diff --git a/CHANGELOG.md b/CHANGELOG.md
index d457b7de9974..ad8f3484d5df 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,7 @@ The format is based on [Keep a Changelog](http://keepachangelog.com/en/1.0.0/).
 
 ### Added
 
+- Added `is_torch_instance` to check against the original class of compiled models ([#8461](https://github.com/pyg-team/pytorch_geometric/pull/8461))
 - Added dense computation for `AddRandomWalkPE` ([#8431](https://github.com/pyg-team/pytorch_geometric/pull/8431))
 - Added a tutorial for point cloud processing ([#8015](https://github.com/pyg-team/pytorch_geometric/pull/8015))
 - Added `fsspec` as file system backend ([#8379](https://github.com/pyg-team/pytorch_geometric/pull/8379), [#8426](https://github.com/pyg-team/pytorch_geometric/pull/8426), [#8434](https://github.com/pyg-team/pytorch_geometric/pull/8434))
diff --git a/pyproject.toml b/pyproject.toml
index b252b5168925..16455501bc3c 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -151,6 +151,9 @@ filterwarnings = [
     "ignore:Sparse CSR tensor support is in beta state:UserWarning",
     "ignore:Sparse CSC tensor support is in beta state:UserWarning",
     "ignore:torch.distributed._sharded_tensor will be deprecated:DeprecationWarning",
+    # Filter `torch.compile` warnings:
+    "ignore:pkg_resources is deprecated as an API",
+    "ignore:Deprecated call to `pkg_resources.declare_namespace",
     # Filter `captum` warnings:
     "ignore:Setting backward hooks on ReLU activations:UserWarning",
     "ignore:.*did not already require gradients, required_grads has been set automatically:UserWarning",
diff --git a/test/data/test_edge_index.py b/test/data/test_edge_index.py
index 518269851445..6e122e50c800 100644
--- a/test/data/test_edge_index.py
+++ b/test/data/test_edge_index.py
@@ -1,10 +1,20 @@
 import os.path as osp
+from typing import Optional
 
 import pytest
 import torch
+from torch import Tensor
 
+import torch_geometric
 from torch_geometric.data.edge_index import EdgeIndex
-from torch_geometric.testing import onlyCUDA, withCUDA
+from torch_geometric.testing import (
+    disableExtensions,
+    onlyCUDA,
+    onlyLinux,
+    withCUDA,
+    withPackage,
+)
+from torch_geometric.utils import scatter
 
 
 def test_basic():
@@ -239,3 +249,71 @@ def test_data_loader(num_workers):
             assert isinstance(adj, EdgeIndex)
             assert adj.is_shared() == (num_workers > 0)
             assert adj._rowptr.is_shared() == (num_workers > 0)
+
+
+def test_torch_script():
+    class Model(torch.nn.Module):
+        def forward(self, x: Tensor, edge_index: EdgeIndex) -> Tensor:
+            row, col = edge_index[0], edge_index[1]
+            x_j = x[row]
+            out = scatter(x_j, col, dim_size=edge_index.num_cols)
+            return out
+
+    x = torch.randn(3, 8)
+    # Test that `num_cols` gets picked up by making last node isolated.
+    edge_index = EdgeIndex([[0, 1, 1, 2], [1, 0, 0, 1]], sparse_size=(3, 3))
+
+    model = Model()
+    expected = model(x, edge_index)
+    assert expected.size() == (3, 8)
+
+    # `torch.jit.script` does not support inheritance at the `Tensor` level :(
+    with pytest.raises(RuntimeError, match="attribute or method 'num_cols'"):
+        torch.jit.script(model)
+
+    # A valid workaround is to treat `EdgeIndex` as a regular PyTorch tensor
+    # whenever we are in script mode:
+    class ScriptableModel(torch.nn.Module):
+        def forward(self, x: Tensor, edge_index: EdgeIndex) -> Tensor:
+            row, col = edge_index[0], edge_index[1]
+            x_j = x[row]
+            dim_size: Optional[int] = None
+            if (not torch.jit.is_scripting()
+                    and isinstance(edge_index, EdgeIndex)):
+                dim_size = edge_index.num_cols
+            out = scatter(x_j, col, dim_size=dim_size)
+            return out
+
+    script_model = torch.jit.script(ScriptableModel())
+    out = script_model(x, edge_index)
+    assert out.size() == (2, 8)
+    assert torch.allclose(out, expected[:2])
+
+
+@onlyLinux
+@disableExtensions
+@withPackage('torch>=2.1.0')
+def test_compile():
+    import torch._dynamo as dynamo
+
+    class Model(torch.nn.Module):
+        def forward(self, x: Tensor, edge_index: EdgeIndex) -> Tensor:
+            row, col = edge_index[0], edge_index[1]
+            x_j = x[row]
+            out = scatter(x_j, col, dim_size=edge_index.num_cols)
+            return out
+
+    x = torch.randn(3, 8)
+    # Test that `num_cols` gets picked up by making last node isolated.
+    edge_index = EdgeIndex([[0, 1, 1, 2], [1, 0, 0, 1]], sparse_size=(3, 3))
+
+    model = Model()
+    expected = model(x, edge_index)
+    assert expected.size() == (3, 8)
+
+    explanation = dynamo.explain(model)(x, edge_index)
+    assert explanation.graph_break_count <= 0
+
+    compiled_model = torch_geometric.compile(model)
+    out = compiled_model(x, edge_index)
+    assert torch.allclose(out, expected)
diff --git a/test/test_isinstance.py b/test/test_isinstance.py
new file mode 100644
index 000000000000..d2360cca780b
--- /dev/null
+++ b/test/test_isinstance.py
@@ -0,0 +1,16 @@
+import torch
+
+from torch_geometric import is_torch_instance
+from torch_geometric.testing import onlyLinux, withPackage
+
+
+def test_basic():
+    assert is_torch_instance(torch.nn.Linear(1, 1), torch.nn.Linear)
+
+
+@onlyLinux
+@withPackage('torch>=2.0.0')
+def test_compile():
+    model = torch.compile(torch.nn.Linear(1, 1))
+    assert not isinstance(model, torch.nn.Linear)
+    assert is_torch_instance(model, torch.nn.Linear)
diff --git a/torch_geometric/__init__.py b/torch_geometric/__init__.py
index 7a9ed82ae1ea..cc3243c16acc 100644
--- a/torch_geometric/__init__.py
+++ b/torch_geometric/__init__.py
@@ -11,6 +11,7 @@
 from .seed import seed_everything
 from .home import get_home_dir, set_home_dir
 from .compile import compile
+from .isinstance import is_torch_instance
 from .debug import is_debug_enabled, debug, set_debug
 from .experimental import (is_experimental_mode_enabled, experimental_mode,
                            set_experimental_mode)
@@ -26,6 +27,7 @@
     'get_home_dir',
     'set_home_dir',
     'compile',
+    'is_torch_instance',
     'is_debug_enabled',
     'debug',
     'set_debug',
diff --git a/torch_geometric/isinstance.py b/torch_geometric/isinstance.py
new file mode 100644
index 000000000000..a64d74cd4ec8
--- /dev/null
+++ b/torch_geometric/isinstance.py
@@ -0,0 +1,25 @@
+from typing import Any, Tuple, Type, Union
+
+import torch
+
+import torch_geometric.typing
+
+if torch_geometric.typing.WITH_PT20:
+    import torch._dynamo
+
+
+def is_torch_instance(obj: Any, cls: Union[Type, Tuple[Type]]) -> bool:
+    r"""Checks if the :obj:`obj` is an instance of a :obj:`cls`.
+
+    This function extends :meth:`isinstance` to be applicable during
+    :meth:`torch.compile` usage by checking against the original class of
+    compiled models.
+    """
+    # `torch.compile` removes the model inheritance and converts the model to
+    # a `torch._dynamo.OptimizedModule` instance, leading to `isinstance` being
+    # unable to check the model's inheritance. This function unwraps the
+    # compiled model before evaluating via `isinstance`.
+    if (torch_geometric.typing.WITH_PT20
+            and isinstance(obj, torch._dynamo.OptimizedModule)):
+        return isinstance(obj._orig_mod, cls)
+    return isinstance(obj, cls)