diff --git a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
index 7457618d89..ba4e5b4fd4 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
@@ -237,8 +237,6 @@ async def async_response_hook(span, request, response):
 
 _logger = logging.getLogger(__name__)
 
-URL = typing.Tuple[bytes, bytes, typing.Optional[int], bytes]
-Headers = typing.List[typing.Tuple[bytes, bytes]]
 RequestHook = typing.Callable[[Span, "RequestInfo"], None]
 ResponseHook = typing.Callable[[Span, "RequestInfo", "ResponseInfo"], None]
 AsyncRequestHook = typing.Callable[
@@ -260,7 +258,7 @@ class RequestInfo(typing.NamedTuple):
 class ResponseInfo(typing.NamedTuple):
     status_code: int
     headers: httpx.Headers | None
-    stream: typing.Iterable[bytes]
+    stream: httpx.SyncByteStream | httpx.AsyncByteStream
     extensions: dict[str, typing.Any] | None
 
 
@@ -272,13 +270,19 @@ def _get_default_span_name(method: str) -> str:
     return method
 
 
-def _prepare_headers(headers: Headers | None) -> httpx.Headers:
+def _prepare_headers(headers: httpx.Headers | None) -> httpx.Headers:
     return httpx.Headers(headers)
 
 
 def _extract_parameters(
     args: tuple[typing.Any, ...], kwargs: dict[str, typing.Any]
-):
+) -> tuple[
+    bytes,
+    httpx.URL,
+    httpx.Headers | None,
+    httpx.SyncByteStream | httpx.AsyncByteStream | None,
+    dict[str, typing.Any],
+]:
     if isinstance(args[0], httpx.Request):
         # In httpx >= 0.20.0, handle_request receives a Request object
         request: httpx.Request = args[0]
@@ -312,8 +316,14 @@ def _inject_propagation_headers(headers, args, kwargs):
 
 def _extract_response(
     response: httpx.Response
-    | tuple[int, Headers, httpx.SyncByteStream, dict[str, typing.Any]],
-) -> tuple[int, Headers, httpx.SyncByteStream, dict[str, typing.Any], str]:
+    | tuple[int, httpx.Headers, httpx.SyncByteStream, dict[str, typing.Any]],
+) -> tuple[
+    int,
+    httpx.Headers,
+    httpx.SyncByteStream | httpx.AsyncByteStream,
+    dict[str, typing.Any],
+    str,
+]:
     if isinstance(response, httpx.Response):
         status_code = response.status_code
         headers = response.headers
@@ -331,7 +341,7 @@ def _extract_response(
 
 def _apply_request_client_attributes_to_span(
     span_attributes: dict[str, typing.Any],
-    url: typing.Union[str, URL, httpx.URL],
+    url: str | httpx.URL,
     method_original: str,
     semconv: _StabilityMode,
 ):
@@ -443,7 +453,7 @@ def handle_request(
         *args: typing.Any,
         **kwargs: typing.Any,
     ) -> (
-        tuple[int, Headers, httpx.SyncByteStream, dict[str, typing.Any]]
+        tuple[int, httpx.Headers, httpx.SyncByteStream, dict[str, typing.Any]]
         | httpx.Response
     ):
         """Add request info to span."""
@@ -531,9 +541,9 @@ class AsyncOpenTelemetryTransport(httpx.AsyncBaseTransport):
     def __init__(
         self,
         transport: httpx.AsyncBaseTransport,
-        tracer_provider: typing.Optional[TracerProvider] = None,
-        request_hook: typing.Optional[AsyncRequestHook] = None,
-        response_hook: typing.Optional[AsyncResponseHook] = None,
+        tracer_provider: TracerProvider | None = None,
+        request_hook: AsyncRequestHook | None = None,
+        response_hook: AsyncResponseHook | None = None,
     ):
         _OpenTelemetrySemanticConventionStability._initialize()
         self._sem_conv_opt_in_mode = _OpenTelemetrySemanticConventionStability._get_opentelemetry_stability_opt_in_mode(
@@ -556,9 +566,9 @@ async def __aenter__(self) -> "AsyncOpenTelemetryTransport":
 
     async def __aexit__(
         self,
-        exc_type: typing.Optional[typing.Type[BaseException]] = None,
-        exc_value: typing.Optional[BaseException] = None,
-        traceback: typing.Optional[TracebackType] = None,
+        exc_type: typing.Type[BaseException] | None = None,
+        exc_value: BaseException | None = None,
+        traceback: TracebackType | None = None,
     ) -> None:
         await self._transport.__aexit__(exc_type, exc_value, traceback)
 
@@ -566,9 +576,7 @@ async def __aexit__(
     async def handle_async_request(
         self, *args: typing.Any, **kwargs: typing.Any
     ) -> (
-        typing.Tuple[
-            int, Headers, httpx.AsyncByteStream, dict[str, typing.Any]
-        ]
+        tuple[int, httpx.Headers, httpx.AsyncByteStream, dict[str, typing.Any]]
         | httpx.Response
     ):
         """Add request info to span."""
@@ -728,7 +736,7 @@ def _handle_request_wrapper(  # pylint: disable=too-many-locals
         args: tuple[typing.Any, ...],
         kwargs: dict[str, typing.Any],
         tracer: Tracer,
-        sem_conv_opt_in_mode: _HTTPStabilityMode,
+        sem_conv_opt_in_mode: _StabilityMode,
         request_hook: RequestHook,
         response_hook: ResponseHook,
     ):
@@ -802,7 +810,7 @@ async def _handle_async_request_wrapper(  # pylint: disable=too-many-locals
         args: tuple[typing.Any, ...],
         kwargs: dict[str, typing.Any],
         tracer: Tracer,
-        sem_conv_opt_in_mode: _HTTPStabilityMode,
+        sem_conv_opt_in_mode: _StabilityMode,
         async_request_hook: AsyncRequestHook,
         async_response_hook: AsyncResponseHook,
     ):