diff --git a/CHANGELOG.md b/CHANGELOG.md
index 000216e2a1..777b5a3530 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+- Instrument all httpx versions >= 0.18. ([#1748](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/1748))
+
 ## Version 1.18.0/0.39b0 (2023-05-10)
 
 - `opentelemetry-instrumentation-system-metrics` Add `process.` prefix to `runtime.memory`, `runtime.cpu.time`, and `runtime.gc_count`. Change `runtime.memory` from count to UpDownCounter. ([#1735](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/1735))
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
index 229fca1611..d079de20b3 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
@@ -32,7 +32,7 @@ dependencies = [
 
 [project.optional-dependencies]
 instruments = [
-  "httpx >= 0.18.0, <= 0.23.0",
+  "httpx >= 0.18.0",
 ]
 test = [
   "opentelemetry-instrumentation-httpx[instruments]",
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py b/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py
index c0d3705dca..86c9a56ab2 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py
@@ -59,7 +59,7 @@ def _async_call(coro: typing.Coroutine) -> asyncio.Task:
 def _response_hook(span, request: "RequestInfo", response: "ResponseInfo"):
     span.set_attribute(
         HTTP_RESPONSE_BODY,
-        response[2].read(),
+        b"".join(response[2]),
     )
 
 
@@ -68,7 +68,7 @@ async def _async_response_hook(
 ):
     span.set_attribute(
         HTTP_RESPONSE_BODY,
-        await response[2].aread(),
+        b"".join([part async for part in response[2]]),
     )
 
 
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index 8200196ca8..f705324289 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -81,7 +81,7 @@
         "instrumentation": "opentelemetry-instrumentation-grpc==0.40b0.dev",
     },
     "httpx": {
-        "library": "httpx >= 0.18.0, <= 0.23.0",
+        "library": "httpx >= 0.18.0",
         "instrumentation": "opentelemetry-instrumentation-httpx==0.40b0.dev",
     },
     "jinja2": {
diff --git a/tox.ini b/tox.ini
index 32656d7214..2313eab1d2 100644
--- a/tox.ini
+++ b/tox.ini
@@ -277,7 +277,7 @@ deps =
   httpx18: httpx>=0.18.0,<0.19.0
   httpx18: respx~=0.17.0
   httpx21: httpx>=0.19.0
-  httpx21: respx~=0.19.0
+  httpx21: respx~=0.20.1
 
   ; FIXME: add coverage testing
   ; FIXME: add mypy testing