diff --git a/expression/integration_test.go b/expression/integration_test.go
index ff4f1871f3c4b..aa8c8eb2fce4d 100644
--- a/expression/integration_test.go
+++ b/expression/integration_test.go
@@ -9810,6 +9810,16 @@ func (s *testIntegrationSuite2) TestIssue25526(c *C) {
 	rows.Check(testkit.Rows())
 }
 
+func (s *testIntegrationSuite) TestIssue27610(c *C) {
+	tk := testkit.NewTestKit(c, s.store)
+	tk.MustExec(`use test;`)
+	tk.MustExec(`drop table if exists PK_TCOLLATION3966STROBJSTROBJ;`)
+	tk.MustExec("CREATE TABLE `PK_TCOLLATION3966STROBJSTROBJ` (\n  `COL1` enum('ll','aa','bb','cc','dd','ee') COLLATE utf8_general_ci NOT NULL,\n  `COL2` varchar(20) COLLATE utf8_general_ci DEFAULT NULL,\n  PRIMARY KEY (`COL1`) /*T![clustered_index] CLUSTERED */\n) ENGINE=InnoDB DEFAULT CHARSET=utf8 COLLATE=utf8_general_ci;")
+	tk.MustExec(`insert into PK_TCOLLATION3966STROBJSTROBJ values("ee", "tttt");`)
+	tk.MustQuery("SELECT col1, COL2 FROM PK_TCOLLATION3966STROBJSTROBJ WHERE COL1 IN ('notexist','6') and col2 not in (\"abcd\");").
+		Check(testkit.Rows())
+}
+
 func (s *testIntegrationSuite) TestIssue26977(c *C) {
 	tk := testkit.NewTestKit(c, s.store)
 	result := tk.MustQuery("select a + 1 as f from (select cast(0xfffffffffffffff0 as unsigned) as a union select cast(1 as unsigned)) t having f != 2;")
diff --git a/util/ranger/points.go b/util/ranger/points.go
index 03b35e367cb00..8030e7ad2bc99 100644
--- a/util/ranger/points.go
+++ b/util/ranger/points.go
@@ -570,7 +570,20 @@ func (r *builder) buildFromIn(expr *expression.ScalarFunction) ([]*point, bool)
 			dt.SetString(dt.GetString(), colCollate)
 		}
 		if expr.GetArgs()[0].GetType().Tp == mysql.TypeEnum {
-			dt, err = dt.ConvertTo(r.sc, expr.GetArgs()[0].GetType())
+			switch dt.Kind() {
+			case types.KindString, types.KindBytes, types.KindBinaryLiteral:
+				// Can't use ConvertTo directly, since we shouldn't convert numerical string to Enum in select stmt.
+				targetType := expr.GetArgs()[0].GetType()
+				enum, parseErr := types.ParseEnumName(targetType.Elems, dt.GetString(), targetType.Collate)
+				if parseErr == nil {
+					dt.SetMysqlEnum(enum, targetType.Collate)
+				} else {
+					err = parseErr
+				}
+			default:
+				dt, err = dt.ConvertTo(r.sc, expr.GetArgs()[0].GetType())
+			}
+
 			if err != nil {
 				// in (..., an impossible value (not valid enum), ...), the range is empty, so skip it.
 				continue