diff --git a/x-pack/plugins/security_solution/common/endpoint/types/index.ts b/x-pack/plugins/security_solution/common/endpoint/types/index.ts
index 1e0d798cf7f07d..7a253ef2e32522 100644
--- a/x-pack/plugins/security_solution/common/endpoint/types/index.ts
+++ b/x-pack/plugins/security_solution/common/endpoint/types/index.ts
@@ -402,6 +402,11 @@ export enum HostStatus {
    * Host is inactive as indicated by its checkin status during the last checkin window
    */
   INACTIVE = 'inactive',
+
+  /**
+   * Host is unenrolled
+   */
+  UNENROLLED = 'unenrolled',
 }
 
 export enum MetadataQueryStrategyVersions {
diff --git a/x-pack/plugins/security_solution/public/common/components/endpoint/agent_status.tsx b/x-pack/plugins/security_solution/public/common/components/endpoint/agent_status.tsx
index f93721349fdac0..d7091059012151 100644
--- a/x-pack/plugins/security_solution/public/common/components/endpoint/agent_status.tsx
+++ b/x-pack/plugins/security_solution/public/common/components/endpoint/agent_status.tsx
@@ -20,7 +20,7 @@ export const AgentStatus = React.memo(({ hostStatus }: { hostStatus: HostStatus
     >
       <FormattedMessage
         id="xpack.securitySolution.endpoint.list.hostStatusValue"
-        defaultMessage="{hostStatus, select, healthy {Healthy} unhealthy {Unhealthy} updating {Updating} offline {Offline} inactive {Inactive} other {Unhealthy}}"
+        defaultMessage="{hostStatus, select, healthy {Healthy} unhealthy {Unhealthy} updating {Updating} offline {Offline} inactive {Inactive} unenrolled {Unenrolled} other {Unhealthy}}"
         values={{ hostStatus }}
       />
     </EuiBadge>
diff --git a/x-pack/plugins/security_solution/public/detections/components/host_isolation/take_action_dropdown.tsx b/x-pack/plugins/security_solution/public/detections/components/host_isolation/take_action_dropdown.tsx
index a10ad901441ea5..1404f7927d6ec8 100644
--- a/x-pack/plugins/security_solution/public/detections/components/host_isolation/take_action_dropdown.tsx
+++ b/x-pack/plugins/security_solution/public/detections/components/host_isolation/take_action_dropdown.tsx
@@ -10,6 +10,7 @@ import { EuiContextMenuItem, EuiContextMenuPanel, EuiButton, EuiPopover } from '
 import { ISOLATE_HOST, UNISOLATE_HOST } from './translations';
 import { TAKE_ACTION } from '../alerts_table/alerts_utility_bar/translations';
 import { useHostIsolationStatus } from '../../containers/detection_engine/alerts/use_host_isolation_status';
+import { HostStatus } from '../../../../common/endpoint/types';
 
 export const TakeActionDropdown = React.memo(
   ({
@@ -19,7 +20,9 @@ export const TakeActionDropdown = React.memo(
     onChange: (action: 'isolateHost' | 'unisolateHost') => void;
     agentId: string;
   }) => {
-    const { loading, isIsolated: isolationStatus } = useHostIsolationStatus({ agentId });
+    const { loading, isIsolated: isolationStatus, agentStatus } = useHostIsolationStatus({
+      agentId,
+    });
     const [isPopoverOpen, setIsPopoverOpen] = useState(false);
 
     const closePopoverHandler = useCallback(() => {
@@ -41,7 +44,7 @@ export const TakeActionDropdown = React.memo(
           iconSide="right"
           fill
           iconType="arrowDown"
-          disabled={loading}
+          disabled={loading || agentStatus === HostStatus.UNENROLLED}
           onClick={() => {
             setIsPopoverOpen(!isPopoverOpen);
           }}
@@ -49,7 +52,7 @@ export const TakeActionDropdown = React.memo(
           {TAKE_ACTION}
         </EuiButton>
       );
-    }, [isPopoverOpen, loading]);
+    }, [isPopoverOpen, loading, agentStatus]);
 
     return (
       <EuiPopover
diff --git a/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/translations.ts b/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/translations.ts
index d5234e719b869c..ed6a22375a7769 100644
--- a/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/translations.ts
+++ b/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/translations.ts
@@ -37,13 +37,3 @@ export const CASES_FROM_ALERTS_FAILURE = i18n.translate(
   'xpack.securitySolution.endpoint.hostIsolation.casesFromAlerts.title',
   { defaultMessage: 'Failed to find associated cases' }
 );
-
-export const ISOLATION_STATUS_FAILURE = i18n.translate(
-  'xpack.securitySolution.endpoint.hostIsolation.isolationStatus.title',
-  { defaultMessage: 'Failed to retrieve current isolation status' }
-);
-
-export const ISOLATION_PENDING_FAILURE = i18n.translate(
-  'xpack.securitySolution.endpoint.hostIsolation.isolationPending.title',
-  { defaultMessage: 'Failed to retrieve isolation pending statuses' }
-);
diff --git a/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/use_host_isolation_status.tsx b/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/use_host_isolation_status.tsx
index 259a377b10b796..6a40898d0a109f 100644
--- a/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/use_host_isolation_status.tsx
+++ b/x-pack/plugins/security_solution/public/detections/containers/detection_engine/alerts/use_host_isolation_status.tsx
@@ -7,9 +7,7 @@
 
 import { isEmpty } from 'lodash';
 import { useEffect, useState } from 'react';
-import { useAppToasts } from '../../../../common/hooks/use_app_toasts';
 import { getHostMetadata } from './api';
-import { ISOLATION_STATUS_FAILURE, ISOLATION_PENDING_FAILURE } from './translations';
 import { fetchPendingActionsByAgentId } from '../../../../common/lib/endpoint_pending_actions';
 import { isEndpointHostIsolated } from '../../../../common/utils/validators';
 import { HostStatus } from '../../../../../common/endpoint/types';
@@ -17,7 +15,7 @@ import { HostStatus } from '../../../../../common/endpoint/types';
 interface HostIsolationStatusResponse {
   loading: boolean;
   isIsolated: boolean;
-  agentStatus: HostStatus;
+  agentStatus: HostStatus | undefined;
   pendingIsolation: number;
   pendingUnisolation: number;
 }
@@ -30,13 +28,11 @@ export const useHostIsolationStatus = ({
   agentId: string;
 }): HostIsolationStatusResponse => {
   const [isIsolated, setIsIsolated] = useState<boolean>(false);
-  const [agentStatus, setAgentStatus] = useState<HostStatus>(HostStatus.UNHEALTHY);
+  const [agentStatus, setAgentStatus] = useState<HostStatus>();
   const [pendingIsolation, setPendingIsolation] = useState(0);
   const [pendingUnisolation, setPendingUnisolation] = useState(0);
   const [loading, setLoading] = useState(false);
 
-  const { addError } = useAppToasts();
-
   useEffect(() => {
     const abortCtrl = new AbortController();
     // isMounted tracks if a component is mounted before changing state
@@ -55,7 +51,10 @@ export const useHostIsolationStatus = ({
         if (error.name === 'AbortError') {
           return;
         }
-        addError(error.message, { title: ISOLATION_STATUS_FAILURE });
+
+        if (isMounted && error.body.statusCode === 404) {
+          setAgentStatus(HostStatus.UNENROLLED);
+        }
       }
 
       try {
@@ -65,7 +64,8 @@ export const useHostIsolationStatus = ({
           setPendingUnisolation(data[0].pending_actions?.unisolate ?? 0);
         }
       } catch (error) {
-        addError(error.message, { title: ISOLATION_PENDING_FAILURE });
+        // silently catch non-user initiated error
+        return;
       }
 
       if (isMounted) {
@@ -87,6 +87,6 @@ export const useHostIsolationStatus = ({
       isMounted = false;
       abortCtrl.abort();
     };
-  }, [addError, agentId]);
+  }, [agentId]);
   return { loading, isIsolated, agentStatus, pendingIsolation, pendingUnisolation };
 };
diff --git a/x-pack/plugins/security_solution/public/management/pages/endpoint_hosts/view/host_constants.ts b/x-pack/plugins/security_solution/public/management/pages/endpoint_hosts/view/host_constants.ts
index fb9661b509a33c..45cf7d725443d0 100644
--- a/x-pack/plugins/security_solution/public/management/pages/endpoint_hosts/view/host_constants.ts
+++ b/x-pack/plugins/security_solution/public/management/pages/endpoint_hosts/view/host_constants.ts
@@ -18,6 +18,7 @@ export const HOST_STATUS_TO_BADGE_COLOR = Object.freeze<
   [HostStatus.UPDATING]: 'primary',
   [HostStatus.OFFLINE]: 'default',
   [HostStatus.INACTIVE]: 'default',
+  [HostStatus.UNENROLLED]: 'default',
 });
 
 export const POLICY_STATUS_TO_HEALTH_COLOR = Object.freeze<
diff --git a/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/agent_statuses.tsx b/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/agent_statuses.tsx
index 2c88b305c7d05f..dac10f46487841 100644
--- a/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/agent_statuses.tsx
+++ b/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/agent_statuses.tsx
@@ -6,11 +6,12 @@
  */
 
 import React from 'react';
-import { EuiFlexGroup, EuiFlexItem } from '@elastic/eui';
+import { EuiFlexGroup, EuiFlexItem, EuiText } from '@elastic/eui';
 import { DefaultDraggable } from '../../../../../common/components/draggables';
 import { EndpointHostIsolationStatus } from '../../../../../common/components/endpoint/host_isolation';
 import { useHostIsolationStatus } from '../../../../../detections/containers/detection_engine/alerts/use_host_isolation_status';
 import { AgentStatus } from '../../../../../common/components/endpoint/agent_status';
+import { EMPTY_STATUS } from './translations';
 
 export const AgentStatuses = React.memo(
   ({
@@ -33,16 +34,22 @@ export const AgentStatuses = React.memo(
     const isolationFieldName = 'host.isolation';
     return (
       <EuiFlexGroup gutterSize="none">
-        <EuiFlexItem grow={false}>
-          <DefaultDraggable
-            field={fieldName}
-            id={`event-details-value-default-draggable-${contextId}-${eventId}-${fieldName}-${value}`}
-            tooltipContent={fieldName}
-            value={`${agentStatus}`}
-          >
-            <AgentStatus hostStatus={agentStatus} />
-          </DefaultDraggable>
-        </EuiFlexItem>
+        {agentStatus !== undefined ? (
+          <EuiFlexItem grow={false}>
+            <DefaultDraggable
+              field={fieldName}
+              id={`event-details-value-default-draggable-${contextId}-${eventId}-${fieldName}-${value}`}
+              tooltipContent={fieldName}
+              value={`${agentStatus}`}
+            >
+              <AgentStatus hostStatus={agentStatus} />
+            </DefaultDraggable>
+          </EuiFlexItem>
+        ) : (
+          <EuiText>
+            <p>{EMPTY_STATUS}</p>
+          </EuiText>
+        )}
         <EuiFlexItem grow={false}>
           <DefaultDraggable
             field={isolationFieldName}
diff --git a/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/translations.ts b/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/translations.ts
index 476fd77ce06476..d00148d41f3f64 100644
--- a/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/translations.ts
+++ b/x-pack/plugins/security_solution/public/timelines/components/timeline/body/renderers/translations.ts
@@ -44,3 +44,10 @@ export const LINK_ELASTIC_ENDPOINT_SECURITY = i18n.translate(
     defaultMessage: 'Open in Endpoint Security',
   }
 );
+
+export const EMPTY_STATUS = i18n.translate(
+  'xpack.securitySolution.hostIsolation.agentStatuses.empty',
+  {
+    defaultMessage: '-',
+  }
+);