulede
creation_date: 2021-05-21T12:40:05Z

[Term]
id: XCO:0000840
name: Eplerenone
def: "Any condition in which the main influencing factor is Eplerenone, a steroidal antimineralocorticoid of the spirolactone group and a selective aldosterone receptor antagonist (SARA)." [https://en.wikipedia.org/wiki/Eplerenone, https://go.drugbank.com/drugs/DB00700]
synonym: "DB00700" EXACT []
synonym: "epoxymexrenone" EXACT []
synonym: "Inspra" EXACT []
xref: PMID:32088716
is_a: XCO:0000838 ! mineralocorticoid receptor antagonist
created_by: slaulede
creation_date: 2021-05-21T12:50:59Z

[Term]
id: XCO:0000841
name: GSK-812
def: "An experimental condition in which the main influencing factor is GSK-812, a potent neuroprotectant that can induce GDNF in normal and diseased retina, and antagonizes multiple receptors, including D2 and D3 receptors, and 5-HT2A, 2C, and 5-HT6 receptors.." [http://www.probechem.com/products_GSK-812.aspx, PMID:28441076]
synonym: "1H-3-Benzazepine, 7-[[4-[(4-chlorophenyl)Methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-Methoxy-3-Methyl-" EXACT []
synonym: "7-[4-[(4-chlorophenyl)methoxy]phenyl]sulfonyl-8-methoxy-3-methyl-1,2,4,5-tetrahydro-3-benzazepine" EXACT []
synonym: "7-[[4-[(4-Chlorophenyl)methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-methoxy-3-methyl-1H-3-benzazepine" EXACT []
synonym: "GSK812" EXACT []
xref: PMID:28441076
is_a: XCO:0000160 ! receptor antagonist
created_by: slaulede
creation_date: 2021-06-04T12:00:41Z

[Term]
id: XCO:0000842
name: nicotinic antagonist
def: "Any condition in which the main influencing factor is a nicotinic antagonist, a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors." [CHEBI:48878, https://en.wikipedia.org/wiki/Nicotinic_antagonist]
synonym: "nicotinic acetylcholine receptor antagonist" EXACT []
synonym: "nicotinic cholinergic antagonist" EXACT []
xref: CHEBI:48878
xref: PMID:24400148
is_a: XCO:0000630 ! cholinergic antagonist
created_by: slaulede
creation_date: 2021-06-10T10:31:44Z

[Term]
id: XCO:0000843
name: mecamylamine
def: "Any condition in which the main influencing factor is mecamylamine, a ganglionic blocking agent that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system." [CHEBI:48878, https://en.wikipedia.org/wiki/Mecamylamine, MESH:D008464]
synonym: "C11H21N" EXACT []
synonym: "Inversine" EXACT []
synonym: "Vecamyl" EXACT []
xref: PMID:24400148
is_a: XCO:0000842 ! nicotinic antagonist
created_by: slaulede
creation_date: 2021-06-10T11:03:37Z

[Term]
id: XCO:0000844
name: sodium phenobarbital
def: "Any condition in which the main influencing factor is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). Sodium phenobarbital is an acvtivator of the constitutive androstane receptor (CAR; Nr1i3)." [CHEBI:8070, PMID:29548889]
synonym: "C12H11N2NaO3" EXACT []
synonym: "NaPB" EXACT []
synonym: "phenobarbital sodium" EXACT []
synonym: "phenobarbital sodium salt" EXACT []
synonym: "Sodium phenobarbitone" EXACT []
xref: PMID:29548889
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000135 ! receptor agonist
created_by: slaulede
creation_date: 2021-06-24T15:00:49Z

[Term]
id: XCO:0000845
name: pregnenolone 16alpha-carbonitrile
def: "Any condition in which the main influencing factor is pregnenolone 16alpha-carbonitrile, a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR; Nr1i2)." [CHEBI:35591, PMID:5793358]
synonym: "3beta-hydroxy-20-oxopregn-5-ene-16alpha-carbonitrile" EXACT []
synonym: "C22H31NO2" EXACT []
synonym: "PCN" EXACT []
xref: MESH:D011285
xref: PMID:29548889
is_a: XCO:0000091 ! steroid
is_a: XCO:0000135 ! receptor agonist
created_by: slaulede
creation_date: 2021-06-24T15:21:50Z

[Term]
id: XCO:0000846
name: Hu-S102-129
def: "Any condition in which the main influencing factor is a 28 amino acid polypeptide representing residues 102 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon." [PMID:1702803]
synonym: "PSQGKGRGLSLSRFSWGAEGQRPGFGYG" EXACT []
xref: PMID:1702803
is_a: XCO:0000828 ! human myelin basic protein
created_by: slaulede
creation_date: 2021-06-28T15:35:55Z

[Term]
id: XCO:0000847
name: Hu-S110-129
def: "Any condition in which the main influencing factor is a 20 amino acid polypeptide representing residues 110 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon." [PMID:1702803]
synonym: "LSLSRFSWGAEGQRPGFGYG" EXACT []
xref: PMID:1702803
is_a: XCO:0000828 ! human myelin basic protein
created_by: slaulede
creation_date: 2021-06-28T15:42:51Z

[Term]
id: XCO:0000848
name: negatively charged liposome-entrapped doxorubicin
def: "An experimental condition in which the main influencing factor is negatively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication." [PMID:6744286]
synonym: "lip- DXR" EXACT []
xref: PMID:6744286
is_a: XCO:0000539 ! doxorubicin
is_a: XCO:0000782 ! negatively charged liposomes
created_by: slaulede
creation_date: 2021-06-28T17:06:42Z

[Term]
id: XCO:0000849
name: positively charged liposome-entrapped doxorubicin
def: "An experimental condition in which the main influencing factor is positively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication." [PMID:6744286]
synonym: "lip+ DXR" EXACT []
xref: PMID:6744286
is_a: XCO:0000539 ! doxorubicin
is_a: XCO:0000781 ! positively charged liposomes
created_by: slaulede
creation_date: 2021-06-28T17:14:08Z

[Term]
id: XCO:0000850
name: therapeutic agent
def: "This is a condition in which the main influencing factor is a chemical, biologic, or organism that exerts some force or effect resulting in a favorable outcome or improvement in the symptoms of a disorder or disease." [https://www.merriam-webster.com/, ISBN-13:978-0683400076]
synonym: "medicinal agent" EXACT []
synonym: "Not4Curation" RELATED []
synonym: "remedial agent" EXACT []
xref: PMID:29273085
is_a: XCO:0000000 ! experimental condition
created_by: slaulede
creation_date: 2021-06-28T18:20:14Z

[Term]
id: XCO:0000851
name: stem cells
def: "This is a condition in which the main influencing factor is a stem cell, an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions." [CL:0000034, https://en.wikipedia.org/wiki/Stem_cell, https://www.merriam-webster.com/]
synonym: "Not4Curation" RELATED []
xref: PMID:29273085
is_a: XCO:0000850 ! therapeutic agent
created_by: slaulede
creation_date: 2021-06-28T18:41:49Z

[Term]
id: XCO:0000852
name: human periodontal ligament-derived stem cells
def: "A condition in which the main influencing factor is human periodontal ligament-derived stem cells, which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal and other tissue type regeneration. The advantages of the use of dental stem cells include their easy isolation by noninvasive routine clinical procedures, their broad differentiation potential, minimal ethical concerns, and that they may enable autologous transplantation." [PMID:25861283, PMID:29273085]
synonym: "hPDLSCs" EXACT []
xref: PMID:29273085
is_a: XCO:0000851 ! stem cells
created_by: slaulede
creation_date: 2021-06-29T11:11:08Z

[Term]
id: XCO:0000853
name: rat serum from subject bearing a B48-14 IgE-producing hybridoma
def: "Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected B48-14 IgE-producing hybridoma. The serum is essentially antiserum containing B48-14 IgE, which are directed against a S. mansoni adult worm antigen." [https://www.merriam-webster.com/, PMID:3108390]
xref: PMID:3108390
is_a: XCO:0000769 ! antiserum
created_by: slaulede
creation_date: 2021-06-29T17:41:28Z

[Term]
id: XCO:0000854
name: rat serum from subject bearing IR983F myeloma
def: "Any condition in which the main influencing factor is serum prepared from rats bearing subcutaneously injected IR983F myeloma cells. The serum is essentially control for antiserum from rats bearing IgE-producing hybridomas." [https://www.merriam-webster.com/, PMID:3108390]
synonym: "rat serum from subject bearing IR 983 F myeloma" EXACT []
xref: PMID:3108390
is_a: XCO:0000769 ! antiserum
created_by: slaulede
creation_date: 2021-06-29T18:07:47Z

[Term]
id: XCO:0000855
name: rat serum from subject bearing a non-specified IgE-producing hybridoma
def: "Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected non-specified IgE-producing hybridoma. The serum is essentially antiserum containing control IgE, which are directed against an unspecified antigen." [https://www.merriam-webster.com/, PMID:3108390]
xref: PMID:3108390
is_a: XCO:0000769 ! antiserum
created_by: slaulede
creation_date: 2021-06-29T18:12:26Z

[Term]
id: XCO:0000856
name: resveratrol
def: "A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups. It is produced by various plants and has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties." [MESH:D000077185]
synonym: "3,4',5-Stilbenetriol" EXACT []
synonym: "3,4',5-Trihydroxystilbene" EXACT []
synonym: "5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol" EXACT []
synonym: "RSV" EXACT []
synonym: "SRT501" EXACT []
xref: PMID:30621358
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: slaulede
creation_date: 2021-06-29T18:22:55Z

[Term]
id: XCO:0000857
name: vildagliptin
def: "Any condition in which the main influencing factor is vildagliptin, a pyrrolidine-carbonitrile derivative and potent inhibitor of dipeptidyl peptidase 4 (DPP-4) that is used in the treatment of type 2 diabetes mellitus." [MESH:D000077597, PMID:23774700]
synonym: "VG" EXACT []
xref: PMID:23774700
is_a: XCO:0000407 ! hypoglycemic agent
created_by: slaulede
creation_date: 2021-07-02T13:08:02Z

[Term]
id: XCO:0000858
name: rat anti-control-Ab2 T cells
def: "Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies." [PMID:1719096]
xref: PMID:1719096
xref: PMID:2494262
is_a: XCO:0000763 ! T cells
created_by: slaulede
creation_date: 2021-07-02T17:20:09Z

[Term]
id: XCO:0000859
name: rat anti-control-Ab2 T cell line
def: "Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies." [PMID:1719096]
xref: PMID:1719096
xref: PMID:2494262
is_a: XCO:0000858 ! rat anti-control-Ab2 T cells
created_by: slaulede
creation_date: 2021-07-02T17:23:47Z

[Term]
id: XCO:0000860
name: anti-rh-VEGF165 monoclonal antibody
def: "A condition in which the main influencing factor is a monoclonal antibody having specific amino acid sequences with the ability to adhere to and interact specifically with recombinant human vascular endothelial growth factor 165." [https://www.merriam-webster.com/, PMID:11316858]
synonym: "anti-recombinant human vascular endothelial growth factor 165 monoclonal antibody" EXACT []
xref: PMID:15702434
is_a: XCO:0000194 ! antibody
created_by: slaulede
creation_date: 2021-07-06T14:53:33Z

[Term]
id: XCO:0000861
name: control IgG monoclonal antibody
def: "A condition in which the main influencing factor is an isotype-matched (IgG) monoclonal antibody to provide a control for some target-specific monoclonal antibody." [https://www.merriam-webster.com/, PMID:11316858]
synonym: "isotype-matched control Ab" EXACT []
xref: PMID:15702434
is_a: XCO:0000194 ! antibody
created_by: slaulede
creation_date: 2021-07-06T15:18:46Z

[Term]
id: XCO:0000862
name: bendroflumethiazide
def: "A condition in which the main influencing factor is bendroflumethiazide, a sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders." [CHEBI:3013, MESH:D001539]
synonym: "Aprinox" EXACT []
synonym: "bendrofluazide" EXACT []
synonym: "BTZ" EXACT []
xref: PMID:18480177
is_a: XCO:0000863 ! antihypertensive agent
created_by: slaulede
creation_date: 2021-07-06T17:28:01Z

[Term]
id: XCO:0000863
name: antihypertensive agent
def: "A condition in which the main influencing factor is any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism." [CHEBI:35674, ISBN-13:9780781733908]
synonym: "antihypertensive drug" EXACT []
xref: PMID:18480177
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2021-07-06T17:35:52Z

[Term]
id: XCO:0000864
name: hepatic portal vein occlusion
def: "A condition involving surgical manipulation causing blockage of one or more branches of the hepatic portal vein, a vein that transports nutrients from the digestive tract to the liver." [ISBN-13:9780781733908, PMID:32156510]
synonym: "hepatic portal vein ligation" RELATED []
synonym: "HPV occlusion" EXACT []
synonym: "liver portal vein occlusion" EXACT []
xref: PMID:32156510
is_a: XCO:0000347 ! blood vessel occlusion
created_by: slaulede
creation_date: 2021-07-08T13:48:54Z

[Term]
id: XCO:0000865
name: dehydroepiandrosterone
def: "A condition in which the main influencing factor is an androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary." [CHEBI:28689, MESH:D003687]
synonym: "androstenolone" EXACT []
synonym: "DHEA" EXACT []
xref: PMID:9415976
is_a: XCO:0000229 ! steroid hormone
created_by: slaulede
creation_date: 2021-07-09T13:35:10Z

[Term]
id: XCO:0000866
name: anal sphincter myotomy
def: "Any process involving manual and instrumental techniques for incision of the internal anal sphincter muscle. The inner is controlled by the nervous system, while the external anal sphincter muscle is under voluntary control." [https://www.merriam-webster.com/medical/myotomy, https://www.verywellhealth.com/sphincterotomy-overview-4584862]
synonym: "lateral internal sphincterotomy" EXACT []
synonym: "sphincterotomy" EXACT []
xref: PMID:29391927
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2021-07-09T16:04:48Z

[Term]
id: XCO:0000867
name: incision repair
def: "A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures, staples, glue, or some other closure material." [https://www.merriam-webster.com/, ISBN-13:9780781733908]
synonym: "incision closure" EXACT []
synonym: "incision stapling" NARROW []
synonym: "incision suturing" NARROW []
xref: PMID:29391927
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2021-07-09T16:46:51Z

[Term]
id: XCO:0000868
name: incision repair with conventional suture
def: "A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures. Surgical sutures are specially made thread that comes in different sizes and different material." [https://www.merriam-webster.com/, ISBN-13:9780781733908]
synonym: "incision suturing" EXACT []
xref: PMID:29391927
is_a: XCO:0000867 ! incision repair
created_by: slaulede
creation_date: 2021-07-09T17:22:07Z

[Term]
id: XCO:0000869
name: incision repair with biosuture
def: "A process in which manual and instrumental techniques are used to close a wound or surgical incision with biosutures. Biosutures are surgical sutures upon which stem cells have been grown in vitro." [https://www.merriam-webster.com/, PMID:29391927]
synonym: "incision suturing with biosuture" EXACT []
xref: PMID:18690635
xref: PMID:29391927
is_a: XCO:0000867 ! incision repair
created_by: slaulede
creation_date: 2021-07-12T10:20:45Z

[Term]
id: XCO:0000870
name: rat adipose-derived stem cells
def: "A condition in which the main influencing factor is a rat stem cell, isolated from subcutaneous fat tissue and cultured in vitro. A stem cell is an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions." [https://www.merriam-webster.com/, PMID:29391927]
synonym: "adipose-derived stem cells" BROAD []
xref: PMID:29391927
is_a: XCO:0000851 ! stem cells
created_by: slaulede
creation_date: 2021-07-12T12:42:34Z

[Term]
id: XCO:0000871
name: 5-fluorouracil
def: "A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. Following conversion to the active deoxynucleotide, It inhibits DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid." [CHEBI:46345, MESH:D005472]
synonym: "5-Fluoracil" EXACT []
synonym: "5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT []
synonym: "5-FU" EXACT []
synonym: "fluorouracil" EXACT []
xref: PMID:10431686
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000636 ! immunosuppressive agent
created_by: slaulede
creation_date: 2021-07-16T15:49:31Z

[Term]
id: XCO:0000872
name: Thymosin alpha-1
def: "Thymosin alpha-1 is one member of a family of heat-stable, polypeptide hormones secreted by the thymus gland. Thymosins are immune response-modulating molecules." [MESH:D013947, PMID:33362999]
synonym: "prothymosin alpha" RELATED []
synonym: "prothymosin, alpha" RELATED []
synonym: "PTMA" RELATED []
synonym: "thymalfasin" EXACT []
synonym: "TMSA" RELATED []
xref: PMID:10431686
is_a: XCO:0000228 ! peptide hormone
is_a: XCO:0000483 ! antibacterial agent
is_a: XCO:0000657 ! antiviral agent
created_by: slaulede
creation_date: 2021-07-16T16:55:07Z

[Term]
id: XCO:0000873
name: DHD/K12/TRb - Sp-5 cells
def: "A condition in which the main influencing factor is the pulmonary metastatic subclone Sp-5 of a rat colonic carcinoma cell line (DHD/K12/TRb) used to study biochemical correlates of metastasis." [PMID:19850492, PMID:7818325]
synonym: "DHD/K12 - Sp-5 cells" EXACT []
synonym: "DHD K12/TRb - Sp-5 cells" EXACT []
synonym: "DHD-K12 TRb - Sp-5 cells" EXACT []
synonym: "TRb - Sp-5 cells" EXACT []
xref: PMID:7818325
is_a: XCO:0000710 ! DHD/K12/TRb cells
created_by: slaulede
creation_date: 2021-07-19T17:18:00Z

[Term]
id: XCO:0000874
name: controlled in situ lung condition
def: "Any experimental condition in which the internal or external environment of one or both lungs is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." [https://www.merriam-webster.com/, ISBN-13:9780781733908]
synonym: "controlled in situ pulmonary condition" EXACT []
synonym: "Not4Curation" EXACT []
xref: PMID:7818325
is_a: XCO:0000166 ! controlled in situ organ condition
created_by: slaulede
creation_date: 2021-07-19T17:25:18Z

[Term]
id: XCO:0000875
name: isolated lung perfusion
def: "An experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle." [PMID:7818325, PMID:8347000]
synonym: "isolated single lung perfusion" EXACT []
xref: PMID:7818325
is_a: XCO:0000874 ! controlled in situ lung condition
created_by: slaulede
creation_date: 2021-07-19T17:33:20Z

[Term]
id: XCO:0000876
name: floxuridine
def: "This is an antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [CHEBI:60761, MESH:D005467]
synonym: "2'-deoxy-5-fluorouridine" EXACT []
synonym: "5FDU" EXACT []
synonym: "5-Fluorodeoxyuridine" EXACT []
synonym: "5-FUdR" EXACT []
synonym: "deoxyfluorouridine" EXACT []
synonym: "fluorodeoxyuridine" EXACT []
synonym: "FUDR" EXACT []
synonym: "PMID:7818325" EXACT []
is_a: XCO:0000390 ! antimetabolite
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000657 ! antiviral agent
created_by: slaulede
creation_date: 2021-07-19T18:12:49Z

[Term]
id: XCO:0000877
name: Hespan buffer
def: "Any condition in which the main influencing factor is Hespan buffer, 6% hetastarch in buffered solution. A buffer is a homogeneous mixture of molecules, atoms and/or ions, one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed in a sufficient quantity of solvent." [https://www.fda.gov, PMID:10155362]
synonym: "HB" EXACT []
xref: PMID:7818325
is_a: XCO:0000315 ! buffer solution
created_by: slaulede
creation_date: 2021-07-19T18:38:39Z

[Term]
id: XCO:0000878
name: Hespan buffer perfusate
def: "Any condition in which the main influencing factor is Hespan buffer (6% hetastarch in buffered solution) injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel." [https://www.fda.gov, PMID:10155362]
synonym: "HB perfusate" EXACT []
xref: PMID:7818325
is_a: XCO:0000115 ! perfusate
is_a: XCO:0000877 ! Hespan buffer
created_by: slaulede
creation_date: 2021-07-20T13:59:06Z

[Term]
id: XCO:0000879
name: triamcinolone acetonide
def: "A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. It is an anti-inflammatory agent used topically in the treatment of various skin disorders." [CHEBI:71418, MESH:D014222]
synonym: "Azmacort" EXACT []
synonym: "Cinonide" EXACT []
synonym: "Kenalog 40" EXACT []
synonym: "Tricort-40" EXACT []
xref: PMID:27856527
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: slaulede
creation_date: 2021-07-20T14:16:29Z

[Term]
id: XCO:0000880
name: mifepristone
def: "Any condition in which the main influencing factor is mifepristone, a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary Cushing Syndrome." [MESH:D015735]
synonym: "Mifegyne" EXACT []
synonym: "Mifeprex" EXACT []
synonym: "RU 38486" EXACT []
synonym: "RU38486" EXACT []
synonym: "RU-486" EXACT []
synonym: "RU486" EXACT []
synonym: "ZK98296" EXACT []
xref: PMID:27856527
is_a: XCO:0000120 ! inhibitor
created_by: slaulede
creation_date: 2021-07-20T14:26:43Z

[Term]
id: XCO:0000881
name: 4[N-methyl-14C] iodoantipyrine
def: "This is 4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine readily crosses the blood-brain barrier, and has been used to measure total and regional cerebral blood flow in vivo." [https://www.perkinelmer.com/product/iodoantipyrine-4-n-methyl-14c-nec712050uc#]
synonym: "4-iodo-5-methyl-1-(114C)methyl-2-phenylpyrazol-3-one" EXACT []
synonym: "4-Iodoantipyrene-N-methyl-14C" EXACT []
synonym: "C11H11IN2O" EXACT []
xref: PMID:29498562
xref: pubchem.compound:101126542
is_a: XCO:0000171 ! radioactively labeled chemical
created_by: slaulede
creation_date: 2021-07-29T17:59:13Z

[Term]
id: XCO:0000882
name: sleeve gastrectomy
def: "This procedure involves removal of about 80% of the stomach, leaving a tube-shaped stomach about the size and shape of a banana. The procedure is typically performed as a surgical intervention for weight control." [https://www.mayoclinic.org/tests-procedures/sleeve-gastrectomy/about/pac-20385183, ISBN-13:9780781733908]
synonym: "vertical sleeve gastrectomy" EXACT []
xref: PMID:29168078
is_a: XCO:0000026 ! surgical removal
created_by: slaulede
creation_date: 2021-08-02T15:06:01Z

[Term]
id: XCO:0000883
name: pantoprazole
def: "This is a substituted benzimidazole and proton pump inhibitor that is used in the treatment of gastroesophageal reflux and peptic ulcer." [CHEBI:7915, MESH:D000077402]
synonym: "5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole" EXACT []
synonym: "BY-1023" EXACT []
synonym: "Protonix" EXACT []
synonym: "SKF-96022" EXACT []
xref: PMID:29168078
is_a: XCO:0000577 ! proton pump inhibitor
created_by: slaulede
creation_date: 2021-08-02T15:19:16Z

[Term]
id: XCO:0000884
name: trypan blue
def: "Any condition in which the main influencing factor is trypan blue, an azo dye used as a vital stain to selectively colour dead tissues or cells blue." [https://en.wikipedia.org/wiki/Trypan_blue, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/trypan-blue]
synonym: "tetrasodium 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonate)" EXACT []
xref: PMID:3347907
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000512 ! teratogen
created_by: slaulede
creation_date: 2021-08-02T16:18:02Z

[Term]
id: XCO:0000885
name: diabetes-inducing chemical
def: "A condition in which the main influencing factor is substance that is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling diabetes mellitus through destruction of the beta cells." [CHEBI:9288, ISBN-13:9780781733908]
xref: PMID:12401717
is_a: XCO:0000259 ! disease-inducing chemical
created_by: slaulede
creation_date: 2021-08-09T17:47:11Z

[Term]
id: XCO:0000886
name: epilepsy-inducing chemical
def: "A condition in which the main influencing factor is substance that causes seizures in experimental animals, initiated by the injection of a drug." [DOID:9007090, PMID:31039378]
synonym: "seizure-inducing chemical" EXACT []
xref: PMID:31039378
is_a: XCO:0000259 ! disease-inducing chemical
created_by: slaulede
creation_date: 2021-08-09T18:13:25Z

[Term]
id: XCO:0000887
name: pentetrazol
def: "This a pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive gamma-aminobutyric acid antagonist. Pentetrazol has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility." [MESH:D010433]
synonym: "1,5-pentamethylenetetrazole" EXACT []
synonym: "pentamethylenetetrazole" EXACT []
synonym: "pentylenetetrazole" EXACT []
synonym: "PTZ" EXACT []
xref: CHEBI:34910
xref: PMID:31039378
is_a: XCO:0000886 ! epilepsy-inducing chemical
created_by: slaulede
creation_date: 2021-08-10T12:49:31Z

[Term]
id: XCO:0000888
name: pilocarpine
def: "Pilocarpine is a miotic alkaloid obtained from jaborandi that is used chiefly in the form of its hydrochloride or nitrate especially in the treatment of glaucoma. It is a cholinergic (muscarinic) agonist and used to cause seizures in animal models of epilepsy." [https://medlineplus.gov/druginfo/meds/a608039.html, https://www.merriam-webster.com/, MESH:D010862]
xref: CHEBI:39462
xref: PMID:31039378
is_a: XCO:0000693 ! cholinergic agonist
is_a: XCO:0000886 ! epilepsy-inducing chemical
created_by: slaulede
creation_date: 2021-08-10T13:18:44Z

[Term]
id: XCO:0000889
name: ionomycin
def: "Ionomycin is a very long-chain fatty acid that is a calcium ionophore produced by Streptomyces conglobatus. It is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes." [CHEBI:63954, MESH:D015759]
synonym: "C41H72O9" EXACT []
xref: CHEBI:63954
xref: MESH:D015759
xref: PMID:32300198
is_a: XCO:0000776 ! fatty acid
is_a: XCO:0000890 ! ionophore
created_by: slaulede
creation_date: 2021-08-10T13:36:53Z

[Term]
id: XCO:0000890
name: ionophore
def: "A compound that facilitates transmission of an ion across a lipid barrier (as in a cell membrane) by combining with the ion or by increasing the permeability of the barrier to it." [CHEBI:24869, https://www.merriam-webster.com/]
synonym: "ion carrier" EXACT []
xref: PMID:32300198
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2021-08-10T13:40:47Z

[Term]
id: XCO:0000891
name: phorbol 13-acetate 12-myristate
def: "Phorbol 13-acetate 12-myristate is a phorbol ester found in croton oil with very effective tumor promoting activity. It is a protein kinase C agonist and stimulates the synthesis of both DNA and RNA." [MESH:D013755]
synonym: "12-O-Tetradecanoyl Phorbol 13-Acetate" EXACT []
synonym: "phorbol myristate acetate" EXACT []
synonym: "PMA" EXACT []
synonym: "tetradecanoylphorbol acetate" EXACT []
synonym: "TPA" EXACT []
xref: CHEBI:37537
is_a: XCO:0000694 ! enzyme activator
is_a: XCO:0000892 ! tumor promoter
created_by: slaulede
creation_date: 2021-08-10T13:54:49Z

[Term]
id: XCO:0000892
name: tumor promoter
def: "Tumor promoters are substances that enhance tumorigenicity when administered after a carcinogen. In general, tumor promoters do not possess tumorigenic activity themselves." [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/tumor-promotion, PMID:10417370]
xref: PMID:32300198
is_a: XCO:0000259 ! disease-inducing chemical
created_by: slaulede
creation_date: 2021-08-10T15:45:15Z

[Term]
id: XCO:0000893
name: controlled ramipril content drinking water
def: "A drink made up of water and a specified amount of ramipril in which the amount of ramipril consumed is maintained at a specified level." [https://www.merriam-webster.com/, PMID:20864942]
synonym: "controlled Altace content drinking water" EXACT []
xref: CHEBI:8774
xref: PMID:20864942
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000548 ! ramipril
created_by: slaulede
creation_date: 2021-08-26T11:53:55Z

[Term]
id: XCO:0000894
name: controlled hesperidin content diet
def: "A regimen of solid food in which the amount of hesperidin, a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage, is controlled." [CHEBI:28775]
synonym: "controlled Hesperetin 7-O-Rutinoside content diet" EXACT []
synonym: "controlled Hesperidin 2S content diet" EXACT []
xref: CHEBI:28775
xref: MESH:D006569
xref: PMID:19966469
is_a: XCO:0000726 ! hesperidin
is_a: XCO:0000896 ! controlled hesperetin content diet
created_by: slaulede
creation_date: 2021-08-27T15:37:24Z

[Term]
id: XCO:0000895
name: controlled cyclodextrin (CD)-clathrated hesperetin content diet
def: "A regimen of solid food in which the amount of cyclodextrin (CD)-clathrated hesperetin is controlled. CD-clathrated hesperetin is the aglycone of hesperidin. Clathration by CD enhances hesperetin solubility." [PMID:19966469]
xref: CHEBI:28230
xref: MESH:C013015
xref: PMID:19966469
is_a: XCO:0000725 ! cyclodextrin (CD)-clathrated hesperetin
is_a: XCO:0000896 ! controlled hesperetin content diet
created_by: slaulede
creation_date: 2021-08-27T15:46:09Z

[Term]
id: XCO:0000896
name: controlled hesperetin content diet
def: "A regimen of solid food in which the amount of hesperetin is controlled. Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges." [drugbank:DB01094]
xref: CHEBI:28230
xref: MESH:C013015
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000603 ! hesperetin
created_by: slaulede
creation_date: 2021-08-27T15:51:49Z

[Term]
id: XCO:0000897
name: capsaicin
def: "This is an alkylamide found in some peppers that acts as an agonist at TRPV1 cation channels." [MESH:D002211]
synonym: "(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide" EXACT []
synonym: "8-Methyl-N-Vanillyl-6-Nonenamide" EXACT []
synonym: "Axsain" EXACT []
synonym: "Capsaicine" EXACT []
xref: CHEBI:3374
xref: PMID:27335281
is_a: XCO:0000217 ! cation channel activator
created_by: slaulede
creation_date: 2021-09-16T12:42:30Z

[Term]
id: XCO:0000898
name: minoxidil
def: "This a pyrimidine N-oxide that is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure." [CHEBI:6942, MESH:D008914]
synonym: "2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide" EXACT []
synonym: "6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide" EXACT []
synonym: "Rogaine" EXACT []
synonym: "U 10858" EXACT []
xref: PMID:27335281
is_a: XCO:0000140 ! vasodilator
created_by: slaulede
creation_date: 2021-09-16T13:23:00Z

[Term]
id: XCO:0000899
name: hydrochlorothiazide
def: "This is a thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism." [MESH:D006852]
synonym: "Dichlothiazide" EXACT []
synonym: "Dihydrochlorothiazide" EXACT []
xref: CHEBI:5778
xref: PMID:3611778
is_a: XCO:0000122 ! diuretic
created_by: slaulede
creation_date: 2021-10-07T13:42:44Z

[Term]
id: XCO:0000900
name: controlled hydrochlorothiazide content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydrochlorothiazide in which the amount of hydrochlorothiazide consumed is maintained at a specified level." [https://www.merriam-webster.com/]
synonym: "controlled dichlothiazide content drinking water" EXACT []
synonym: "controlled dihydrochlorothiazide content drinking water" EXACT []
synonym: "controlled Microzide content drinking water" EXACT []
xref: CHEBI:5778
xref: PMID:3611778
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000899 ! hydrochlorothiazide
created_by: slaulede
creation_date: 2021-10-07T14:29:25Z

[Term]
id: XCO:0000901
name: controlled delapril content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of delapril in which the amount of delapril consumed is maintained at a specified level." [https://www.merriam-webster.com/]
xref: CHEBI:135735
xref: PMID:8505110
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000540 ! delapril
created_by: slaulede
creation_date: 2021-10-07T15:05:11Z

[Term]
id: XCO:0000902
name: controlled candesartan content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of candesartan in which the amount of candesartan consumed is maintained at a specified level." [https://www.merriam-webster.com/]
xref: CHEBI:3348
xref: MESH:C081643
xref: PMID:8505110
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000438 ! candesartan
created_by: slaulede
creation_date: 2021-10-07T15:17:01Z

[Term]
id: XCO:0000903
name: 99mTc-mebrofenin
def: "Technetium (99mTc) mebrofenin is a diagnostic radiopharmaceutical used for imaging of the liver and the gallbladder." [https://en.wikipedia.org/wiki/Technetium_(99mTc)_mebrofenin]
synonym: "99mTc-N-(3-bromo-2,4,6-trimethylphenylcarbamoilmethyl 1-iminodiacetic acid" EXACT []
synonym: "Choletec" EXACT []
synonym: "Technetium mebrofenin" EXACT []
xref: CHEBI:135608
xref: PMID:30208622
is_a: XCO:0000171 ! radioactively labeled chemical
created_by: slaulede
creation_date: 2021-10-07T18:18:21Z

[Term]
id: XCO:0000904
name: controlled resveratrol content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of resveratrol in which the amount of resveratrol consumed is maintained at a specified level." [https://www.merriam-webster.com/, PMID:30621358]
synonym: "controlled 3,4',5-Stilbenetriol content drinking water" EXACT []
synonym: "controlled RSV content drinking water" EXACT []
synonym: "controlled SRT501 content drinking water" EXACT []
xref: MESH:D000077185
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000856 ! resveratrol
created_by: slaulede
creation_date: 2021-10-08T18:16:04Z

[Term]
id: XCO:0000905
name: castor oil
def: "Any condition in which the main influencing factor is castor oil, a mixture of triglycerides obtained by pressing the seeds of the castor oil plant, Ricinus communis It is used as a cathartic and as a plasticizer." [CHEBI:140618, MESH:D002368]
synonym: "oil of Palma Christi" EXACT []
synonym: "Ricinus communis oil" EXACT []
synonym: "Ricinus oil" EXACT []
synonym: "tangantangan oil" EXACT []
xref: PMID:10023637
is_a: XCO:0000774 ! oil
created_by: slaulede
creation_date: 2021-10-12T18:50:59Z

[Term]
id: XCO:0000906
name: ovalbumin
def: "Any condition in which the main influencing factor is ovalbumin, the main protein found in egg white. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor." [https://en.wikipedia.org/wiki/Ovalbumin, ISBN-13:9780781733908]
synonym: "OVA" EXACT []
xref: https://en.wikipedia.org/wiki/Ovalbumin
is_a: XCO:0000193 ! peptide/protein
created_by: slaulede
creation_date: 2021-10-14T16:18:19Z

[Term]
id: XCO:0000907
name: liraglutide
def: "Any condition in which the main influencing factor is liraglutide, a lipopeptide that is an analogue of human GLP-1 and an agonist of the GLP-1 receptor. Liraglutide is used as a hypoglycemic agent and supplemental therapy in the treatment of diabetes mellitus." [CHEBI:71193, MESH:D000069450]
synonym: "NN-2211" EXACT []
synonym: "Saxenda" EXACT []
synonym: "Victoza" EXACT []
xref: PMID:29976929
is_a: XCO:0000135 ! receptor agonist
is_a: XCO:0000407 ! hypoglycemic agent
created_by: slaulede
creation_date: 2021-10-15T10:42:36Z

[Term]
id: XCO:0000908
name: potassium aluminium sulfate
def: "A condition in which the main influencing factor is a metal sulfate composed of potassium, aluminium and sulfate ions in the ratio 1:1:2." [CHEBI:86463]
synonym: "AlK(SO4)2" EXACT []
synonym: "alum" EXACT []
synonym: "aluminium potassium sulfate" EXACT []
synonym: "aluminum sulfate" EXACT []
synonym: "potassium alum" EXACT []
xref: CHEBI:26218
xref: MESH:C041524
is_a: XCO:0000909 ! potassium salt
created_by: slaulede
creation_date: 2021-10-21T15:54:45Z

[Term]
id: XCO:0000909
name: potassium salt
def: "A condition in which the main influencing factor is any alkali metal salt having potassium(1+) as the cation." [CHEBI:26218]
synonym: "Kaliumsalz" EXACT []
synonym: "potassium salts" EXACT []
xref: CHEBI:26218
is_a: XCO:0000150 ! potassium ion
created_by: slaulede
creation_date: 2021-10-21T16:00:13Z

[Term]
id: XCO:0000910
name: controlled dehydroepiandrosterone content diet
def: "A regimen of solid food in which the amount of dehydroepiandrosterone consumed is controlled." [PMID:9415976]
synonym: "controlled androstenolone content diet" EXACT []
synonym: "controlled DHEA content diet" EXACT []
xref: CHEBI:28689
xref: MESH:D003687
xref: PMID:9415976
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000865 ! dehydroepiandrosterone
created_by: slaulede
creation_date: 2021-10-25T15:20:22Z

[Term]
id: XCO:0000911
name: sodium bicarbonate
def: "A condition in which the main influencing factor is sodium bicarbonate, a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions." [MESH:D017693]
synonym: "baking soda" EXACT []
synonym: "bicarbonate of soda" EXACT []
synonym: "sodium hydrogen carbonate" EXACT []
synonym: "sodium hydrogencarbonate" EXACT []
xref: PMID:29168078
is_a: XCO:0000253 ! sodium ion
created_by: slaulede
creation_date: 2021-10-25T17:24:20Z

[Term]
id: XCO:0000912
name: controlled exposure to red light
def: "Condition in which the environmental level and/or time of exposure to red light (wavelength range of 630–740 nm) is controlled." [https://en.wikipedia.org/wiki/Red]
xref: PMID:28341233
is_a: XCO:0000284 ! controlled visible light exposure
created_by: slaulede
creation_date: 2021-10-26T18:33:13Z

[Term]
id: XCO:0000913
name: ethosuximide
def: "Any condition in which the main influencing factor is ethosuximide, a dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. Ethosuximide is an antiepileptic used in the treatment of absence seizures and potentially myoclonic seizures, but is ineffective against tonic-clonic seizures." [CHEBI:4887]
synonym: "3-ethyl-3-methylpyrrolidine-2,5-dione" EXACT []
synonym: "Zarontin" EXACT []
xref: MESH:D005013
xref: PMID:30408474
is_a: XCO:0000269 ! calcium channel inhibitor
created_by: slaulede
creation_date: 2021-10-29T11:04:35Z

[Term]
id: XCO:0000914
name: cafeteria diet
def: "A dietary regimen in which access to food is unlimited and consists of energy-dense, highly palatable food. The diet is technically undefined as to ratio of components, but recapitulates the orosensory properties (such as smell and texture) and palatability of foodstuffs that promote overconsumption (voluntary hyperphagia). It has been proven to not only increase body weight and induce obesity, but to also cause metabolic syndrome, severe diabetic symptoms, liver inflammation, and other metabolic dysregulations." [PMID:33309818]
synonym: "junk food diet" EXACT []
synonym: "supermarket diet" EXACT []
synonym: "Western diet" EXACT []
is_a: XCO:0000019 ! solid diet
created_by: slaulede
creation_date: 2021-10-29T14:53:10Z

[Term]
id: XCO:0000915
name: controlled ethanol content drinking water used as vehicle
def: "Any condition in which the main influencing factor is a drink made up of water and a specified amount of ethanol, serving as a control condition for some chemical delivered in ethanol and drinking water." [https://www.merriam-webster.com/]
xref: PMID30621358
is_a: XCO:0000023 ! controlled ethanol content drinking water
is_a: XCO:0000325 ! ethanol
created_by: slaulede
creation_date: 2021-11-01T12:46:32Z

[Term]
id: XCO:0000916
name: gelled diet
def: "This is a regimen of semisolid food in which the amount of solid elements and water in the diet are controlled. The diet resembles jelly in consistency and is about 62.5% H2O, 37.5% synthetic food (Ziegler Bros., formula 53140000),0.3% NaCl, and 0.3% agar wt/wt." [PMID:12684228]
synonym: "gel-agar diet" RELATED []
synonym: "gel diet" EXACT []
synonym: "semisolid diet" RELATED []
is_a: XCO:0000013 ! diet
created_by: slaulede
creation_date: 2021-11-30T17:49:55Z

[Term]
id: XCO:0000917
name: distilled water
def: "The clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), purified by successive evaporation and condensation. It is experimentally provided for hydration or as a vehicle control for some dissolved substance." [https://www.merriam-webster.com/, ISBN-13:9780781733908]
synonym: "clarified water" RELATED []
synonym: "distilled H2O" EXACT []
synonym: "purified water" RELATED []
xref: PMID:12684228
is_a: XCO:0000021 ! water
created_by: slaulede
creation_date: 2021-11-30T18:14:19Z

[Term]
id: XCO:0000918
name: ambient air
def: "A condition in which the major influencing factor is atmospheric air in its natural state. The composition of ambient air varies depending on the elevation above sea level, but is typically 78% nitrogen and 21% oxygen." [https://www.thermofisher.com]
synonym: "atmospheric air" EXACT []
synonym: "room air" EXACT []
is_a: XCO:0000099 ! control condition
created_by: slaulede
creation_date: 2021-12-07T15:31:29Z

[Term]
id: XCO:0000919
name: N-nitroso-N-methyl-4-aminobutyric acid
def: "A nitrosamine that has methyl and 3-carboxypropyl substituents. It is a tobacco-derived nitrosamino acid that is a known animal and potential human carcinogen. It induces bladder transitional cell carcinomas in rats and has recently been identified as a contaminant in certain blood pressure medications." [CHEBI:176579]
synonym: "4-[methyl(nitroso)amino]butanoic acid" EXACT []
synonym: "NMBA" EXACT []
synonym: "N-nitrosomethylaminobutyric acid" EXACT []
synonym: "N-nitrosomethylbenzylamine" EXACT []
xref: PMID:32123074
xref: pubchem.compound:13643
is_a: XCO:0000089 ! neoplasm-inducing chemical
created_by: slaulede
creation_date: 2022-02-03T13:23:56Z

[Term]
id: XCO:0000920
name: controlled mineral content diet
def: "A regimen of solid food in which the amount of an inorganic element or compound containing a metal, nonmetal, radical, or phosphate that is needed for proper body function and maintenance of health, is controlled." [https://www.merriam-webster.com, ISBN-13:9780781733908]
xref: PMID:32123074
is_a: XCO:0000014 ! controlled content diet
created_by: slaulede
creation_date: 2022-02-03T13:41:46Z

[Term]
id: XCO:0000921
name: controlled zinc content diet
def: "A regimen of solid food in which the amount of zinc is controlled." [https://www.merriam-webster.com, ISBN-13:9780781733908]
synonym: "controlled Zn content diet" EXACT []
is_a: XCO:0000920 ! controlled mineral content diet
created_by: slaulede
creation_date: 2022-02-03T13:49:41Z

[Term]
id: XCO:0000922
name: semaxanib
def: "An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has been used to produce pulmonary arterial hypertension in animal models." [CHEBI:91083]
synonym: "(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one" EXACT []
synonym: "SU" EXACT []
synonym: "SU 5416" EXACT []
synonym: "SU5416" EXACT []
xref: PMID:24113457
is_a: XCO:0000160 ! receptor antagonist
is_a: XCO:0000259 ! disease-inducing chemical
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2022-02-03T14:10:08Z

[Term]
id: XCO:0000923
name: isolated lung perfusion with Hespan buffer
def: "This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with Hespan buffer, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle." [PMID:10155362, PMID:7818325]
synonym: "isolated lung perfusion with HB" EXACT []
xref: PMID:7818325
is_a: XCO:0000875 ! isolated lung perfusion
is_a: XCO:0000877 ! Hespan buffer
created_by: slaulede
creation_date: 2022-02-08T16:35:19Z

[Term]
id: XCO:0000924
name: isolated lung perfusion with floxuridine
def: "This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with a solution containing floxuridine, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle." [ISBN-13:9780781733908, PMID:7818325]
synonym: "isolated lung perfusion with FUDR" EXACT []
synonym: "PMID:7818325" EXACT []
is_a: XCO:0000875 ! isolated lung perfusion
is_a: XCO:0000876 ! floxuridine
created_by: slaulede
creation_date: 2022-02-08T16:41:10Z

[Term]
id: XCO:0000925
name: bumetanide
def: "Bumetanide is a member of the class of benzoic acids, and a diuretic used for treatment of edema associated with congestive heart failure, hepatic and renal disease." [CHEBI:3213]
synonym: "3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic aci" EXACT []
synonym: "Bumex" EXACT []
synonym: "Burinex" EXACT []
xref: MESH:D002034
xref: PMID:30385718
is_a: XCO:0000122 ! diuretic
created_by: slaulede
creation_date: 2022-03-01T17:38:17Z

[Term]
id: XCO:0000926
name: polyethylene glycol
def: "This is a is a polyether compound, composed of repeating ethyleneoxy units, derived from petroleum with many applications, including medical uses like in the composition of some laxatives." [CHEBI:46793, https://en.wikipedia.org/wiki/Polyethylene_glycol]
synonym: "PEG" EXACT []
synonym: "PEO" EXACT []
synonym: "POE" EXACT []
synonym: "poly(ethylene oxide)" EXACT []
synonym: "poly(oxyethylene)" EXACT []
synonym: "polyethylene oxide" EXACT []
synonym: "polyoxyethylene" EXACT []
xref: PMID:32084371
is_a: XCO:0000927 ! hydroxypolyether
created_by: slaulede
creation_date: 2022-03-07T11:51:41Z

[Term]
id: XCO:0000927
name: hydroxypolyether
def: "A hydroxyether compound containing more than one ether group." [CHEBI:46789]
xref: PMID:32084371
is_a: XCO:0000342 ! chemical with specified structure
created_by: slaulede
creation_date: 2022-03-07T11:58:38Z

[Term]
id: XCO:0000928
name: ColonLYTELY
def: "This is a colonoscopy prep composed of 5.9% Macrogol 3350 (polyethylene glycol) and electrolytes." [https://www.colonprep.com.au]
synonym: "Macrogol 3350" NARROW []
relationship: has_component XCO:0000926 ! polyethylene glycol
created_by: slaulede
creation_date: 2022-03-07T12:43:59Z

[Term]
id: XCO:0000929
name: controlled ColonLYTELY content drinking water
def: "Thia is a drink made up of water and a specified amount of ColonLYTELY (5.9% Macrogol 3350 solution) in which the amount of ColonLYTELY consumed is maintained at a specified level." [https://www.colonprep.com.au, PMID:32084371]
synonym: "controlled Macrogol 3350 content drinking water" NARROW []
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000928 ! ColonLYTELY
created_by: slaulede
creation_date: 2022-03-07T12:52:46Z

[Term]
id: XCO:0000930
name: renal denervation
def: "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
synonym: "denervation of kidneys" EXACT []
synonym: "RDN" EXACT []
synonym: "surgical denervation of kidneys" EXACT []
xref: PMID:15894899
is_a: XCO:0000373 ! surgical denervation
created_by: slaulede
creation_date: 2022-04-26T15:38:47Z

[Term]
id: XCO:0000931
name: celiac artery and superior mesenteric artery constriction
def: "This is any condition in which the main influencing factor is surgical narrowing of the lumen of the celiac artery and superior mesenteric artery." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
xref: PMID:15894899
is_a: XCO:0000596 ! blood vessel constriction
created_by: slaulede
creation_date: 2022-04-26T16:02:24Z

[Term]
id: XCO:0000932
name: vasopressin
def: "This is a family of cyclic nonapeptide hormones found in most mammals. Synthesized in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Vasopressin acts as a vasoconstrictor to increase blood pressure, blood volume, and water reabsorption by the renal collecting ducts." [CHEBI:9937, MESH:D014667]
synonym: "ADH" EXACT []
synonym: "antidiuretic hormone" EXACT []
synonym: "AVP" EXACT []
is_a: XCO:0000228 ! peptide hormone
created_by: slaulede
creation_date: 2022-04-26T16:45:16Z

[Term]
id: XCO:0000933
name: argipressin
def: "This molecule is the predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6." [CHEBI:34543, MESH:D001127]
synonym: "Arg8-vasopressin" EXACT []
synonym: "arginine vasopressin" EXACT []
synonym: "arg-vasopressin" EXACT []
is_a: XCO:0000932 ! vasopressin
created_by: slaulede
creation_date: 2022-04-26T16:50:12Z

[Term]
id: XCO:0000934
name: bilateral renal denervation
def: "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and both kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
synonym: "denervation of both kidneys" EXACT []
xref: PMID:15894899
is_a: XCO:0000930 ! renal denervation
created_by: slaulede
creation_date: 2022-04-28T16:36:07Z

[Term]
id: XCO:0000935
name: unilateral renal denervation
def: "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and only one kidney, left or right. It is followed by painting of the renal blood vessels with a solution of 10% phenol." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
synonym: "denervation of a single kidney" EXACT []
xref: PMID:15894899
is_a: XCO:0000930 ! renal denervation
created_by: slaulede
creation_date: 2022-04-28T16:39:29Z

[Term]
id: XCO:0000936
name: left kidney denervation
def: "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the left side of the body. It is followed by painting of the left side renal blood vessels with a solution of 10% phenol." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
synonym: "left side renal denervation" EXACT []
xref: PMID:15894899
is_a: XCO:0000935 ! unilateral renal denervation
created_by: slaulede
creation_date: 2022-04-28T16:47:06Z

[Term]
id: XCO:0000937
name: right kidney denervation
def: "This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the right side of the body. It is followed by painting of the right side renal blood vessels with a solution of 10% phenol." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
synonym: "right side renal denervation" EXACT []
xref: PMID:15894899
is_a: XCO:0000935 ! unilateral renal denervation
created_by: slaulede
creation_date: 2022-04-28T16:51:47Z

[Term]
id: XCO:0000938
name: bovine serum albumin
def: "This is a serum albumin protein derived from cow blood. It is used as an enzyme-stabilizing agent, a blocking reagent, etc. for laboratory experiments." [https://en.wikipedia.org/wiki/Bovine_serum_albumin, ISBN-13:978-0781733908]
synonym: "BSA" EXACT []
synonym: "Fraction V" EXACT []
synonym: "https://en.wikipedia.org/wiki/Bovine_serum_albumin" EXACT []
xref: PMID:15894899
is_a: XCO:0000193 ! peptide/protein
created_by: slaulede
creation_date: 2022-04-28T17:42:46Z

[Term]
id: XCO:0000939
name: JTT-608
def: "This is a hypoglycemic drug which enhances glucose-stimulated insulin secretion." [PMID:10323602]
synonym: "4-(4beta-Methylcyclohexane-1-yl)-4-oxobutanoic acid" EXACT []
synonym: "4-(4-Methylcyclohexyl)-4-oxobutanoic acid" EXACT []
synonym: "Cyclohexanebutanoic acid, 4-methyl-gamma-oxo-, trans-" EXACT []
synonym: "trans&#8201;-&#8201;4&#8201;-&#8201;(4&#8201;-&#8201;methylcyclohexyl)&#8201;-&#8201;4&#8201;-&#8201;oxobutyric acid" EXACT []
is_a: XCO:0000251 ! secretagogue
is_a: XCO:0000407 ! hypoglycemic agent
created_by: slaulede
creation_date: 2022-05-02T16:49:07Z

[Term]
id: XCO:0000940
name: controlled ex vivo pancreas condition
def: "This is an experimental condition in which the internal or external environment of a pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
xref: PMID:10323602
is_a: XCO:0000464 ! controlled ex vivo organ condition
created_by: slaulede
creation_date: 2022-05-05T16:23:16Z

[Term]
id: XCO:0000941
name: controlled ex vivo pancreas perfusion
def: "This is an experimental condition consisting of perfusion of the isolated pancreas with some physiological buffer (consisting of controlled solute composition and specific flow rate) in through the celiac artery and out through a portal vein." [https://www.merriam-webster.com/, ISBN-13:978-0781733908]
xref: PMID:10323602
xref: PMID:1097860
is_a: XCO:0000940 ! controlled ex vivo pancreas condition
created_by: slaulede
creation_date: 2022-05-05T16:44:35Z

[Term]
id: XCO:0000942
name: controlled saxagliptin content diet
def: "A solid diet in which the amount of saxagliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, is maintained at a specified level." [https://en.wikipedia.org/wiki/Saxagliptin, https://www.merriam-webster.com/]
synonym: "controlled 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate content diet" EXACT []
synonym: "controlled Onglyza content diet" EXACT []
xref: CHEBI:71272
xref: MESH:C502994
is_a: XCO:0000014 ! controlled content diet
is_a: XCO:0000632 ! saxagliptin
created_by: slaulede
creation_date: 2022-05-27T17:31:25Z

[Term]
id: XCO:0000943
name: controlled glucosamine content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine in which the amount of glucosamine consumed is maintained at a specified level." [https://www.merriam-webster.com/]
synonym: "controlled 2-amino-2-deoxyglucose content drinking water" EXACT []
xref: CHEBI:5417
xref: PMID:22446865
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000557 ! glucosamine
created_by: slaulede
creation_date: 2022-06-03T16:16:44Z

[Term]
id: XCO:0000944
name: controlled alendronate content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of alendronate in which the amount of alendronate consumed is maintained at a specified level." [http://en.wikipedia.org/wiki/Alendronic_acid, https://www.merriam-webster.com/]
synonym: "controlled alendronic acid content drinking water" RELATED []
synonym: "controlled Fosamax content drinking water" EXACT []
synonym: "controlled sodium alendronate content drinking water" EXACT []
xref: PMID:22446865
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000474 ! alendronate
created_by: slaulede
creation_date: 2022-06-03T16:38:25Z

[Term]
id: XCO:0000945
name: controlled taxifolin content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of taxifolin in which the amount of taxifolin consumed is maintained at a specified level." [https://en.wikipedia.org/wiki/Taxifolin, https://www.merriam-webster.com/]
synonym: "controlled catechin hydrate content drinking water" EXACT []
synonym: "controlled DHQ content drinking water" EXACT []
synonym: "controlled dihydroquercetin content drinking water" EXACT []
xref: CHEBI:38747
xref: PMID:22446865
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000558 ! taxifolin
created_by: slaulede
creation_date: 2022-06-03T16:45:16Z

[Term]
id: XCO:0000946
name: midafotel
def: "This is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and originally designed as a potential therapy for excitotoxicity, epilepsy or neuropathic pain." [CHEBI:180900, https://en.wikipedia.org/wiki/Midafotel]
synonym: "(2R4-[(2E)-3-phosphonoprop-2-en-1-yl]piperazine-2-carboxylic acid" EXACT []
synonym: "CPPene" EXACT []
synonym: "D-Cpp-ene" EXACT []
synonym: "SDZ EAA 494" EXACT []
xref: PMID:32507787
xref: pubchem.compound:6435801
is_a: XCO:0000947 ! NMDA receptor antagonist
created_by: slaulede
creation_date: 2022-06-09T14:54:14Z

[Term]
id: XCO:0000947
name: NMDA receptor antagonist
def: "This is a condition in which the main influencing factor is a drug or agent that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs." [CHEBI:60643]
synonym: "NMDAR antagonist" EXACT []
synonym: "N-methyl-D-aspartate receptor antagonist" EXACT []
xref: PMID:32507787
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000160 ! receptor antagonist
created_by: slaulede
creation_date: 2022-06-09T15:08:40Z

[Term]
id: XCO:0000948
name: Ro 25-6981
def: "This is a condition in which the main influencing factor is a member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor." []
synonym: "4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol" EXACT []
xref: MESH:C109643
xref: PMID:32507787
is_a: XCO:0000947 ! NMDA receptor antagonist
created_by: slaulede
creation_date: 2022-06-09T15:23:24Z

[Term]
id: XCO:0000949
name: PPDA
def: "This is a condition in which the main influencing factor is PPDA, a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (NR2C/NR2D) containing receptors." [CHEBI:189866]
synonym: "(2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid" EXACT []
synonym: "cis-piperidine dicarboxylic acid" EXACT []
synonym: "Cis-PPDA" EXACT []
xref: CAS:684283-16-7
xref: PMID:32507787
is_a: XCO:0000947 ! NMDA receptor antagonist
created_by: slaulede
creation_date: 2022-06-09T15:28:58Z

[Term]
id: XCO:0000950
name: anticonvulsant
def: "This is a condition in which the main influencing factor is a drug or agent used to prevent seizures or reduce their severity. Anticonvulsants suppress the excessive rapid firing of neurons during seizures and prevent the spread of the seizure within the brain." [CHEBI:35623, https://en.wikipedia.org/wiki/Anticonvulsant]
synonym: "antiepileptic" EXACT []
synonym: "antiepileptic drug" EXACT []
synonym: "antiseizure drug" EXACT []
xref: MESH:D000927
xref: PMID:32507787
is_a: XCO:0000341 ! chemical with specified function
created_by: slaulede
creation_date: 2022-06-09T15:44:11Z

[Term]
id: XCO:0000951
name: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
def: "This is a condition in which the main influencing factor is an AMPA and KA receptor antagonist and a neuroprotectant for cerebral ischemia." [MESH:C062865, PMID:32507787]
synonym: "6-nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione" EXACT []
synonym: "NBQX" EXACT []
xref: CAS:118876-58-7
xref: CHEBI:31073
is_a: XCO:0000160 ! receptor antagonist
is_a: XCO:0000950 ! anticonvulsant
created_by: slaulede
creation_date: 2022-06-09T15:57:30Z

[Term]
id: XCO:0000952
name: controlled perindopril content drinking water
def: "This is a condition in which the main influencing factor is a drink made up of water and a specified amount of perindopril consumed by an organism as part of an experiment. Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE." [https://www.drugbank.ca/drugs/DB00790, https://www.merriam-webster.com/]
synonym: "controlled Aceon content drinking water" EXACT []
synonym: "controlled Coversum content drinking water" EXACT []
synonym: "controlled Coversyl content drinking water" EXACT []
xref: CHEBI:8024
xref: MESH:D020913
xref: PMID:12376396
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0000588 ! perindopril
created_by: slaulede
creation_date: 2022-06-10T15:10:29Z

[Term]
id: XCO:0000953
name: controlled reserpine content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of reserpine consumed by an organism as part of an experiment. Reserpine is an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2, and has been used as both an antihypertensive drug and an antipsychotic drug." [https://en.wikipedia.org/wiki/Reserpine, https://www.drugbank.ca/drugs/DB00206]
synonym: "controlled Serpasil content drinking water" EXACT []
xref: CHEBI:28487
xref: PMID:21107278
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000550 ! reserpine
created_by: slaulede
creation_date: 2022-06-10T16:51:15Z

[Term]
id: XCO:0000954
name: glucosamine - alendronate
def: "This is a condition in which the main influencing factor is an aqueous mix of glucosamine and alendronic acid (the acid form of alendronate), two chemicals used to promote bone health." [PMID:22446865]
synonym: "GA" EXACT []
synonym: "glucosamine alendronate" EXACT []
xref: CHEBI:50647
xref: CHEBI:5417
relationship: has_component XCO:0000474 ! alendronate
relationship: has_component XCO:0000557 ! glucosamine
created_by: slaulede
creation_date: 2022-06-16T17:17:55Z

[Term]
id: XCO:0000955
name: controlled glucosamine - alendronate content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine - alendronate in which the amount of glucosamine - alendronate consumed is maintained at a specified level." [https://www.merriam-webster.com/, PMID:22446865]
synonym: "CHEBI:50647" EXACT []
synonym: "CHEBI:5417" EXACT []
synonym: "controlled GA content drinking water" EXACT []
synonym: "controlled glucosamine alendronate content drinking water" EXACT []
is_a: XCO:0000943 ! controlled glucosamine content drinking water
is_a: XCO:0000944 ! controlled alendronate content drinking water
created_by: slaulede
creation_date: 2022-06-16T17:23:21Z

[Term]
id: XCO:0000956
name: artificial cerebrospinal fluid with 0.14 M sodium
def: "This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.14 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid." [https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid, PMID:15458950]
synonym: "aCSF with 0.14 M Na+" EXACT []
synonym: "aCSF with 0.14 M sodium" EXACT []
synonym: "artificial cerebrospinal fluid with 0.14 M Na+" EXACT []
xref: PMID:15458950
is_a: XCO:0000830 ! artificial cerebrospinal fluid
created_by: slaulede
creation_date: 2022-06-30T16:30:19Z

[Term]
id: XCO:0000957
name: artificial cerebrospinal fluid with 0.15 M sodium
def: "This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.15 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid." [https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid, PMID:15458950]
synonym: "aCSF with 0.15 M Na+" EXACT []
synonym: "aCSF with 0.15 M sodium" EXACT []
synonym: "artificial cerebrospinal fluid with 0.15 M Na+" EXACT []
xref: PMID:15458950
is_a: XCO:0000830 ! artificial cerebrospinal fluid
created_by: slaulede
creation_date: 2022-06-30T17:02:45Z

[Term]
id: XCO:0000958
name: artificial cerebrospinal fluid with 0.16 M sodium
def: "This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.16 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid." [https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid, PMID:15458950]
synonym: "aCSF with 0.16 M Na+" EXACT []
synonym: "aCSF with 0.16 M sodium" EXACT []
synonym: "artificial cerebrospinal fluid with 0.16 M Na+" EXACT []
xref: PMID:15458950
is_a: XCO:0000830 ! artificial cerebrospinal fluid
created_by: slaulede
creation_date: 2022-06-30T17:07:23Z

[Term]
id: XCO:0000959
name: Guanabenz
def: "This is any condition in which the main influencing factor is a dichlorobenzene derivative that is a cell-permeable &#945;2-adrenoceptor agonist used as an antihypertensive agent." [CHEBI:5553, MESH:D006143]
synonym: "2,6-Dichlorobenzylideneaminoguanidine" EXACT []
synonym: "Guanabenz" EXACT []
xref: PMID:15458950
is_a: XCO:0000673 ! alpha-adrenergic agonist
is_a: XCO:0000863 ! antihypertensive agent
created_by: slaulede
creation_date: 2022-07-11T17:40:30Z

[Term]
id: XCO:0000960
name: 10% CO2, 20% O2, 70% N2
def: "This is a condition in which the level of carbon dioxide (10%), oxygen (20%), and nitrogen (70%) in the air surrounding the organism or breathed by the organism is controlled as part of the experiment." [https://www.merriam-webster.com/, PMID:21421817]
xref: PMID:21421817
is_a: XCO:0000010 ! air oxygen content
is_a: XCO:0000012 ! air carbon dioxide content
created_by: slaulede
creation_date: 2022-07-18T18:12:29Z

[Term]
id: XCO:0000961
name: controlled ex vivo heart condition
def: "This is an experimental condition in which the internal or external environment of a heart is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body." [https://www.merriam-webster.com, ISBN-13:978-0781733908]
synonym: "controlled isolated heart condition" EXACT []
is_a: XCO:0000464 ! controlled ex vivo organ condition
created_by: slaulede
creation_date: 2022-10-10T11:29:50Z

[Term]
id: XCO:0000962
name: controlled ex vivo heart perfusion
def: "This is an experimental condition consisting of perfusion (retrograde or forward) of the isolated heart with some physiological buffer (consisting of controlled solute composition and specific flow rate) through the aorta. In retrograde perfusion the backwards pressure causes the aortic valve to shut, forcing the solution into the coronary vessels, which normally supply the heart tissue with blood." [https://www.harvardapparatus.com/physiology/isolated-organ-perfusion-studies/isolated-heart-perfusion-systems.html, https://www.merriam-webster.com]
synonym: "biventricular working heart perfusion" NARROW []
synonym: "Langendorff heart perfusion" NARROW []
synonym: "working (ejecting) heart perfusion" NARROW []
is_a: XCO:0000961 ! controlled ex vivo heart condition
created_by: slaulede
creation_date: 2022-10-10T12:35:44Z

[Term]
id: XCO:0000963
name: controlled NG-nitroarginine methyl ester content in acidified drinking water
def: "This is a drink made up of acidified water (pH 2.4-2.8) and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment." [ISBN-13:978-0781733908, MESH:D019331]
synonym: "controlled L-NAME content in acidified drinking water" EXACT []
is_a: XCO:0000285 ! controlled NG-nitroarginine methyl ester content drinking water
created_by: slaulede
creation_date: 2022-10-18T11:24:31Z

[Term]
id: XCO:0000964
name: perfluorooctanoic acid
def: "This is is perfluorinated octanoic acid, a fluoroalkanoic acid." [CHEBI:35549]
synonym: "pentadecafluorooctanoic acid" EXACT []
xref: MESH:C023036
is_a: XCO:0000089 ! neoplasm-inducing chemical
is_a: XCO:0000757 ! surfactant
created_by: slaulede
creation_date: 2023-02-14T11:34:01Z

[Term]
id: XCO:0000965
name: controlled in vitro cell condition
def: "This is any experimental condition in which cells derived from a multicellular organism are cultured and experimentally manipulated or regulated, for example through drug treatment or nutrient availability, in an artificial environment outside the living body." [https://www.merriam-webster.com, ISBN-13:978-0781733908]
synonym: "controlled petri dish condition" EXACT []
synonym: "controlled test tube condition" EXACT []
is_a: XCO:0000000 ! experimental condition
created_by: slaulede
creation_date: 2023-02-14T12:04:36Z

[Term]
id: XCO:0000966
name: controlled serum-free condition
def: "This is any experimental condition in which cultured cells are grown in a defined medium without added animal serum." [https://www.merriam-webster.com, ISBN-13:978-0781733908]
synonym: "condition of growth medium without serum" EXACT []
synonym: "serum starvation" EXACT []
is_a: XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-02-14T12:17:04Z

[Term]
id: XCO:0000967
name: gastric bypass
def: "This is is a type of weight-loss surgery that involves creating a small pouch from the stomach and connecting the newly created pouch directly to the small intestine. After gastric bypass, swallowed food will go into this small pouch of stomach and then directly into the small intestine, thereby bypassing most of the stomach and the first section of the small intestine." [https://www.mayoclinic.org/tests-procedures/gastric-bypass-surgery/about/pac-20385189, https://www.merriam-webster.com]
synonym: "gastric bypass surgery" EXACT []
synonym: "Roux-en-Y gastric bypass" EXACT []
synonym: "Roux-en-Y gastric bypass surgery" EXACT []
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2023-02-27T18:10:08Z

[Term]
id: XCO:0000968
name: experimental traumatic brain injury
def: "This is a condition induced by an experimental surgical procedure involving fluid percussion, cortical impact, or weight drop/impact acceleration to produce controlled injury to the surface of the brain." [PMID:21876530]
synonym: "experimental TBI" EXACT []
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2023-02-27T18:45:54Z

[Term]
id: XCO:0000969
name: lateral fluid percussion injury
def: "This is an experimental injury condition produced by a pendulum-and-piston-based device applying a brief fluid pressure pulse onto the intact dura after performing a craniectomy on the head of the subject." [PMID:19022291, PMID:21876530]
synonym: "lateral fluid-percussion injury" EXACT []
synonym: "LFPI" EXACT []
synonym: "parasagittal fluid percussion injury" EXACT []
is_a: XCO:0000968 ! experimental traumatic brain injury
created_by: slaulede
creation_date: 2023-03-02T13:40:02Z

[Term]
id: XCO:0000970
name: protein kinase inhibitor
def: "This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a protein kinase inhibitor. A protein kinase is an enzyme that regulates the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein." [https://en.wikipedia.org/wiki/Protein_kinase, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/protein-kinases]
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2023-03-02T14:39:02Z

[Term]
id: XCO:0000971
name: SB525334
def: "This is any condition in which the main influencing factor is the chemical SB525334, which decreases or interferes with the activity of the serine/threonine protein kinase Alk5 (activin receptor-like kinase-5)." [RGD:733386]
synonym: "6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline" EXACT []
synonym: "SB 525334" EXACT []
synonym: "TGF- beta RI Kinase Inhibitor VIII" EXACT []
is_a: XCO:0000970 ! protein kinase inhibitor
created_by: slaulede
creation_date: 2023-03-02T14:58:14Z

[Term]
id: XCO:0000972
name: nintedanib
def: "This is any condition in which the main influencing factor is the chemical nintedanib, a member of the class of oxindoles that is a multi-kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and cancer." [CHEBI:85164]
synonym: "(Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate" EXACT []
synonym: "Intedanib" EXACT []
synonym: "methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate" EXACT []
synonym: "Ofev" EXACT []
synonym: "Vargatef" EXACT []
xref: MESH:C530716
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000970 ! protein kinase inhibitor
created_by: slaulede
creation_date: 2023-03-02T15:05:33Z

[Term]
id: XCO:0000973
name: sorafenib
def: "This is any condition in which the main influencing factor is the chemical sorafenib, a member of the class of phenylureas that are multi-kinase inhibitors and anti-neoplastic agents." [CHEBI:50924]
synonym: "4-(4-(3-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)-N-METHYLPICOLINAMIDE" EXACT []
synonym: "4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide" EXACT []
synonym: "BAY 43-9006" EXACT []
synonym: "Nexavar" EXACT []
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000970 ! protein kinase inhibitor
created_by: slaulede
creation_date: 2023-03-02T15:15:18Z

[Term]
id: XCO:0000974
name: bile duct ligation
def: "This is a condition in which the main influencing factor is a surgical procedure causing blockage of the bile duct, which leads to acute obstructive jaundice and eventually to liver fibrosis." [https://www.sciencedirect.com/topics/medicine-and-dentistry/bile-duct-ligation]
synonym: "CBDL" EXACT []
synonym: "common bile duct ligation" EXACT []
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2023-03-02T15:29:13Z

[Term]
id: XCO:0000975
name: carbon tetrachloride
def: "This chlorocarbon is methane in which all the hydrogens have been replaced by chloro groups. It is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds." [CHEBI:27385, MESH:D002251]
synonym: "CCl4" EXACT []
synonym: "tetrachloromethane" EXACT []
xref: CHEBI:27385
xref: MESH:D002251
is_a: XCO:0000240 ! toxin
created_by: slaulede
creation_date: 2023-03-06T12:33:48Z

[Term]
id: XCO:0000976
name: trichlorethylene
def: "This is a chloroethene that is ethene substituted by chlorides at positions 1, 1 and 2. It is a highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent." [CHEBI:16602, MESH:D014241]
synonym: "1,1,2-trichloroethene" EXACT []
synonym: "trichloroethene" EXACT []
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000276 ! hydrocarbon
created_by: slaulede
creation_date: 2023-03-06T13:54:06Z

[Term]
id: XCO:0000977
name: supplemented Williams' E Medium
def: "This is any experimental condition in which cells derived from a multicellular organism are cultured in medium enriched in amino acids, glucose, and other unique ingredients and supplemented with dexamethasone, penicillin/streptomycin, ITS+, GlutaMAX and HEPES; Gibco #CM4000. William's E Medium was originally developed by Williams and Gunn as reduced serum-supplemented medium for long-term cell cultures of adult rat liver epithelial cells." [https://www.thermofisher.com/order/catalog/product/12551032, PMID:31501904]
synonym: "supplemented William’s E Medium" EXACT []
xref: PMID:31501904
is_a: XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-03-06T14:19:01Z

[Term]
id: XCO:0000978
name: acetyl-L-carnitine
def: "This is any condition in which the main influencing factor is an acetylated form of L-carnitine. It is naturally produced by the human body, and it is available as a dietary supplement. Acetyl-L-carnitine is broken down in the blood by plasma esterases to carnitine which is used by the body to transport fatty acids into the mitochondria for breakdown." [https://en.wikipedia.org/wiki/Acetylcarnitine]
synonym: "acetylcarnitine" EXACT []
synonym: "ALC" EXACT []
synonym: "ALCAR" EXACT []
synonym: "LAC" EXACT []
synonym: "L-ACETYLCARNITINE" EXACT []
synonym: "L-acetyl-carnitine" EXACT []
synonym: "O-Acetyl-L-carnitine" EXACT []
xref: CHEBI:57589
xref: MESH:D000108
is_a: XCO:0000561 ! antidepressant
created_by: slaulede
creation_date: 2023-03-09T13:05:38Z

[Term]
id: XCO:0000979
name: controlled acetyl-L-carnitine content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of acetyl-L-carnitine in which the amount of acetyl-L-carnitine consumed is maintained at a specified level." [https://www.merriam-webster.com, ISBN-13:978-0781733908]
synonym: "controlled acetylcarnitine content drinking water" EXACT []
synonym: "controlled ALCAR content drinking water" EXACT []
synonym: "controlled ALC content drinking water" EXACT []
synonym: "controlled LAC content drinking water" EXACT []
synonym: "controlled L-acetyl-carnitine content drinking water" EXACT []
synonym: "controlled L-ACETYLCARNITINE L-ACETYLCARNITINE content drinking water" EXACT []
synonym: "controlled O-Acetyl-L-carnitine content drinking water" EXACT []
xref: CHEBI:57589
xref: MESH:D000108
is_a: XCO:0000163 ! controlled content drinking water
is_a: XCO:0000978 ! acetyl-L-carnitine
created_by: slaulede
creation_date: 2023-03-09T13:19:08Z

[Term]
id: XCO:0000980
name: controlled content gelled diet
def: "This is an experimental regimen of gelled food in which the amount of solid elements, water, and some other component(s) in the diet are controlled." [https://www.merriam-webster.com, PMID:12684228]
synonym: "controlled content gel-agar diet" RELATED []
synonym: "controlled content gel diet" EXACT []
synonym: "controlled content semisolid diet" RELATED []
is_a: XCO:0000916 ! gelled diet
created_by: slaulede
creation_date: 2023-03-09T13:43:10Z

[Term]
id: XCO:0000981
name: controlled lithium chloride content gelled diet
def: "This is an experimental regimen of gelled food in which the amount of solid elements, water, and lithium chloride in the diet are controlled." [PMID:12684228, PMID:31146973]
synonym: "controlled LiCl content gelled diet" EXACT []
is_a: XCO:0000980 ! controlled content gelled diet
created_by: slaulede
creation_date: 2023-03-09T13:47:41Z

[Term]
id: XCO:0000982
name: gene transfer using lentivirus vector
def: "This is a condition in which gene transfer has been performed using a lentivirus as the carrier of the genetic material. Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. Lentiviruses are distributed worldwide, and are known to be hosted in apes, cows, goats, horses, cats, and sheep as well as several other mammals." [https://en.wikipedia.org/wiki/Lentivirus, ISBN-13:978-0781733908]
synonym: "lentiviral gene transfer" EXACT []
synonym: "lentivirus transfer" EXACT []
is_a: XCO:0000528 ! gene transfer
created_by: slaulede
creation_date: 2023-03-13T13:28:54Z

[Term]
id: XCO:0000983
name: gene transfer of the EGFP gene using a lentivirus vector
def: "This is a condition in which the enhanced green fluorescent protein (EGFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EGFP in the recipient cell or organism." [https://www.merriam-webster.com, PMID:28241067]
synonym: "gene transduction of the enhanced green fluorescent protein gene using a lentivirus vector" EXACT []
synonym: "gene transfer of the eGFP gene using a lentivirus vector" EXACT []
synonym: "gene transfer of the enhanced green fluorescent protein gene using a lentivirus vector" EXACT []
synonym: "lentiviral transfer of the EGFP gene" EXACT []
synonym: "transduction of recombinant lentivirus containing the EGFP gene" EXACT []
synonym: "transfer of recombinant lentivirus containing the EGFP gene" EXACT []
is_a: XCO:0000982 ! gene transfer using lentivirus vector
created_by: slaulede
creation_date: 2023-03-13T13:41:04Z

[Term]
id: XCO:0000984
name: gene transfer of the rat wild type Ccny gene using a lentivirus vector
def: "This is a condition in which the rat wild type cyclin Y gene (Ccny) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of rat cyclin Y in the recipient cell or organism." [PMID:26220330]
synonym: "lentiviral transfer of the rat wild type Ccny gene" EXACT []
synonym: "transfer of recombinant lentivirus containing the rat wild type Ccny gene" EXACT []
is_a: XCO:0000982 ! gene transfer using lentivirus vector
created_by: slaulede
creation_date: 2023-03-13T14:07:11Z

[Term]
id: XCO:0000985
name: transfer of rat wild type Ccny-specific shRNA  using a lentivirus vector
def: "This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y in the recipient cell or organism." [https://www.merriam-webster.com, PMID:28241067]
synonym: "lentiviral transfer of the rat wild type Ccny-specific shRNA" EXACT []
synonym: "transduction of recombinant lentivirus containing the rat wild type-specific shRNA" EXACT []
synonym: "transfer of recombinant lentivirus containing the rat wild type-specific shRNA" EXACT []
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-03-13T14:27:37Z

[Term]
id: XCO:0000986
name: transfer of the rat wild type Ccny-specific shRNA and EGFP gene using a lentivirus vector
def: "This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y while inducing EGFP synthesis in the recipient cell or organism." [https://www.merriam-webster.com, PMID:28241067]
synonym: "lentiviral transfer of the rat wild type Ccny-specific shRNA and the EGFP gene" EXACT []
synonym: "transduction of recombinant lentivirus containing the rat wild type-specific shRNA and the EGFP gene" EXACT []
synonym: "transfer of recombinant lentivirus containing the rat wild type-specific shRNA and the EGFP gene" EXACT []
is_a: XCO:0000983 ! gene transfer of the EGFP gene using a lentivirus vector
is_a: XCO:0000985 ! transfer of rat wild type Ccny-specific shRNA  using a lentivirus vector
created_by: slaulede
creation_date: 2023-03-13T14:36:52Z

[Term]
id: XCO:0000987
name: gene transfer of the rat wild type Ccny gene and EGFP gene using a lentivirus vector
def: "This is a condition in which the rat wild type cyclin Y gene (Ccny-WT) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism." [https://www.merriam-webster.com, PMID:28241067]
synonym: "lentiviral transfer of the rat wild type Ccny gene and the EGFP gene" EXACT []
synonym: "transduction of recombinant lentivirus containing the rat wild type Ccny gene and the EGFP gene" EXACT []
synonym: "transfer of recombinant lentivirus containing the rat wild type Ccny gene and the EGFP gene" EXACT []
is_a: XCO:0000983 ! gene transfer of the EGFP gene using a lentivirus vector
is_a: XCO:0000984 ! gene transfer of the rat wild type Ccny gene using a lentivirus vector
created_by: slaulede
creation_date: 2023-03-13T14:42:14Z

[Term]
id: XCO:0000988
name: Dulbecco's Modified Eagle's Medium
def: "This is any experimental condition in which the main influencing factor is Dulbecco's Modified Eagle's Medium. Typically, cells derived from a multicellular organism are cultured in this synthetic medium originally formulated by Dulbecco and Freeman and based on Eagle's Minimal Essential Medium." [https://en.wikipedia.org/wiki/Eagle%27s_minimal_essential_medium, https://www.thermofisher.com/us/en/home/technical-resources/media-formulation.48.html]
synonym: "DMEM" EXACT []
synonym: "DMEM, low glucose, pyruvate" NARROW []
is_a: XCO:0000966 ! controlled serum-free condition
created_by: slaulede
creation_date: 2023-03-14T11:55:08Z

[Term]
id: XCO:0000989
name: fetal bovine serum
def: "This is any experimental condition in which the main influencing factor is fetal bovine serum. Fetal bovine serum is the most widely used serum-supplement for the in vitro cell culture of eukaryotic cells. Fetal bovine serum is derived from the blood drawn from a bovine fetus via a closed system of collection at a slaughterhouse." [https://en.wikipedia.org/wiki/Fetal_bovine_serum, PMID:13598821]
synonym: "FBS" EXACT []
synonym: "fetal calf serum" EXACT []
relationship: part_of XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-03-14T12:20:39Z

[Term]
id: XCO:0000990
name: Neurobasal medium
def: "This is any experimental condition in which the main influencing factor is Neurobasal medium, a culture medium formulated to meet the special requirements of neuronal cells. This medium allows for the long-term maintenance of normal phenotype and growth of neuronal cells, and the maintenance of pure populations of neuronal cells without the need of an astrocyte feeder layer." [https://www.thermofisher.com/us/en/home/technical-resources/media-formulation.251.html]
xref: PMID:26640375
is_a: XCO:0000966 ! controlled serum-free condition
created_by: slaulede
creation_date: 2023-03-14T12:39:34Z

[Term]
id: XCO:0000991
name: GlutaMAX-I
def: "This is any experimental condition in which the main influencing factor is GlutaMAX-I, a dipeptide (L-alanyl-L-glutamine) substitute for L-glutamine that can be used as a direct substitute for L-Glutamine at equimolar concentrations in mammalian and stem cell culture with minimal or no adaptation. L-alanyl-L-glutamine eliminates problems associated with the spontaneous breakdown of L-glutamine during incubation, is highly soluble in aqueous solution, and is heat stable." [https://www.fishersci.com]
synonym: "L-alanyl-L-glutamine" EXACT []
xref: PMID:26640375
relationship: part_of XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-03-14T14:17:15Z

[Term]
id: XCO:0000992
name: B-27
def: "This is any experimental condition in which the main influencing factor is B-27, an optimized serum-free supplement used to support the low- or high-density growth and short- or long-term viability of embryonic, post-natal, and adult hippocampal and other CNS neurons. It is meant to supplement a basal medium such as Neurobasal medium." [https://www.thermofisher.com/order/catalog/product/17504044]
xref: PMID:26640375
relationship: part_of XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-03-14T14:27:51Z

[Term]
id: XCO:0000993
name: controlled humidity
def: "This is any experimental condition in which the main influencing factor is a controlled level of moisture in the air provided to an organism, ex vivo tissue, or cultured cells." [https://www.merriam-webster.com]
synonym: "air H2O content" EXACT []
synonym: "controlled H2O content air" EXACT []
synonym: "controlled water content air" EXACT []
xref: PMID:26640375
is_a: XCO:0000009 ! controlled atmosphere composition
created_by: slaulede
creation_date: 2023-03-14T14:39:30Z

[Term]
id: XCO:0000994
name: StemPro NSC SFM
def: "This is any experimental condition in which the main influencing factor is StemPro NSC SFM, a serum-free culture medium formulated to meet the special requirements of neuronal stem cells. This medium supports expansion of both adherent and spheroid cultures, and differentiation capability into astrocytes, oligodendrocytes and neurons." [https://www.thermofisher.com/order/catalog/product/A1050901]
synonym: "neuralstem cell serum free medium" EXACT []
xref: PMID:2664037
is_a: XCO:0000966 ! controlled serum-free condition
created_by: slaulede
creation_date: 2023-03-14T14:52:39Z

[Term]
id: XCO:0000995
name: PDGF-AA
def: "This is any experimental condition in which the main influencing factor is a dimeric isoform of platelet-derived growth factor (PDGF-AA). All PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. PDGF appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation." [https://www.thermofisher.com/antibody/product/Human-PDGF-AA-Animal-Free-Recombinant-Protein/AF-100-13A-1MG]
synonym: "platelet-derived growth factor-AA" EXACT []
synonym: "platelet-derived growth factor-AA isoform" EXACT []
synonym: "platelet-derived growth factor-alpha/alpha isoform" EXACT []
xref: PMID:26640375
relationship: part_of XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-03-14T15:14:58Z

[Term]
id: XCO:0000996
name: transfer of CHAER1 siRNA using Lipofectamine reagent
def: "This is any condition in which the main influencing factor is CHAER1 (cardiac hypertrophy associated epigenetic regulator 1) siRNA. CHAER1 is an ncRNA involved in epigenetic regulation of gene expression. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells." [https://en.wikipedia.org/wiki/Small_interfering_RNA, https://www.thermofisher.com/us/en/home/life-science/cell-culture/transfection/transfection-reagents/lipofectamine-rnaimax-reagent.html]
synonym: "transfection of CHAER1 short interfering RNA using Lipofectamine reagent" EXACT []
synonym: "transfection of CHAER1 silencing RNA using Lipofectamine reagent" EXACT []
synonym: "transfection of CHAER1 siRNA using Lipofectamine reagent" EXACT []
synonym: "transfection of CHAER1 small interfering RNA using Lipofectamine reagent" EXACT []
xref: PMID:27618650
is_a: XCO:0000233 ! ribonucleic acid
is_a: XCO:0000528 ! gene transfer
created_by: slaulede
creation_date: 2023-03-23T13:58:48Z

[Term]
id: XCO:0000997
name: transfer of negative control siRNA using Lipofectamine reagent
def: "This is any condition in which the main influencing factor is negative control siRNA. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells." [https://en.wikipedia.org/wiki/Small_interfering_RNA, https://www.thermofisher.com/us/en/home/life-science/cell-culture/transfection/transfection-reagents/lipofectamine-rnaimax-reagent.html]
synonym: "transfection of negative control short interfering RNA using Lipofectamine reagent" EXACT []
synonym: "transfection of negative control silencing RNA using Lipofectamine reagent" EXACT []
synonym: "transfection of negative control siRNA using Lipofectamine reagent" EXACT []
synonym: "transfection of negative control small interfering RNA using Lipofectamine reagent" EXACT []
xref: PMID:27618650
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-03-23T14:11:37Z

[Term]
id: XCO:0000998
name: controlled breathing condition
def: "This is any condition in which the main influencing factor is control of the process of breathing, whether by the control of the volume of air breathed or by control of the contents of the breathed air. This may be for the treatment of disease or for the experimental study of physiology or pathology." [https://www.merriam-webster.com]
is_a: XCO:0000000 ! experimental condition
created_by: slaulede
creation_date: 2023-03-23T14:43:17Z

[Term]
id: XCO:0000999
name: mechanical ventilation
def: "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator. The controlled parameters may be volume, pressure, and/or air component content." [https://my.clevelandclinic.org/health/treatments/15368-mechanical-ventilation, ISBN-13:978-0781733908]
synonym: "controlled mechanical ventilation" EXACT []
is_a: XCO:0000998 ! controlled breathing condition
created_by: slaulede
creation_date: 2023-03-23T14:49:38Z

[Term]
id: XCO:0001000
name: mechanical ventilation with assist/control
def: "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with assist/control (A/C), meaning the breathing rate is set and the tidal volume or pressure is set. When the subject triggers a breath, a full set tidal volume (or pressure) breath is delivered. When the vent delivers a subject-triggered breath, the next breath is timed in relation to this." [https://ventbasics.com/modes/modes-overview/, ISBN-13:978-0781733908]
synonym: "A/C" EXACT []
synonym: "assist/control" EXACT []
synonym: "volume controlled ventilation" NARROW []
synonym: "volume-controlled ventilation with constant tidal volumes" NARROW []
is_a: XCO:0000999 ! mechanical ventilation
created_by: slaulede
creation_date: 2023-03-23T15:26:05Z

[Term]
id: XCO:0001001
name: synchronized intermittent mandatory ventilation
def: "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with synchronized intermittent mandatory ventilation, meaning the breathing rate is set and the tidal volume is set with pressure support. The subject receives a set minimum number of breaths (the set rate) and any additional breaths are determined by the subject." [https://ventbasics.com/modes/modes-overview/, ISBN-13:978-0781733908]
synonym: "SIMV" EXACT []
is_a: XCO:0000999 ! mechanical ventilation
created_by: slaulede
creation_date: 2023-03-23T15:36:28Z

[Term]
id: XCO:0001002
name: variable ventilation
def: "This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator using variable tidal volume, or variable pressure support, and/or variable respiratory rate." [ISBN-13:978-0781733908, PMID:26979175]
synonym: "mechanical ventilation with variable tidal volume" NARROW []
is_a: XCO:0000999 ! mechanical ventilation
created_by: slaulede
creation_date: 2023-03-23T17:26:15Z

[Term]
id: XCO:0001003
name: magnetic field
def: "This is any condition in which the main influencing factor is a magnetic field, a vector field in the neighborhood of a magnet, electric current, or changing electric field in which magnetic forces are observable." [https://byjus.com/physics/, https://www.merriam-webster.com]
xref: PMID:24407149
is_a: XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-03-24T14:19:32Z

[Term]
id: XCO:0001004
name: uniform magnetic field
def: "This is any condition in which the main influencing factor is a uniform magnetic field. A uniform magnetic field may be generated by an apparatus such as a Halbach cylinder. A Halbach cylinder is a magnetized cylinder composed of ferromagnetic material which can produce a uniform magnetic field across a plate of cultured cells which is surrounded by the cylinder." [https://en.wikipedia.org/wiki/Halbach_array, https://en.wikipedia.org/wiki/Magnetism]
xref: PMID:24407149
is_a: XCO:0001003 ! magnetic field
created_by: slaulede
creation_date: 2023-03-24T14:51:33Z

[Term]
id: XCO:0001005
name: transfer of PIWIL1 siRNA using pSUPER plasmid
def: "This is any condition in which the main influencing factor is PIWIL1 (piwi-like RNA-mediated gene silencing 1) siRNA. The PIWIL1 protein may play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The pSUPER plasmid was designed for eukaryotic expression/RNAi." [https://www.addgene.org, PMID:26104391]
synonym: "PIWIL1 siRNA transfection" BROAD []
synonym: "transfection of PIWIL1 siRNA using pSUPER plasmid" EXACT []
xref: PMID:26104391
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-03-28T17:14:00Z

[Term]
id: XCO:0001006
name: transfer of negative control siRNA using pSUPER plasmid
def: "This is any condition in which the main influencing factor is negative control siRNA delivered with a pSUPER plasmid. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used." [https://www.addgene.org, PMID:26104391]
synonym: "negative control siRNA transfection" BROAD []
synonym: "scrambled siRNA transfection" BROAD []
synonym: "transfection of negative control siRNA using pSUPER plasmid" EXACT []
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-03-28T17:21:28Z

[Term]
id: XCO:0001007
name: transfer of negative control shRNA using a lentiviral vector
def: "This is any condition in which the main influencing factor is negative control shRNA delivered with a lentivirus vector. Negative control shRNA is an shRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental shRNA used." [https://www.origene.com/products/cdna-clones/lentiviral-particles/control-particles, PMID:31606248]
synonym: "transduction of negative control shRNA using a lentivirus" EXACT []
synonym: "transduction of negative control shRNA using a lentivirus vector" EXACT []
synonym: "transfer of negative control shRNA using a lentivirus" EXACT []
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-03-31T11:00:04Z

[Term]
id: XCO:0001008
name: transfer of Pum2 shRNA using a lentiviral vector
def: "This is any condition in which the main influencing factor is Pum2 (pumilio RNA-binding family member 2) shRNA. Pum2 is a protein that exhibits lncRNA binding, miRNA binding, and mRNA 3'-UTR binding. Pum2 is involved in negative regulation of gene expression and regulation of intracellular mRNA localization." [https://blog.addgene.org, PMID:31606248]
synonym: "transduction of Pum2 shRNA using a lentivirus" EXACT []
synonym: "transduction of Pum2 shRNA using a lentivirus vector" EXACT []
synonym: "transfer of Pum2 shRNA using a lentivirus" EXACT []
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-03-31T11:37:24Z

[Term]
id: XCO:0001009
name: Media 199
def: "This is any experimental condition in which the main influencing factor is M199 medium, which is useful across a wide range of species and applications but is particularly suitable for the culturing of non-transformed cells. M199 medium ingredients may include Earle’s salts and a bicarbonate/carbonic acid buffering system for the maintenance of pH in a CO2 incubator or Hank’s salts with salt solutions designed for atmospheric equilibrium." [https://www.thermofisher.com]
synonym: "M199" EXACT []
synonym: "M199 media" EXACT []
synonym: "M199 medium" EXACT []
synonym: "Medium 199" EXACT []
xref: PMID:31283468
is_a: XCO:0000966 ! controlled serum-free condition
created_by: slaulede
creation_date: 2023-04-06T12:56:12Z

[Term]
id: XCO:0001010
name: glutamine
def: "This is any experimental condition in which the main influencing factor is glutamine, an alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4. Glutamine is used as a supplement in cell culture media." [CHEBI:28300, https://www.merriam-webster.com]
synonym: "L-glutamine" EXACT []
xref: CHEBI:28300
is_a: XCO:0000119 ! amino acid
relationship: part_of XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-04-06T13:12:19Z

[Term]
id: XCO:0001011
name: penicillin-streptomycin
def: "This is any experimental condition in which the main influencing factor is a mixture of penicillin G and streptomycin (penicillin-streptomycin) that is widely used in mammalian cell culture media to prevent bacterial contamination. The solution contains 5,000 units of penicillin G (sodium salt) which acts as the active base, and 5,000 micrograms of streptomycin (sulfate) (base per milliliter), formulated in 0.85% saline." [https://en.wikipedia.org/wiki/Pen-Strep]
synonym: "Pen-Strep" EXACT []
xref: PMID:31283468
is_a: XCO:0000483 ! antibacterial agent
relationship: part_of XCO:0000965 ! controlled in vitro cell condition
created_by: slaulede
creation_date: 2023-04-06T13:28:20Z

[Term]
id: XCO:0001012
name: gene transfer of the rat Rbpms gene using a lentivirus vector
def: "This is a condition in which the rat Rbpms (RNA binding protein, mRNA processing factor) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rbpms in the recipient cell or organism." [https://www.merriam-webster.com, PMID:31283468]
synonym: "gene transfer of rat Rbpms using a lentiviral vector" EXACT []
synonym: "gene transfer of rat Rbpms using a lentivirus vector" EXACT []
synonym: "transduction of rat Rbpms using a lentiviral vector" EXACT []
synonym: "transduction of rat Rbpms using a lentivirus vector" EXACT []
is_a: XCO:0000982 ! gene transfer using lentivirus vector
created_by: slaulede
creation_date: 2023-04-06T14:09:22Z

[Term]
id: XCO:0001013
name: transfer of rat RBPMS siRNA using a lentivirus vector
def: "This is any condition in which the main influencing factor is rat RBPMS (RNA binding protein, mRNA processing factor)-specific siRNA. This siRNA has been transferred into a cell or organism using a lentivirus carrier in order to block synthesis of RBPMS in the recipient cell or organism." [https://en.wikipedia.org/wiki/Small_interfering_RNA, PMID:31283468]
synonym: "transduction of RBPMS siRNA using a lentivirus vector" EXACT []
xref: PMID:31283468
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-04-06T14:34:10Z

[Term]
id: XCO:0001014
name: transfer of negative control siRNA using a lentiviral vector
def: "This is any condition in which the main influencing factor is negative control siRNA delivered with a lentivirus vector. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used." [https://www.origene.com/products/cdna-clones/lentiviral-particles/control-particles, PMID:31283468]
synonym: "transduction of negative control siRNA using a lentivirus" EXACT []
synonym: "transduction of negative control siRNA using a lentivirus vector" EXACT []
synonym: "transfer of negative control siRNA using a lentivirus" EXACT []
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-04-06T14:42:17Z

[Term]
id: XCO:0001015
name: myectomy
def: "This is any condition in which the main influencing factor is creating a volumetric muscle loss (VML) of 20% or more of the total amount of mass in the targeted muscle through surgical removal (myectomy)." [https://study.com/, PMID:34146835]
xref: PMID:29531830
is_a: XCO:0000026 ! surgical removal
created_by: slaulede
creation_date: 2023-04-06T16:01:25Z

[Term]
id: XCO:0001016
name: minced muscle graft
def: "This is any condition in which the main influencing factor is implantation of a minced muscle graft. It is a surgical procedure intended to induce healing of a skeletal muscle injured by volumetric muscle loss." [PMID:29531830]
synonym: "autologous minced muscle graft" EXACT []
synonym: "MMG" EXACT []
xref: PMID:29531830
is_a: XCO:0000027 ! surgical implantation
created_by: slaulede
creation_date: 2023-04-06T16:32:30Z

[Term]
id: XCO:0001017
name: cocaine
def: "This is a bitter crystalline alkaloid C17H21NO4 obtained from coca leaves that is used especially in the form of its hydrochloride medically as a topical anesthetic and illicitly for its euphoric effects and that may result in a compulsive psychological need." [https://www.merriam-webster.com]
synonym: "(1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate" EXACT []
xref: CHEBI:27958
xref: MESH:D003042
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000141 ! vasoconstrictor
is_a: XCO:0000618 ! sodium channel inhibitor
created_by: slaulede
creation_date: 2023-04-27T12:51:11Z

[Term]
id: XCO:0001018
name: WIN 55,212-2
def: "This is an organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group." [CHEBI:73295]
synonym: "[(3R)-5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl](1-naphthyl)methanone" EXACT []
synonym: "WIN 55,212" EXACT []
xref: MESH:C070417
is_a: XCO:0000106 ! anesthetic/analgesic
is_a: XCO:0000269 ! calcium channel inhibitor
created_by: slaulede
creation_date: 2023-04-27T13:02:47Z

[Term]
id: XCO:0001019
name: olanzapine
def: "This is any condition in which the main influencing factor is olanzapine, a benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy." [MESH:D000077152]
synonym: "2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine" EXACT []
xref: CHEBI:7735
xref: MESH:D000077152
is_a: XCO:0000160 ! receptor antagonist
created_by: slaulede
creation_date: 2023-05-02T13:01:59Z

[Term]
id: XCO:0001020
name: docosahexaenoic acid
def: "This is any condition in which the main influencing factor is docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds." [CHEBI:36005]
synonym: "cervonic acid" EXACT []
synonym: "DHA" EXACT []
xref: CHEBI:36005
is_a: XCO:0000776 ! fatty acid
created_by: slaulede
creation_date: 2023-05-02T13:31:17Z

[Term]
id: XCO:0001021
name: controlled docosahexaenoic acid content diet
def: "This is any condition in which the main influencing factor is a solid diet in which the amount of docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds, is maintained at a specified level." [CHEBI:36005]
synonym: "controlled DHA content diet" EXACT []
xref: CHEBI:36005
xref: PMID:27322469
is_a: XCO:0000014 ! controlled content diet
relationship: has_component XCO:0001020 ! docosahexaenoic acid
created_by: slaulede
creation_date: 2023-05-02T13:37:56Z

[Term]
id: XCO:0001022
name: flaxseed oil
def: "This is any condition in which the main influencing factor is flaxseed oil, an edible oil in demand as a dietary supplement, as a source of &#945;-Linolenic acid, an omega-3 fatty acid." [https://en.wikipedia.org/wiki/Linseed_oil]
synonym: "flax oil" EXACT []
synonym: "linseed oil" EXACT []
is_a: XCO:0000774 ! oil
created_by: slaulede
creation_date: 2023-05-02T13:50:29Z

[Term]
id: XCO:0001023
name: controlled flaxseed oil content diet
def: "This is any condition in which the main influencing factor is a solid diet in which the amount of flaxseed oil, an edible oil rich in &#945;-Linolenic acid (an omega-3 fatty acid), is maintained at a specified level." [https://en.wikipedia.org/wiki/Linseed_oil]
synonym: "controlled flaxs oil content diet" EXACT []
synonym: "controlled linseed oil content diet" EXACT []
xref: PMID:27322469
is_a: XCO:0000454 ! controlled oil content diet
relationship: has_component XCO:0001022 ! flaxseed oil
created_by: slaulede
creation_date: 2023-05-02T13:57:19Z

[Term]
id: XCO:0001024
name: BNTA
def: "This is any condition in which the main influencing factor is BNTA, a small molecule with ECM modulatory and anti-inflammatory properties that is a potential therapeutic agent for osteoarthritis." [PMID:31015473]
synonym: "N-(2-bromo-4-(phenylsulfonyl)thiophen-3-yl)-2-chlorobenzamide" EXACT []
synonym: "N-[2-bromo-4-(phenylsulfonyl)-3-thienyl]-2-chlorobenzamide" EXACT []
synonym: "N-[4-(benzenesulfonyl)-2-bromothiophen-3-yl]-2-chlorobenzamide" EXACT []
xref: CID:2819453
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: slaulede
creation_date: 2023-05-09T14:19:20Z

[Term]
id: XCO:0001025
name: UNC0638
def: "This is any condition in which the main influencing factor is UNC0638, a histone methyltransferase Inhibitor that is a trial drug for cancer." [https://www.sigmaaldrich.com/US/en/product/mm/382192]
synonym: "2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine" EXACT []
synonym: "DNA Methyltransferase Inhibitor III" EXACT []
synonym: "DNA MTase Inhibitor III" EXACT []
synonym: "EHMT1/GLP Inhibitor II" EXACT []
synonym: "EHMT2/G9a Inhibitor IV" EXACT []
synonym: "HMTase Inhibitor IV" EXACT []
xref: PMID:26551542
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2023-05-09T15:04:55Z

[Term]
id: XCO:0001026
name: spinal nerve ligation
def: "This is any condition in which the main influencing factor is the tight ligation of one or more segmental spinal nerves at a point before the spinal nerve joins a common nerve (most commonly: ligation of L5 and/or L6 nerves which, with L4, make up the sciatic nerve in rats). This is a model of chronic neuropathic pain." [https://link.springer.com/referenceworkentry/10.1007/978-3-540-29805-2_2683, PMID:1333581]
synonym: "Chung model" RELATED []
synonym: "SNL" EXACT []
synonym: "SNL model" RELATED []
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2023-05-09T16:38:20Z

[Term]
id: XCO:0001027
name: gene transfer of the Rpl10a gene using a lentivirus vector
def: "This is a condition in which the Rpl10a (ribosomal protein L10A) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rpl10a in the recipient cell or organism." [https://www.merriam-webster.com, PMID:31825308]
synonym: "gene transfer of Rpl10a using a lentivirus vector" EXACT []
synonym: "transduction of ribosomal protein L10A using a lentiviral vector" EXACT []
synonym: "transduction of ribosomal protein L10A using a lentivirus vector" EXACT []
synonym: "transduction of Rpl10a using a lentiviral vector" EXACT []
is_a: XCO:0000982 ! gene transfer using lentivirus vector
created_by: slaulede
creation_date: 2023-05-11T15:08:39Z

[Term]
id: XCO:0001028
name: gene transfer of the EYFP gene using a lentivirus vector
def: "This is a condition in which the enhanced yellow fluorescent protein (EYFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EYFP in the recipient cell or organism." [https://www.merriam-webster.com, PMID:31825308]
synonym: "gene transduction of the enhanced yellow fluorescent protein gene using a lentivirus vector" EXACT []
synonym: "gene transfer of the EYFP gene using a lentivirus vector" EXACT []
synonym: "lentiviral transfer of the EYFP gene" EXACT []
synonym: "transduction of recombinant lentivirus containing the EYFP gene" EXACT []
synonym: "transfer of recombinant lentivirus containing the EYFP gene" EXACT []
is_a: XCO:0000982 ! gene transfer using lentivirus vector
created_by: slaulede
creation_date: 2023-05-11T15:33:38Z

[Term]
id: XCO:0001029
name: gene transfer of the Rpl10a gene and EYFP gene using a lentivirus vector
def: "This is a condition in which the Rpl10a (ribosomal protein L10A) gene and enhanced yellow fluorescent protein (EYFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism." [https://www.merriam-webster.com, PMID:31825308]
synonym: "lentiviral transfer of the Rpl10a gene and the EYFP gene" EXACT []
synonym: "transduction of recombinant lentivirus containing the Rpl10a gene and the EYFP gene" EXACT []
synonym: "transfer of recombinant lentivirus containing the Rpl10a gene and the EYFP gene" EXACT []
is_a: XCO:0001027 ! gene transfer of the Rpl10a gene using a lentivirus vector
is_a: XCO:0001028 ! gene transfer of the EYFP gene using a lentivirus vector
created_by: slaulede
creation_date: 2023-05-11T15:56:41Z

[Term]
id: XCO:0001030
name: acupuncture
def: "This is any condition in which the main influencing factor is acupuncture, a technique in which practitioners insert fine needles into the skin to treat health problems. The needles may be manipulated manually or stimulated with small electrical currents (electroacupuncture). Acupuncture has been in use in some form for at least 2,500 years." [https://www.nccih.nih.gov/health/acupuncture-what-you-need-to-know]
synonym: "acupotomy" EXACT []
synonym: "acupuncture treatment" EXACT []
synonym: "pharmacoacupuncture therapy" NARROW []
synonym: "pharmacoacupuncture treatment" NARROW []
xref: MESH:D015670
is_a: XCO:0000000 ! experimental condition
created_by: slaulede
creation_date: 2023-05-12T14:51:55Z

[Term]
id: XCO:0001031
name: electroacupuncture
def: "This is any condition in which the main influencing factor is electroacupuncture, a form of acupuncture where a small electric current is passed between pairs of acupuncture needles. According to some acupuncturists, this practice augments the use of regular acupuncture, can restore health and well-being, and is particularly good for treating pain." [https://en.wikipedia.org/wiki/Electroacupuncture]
synonym: "electro-acupuncture" EXACT []
xref: MESH:D015671
xref: PMID:24722278
is_a: XCO:0001030 ! acupuncture
created_by: slaulede
creation_date: 2023-05-12T14:58:31Z

[Term]
id: XCO:0001032
name: human neural progenitor cells
def: "This is any condition in which the main influencing factor is neural progenitor cells, which are isolated from embryonic or fetal CNS tissue and can be expanded in culture for prolonged periods using genetic or epigenetic approaches. Expanded cells have the capacity to differentiate into neurons, oligodendrocytes, or astrocytes." [PMID:18341406]
synonym: "hNPCs" EXACT []
is_a: XCO:0000850 ! therapeutic agent
created_by: slaulede
creation_date: 2023-05-18T14:23:53Z

[Term]
id: XCO:0001033
name: balanced salt solution cell carrying medium
def: "This is any condition in which the main influencing factor is a balanced salt solution-based medium for the delivery of a suspension of cells." [PMID:27217715]
synonym: "BSS cell carrying medium" EXACT []
is_a: XCO:0000154 ! ion/salt solution
created_by: slaulede
creation_date: 2023-05-18T14:35:36Z

[Term]
id: XCO:0001034
name: hawk tea extract
def: "This is any condition in which the main influencing factor is hawk tea extract (HTE), a potential cholesterol-lowering agent and antioxidant. Hawk tea is a medicinal herbal and caffeine-free drink popular in China." [PMID:31098406]
synonym: "HTE" EXACT []
synonym: "Litsea coreana extract" EXACT []
synonym: "Litsea coreana Levl. var. lanuginose extract" EXACT []
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000680 ! antilipemic agent
created_by: slaulede
creation_date: 2023-05-19T13:15:55Z

[Term]
id: XCO:0001035
name: controlled HTE content drinking water
def: "This is any condition in which the main influencing factor is a drink made up of water and a specified amount of hawk tea extract consumed by an organism as part of an experiment. Hawk tea extract is a potential cholesterol-lowering agent and antioxidant. Hawk tea is a traditional herbal and caffeine-free drink popular in China." [PMID:31098406]
synonym: "controlled hawk tea extract content drinking water" EXACT []
synonym: "controlled Litsea coreana extract content drinking water" EXACT []
xref: PMID:23618259
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0001034 ! hawk tea extract
created_by: slaulede
creation_date: 2023-05-19T13:25:24Z

[Term]
id: XCO:0001036
name: peripheral myelin protein 2 peptide 53-78
def: "This is any condition in which the major influencing factor is the peptide (TESPFKNTEISFKLGQEFEETTADNR) representing residues 53 to 78 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins." [PMID:31344254]
synonym: "Pmp2 peptide 53-78" EXACT []
synonym: "TESPFKNTEISFKLGQEFEETTADNR" EXACT []
is_a: XCO:0000290 ! peripheral myelin protein 2
created_by: slaulede
creation_date: 2023-05-19T13:48:55Z

[Term]
id: XCO:0001037
name: Mycobacterium tuberculosis H37Ra
def: "This is any condition in which the main influencing factor is Mycobacterium tuberculosis H37Ra (a high G+C gram-positive bacteria) introduced externally or internally, alive or dead, to a subject to effect a change in phenotype of the subject" [NCBI:txid419947]
synonym: "Mycobacterium tuberculosis ATCC 25177" EXACT []
synonym: "Mycobacterium tuberculosis strain H37Ra" EXACT []
synonym: "MYCTA" EXACT []
xref: PMID:31344254
xref: UniProt:419947
is_a: XCO:0000761 ! biologic
created_by: slaulede
creation_date: 2023-05-19T14:35:05Z

[Term]
id: XCO:0001038
name: PBS-filled liposomes
def: "This is any condition in which the main influencing factor is PBS-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing phosphate buffered saline." [PMID:30485549]
synonym: "PBS containing liposomes" EXACT []
synonym: "PBS-liposomes" EXACT []
synonym: "phosphate buffered saline-filled liposomes" EXACT []
is_a: XCO:0000780 ! liposomes
created_by: slaulede
creation_date: 2023-05-19T16:16:35Z

[Term]
id: XCO:0001039
name: Clodronate-filled liposomes
def: "This is any condition in which the main influencing factor is clodronate-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing clodronate." [PMID:30485549]
synonym: "clodronate containing liposomes" EXACT []
synonym: "clodronate liposomes" EXACT []
xref: http://clodronateliposomes.com/
is_a: XCO:0000648 ! clodronic acid
is_a: XCO:0000780 ! liposomes
created_by: slaulede
creation_date: 2023-05-19T16:23:46Z

[Term]
id: XCO:0001040
name: (R)-lipoic acid
def: "This is any condition in which the main influencing factor is (R)-lipoic acid, the (R)-enantiomer of lipoic acid. Lipoic acid is a vitamin-like, C8 thia fatty acid with anti-oxidant properties." [CHEBI:30314]
synonym: "R-&#945;-lipoic acid" EXACT []
xref: MESH:D008063
xref: PMID:24104204
is_a: XCO:0000777 ! lipoic acid
created_by: slaulede
creation_date: 2023-05-23T16:56:01Z

[Term]
id: XCO:0001041
name: experimental spinal cord contusion
def: "This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy and delivery of a controlled contusion of the spinal cord by a mechanical apparatus." [PMID:15629760]
synonym: "spinal cord injury" BROAD []
xref: PMID:15629760
xref: PMID:28106101
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2023-05-26T10:20:43Z

[Term]
id: XCO:0001042
name: T9 spinal cord contusion
def: "This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy of the ninth thoracic vertebra and delivery of a controlled contusion of the spinal cord by a mechanical apparatus." [PMID:15629760]
synonym: "spinal cord contusion at T9" EXACT []
synonym: "spinal cord injury at T9" BROAD []
synonym: "spinal cord injury at  the ninth thoracic vertebra" BROAD []
is_a: XCO:0001041 ! experimental spinal cord contusion
created_by: slaulede
creation_date: 2023-05-26T10:31:57Z

[Term]
id: XCO:0001043
name: laminectomy
def: "This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of one or more vertebrae. This procedure can serve as sham condition for a spinal cord contusion study." [https://www.mayoclinic.org/tests-procedures/laminectomy/about/pac-20394533, PMID:15629760]
synonym: "dorsal laminectomy" EXACT []
synonym: "surgical removal of vertebral lamina" EXACT []
xref: PMID:15629760
is_a: XCO:0000026 ! surgical removal
created_by: slaulede
creation_date: 2023-05-26T10:55:47Z

[Term]
id: XCO:0001044
name: T9 laminectomy
def: "This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of the ninth thoracic vertebra." [https://www.mayoclinic.org/tests-procedures/laminectomy/about/pac-20394533, PMID:15629760]
synonym: "surgical removal of the lamina of the ninth thoracic vertebra" EXACT []
xref: PMID:15629760
is_a: XCO:0001043 ! laminectomy
created_by: slaulede
creation_date: 2023-05-26T11:29:44Z

[Term]
id: XCO:0001045
name: Walker 256 cells
def: "This is any condition in which the main influencing factor is Walker 256, a rat mammary gland carcinoma cell line." [https://www.atcc.org/products/ccl-38, https://www.merriam-webster.com]
synonym: "LLC-WRC 256 cells" EXACT []
synonym: "W256 cells" EXACT []
xref: Cellosaurus CVCL_3537
xref: PMID:32209134
is_a: XCO:0000709 ! cancer cells
created_by: slaulede
creation_date: 2023-05-26T12:12:33Z

[Term]
id: XCO:0001046
name: Dnmt3a gapmer antisense oligonucleotide
def: "This is any condition in which the main influencing factor is a Dnmt3a gapmer (Dnmt3a-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence." [https://en.wikipedia.org/wiki/Gapmer]
synonym: "DNA methyltransferase 3 alpha GapmeR" EXACT []
synonym: "DNA methyltransferase 3 alpha gapmer antisense oligonucleotide" EXACT []
synonym: "Dnmt3a GapmeR" EXACT []
xref: PMID:30354815
is_a: XCO:0000234 ! deoxyribonucleic acid
created_by: slaulede
creation_date: 2023-06-01T15:19:05Z

[Term]
id: XCO:0001047
name: Tet3 gapmer antisense oligonucleotide
def: "This is any condition in which the main influencing factor is a Tet3 gapmer (Tet3-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence." [https://en.wikipedia.org/wiki/Gapmer]
synonym: "Tet3 GapmeR" EXACT []
synonym: "tet methylcytosine dioxygenase 3 GapmeR" EXACT []
synonym: "tet methylcytosine dioxygenase 3 gapmer antisense oligonucleotide" EXACT []
xref: PMID:30354815
is_a: XCO:0000234 ! deoxyribonucleic acid
created_by: slaulede
creation_date: 2023-06-01T15:28:16Z

[Term]
id: XCO:0001048
name: scrambled gapmer antisense oligonucleotide
def: "This is any condition in which the main influencing factor is a negative control gapmer. A negative control gapmer is a gapmer with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental gapmer used." [https://en.wikipedia.org/wiki/Gapmer, PMID:30354815]
synonym: "control GapmeR" EXACT []
synonym: "scrambled GapmeR" EXACT []
synonym: "scrambled GapmeR antisense oligonucleotide" EXACT []
synonym: "SCR GapmeR" EXACT []
xref: PMID:30354815
is_a: XCO:0000585 ! scrambled control oligodeoxynucleotide
created_by: slaulede
creation_date: 2023-06-01T15:36:36Z

[Term]
id: XCO:0001049
name: nicotine
def: "This is any condition in which the main influencing factor is nicotine, a highly toxic alkaloid. Nicotine is a racemate composed of equimolar amounts of (R)- and (S)-nicotine. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission." [CHEBI:18723, MESH:D009538]
synonym: "(R,S)-nicotine" EXACT []
synonym: "(RS)-nicotine" EXACT []
synonym: "rac-3-(1-methylpyrrolidin-2-yl)pyridine" EXACT []
xref: PMID:23874651
is_a: XCO:0000496 ! neurotoxin
is_a: XCO:0000693 ! cholinergic agonist
created_by: slaulede
creation_date: 2023-06-01T17:01:56Z

[Term]
id: XCO:0001050
name: T8/T9 laminectomy
def: "This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) from both the eighth and the ninth thoracic vertebrae." [https://www.mayoclinic.org/tests-procedures/laminectomy/about/pac-20394533, PMID:26546062]
synonym: "surgical removal of the lamina of the eighth and ninth thoracic vertebrae" EXACT []
xref: PMID:26546062
relationship: has_component XCO:0001044 ! T9 laminectomy
created_by: slaulede
creation_date: 2023-06-02T14:15:42Z

[Term]
id: XCO:0001051
name: controlled soy protein isolate content diet
def: "This is any condition in which the main influencing factor is a solid diet in which the amount of soy protein isolate, usually containing 85%–90% protein (dry basis), is maintained at a specified level. Soy protein isolates (SPI) are prepared by separating the fibers and insoluble carbohydrates from soy protein concentrate." [https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/soy-protein-isolate]
synonym: "controlled SPI content diet" EXACT []
is_a: XCO:0000014 ! controlled content diet
created_by: slaulede
creation_date: 2023-06-06T15:19:14Z

[Term]
id: XCO:0001052
name: 5-aza-2&#8242;-deoxycytidine
def: "This is any condition in which the main influencing factor is a 2'-deoxyribonucleoside that has formula C8H12N4O4. 5-aza-2&#8242;-deoxycytidine is a chemotherapeutic pyrimidine nucleoside analogue that integrates into cellular DNA and inhibits the action of DNA methyltransferases." [CID:451668, https://go.drugbank.com/drugs/DB01262]
synonym: "2'-Deoxy-5-azacytidine" EXACT []
synonym: "4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one" EXACT []
synonym: "5-AzaD" EXACT []
synonym: "5AzadC" EXACT []
synonym: "Dacogen" EXACT []
synonym: "decitabine" EXACT []
xref: PMID:37288607
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2023-06-19T13:59:50Z

[Term]
id: XCO:0001053
name: surgical closure
def: "This is any condition in which the main influencing factor is closure of a wound, body parts, or anatomical orifices by the use of sutures, staples, or surgical adhesive/sealant." [https://www.merriam-webster.com, https://www.sciencedirect.com/topics/medicine-and-dentistry/surgical-glue]
synonym: "surgical gluing" NARROW []
synonym: "surgical stapling" NARROW []
synonym: "surgical suturing" NARROW []
xref: GSE72787
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2023-06-20T15:13:05Z

[Term]
id: XCO:0001054
name: Qingda granule
def: "This is any condition in which the main influencing factor is Qingda granule, derived from Qingxuan Jiangya Decoction (QXJYD), which has been in usage for a long time as a traditional Chinese medicine formula." [PMID:32199989]
synonym: "QDG" EXACT []
synonym: "Qingda granules" EXACT []
xref: GSE144548
is_a: XCO:0000863 ! antihypertensive agent
created_by: slaulede
creation_date: 2023-06-20T16:42:57Z

[Term]
id: XCO:0001055
name: luteolin
def: "This is any condition in which the main influencing factor is luteolin, a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. Luteolin is a common flavonoid abundantly present in several plant products, including broccoli, pepper, thyme, and celery." [CHEBI:15864, https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/luteolin]
synonym: "2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one" EXACT []
synonym: "3',4',5,7-Tetrahydroxyflavone" EXACT []
xref: CHEBI:15864
xref: MESH:D047311
is_a: XCO:0000271 ! antioxidant
is_a: XCO:0000435 ! antineoplastic agent
is_a: XCO:0000470 ! flavonoid
is_a: XCO:0000505 ! anti-inflammatory agent
created_by: slaulede
creation_date: 2023-06-22T14:33:16Z

[Term]
id: XCO:0001056
name: methylglyoxal
def: "This is any condition in which the main influencing factor is methylglyoxal, a 2-oxo aldehyde derived from propanal. Methylglyoxal is an organic compound used often as a reagent in organic synthesis, as a flavoring agent, in tanning and as an experimental antidepressant. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals." [CHEBI:17158, MESH:D011765]
synonym: "2-Oxopropanal" EXACT []
synonym: "MGO" EXACT []
synonym: "pyruvaldehyde" EXACT []
xref: GSE119482
is_a: XCO:0000561 ! antidepressant
created_by: slaulede
creation_date: 2023-06-22T14:51:02Z

[Term]
id: XCO:0001057
name: corticosterone
def: "This is any condition in which the main influencing factor is corticosterone, a 21-carbon adrenocortical steroid hormone that has modest but significant activities as both a mineralocorticoid and a glucocorticoid." [ISBN:978-1455756438, MESH:D003345]
synonym: "11beta,21-dihydroxypregn-4-ene-3,20-dione" EXACT []
xref: CHEBI:16827
is_a: XCO:0000229 ! steroid hormone
created_by: slaulede
creation_date: 2023-06-23T14:29:08Z

[Term]
id: XCO:0001058
name: controlled corticosterone content drinking water
def: "This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level." [https://www.merriam-webster.com, MESH:D003345]
xref: CHEBI:16827
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0001057 ! corticosterone
created_by: slaulede
creation_date: 2023-06-23T14:40:29Z

[Term]
id: XCO:0001059
name: controlled content saline drink
def: "This is an experimental condition in which the main influencing factor is a drink made up of saline (0.9% sodium chloride solution) and a specified amount of one or more solutes." [https://www.merriam-webster.com, ISBN:978-1455756438]
synonym: "controlled content 0.9% sodium chloride drink" EXACT []
synonym: "controlled content drinking saline" EXACT []
synonym: "controlled content normal saline drink" EXACT []
xref: PMID:30364965
is_a: XCO:0000020 ! drink
is_a: XCO:0000156 ! 0.9% sodium chloride solution
created_by: slaulede
creation_date: 2023-06-23T14:54:26Z

[Term]
id: XCO:0001060
name: controlled corticosterone content saline drink
def: "This is an experimental condition in which the main influencing factor is a drink made up of normal saline (0.9% sodium chloride) and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level." [https://www.merriam-webster.com, ISBN:978-1455756438]
synonym: "controlled corticosterone content 0.9% sodium chloride drink" EXACT []
synonym: "controlled corticosterone content normal saline drink" EXACT []
xref: PMID:30364965
is_a: XCO:0001059 ! controlled content saline drink
relationship: has_component XCO:0001057 ! corticosterone
created_by: slaulede
creation_date: 2023-06-23T15:03:59Z

[Term]
id: XCO:0001061
name: oligosaccharide
def: "This is any condition in which the main influencing factor is an oligosaccharide, a compound in which a small number of monosaccharide units (2-10) are joined by alpha- or beta-glycosidic linkages." [ISBN:978-1455756438, MESH:D009844]
synonym: "oligosaccharides" EXACT []
xref: CHEBI:50699
xref: MESH:D009844
is_a: XCO:0000172 ! carbohydrate
created_by: slaulede
creation_date: 2023-06-23T15:27:30Z

[Term]
id: XCO:0001062
name: 2-hydroxypropyl-&#946;-cyclodextrin
def: "This is any condition in which the main influencing factor is 2-hydroxypropyl-&#946;-cyclodextrin, a hydroxypropyl-substituted heptasaccharide made up of a ring of seven glucose subunits joined by &#945;-1,4 glycosidic bonds." [https://en.wikipedia.org/wiki/Cyclodextrin]
synonym: "2 Hydroxylpropyl beta cyclodextrin" EXACT []
synonym: "2-Hydroxylpropyl-beta-cyclodextrin" EXACT []
synonym: "HP&#946;CD" EXACT []
synonym: "HP-beta-CD" EXACT []
xref: CHEBI:495055
xref: MESH:C031215
is_a: XCO:0001061 ! oligosaccharide
created_by: slaulede
creation_date: 2023-06-23T15:43:12Z

[Term]
id: XCO:0001063
name: pinealectomy
def: "This is any condition in which the main influencing factor is the surgical excision of the pineal body, a midline, cone-like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures." [https://www.merriam-webster.com, UBERON:0001905]
is_a: XCO:0000026 ! surgical removal
created_by: slaulede
creation_date: 2023-06-26T17:12:25Z

[Term]
id: XCO:0001064
name: 5/6 nephrectomy
def: "This is any condition in which the main influencing factor is a 5/6 nephrectomy, which is an experimental procedure performed to produce an animal model of chronic kidney disease in rodents. Typically, the right kidney is removed and the poles of the left kidney are removed to produce a total renal system which is 1/6 of original capacity." [ISBN:978-1455756438, PMID:32001792]
synonym: "5/6 nephrectomy" EXACT []
synonym: "5/6 Nx" EXACT []
synonym: "five-sixths partial nephrectomy" EXACT []
synonym: "subtotal 5/6 nephrectomy" EXACT []
synonym: "subtotal nephrectomy" EXACT []
xref: PMID:28760335
is_a: XCO:0000017 ! nephrectomy
created_by: slaulede
creation_date: 2023-06-26T18:07:22Z

[Term]
id: XCO:0001065
name: scrambled control LNA-modified oligonucleotide
def: "This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)–modified oligonucleotide with a non-specific scrambled sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide." [https://en.wikipedia.org/wiki/Locked_nucleic_acid, https://www.idtdna.com/pages/technology/custom-dna-rna/locked-nucleic-acids]
synonym: "scrambled control BNA oligonucleotide" EXACT []
synonym: "scrambled control LNA oligonucleotide" EXACT []
synonym: "scrambled control locked nucleic acid oligonucleotide" EXACT []
xref: PMID:28760335
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-06-27T13:16:05Z

[Term]
id: XCO:0001066
name: LNA-modified anti–rno-miR-21-5p oligonucleotide
def: "This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)–modified oligonucleotide with an anti–rat miR-21-5p sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide." [https://en.wikipedia.org/wiki/Locked_nucleic_acid, https://www.idtdna.com/pages/technology/custom-dna-rna/locked-nucleic-acids]
synonym: "BNA-modified anti–rno-miR-21-5p oligonucleotide" EXACT []
synonym: "LNA-modified anti-microRNA-21-5p oligonucleotide" EXACT []
xref: PMID:28760335
is_a: XCO:0000233 ! ribonucleic acid
created_by: slaulede
creation_date: 2023-06-27T14:04:55Z

[Term]
id: XCO:0001067
name: nitroglycerin
def: "This is any condition in which the main influencing factor is nitroglycerin, a volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. It is also sometimes used for tocolysis." [MESH:D005996]
synonym: "1,2,3-trinitrooxypropane" EXACT []
xref: CHEBI:28787
is_a: XCO:0000140 ! vasodilator
created_by: slaulede
creation_date: 2023-07-06T16:25:28Z

[Term]
id: XCO:0001068
name: sleep
def: "This is any condition in which the main influencing factor is sleep, the natural, easily reversible periodic state of many living things that is marked by the absence of wakefulness and by the loss of consciousness of one's surroundings, is accompanied by a typical body posture (such as lying down with the eyes closed), the occurrence of dreaming, and changes in brain activity and physiological functioning." [https://www.merriam-webster.com]
synonym: "napping" EXACT []
synonym: "slumber" EXACT []
synonym: "snoozing" EXACT []
is_a: XCO:0000000 ! experimental condition
created_by: slaulede
creation_date: 2023-07-17T17:37:42Z

[Term]
id: XCO:0001069
name: sleep restriction
def: "This is any condition in which the main influencing factor is sleep restriction, a state caused by inadequate quantity or quality of sleep, including voluntary or involuntary sleeplessness and circadian rhythm sleep. Sleep restriction may be caused by stress, school or job requirements, poor sleeping habits, or an experimentally arranged situation." [https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/sleep-deprivation]
synonym: "insomnia" RELATED []
synonym: "sleep deprivation" EXACT []
xref: PMID:32040351
is_a: XCO:0001068 ! sleep
created_by: slaulede
creation_date: 2023-07-17T17:58:29Z

[Term]
id: XCO:0001070
name: papain
def: "This is any condition in which the main influencing factor is papain, a cysteine protease present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis). In addition to experimental uses in biology research, it has wide ranging commercial applications in the leather, cosmetic, textiles, detergents, food and pharmaceutical industries." [https://en.wikipedia.org/wiki/Papain]
synonym: "papaya proteinase 1" EXACT []
xref: EC 3.4.22.2
xref: MESH:D010206
is_a: XCO:0000176 ! enzyme
created_by: slaulede
creation_date: 2023-07-18T14:25:07Z

[Term]
id: XCO:0001071
name: L-cysteine
def: "This is any condition in which the main influencing factor is L-cysteine, an optically active form of cysteine having the L-configuration at the alpha-carbon. It is a thiol-containing non-essential amino acid that is oxidized to form cystine." [CHEBI:17561, MESH:D003545]
synonym: "half-cystine" EXACT []
xref: PMID:31950348
is_a: XCO:0000119 ! amino acid
created_by: slaulede
creation_date: 2023-07-18T16:58:46Z

[Term]
id: XCO:0001072
name: gene transfer of the sTGF&#946;R2 gene using an adenovirus vector
def: "This is any condition in which the main influencing factor is the soluble transforming growth factor-beta receptor 2 gene (sTGF&#946;R2) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [PMID:31950348]
synonym: "gene transfer of the soluble transforming growth factor-beta receptor 2 gene using a adenoviral vector" EXACT []
synonym: "gene transfer of the sTGF&#946;R2 gene using an adenoviral vector" EXACT []
synonym: "transduction of sTGF&#946;R2 using an adenoviral vector" EXACT []
synonym: "transduction of sTGF&#946;R2 using an adenovirus vector" EXACT []
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: slaulede
creation_date: 2023-07-20T14:03:21Z

[Term]
id: XCO:0001073
name: gene transfer of the KL gene using an adenovirus vector
def: "This is any condition in which the main influencing factor is the klotho gene (KL) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism." [PMID:31950348]
synonym: "gene transfer of the alpha klotho gene using a adenoviral vector" EXACT []
synonym: "gene transfer of the KL gene using an adenoviral vector" EXACT []
synonym: "gene transfer of the klotho gene using a adenoviral vector" EXACT []
synonym: "transduction of KL using an adenoviral vector" EXACT []
synonym: "transduction of KL using an adenovirus vector" EXACT []
is_a: XCO:0000529 ! gene transfer using adenovirus vector
created_by: slaulede
creation_date: 2023-07-20T14:15:01Z

[Term]
id: XCO:0001074
name: ureter ligation
def: "This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one or both ureters. Ureters are the muscular ducts that propel urine from the kidneys to the urinary bladder." [ISBN:978-1455756438, UBERON:0000056]
synonym: "UO" RELATED []
synonym: "ureteral obstruction" RELATED []
is_a: XCO:0000165 ! surgical manipulation
created_by: slaulede
creation_date: 2023-08-01T13:28:25Z

[Term]
id: XCO:0001075
name: unilateral ureter ligation
def: "This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one ureter. Unilateral ureter ligation is used in experimental animals to create a model of unilateral ureteral obstruction and renal fibrosis." [ISBN:978-1455756438, PMID:28912732]
synonym: "unilateral ureteral obstruction" RELATED []
synonym: "UUO" RELATED []
is_a: XCO:0001074 ! ureter ligation
created_by: slaulede
creation_date: 2023-08-01T14:00:10Z

[Term]
id: XCO:0001076
name: bilateral ureter ligation
def: "This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of both ureters. Bilateral ureter ligation (BUL) is used in experimental animals to create a model of renal failure." [ISBN:978-1455756438, PMID:20797570]
synonym: "bilateral ureteral obstruction" RELATED []
synonym: "BUL" EXACT []
synonym: "BUO" RELATED []
is_a: XCO:0001074 ! ureter ligation
created_by: slaulede
creation_date: 2023-08-01T14:15:15Z

[Term]
id: XCO:0001077
name: bisphenol F
def: "This is any condition in which the main influencing factor is bisphenol F, an organic compound with the chemical formula (HOC6H4)2CH2. It is structurally related to bisphenol A (BPA), a popular precursor for forming plastics, as both belong to the category of molecules known as bisphenols, which feature two phenol groups connected via a linking group." [https://en.wikipedia.org/wiki/Bisphenol_F]
synonym: "4-(4-hydroxybenzyl)phenol" EXACT []
synonym: "4,4&#8242;-Dihydroxydiphenylmethane" EXACT []
synonym: "4,4&#8242;-Methylenediphenol" EXACT []
synonym: "4,4'-bisphenol F" EXACT []
synonym: "BPF" EXACT []
xref: CHEBI:34575
xref: MESH:C008745
is_a: XCO:0000396 ! phenolic/phenol derivative
created_by: slaulede
creation_date: 2023-08-08T16:49:17Z

[Term]
id: XCO:0001078
name: controlled bisphenol F content drinking water
def: "This is any condition in which the main influencing factor is bisphenol F in a drink made up of water and a specified amount of bisphenol F consumed by an organism as part of an experiment. Bisphenol F is an organic compound with the chemical formula (HOC6H4)2CH2." [https://en.wikipedia.org/wiki/Bisphenol_F, https://www.merriam-webster.com/]
synonym: "controlled 4,4&#8242;-Dihydroxydiphenylmethane content drinking water" EXACT []
synonym: "controlled 4,4&#8242;-Methylenediphenol content drinking water" EXACT []
synonym: "controlled BPF content drinking water" EXACT []
xref: CHEBI:34575
xref: MESH:C008745
is_a: XCO:0000163 ! controlled content drinking water
relationship: has_component XCO:0001077 ! bisphenol F
created_by: slaulede
creation_date: 2023-08-08T17:13:41Z

[Term]
id: XCO:0001079
name: adenine
def: "This is any condition in which the main influencing factor is adenine, the parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6. Adenine is one of the five constituent bases of nucleic acids.The shape of adenine is complementary to either thymine in DNA or uracil in RNA." [CHEBI:16708, https://en.wikipedia.org/wiki/Adenine]
synonym: "1H-Purin-6-amine" EXACT []
synonym: "6-Aminopurine" EXACT []
synonym: "9H-purin-6-amine" EXACT []
xref: MESH:D000225
is_a: XCO:0000342 ! chemical with specified structure
created_by: slaulede
creation_date: 2023-09-14T15:58:46Z

[Term]
id: XCO:0001080
name: monoiodoacetate
def: "This is any condition in which the main influencing factor is monoiodoacetate, a haloacetate(1-) resulting from the deprotonation of the carboxy group of iadoacetic acid." [CHEBI:23123]
synonym: "iodoacetate" EXACT []
synonym: "MIA" EXACT []
is_a: XCO:0000149 ! ion/salt
is_a: XCO:0000261 ! arthritis inducing chemical
created_by: slaulede
creation_date: 2023-10-02T13:55:23Z

[Term]
id: XCO:0001081
name: SBFI-103
def: "This is any condition in which the main influencing factor is SBFI-103, a selective FABP5 inhibitor. It is an experimental drug for treatment of cancer and osteoarthritis." [https://synapse.patsnap.com/drug/8addafe1559d4e20a32638b36f0515ec, PMID:35650684]
synonym: "9-Fluorenylmethyl a-3-hydroxycarbonyl-2,4-di(2-methoxylphenyl)-cyclobutane-1-carboxylate" EXACT []
synonym: "alpha-SBFI-103" EXACT []
synonym: "FABP5-IN-1" EXACT []
synonym: "SB-FI-103" EXACT []
xref: CAS:2132990-98-6
is_a: XCO:0000120 ! inhibitor
created_by: slaulede
creation_date: 2023-10-02T14:40:38Z

[Term]
id: XCO:0001082
name: bovine type II collagen
def: "This is any condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye. Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility." [http://en.wikipedia.org/wiki/Collagen, ISBN:978-1455756438]
synonym: "Bos taurus type II collagen" EXACT []
synonym: "cattle type II collagen" EXACT []
is_a: XCO:0000281 ! type II collagen
created_by: slaulede
creation_date: 2023-10-03T13:13:21Z

[Term]
id: XCO:0001083
name: imperatorin
def: "This is any condition in which the main influencing factor is imperatorin, a member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor." [CHEBI:5885]
synonym: "9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one" EXACT []
synonym: "IMP" EXACT []
xref: CAS:482-44-0
xref: MESH:C031534
xref: PMID:32392637
is_a: XCO:0000523 ! enzyme inhibitor
created_by: slaulede
creation_date: 2023-10-03T13:24:53Z

[Term]
id: XCO:0001084
name: beta-Sitosterol
def: "This is any condition in which the main influencing factor is beta-Sitosterol, one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. It is a white, waxy powder with a characteristic odor, and is one of the components of the food additive E499." [https://en.wikipedia.org/wiki/Beta-Sitosterol]
synonym: "beta-sitosterol" EXACT []
xref: CAS:83-46-5
xref: PMID:32392637
is_a: XCO:0000091 ! steroid
created_by: slaulede
creation_date: 2023-10-03T14:44:34Z

[Typedef]
id: has_component
name: has_component
xref: RO:0002211
created_by: JSmith
creation_date: 2014-03-07T11:34:22Z

[Typedef]
id: has_part
name: has_part
xref: BFO:0000051
is_transitive: true
created_by: JSmith
creation_date: 2014-03-07T11:32:23Z

[Typedef]
id: part_of
name: part_of
xref: BFO:0000050
is_transitive: true