diff --git a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
index bb40adbc26..10a9d259eb 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
@@ -527,11 +527,11 @@ def _instrument(self, **kwargs):
         tracer_provider = kwargs.get("tracer_provider")
         _InstrumentedClient._tracer_provider = tracer_provider
         _InstrumentedAsyncClient._tracer_provider = tracer_provider
-        httpx.Client = _InstrumentedClient
+        httpx.Client = httpx._api.Client = _InstrumentedClient
         httpx.AsyncClient = _InstrumentedAsyncClient
 
     def _uninstrument(self, **kwargs):
-        httpx.Client = self._original_client
+        httpx.Client = httpx._api.Client = self._original_client
         httpx.AsyncClient = self._original_async_client
         _InstrumentedClient._tracer_provider = None
         _InstrumentedClient._request_hook = None