diff --git a/pandas/_typing.py b/pandas/_typing.py
index 431c3e8e24d26..07ae70e51edf8 100644
--- a/pandas/_typing.py
+++ b/pandas/_typing.py
@@ -31,5 +31,9 @@
 
 # Type for index and columns of DataFrame
 Axes = Iterable[Union[ABCIndexClass, Iterable[str]]]
+
+# Type for data of DataFrame
+Data = TypeVar("Data", ABCDataFrame, dict, np.ndarray)
+
 FrameOrSeries = TypeVar("FrameOrSeries", ABCSeries, ABCDataFrame)
 Scalar = Union[str, int, float]
diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 4ffb617138f45..6836a5637dc92 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -80,7 +80,7 @@
 )
 from pandas.core.dtypes.missing import isna, notna
 
-from pandas._typing import Axes, Dtype
+from pandas._typing import Axes, Data, Dtype
 from pandas.core import algorithms, common as com, nanops, ops
 from pandas.core.accessor import CachedAccessor
 from pandas.core.arrays import Categorical, ExtensionArray
@@ -391,7 +391,7 @@ def _constructor_expanddim(self):
     # Constructors
 
     def __init__(self,
-                 data=None,
+                 data: Optional[Data] = None,
                  index: Optional[Axes] = None,
                  columns: Optional[Axes] = None,
                  dtype: Optional[Dtype] = None,