diff --git a/R/derive_extreme_event.R b/R/derive_extreme_event.R
index 4baf9f2da7..bdf3f39e28 100644
--- a/R/derive_extreme_event.R
+++ b/R/derive_extreme_event.R
@@ -647,6 +647,52 @@ derive_extreme_event <- function(dataset,
 #'   keep_source_vars = exprs(STUDYID, USUBJID),
 #'   new_vars = exprs(LSTALVDT = LSTALVDT, DTHFL = DTHFL)
 #' )
+#'
+#' # Derive DTHCAUS from AE and DS domain data
+#' adsl <- tribble(
+#'   ~STUDYID,  ~USUBJID,
+#'   "STUDY01", "PAT01",
+#'   "STUDY01", "PAT02",
+#'   "STUDY01", "PAT03"
+#' )
+#' ae <- tribble(
+#'   ~STUDYID,  ~USUBJID, ~AESEQ, ~AEDECOD,       ~AEOUT,  ~AEDTHDTC,
+#'   "STUDY01", "PAT01",  12,     "SUDDEN DEATH", "FATAL", "2021-04-04",
+#'   "STUDY01", "PAT01",  13,     "CARDIAC ARREST", "FATAL", "2021-04-03",
+#' )
+#'
+#' ds <- tribble(
+#'   ~STUDYID, ~USUBJID, ~DSSEQ, ~DSDECOD, ~DSTERM, ~DSSTDTC,
+#'   "STUDY01", "PAT02", 1, "INFORMED CONSENT OBTAINED", "INFORMED CONSENT OBTAINED", "2021-04-03",
+#'   "STUDY01", "PAT02", 2, "RANDOMIZATION", "RANDOMIZATION", "2021-04-11",
+#'   "STUDY01", "PAT02", 3, "DEATH", "DEATH DUE TO PROGRESSION OF DISEASE", "2022-02-01",
+#'   "STUDY01", "PAT03", 1, "DEATH", "POST STUDY REPORTING OF DEATH", "2022-03-03"
+#' )
+#'
+#' derive_vars_extreme_event(
+#'   adsl,
+#'   by_vars = exprs(STUDYID, USUBJID),
+#'   events = list(
+#'     event(
+#'       dataset_name = "ae",
+#'       condition = AEOUT == "FATAL",
+#'       set_values_to = exprs(DTHCAUS = AEDECOD, DTHDT = convert_dtc_to_dt(AEDTHDTC)),
+#'       order = exprs(DTHDT)
+#'     ),
+#'     event(
+#'       dataset_name = "ds",
+#'       condition = DSDECOD == "DEATH" & grepl("DEATH DUE TO", DSTERM),
+#'       set_values_to = exprs(DTHCAUS = DSTERM, DTHDT = convert_dtc_to_dt(DSSTDTC)),
+#'       order = exprs(DTHDT)
+#'     )
+#'   ),
+#'   source_datasets = list(ae = ae, ds = ds),
+#'   tmp_event_nr_var = event_nr,
+#'   order = exprs(USUBJID, DTHDT, event_nr),
+#'   mode = "first",
+#'   keep_source_vars = exprs(STUDYID, USUBJID),
+#'   new_vars = exprs(DTHCAUS = DTHCAUS, DTHDT = DTHDT)
+#' )
 derive_vars_extreme_event <- function(dataset,
                                       by_vars = NULL,
                                       events,
diff --git a/man/derive_vars_extreme_event.Rd b/man/derive_vars_extreme_event.Rd
index 44bb4e5988..71029e36f5 100644
--- a/man/derive_vars_extreme_event.Rd
+++ b/man/derive_vars_extreme_event.Rd
@@ -192,6 +192,52 @@ derive_vars_extreme_event(
   keep_source_vars = exprs(STUDYID, USUBJID),
   new_vars = exprs(LSTALVDT = LSTALVDT, DTHFL = DTHFL)
 )
+
+# Derive DTHCAUS from AE and DS domain data
+adsl <- tribble(
+  ~STUDYID,  ~USUBJID,
+  "STUDY01", "PAT01",
+  "STUDY01", "PAT02",
+  "STUDY01", "PAT03"
+)
+ae <- tribble(
+  ~STUDYID,  ~USUBJID, ~AESEQ, ~AEDECOD,       ~AEOUT,  ~AEDTHDTC,
+  "STUDY01", "PAT01",  12,     "SUDDEN DEATH", "FATAL", "2021-04-04",
+  "STUDY01", "PAT01",  13,     "CARDIAC ARREST", "FATAL", "2021-04-03",
+)
+
+ds <- tribble(
+  ~STUDYID, ~USUBJID, ~DSSEQ, ~DSDECOD, ~DSTERM, ~DSSTDTC,
+  "STUDY01", "PAT02", 1, "INFORMED CONSENT OBTAINED", "INFORMED CONSENT OBTAINED", "2021-04-03",
+  "STUDY01", "PAT02", 2, "RANDOMIZATION", "RANDOMIZATION", "2021-04-11",
+  "STUDY01", "PAT02", 3, "DEATH", "DEATH DUE TO PROGRESSION OF DISEASE", "2022-02-01",
+  "STUDY01", "PAT03", 1, "DEATH", "POST STUDY REPORTING OF DEATH", "2022-03-03"
+)
+
+derive_vars_extreme_event(
+  adsl,
+  by_vars = exprs(STUDYID, USUBJID),
+  events = list(
+    event(
+      dataset_name = "ae",
+      condition = AEOUT == "FATAL",
+      set_values_to = exprs(DTHCAUS = AEDECOD, DTHDT = convert_dtc_to_dt(AEDTHDTC)),
+      order = exprs(DTHDT)
+    ),
+    event(
+      dataset_name = "ds",
+      condition = DSDECOD == "DEATH" & grepl("DEATH DUE TO", DSTERM),
+      set_values_to = exprs(DTHCAUS = DSTERM, DTHDT = convert_dtc_to_dt(DSSTDTC)),
+      order = exprs(DTHDT)
+    )
+  ),
+  source_datasets = list(ae = ae, ds = ds),
+  tmp_event_nr_var = event_nr,
+  order = exprs(USUBJID, DTHDT, event_nr),
+  mode = "first",
+  keep_source_vars = exprs(STUDYID, USUBJID),
+  new_vars = exprs(DTHCAUS = DTHCAUS, DTHDT = DTHDT)
+)
 }
 \seealso{
 \code{\link[=event]{event()}}, \code{\link[=event_joined]{event_joined()}}, \code{\link[=derive_extreme_event]{derive_extreme_event()}}