diff --git a/.github/workflows/test_python.yml b/.github/workflows/test_python.yml
index e47b978ae1ad3..7c52022c01293 100644
--- a/.github/workflows/test_python.yml
+++ b/.github/workflows/test_python.yml
@@ -28,7 +28,7 @@ jobs:
       fail-fast: false   # Don't cancel all jobs if one fails.
       matrix:
         type: [ Pure, C++]
-        version: ["3.8", "3.9", "3.10", "3.11", "3.12"]
+        version: ["3.8", "3.9", "3.10", "3.11", "3.12", "3.13.0rc2"]
         include:
           - type: Pure
             targets: //python/... //python:python_version_test
@@ -48,6 +48,9 @@ jobs:
           - version: "3.10"
             continuous-only: true
           - version: "3.11"
+          - version: "3.12"
+          - version: "3.13.0rc2"
+            continuous-only: true
 
     name: ${{ matrix.continuous-only && inputs.continuous-prefix || '' }} Linux ${{ matrix.type }} ${{ matrix.version }}
     runs-on: ubuntu-latest
@@ -61,7 +64,7 @@ jobs:
         if: ${{ !matrix.continuous-only || inputs.continuous-run }}
         uses: protocolbuffers/protobuf-ci/bazel-docker@v3
         with:
-          image: ${{ matrix.image || format('us-docker.pkg.dev/protobuf-build/containers/test/linux/python:6.4.0-{0}-27cf7b86212020d7e552bc13b1e084abb971da75', matrix.version) }}
+          image: ${{ matrix.image || format('us-docker.pkg.dev/protobuf-build/containers/test/linux/python:6.4.0-{0}-2920199ab0090ed427413a8e422e62695c8392a8', matrix.version) }}
           credentials: ${{ secrets.GAR_SERVICE_ACCOUNT }}
           bazel-cache: python_linux/${{ matrix.type }}_${{ matrix.version }}
           bazel: test ${{ matrix.targets }} ${{ matrix.flags }} --test_env=KOKORO_PYTHON_VERSION
@@ -73,8 +76,7 @@ jobs:
       fail-fast: false   # Don't cancel all jobs if one fails.
       matrix:
         type: [ Pure, C++]
-        # TODO Consider expanding this set of versions.
-        version: [ "3.12" ]
+        version: [ "3.12", "3.13.0-rc.2" ]
         include:
           - type: Pure
             targets: //python/... //python:python_version_test
@@ -91,11 +93,12 @@ jobs:
           ref: ${{ inputs.safe-checkout }}
 
       - name: Pin Python version
-        uses: actions/setup-python@61a6322f88396a6271a6ee3565807d608ecaddd1 # v4.7.0
+        uses: actions/setup-python@39cd14951b08e74b54015e9e001cdefcf80e669f #v5.1.1
         with:
           python-version: ${{ matrix.version }}
           cache: pip
           cache-dependency-path: 'python/requirements.txt'
+          allow-prereleases: true
 
       - name: Validate version
         run: python3 --version | grep ${{ matrix.version }} || (echo "Invalid Python version - $(python3 --version)" && exit 1)
diff --git a/.github/workflows/test_upb.yml b/.github/workflows/test_upb.yml
index 46e5abef1ce68..03f996985530c 100644
--- a/.github/workflows/test_upb.yml
+++ b/.github/workflows/test_upb.yml
@@ -87,10 +87,11 @@ jobs:
         uses: protocolbuffers/protobuf-ci/checkout@v3
         with:
           ref: ${{ inputs.safe-checkout }}
-      - uses: actions/setup-python@61a6322f88396a6271a6ee3565807d608ecaddd1 # v4.7.0
+      - uses: actions/setup-python@39cd14951b08e74b54015e9e001cdefcf80e669f #v5.1.1
         with:
           cache: pip
           cache-dependency-path: 'python/requirements.txt'
+          allow-prereleases: true
       - name: Run tests
         uses: protocolbuffers/protobuf-ci/bazel@v3
         with:
@@ -114,10 +115,11 @@ jobs:
         uses: protocolbuffers/protobuf-ci/checkout@v3
         with:
           ref: ${{ inputs.safe-checkout }}
-      - uses: actions/setup-python@61a6322f88396a6271a6ee3565807d608ecaddd1 # v4.7.0
+      - uses: actions/setup-python@39cd14951b08e74b54015e9e001cdefcf80e669f #v5.1.1
         with:
           cache: pip
           cache-dependency-path: 'python/requirements.txt'
+          allow-prereleases: true
       - name: Run tests
         uses: protocolbuffers/protobuf-ci/bazel@v3
         with:
@@ -189,10 +191,14 @@ jobs:
           - { os: macos-12, python-version: "3.8", architecture: x64, type: 'binary' }
           - { os: ubuntu-latest, python-version: "3.12", architecture: x64, type: 'binary' }
           - { os: macos-13, python-version: "3.12", architecture: x64, type: 'binary' }
+          - { os: ubuntu-latest, python-version: "3.13.0-rc.2", architecture: x64, type: 'binary', continuous-only: true }
+          - { os: macos-13, python-version: "3.13.0-rc.2", architecture: x64, type: 'binary', continuous-only: true }
           - { os: ubuntu-latest, python-version: "3.8", architecture: x64, type: 'source', continuous-only: true }
           - { os: macos-12, python-version: "3.8", architecture: x64, type: 'source', continuous-only: true }
           - { os: ubuntu-latest, python-version: "3.12", architecture: x64, type: 'source', continuous-only: true }
           - { os: macos-13, python-version: "3.12", architecture: x64, type: 'source', continuous-only: true }
+          - { os: ubuntu-latest, python-version: "3.13.0-rc.2", architecture: x64, type: 'source', continuous-only: true }
+          - { os: macos-13, python-version: "3.13.0-rc.2", architecture: x64, type: 'source', continuous-only: true }
 
           # Windows uses the full API up until Python 3.10.
           - { os: windows-2019, python-version: "3.8", architecture: x86, type: 'binary', continuous-only: true }
@@ -200,11 +206,13 @@ jobs:
           - { os: windows-2019, python-version: "3.10", architecture: x86, type: 'binary', continuous-only: true }
           - { os: windows-2019, python-version: "3.11", architecture: x86, type: 'binary', continuous-only: true }
           - { os: windows-2019, python-version: "3.12", architecture: x86, type: 'binary', continuous-only: true }
+          - { os: windows-2019, python-version: "3.13.0-rc.2", architecture: x86, type: 'binary', continuous-only: true }
           - { os: windows-2019, python-version: "3.8", architecture: x64, type: 'binary' }
           - { os: windows-2019, python-version: "3.9", architecture: x64, type: 'binary', continuous-only: true }
           - { os: windows-2019, python-version: "3.10", architecture: x64, type: 'binary', continuous-only: true }
           - { os: windows-2019, python-version: "3.11", architecture: x64, type: 'binary', continuous-only: true }
           - { os: windows-2019, python-version: "3.12", architecture: x64, type: 'binary' }
+          - { os: windows-2019, python-version: "3.13.0-rc.2", architecture: x64, type: 'binary', continuous-only: true }
     name: ${{ matrix.continuous-only && inputs.continuous-prefix || '' }} Test Wheels Python ${{ matrix.python-version }} ${{ matrix.os }} ${{ matrix.architecture }} ${{ matrix.type }}
     needs: build_wheels
     runs-on: ${{ matrix.os }}
@@ -225,11 +233,12 @@ jobs:
         with:
           name: requirements
           path: requirements
-      - uses: actions/setup-python@61a6322f88396a6271a6ee3565807d608ecaddd1 # v4.7.0
+      - uses: actions/setup-python@39cd14951b08e74b54015e9e001cdefcf80e669f #v5.1.1
         if: ${{ !matrix.continuous-only || inputs.continuous-run }}
         with:
           python-version: ${{ matrix.python-version }}
           architecture: ${{ matrix.architecture }}
+          allow-prereleases: true
       - name: Setup Python venv
         if: ${{ !matrix.continuous-only || inputs.continuous-run }}
         run: |
@@ -275,7 +284,7 @@ jobs:
     strategy:
       fail-fast: false   # Don't cancel all jobs if one fails.
       matrix:
-        python-version: ["3.8", "3.12"]
+        python-version: ["3.8", "3.12", "3.13.0-rc.2"]
     runs-on: ubuntu-latest
     if: ${{ github.event_name != 'pull_request_target' }}
     steps:
@@ -286,9 +295,10 @@ jobs:
           path: wheels
       - name: Delete Binary Wheels
         run: find wheels -type f | grep -v none-any | xargs rm
-      - uses: actions/setup-python@61a6322f88396a6271a6ee3565807d608ecaddd1 # v4.7.0
+      - uses: actions/setup-python@39cd14951b08e74b54015e9e001cdefcf80e669f #v5.1.1
         with:
           python-version: ${{ matrix.python-version }}
+          allow-prereleases: true
       - name: Setup Python venv
         run: |
           python -m pip install --upgrade pip
diff --git a/python/dist/BUILD.bazel b/python/dist/BUILD.bazel
index 764fc7054d670..04adff19ce0f4 100644
--- a/python/dist/BUILD.bazel
+++ b/python/dist/BUILD.bazel
@@ -315,6 +315,7 @@ py_wheel(
         "Programming Language :: Python :: 3.10",
         "Programming Language :: Python :: 3.11",
         "Programming Language :: Python :: 3.12",
+        "Programming Language :: Python :: 3.13.Orc2",
     ],
     distribution = "protobuf",
     extra_distinfo_files = {
@@ -376,6 +377,7 @@ py_wheel(
         "Programming Language :: Python :: 3.10",
         "Programming Language :: Python :: 3.11",
         "Programming Language :: Python :: 3.12",
+        "Programming Language :: Python :: 3.13.Orc2",
     ],
     distribution = "protobuf",
     extra_distinfo_files = {
diff --git a/python/dist/setup.py b/python/dist/setup.py
index 3ace6a88185da..800c651d91cb7 100755
--- a/python/dist/setup.py
+++ b/python/dist/setup.py
@@ -58,6 +58,7 @@ def GetVersion():
         'Programming Language :: Python :: 3.10',
         'Programming Language :: Python :: 3.11',
         'Programming Language :: Python :: 3.12',
+        'Programming Language :: Python :: 3.13',
     ],
     namespace_packages=['google'],
     packages=find_packages(),
diff --git a/python/protobuf_distutils/setup.py b/python/protobuf_distutils/setup.py
index e7a499803b9ee..a44ad818d7365 100644
--- a/python/protobuf_distutils/setup.py
+++ b/python/protobuf_distutils/setup.py
@@ -35,6 +35,7 @@
         'Programming Language :: Python :: 3.10',
         'Programming Language :: Python :: 3.11',
         'Programming Language :: Python :: 3.12',
+        'Programming Language :: Python :: 3.13.Orc2',
         'Topic :: Software Development :: Code Generators',
     ],
     description=(
diff --git a/python/requirements.txt b/python/requirements.txt
index dd0ac27ce2ee1..153a5054dde13 100644
--- a/python/requirements.txt
+++ b/python/requirements.txt
@@ -1,2 +1,2 @@
-numpy<=1.26.1
+numpy<=2.1.0
 setuptools<=70.3.0