diff --git a/.github/workflows/test_0.yml b/.github/workflows/test_0.yml
index ec189c09b1..d251737227 100644
--- a/.github/workflows/test_0.yml
+++ b/.github/workflows/test_0.yml
@@ -2194,8 +2194,8 @@ jobs:
       - name: Run tests
         run: tox -e pypy3-test-instrumentation-falcon-2 -- -ra
 
-  py38-test-instrumentation-fastapi-main_ubuntu-latest:
-    name: instrumentation-fastapi-main 3.8 Ubuntu
+  py38-test-instrumentation-fastapi_ubuntu-latest:
+    name: instrumentation-fastapi 3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -2210,28 +2210,10 @@ jobs:
         run: pip install tox
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-fastapi-main -- -ra
+        run: tox -e py38-test-instrumentation-fastapi -- -ra
 
-  py38-test-instrumentation-fastapi-slim_ubuntu-latest:
-    name: instrumentation-fastapi-slim 3.8 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.8
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.8"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py38-test-instrumentation-fastapi-slim -- -ra
-
-  py39-test-instrumentation-fastapi-main_ubuntu-latest:
-    name: instrumentation-fastapi-main 3.9 Ubuntu
+  py39-test-instrumentation-fastapi_ubuntu-latest:
+    name: instrumentation-fastapi 3.9 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -2246,46 +2228,10 @@ jobs:
         run: pip install tox
 
       - name: Run tests
-        run: tox -e py39-test-instrumentation-fastapi-main -- -ra
-
-  py39-test-instrumentation-fastapi-slim_ubuntu-latest:
-    name: instrumentation-fastapi-slim 3.9 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.9
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.9"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py39-test-instrumentation-fastapi-slim -- -ra
-
-  py310-test-instrumentation-fastapi-main_ubuntu-latest:
-    name: instrumentation-fastapi-main 3.10 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.10
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.10"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py310-test-instrumentation-fastapi-main -- -ra
+        run: tox -e py39-test-instrumentation-fastapi -- -ra
 
-  py310-test-instrumentation-fastapi-slim_ubuntu-latest:
-    name: instrumentation-fastapi-slim 3.10 Ubuntu
+  py310-test-instrumentation-fastapi_ubuntu-latest:
+    name: instrumentation-fastapi 3.10 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -2300,10 +2246,10 @@ jobs:
         run: pip install tox
 
       - name: Run tests
-        run: tox -e py310-test-instrumentation-fastapi-slim -- -ra
+        run: tox -e py310-test-instrumentation-fastapi -- -ra
 
-  py311-test-instrumentation-fastapi-main_ubuntu-latest:
-    name: instrumentation-fastapi-main 3.11 Ubuntu
+  py311-test-instrumentation-fastapi_ubuntu-latest:
+    name: instrumentation-fastapi 3.11 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -2318,28 +2264,10 @@ jobs:
         run: pip install tox
 
       - name: Run tests
-        run: tox -e py311-test-instrumentation-fastapi-main -- -ra
+        run: tox -e py311-test-instrumentation-fastapi -- -ra
 
-  py311-test-instrumentation-fastapi-slim_ubuntu-latest:
-    name: instrumentation-fastapi-slim 3.11 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.11
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.11"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py311-test-instrumentation-fastapi-slim -- -ra
-
-  py312-test-instrumentation-fastapi-main_ubuntu-latest:
-    name: instrumentation-fastapi-main 3.12 Ubuntu
+  py312-test-instrumentation-fastapi_ubuntu-latest:
+    name: instrumentation-fastapi 3.12 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -2354,46 +2282,10 @@ jobs:
         run: pip install tox
 
       - name: Run tests
-        run: tox -e py312-test-instrumentation-fastapi-main -- -ra
-
-  py312-test-instrumentation-fastapi-slim_ubuntu-latest:
-    name: instrumentation-fastapi-slim 3.12 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.12
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.12"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py312-test-instrumentation-fastapi-slim -- -ra
-
-  pypy3-test-instrumentation-fastapi-main_ubuntu-latest:
-    name: instrumentation-fastapi-main pypy-3.8 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python pypy-3.8
-        uses: actions/setup-python@v5
-        with:
-          python-version: "pypy-3.8"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e pypy3-test-instrumentation-fastapi-main -- -ra
+        run: tox -e py312-test-instrumentation-fastapi -- -ra
 
-  pypy3-test-instrumentation-fastapi-slim_ubuntu-latest:
-    name: instrumentation-fastapi-slim pypy-3.8 Ubuntu
+  pypy3-test-instrumentation-fastapi_ubuntu-latest:
+    name: instrumentation-fastapi pypy-3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -2408,7 +2300,7 @@ jobs:
         run: pip install tox
 
       - name: Run tests
-        run: tox -e pypy3-test-instrumentation-fastapi-slim -- -ra
+        run: tox -e pypy3-test-instrumentation-fastapi -- -ra
 
   py38-test-instrumentation-flask-0_ubuntu-latest:
     name: instrumentation-flask-0 3.8 Ubuntu
@@ -4515,3 +4407,111 @@ jobs:
 
       - name: Run tests
         run: tox -e py311-test-instrumentation-pymemcache-2 -- -ra
+
+  py311-test-instrumentation-pymemcache-3_ubuntu-latest:
+    name: instrumentation-pymemcache-3 3.11 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.11
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.11"
+
+      - name: Install tox
+        run: pip install tox
+
+      - name: Run tests
+        run: tox -e py311-test-instrumentation-pymemcache-3 -- -ra
+
+  py311-test-instrumentation-pymemcache-4_ubuntu-latest:
+    name: instrumentation-pymemcache-4 3.11 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.11
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.11"
+
+      - name: Install tox
+        run: pip install tox
+
+      - name: Run tests
+        run: tox -e py311-test-instrumentation-pymemcache-4 -- -ra
+
+  py312-test-instrumentation-pymemcache-0_ubuntu-latest:
+    name: instrumentation-pymemcache-0 3.12 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.12
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.12"
+
+      - name: Install tox
+        run: pip install tox
+
+      - name: Run tests
+        run: tox -e py312-test-instrumentation-pymemcache-0 -- -ra
+
+  py312-test-instrumentation-pymemcache-1_ubuntu-latest:
+    name: instrumentation-pymemcache-1 3.12 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.12
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.12"
+
+      - name: Install tox
+        run: pip install tox
+
+      - name: Run tests
+        run: tox -e py312-test-instrumentation-pymemcache-1 -- -ra
+
+  py312-test-instrumentation-pymemcache-2_ubuntu-latest:
+    name: instrumentation-pymemcache-2 3.12 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.12
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.12"
+
+      - name: Install tox
+        run: pip install tox
+
+      - name: Run tests
+        run: tox -e py312-test-instrumentation-pymemcache-2 -- -ra
+
+  py312-test-instrumentation-pymemcache-3_ubuntu-latest:
+    name: instrumentation-pymemcache-3 3.12 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.12
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.12"
+
+      - name: Install tox
+        run: pip install tox
+
+      - name: Run tests
+        run: tox -e py312-test-instrumentation-pymemcache-3 -- -ra
diff --git a/.github/workflows/test_1.yml b/.github/workflows/test_1.yml
index e1ce8cd445..f7e71dd6b6 100644
--- a/.github/workflows/test_1.yml
+++ b/.github/workflows/test_1.yml
@@ -16,114 +16,6 @@ env:
 
 jobs:
 
-  py311-test-instrumentation-pymemcache-3_ubuntu-latest:
-    name: instrumentation-pymemcache-3 3.11 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.11
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.11"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py311-test-instrumentation-pymemcache-3 -- -ra
-
-  py311-test-instrumentation-pymemcache-4_ubuntu-latest:
-    name: instrumentation-pymemcache-4 3.11 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.11
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.11"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py311-test-instrumentation-pymemcache-4 -- -ra
-
-  py312-test-instrumentation-pymemcache-0_ubuntu-latest:
-    name: instrumentation-pymemcache-0 3.12 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.12
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.12"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py312-test-instrumentation-pymemcache-0 -- -ra
-
-  py312-test-instrumentation-pymemcache-1_ubuntu-latest:
-    name: instrumentation-pymemcache-1 3.12 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.12
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.12"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py312-test-instrumentation-pymemcache-1 -- -ra
-
-  py312-test-instrumentation-pymemcache-2_ubuntu-latest:
-    name: instrumentation-pymemcache-2 3.12 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.12
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.12"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py312-test-instrumentation-pymemcache-2 -- -ra
-
-  py312-test-instrumentation-pymemcache-3_ubuntu-latest:
-    name: instrumentation-pymemcache-3 3.12 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.12
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.12"
-
-      - name: Install tox
-        run: pip install tox
-
-      - name: Run tests
-        run: tox -e py312-test-instrumentation-pymemcache-3 -- -ra
-
   py312-test-instrumentation-pymemcache-4_ubuntu-latest:
     name: instrumentation-pymemcache-4 3.12 Ubuntu
     runs-on: ubuntu-latest
diff --git a/CHANGELOG.md b/CHANGELOG.md
index e3b91462ba..d1a113a91e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -11,24 +11,29 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 - `opentelemetry-instrumentation-kafka-python` Instrument temporary fork, kafka-python-ng
   inside kafka-python's instrumentation
-  ([#2537](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2537)))
+  ([#2537](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2537))
 
 ## Breaking changes
 
+- `opentelemetry-bootstrap` Remove `opentelemetry-instrumentation-aws-lambda` from the defaults instrumentations
+  ([#2786](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2786))
+
 ## Fixed
 
+- `opentelemetry-instrumentation-fastapi` fix `fastapi` auto-instrumentation by removing `fastapi-slim` support, `fastapi-slim` itself is discontinued from maintainers
+  ([2783](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2783))
 - `opentelemetry-instrumentation-aws-lambda` Avoid exception when a handler is not present.
   ([#2750](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2750))
 - `opentelemetry-instrumentation-django` Fix regression - `http.target` re-added back to old semconv duration metrics
   ([#2746](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2746))
 - `opentelemetry-instrumentation-grpc` Fixes the issue with the gRPC instrumentation not working with the 1.63.0 and higher version of gRPC
   ([#2483](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2484))
-- `opentelemetry-instrumentation-fastapi` Fix fastapi-slim support
-  ([#2756](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2756))
 - `opentelemetry-instrumentation-aws-lambda` Fixing w3c baggage support
   ([#2589](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2589))
 - `opentelemetry-instrumentation-celery` propagates baggage
   ([#2385](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2385))
+- `opentelemetry-instrumentation-asyncio` Fixes async generator coroutines not being awaited
+  ([#2792](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2792))
 
 ## Version 1.26.0/0.47b0 (2024-07-23)
 
diff --git a/instrumentation/README.md b/instrumentation/README.md
index 378497db79..22c4241bab 100644
--- a/instrumentation/README.md
+++ b/instrumentation/README.md
@@ -19,7 +19,7 @@
 | [opentelemetry-instrumentation-django](./opentelemetry-instrumentation-django) | django >= 1.10 | Yes | experimental
 | [opentelemetry-instrumentation-elasticsearch](./opentelemetry-instrumentation-elasticsearch) | elasticsearch >= 6.0 | No | experimental
 | [opentelemetry-instrumentation-falcon](./opentelemetry-instrumentation-falcon) | falcon >= 1.4.1, < 4.0.0 | Yes | experimental
-| [opentelemetry-instrumentation-fastapi](./opentelemetry-instrumentation-fastapi) | fastapi ~= 0.58,fastapi-slim ~= 0.111 | Yes | migration
+| [opentelemetry-instrumentation-fastapi](./opentelemetry-instrumentation-fastapi) | fastapi ~= 0.58 | Yes | migration
 | [opentelemetry-instrumentation-flask](./opentelemetry-instrumentation-flask) | flask >= 1.0 | Yes | migration
 | [opentelemetry-instrumentation-grpc](./opentelemetry-instrumentation-grpc) | grpcio ~= 1.27 | No | experimental
 | [opentelemetry-instrumentation-httpx](./opentelemetry-instrumentation-httpx) | httpx >= 0.18.0 | No | migration
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py b/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py
index f5f0d34c4f..ae10560861 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/src/opentelemetry/instrumentation/asyncio/__init__.py
@@ -262,7 +262,7 @@ def trace_item(self, coro_or_future):
 
     async def trace_coroutine(self, coro):
         if not hasattr(coro, "__name__"):
-            return coro
+            return await coro
         start = default_timer()
         attr = {
             "type": "coroutine",
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/tests/test_asyncio_anext.py b/instrumentation/opentelemetry-instrumentation-asyncio/tests/test_asyncio_anext.py
index e51f059ca0..5241b3f2cc 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/tests/test_asyncio_anext.py
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/tests/test_asyncio_anext.py
@@ -43,19 +43,23 @@ def tearDown(self):
 
     # Asyncio anext() does not have __name__ attribute, which is used to determine if the coroutine should be traced.
     # This test is to ensure that the instrumentation does not break when the coroutine does not have __name__ attribute.
+    # Additionally, ensure the coroutine is actually awaited.
     @skipIf(
         sys.version_info < (3, 10), "anext is only available in Python 3.10+"
     )
     def test_asyncio_anext(self):
         async def main():
             async def async_gen():
-                for it in range(2):
+                # nothing special about this range other than to avoid returning a zero
+                # from a function named 'main' (which might cause confusion about intent)
+                for it in range(2, 4):
                     yield it
 
             async_gen_instance = async_gen()
             agen = anext(async_gen_instance)
-            await asyncio.create_task(agen)
+            return await asyncio.create_task(agen)
 
-        asyncio.run(main())
+        ret = asyncio.run(main())
+        self.assertEqual(ret, 2)  # first iteration from range()
         spans = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans), 0)
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
index 2ed199fbf3..4f49efb39e 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
@@ -1,7 +1,7 @@
 asgiref==3.7.2
 backports.zoneinfo==0.2.1
 Deprecated==1.2.14
-Django==4.2.14
+Django==4.2.15
 importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
index c3e65be730..9be1266014 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
@@ -1,6 +1,6 @@
 asgiref==3.7.2
 Deprecated==1.2.14
-Django==4.2.14
+Django==4.2.15
 importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
index eec5b0f10f..3017dc040a 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
@@ -35,7 +35,6 @@ dependencies = [
 [project.optional-dependencies]
 instruments = [
     "fastapi ~= 0.58",
-    "fastapi-slim ~= 0.111",
 ]
 
 [project.entry-points.opentelemetry_instrumentor]
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
index fdb035baa8..37a293764e 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/__init__.py
@@ -179,7 +179,6 @@ def client_response_hook(span: Span, scope: dict[str, Any], message: dict[str, A
 from __future__ import annotations
 
 import logging
-from importlib.metadata import PackageNotFoundError, distribution
 from typing import Collection
 
 import fastapi
@@ -197,11 +196,7 @@ def client_response_hook(span: Span, scope: dict[str, Any], message: dict[str, A
     ClientResponseHook,
     ServerRequestHook,
 )
-from opentelemetry.instrumentation.fastapi.package import (
-    _fastapi,
-    _fastapi_slim,
-    _instruments,
-)
+from opentelemetry.instrumentation.fastapi.package import _instruments
 from opentelemetry.instrumentation.fastapi.version import __version__
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
 from opentelemetry.metrics import get_meter
@@ -298,21 +293,6 @@ def uninstrument_app(app: fastapi.FastAPI):
         app._is_instrumented_by_opentelemetry = False
 
     def instrumentation_dependencies(self) -> Collection[str]:
-        # need to use distribution because find_spec("fastapi") will return
-        # something even with just fastapi-slim installed
-        try:
-            distribution("fastapi-slim")
-            return (_fastapi_slim,)
-        except PackageNotFoundError:
-            pass
-
-        try:
-            distribution("fastapi")
-            return (_fastapi,)
-        except PackageNotFoundError:
-            pass
-
-        # If neither is installed, return both as potential dependencies
         return _instruments
 
     def _instrument(self, **kwargs):
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py
index 55cf4b3646..d95a2cf6d5 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/src/opentelemetry/instrumentation/fastapi/package.py
@@ -13,10 +13,7 @@
 # limitations under the License.
 
 
-_fastapi = "fastapi ~= 0.58"
-_fastapi_slim = "fastapi-slim ~= 0.111"
-
-_instruments = (_fastapi, _fastapi_slim)
+_instruments = ("fastapi ~= 0.58",)
 
 _supports_metrics = True
 
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt
deleted file mode 100644
index 2ea55f1b91..0000000000
--- a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt
+++ /dev/null
@@ -1,32 +0,0 @@
-annotated-types==0.6.0
-anyio==4.3.0
-asgiref==3.7.2
-certifi==2024.7.4
-charset-normalizer==3.3.2
-Deprecated==1.2.14
-exceptiongroup==1.2.0
-fastapi-slim==0.111.0
-h11==0.14.0
-httpcore==1.0.4
-httpx==0.27.0
-idna==3.7
-importlib-metadata==6.11.0
-iniconfig==2.0.0
-packaging==24.0
-pluggy==1.5.0
-py-cpuinfo==9.0.0
-pydantic==2.6.2
-pydantic_core==2.16.3
-pytest==7.4.4
-requests==2.32.3
-sniffio==1.3.0
-starlette==0.37.2
-tomli==2.0.1
-typing_extensions==4.9.0
-urllib3==2.2.2
-wrapt==1.16.0
-zipp==3.19.2
--e opentelemetry-instrumentation
--e instrumentation/opentelemetry-instrumentation-asgi
--e util/opentelemetry-util-http
--e instrumentation/opentelemetry-instrumentation-fastapi
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
index 03fdd6749d..91ed514096 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
@@ -1069,6 +1069,18 @@ def test_uninstrument_after_instrument(self):
         spans = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans), 3)
 
+    def test_no_op_tracer_provider(self):
+        self._instrumentor.uninstrument()
+        self._instrumentor.instrument(
+            tracer_provider=trace.NoOpTracerProvider()
+        )
+
+        app = self._create_fastapi_app()
+        client = TestClient(app)
+        client.get("/foobar")
+        spans = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans), 0)
+
     def tearDown(self):
         self._instrumentor.uninstrument()
         super().tearDown()
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index 1c9bd63874..c31863bd31 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -84,10 +84,6 @@
         "library": "fastapi ~= 0.58",
         "instrumentation": "opentelemetry-instrumentation-fastapi==0.48b0.dev",
     },
-    {
-        "library": "fastapi-slim ~= 0.111",
-        "instrumentation": "opentelemetry-instrumentation-fastapi==0.48b0.dev",
-    },
     {
         "library": "flask >= 1.0",
         "instrumentation": "opentelemetry-instrumentation-flask==0.48b0.dev",
@@ -191,7 +187,6 @@
 ]
 default_instrumentations = [
     "opentelemetry-instrumentation-asyncio==0.48b0.dev",
-    "opentelemetry-instrumentation-aws-lambda==0.48b0.dev",
     "opentelemetry-instrumentation-dbapi==0.48b0.dev",
     "opentelemetry-instrumentation-logging==0.48b0.dev",
     "opentelemetry-instrumentation-sqlite3==0.48b0.dev",
diff --git a/scripts/generate_instrumentation_bootstrap.py b/scripts/generate_instrumentation_bootstrap.py
index 1c0cc30f7b..57af33e303 100755
--- a/scripts/generate_instrumentation_bootstrap.py
+++ b/scripts/generate_instrumentation_bootstrap.py
@@ -53,12 +53,21 @@
     "bootstrap_gen.py",
 )
 
+# AWS Lambda instrumentation is excluded from the default list because it often
+# requires specific configurations and dependencies that may not be set up
+# in all environments. Instead, users who need AWS Lambda support can opt-in
+# by manually adding it to their environment.
+# See https://github.com/open-telemetry/opentelemetry-python-contrib/issues/2787
+packages_to_exclude = ["opentelemetry-instrumentation-aws-lambda"]
+
 
 def main():
     # pylint: disable=no-member
     default_instrumentations = ast.List(elts=[])
     libraries = ast.List(elts=[])
     for pkg in get_instrumentation_packages():
+        if pkg.get("name") in packages_to_exclude:
+            continue
         if not pkg["instruments"]:
             default_instrumentations.elts.append(ast.Str(pkg["requirement"]))
         for target_pkg in pkg["instruments"]:
diff --git a/tox.ini b/tox.ini
index 75e8a7f5a0..8552948b6b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -112,8 +112,8 @@ envlist =
     lint-instrumentation-falcon
 
     ; opentelemetry-instrumentation-fastapi
-    py3{8,9,10,11,12}-test-instrumentation-fastapi-{main,slim}
-    pypy3-test-instrumentation-fastapi-{main,slim}
+    py3{8,9,10,11,12}-test-instrumentation-fastapi
+    pypy3-test-instrumentation-fastapi
     lint-instrumentation-fastapi
 
     ; opentelemetry-instrumentation-flask
@@ -556,9 +556,7 @@ commands_pre =
   fastapi: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
   fastapi: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
   fastapi: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  fastapi-main: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
-  fastapi-slim: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements-slim.txt
-  lint-instrumentation-fastapi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
+  fastapi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
 
   mysql: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   mysql: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions