diff --git a/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3AsyncService.java b/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3AsyncService.java
index 653034ee9afde..4756cca7cba47 100644
--- a/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3AsyncService.java
+++ b/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3AsyncService.java
@@ -59,7 +59,7 @@ class S3AsyncService implements Closeable {
 
     private static final String STS_ENDPOINT_OVERRIDE_SYSTEM_PROPERTY = "aws.stsEndpointOverride";
 
-    private static final String DEFAULT_S3_ENDPOINT = "s3.amazonaws.com";
+    private static final String REGION_SPECIFIC_S3_ENDPOINT_FORMAT = "s3.%s.amazonaws.com";
 
     private volatile Map<S3ClientSettings, AmazonAsyncS3Reference> clientsCache = emptyMap();
 
@@ -173,7 +173,9 @@ synchronized AmazonAsyncS3WithCredentials buildClient(
         final AwsCredentialsProvider credentials = buildCredentials(logger, clientSettings);
         builder.credentialsProvider(credentials);
 
-        String endpoint = Strings.hasLength(clientSettings.endpoint) ? clientSettings.endpoint : DEFAULT_S3_ENDPOINT;
+        String regionSpecificS3Endpoint = String.format(REGION_SPECIFIC_S3_ENDPOINT_FORMAT, Region.of(clientSettings.region).toString());
+
+        String endpoint = Strings.hasLength(clientSettings.endpoint) ? clientSettings.endpoint : regionSpecificS3Endpoint;
         if ((endpoint.startsWith("http://") || endpoint.startsWith("https://")) == false) {
             // Manually add the schema to the endpoint to work around https://github.com/aws/aws-sdk-java/issues/2274
             endpoint = clientSettings.protocol.toString() + "://" + endpoint;
diff --git a/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3Service.java b/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3Service.java
index c13e5b76b9269..3305a46548533 100644
--- a/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3Service.java
+++ b/plugins/repository-s3/src/main/java/org/opensearch/repositories/s3/S3Service.java
@@ -96,7 +96,7 @@ class S3Service implements Closeable {
 
     private static final String STS_ENDPOINT_OVERRIDE_SYSTEM_PROPERTY = "aws.stsEndpointOverride";
 
-    private static final String DEFAULT_S3_ENDPOINT = "s3.amazonaws.com";
+    private static final String REGION_SPECIFIC_S3_ENDPOINT_FORMAT = "s3.%s.amazonaws.com";
 
     private volatile Map<S3ClientSettings, AmazonS3Reference> clientsCache = emptyMap();
 
@@ -202,7 +202,9 @@ AmazonS3WithCredentials buildClient(final S3ClientSettings clientSettings) {
         builder.httpClientBuilder(buildHttpClient(clientSettings));
         builder.overrideConfiguration(buildOverrideConfiguration(clientSettings));
 
-        String endpoint = Strings.hasLength(clientSettings.endpoint) ? clientSettings.endpoint : DEFAULT_S3_ENDPOINT;
+        String regionSpecificS3Endpoint = String.format(REGION_SPECIFIC_S3_ENDPOINT_FORMAT, Region.of(clientSettings.region).toString());
+
+        String endpoint = Strings.hasLength(clientSettings.endpoint) ? clientSettings.endpoint : regionSpecificS3Endpoint;
         if ((endpoint.startsWith("http://") || endpoint.startsWith("https://")) == false) {
             // Manually add the schema to the endpoint to work around https://github.com/aws/aws-sdk-java/issues/2274
             // TODO: Remove this once fixed in the AWS SDK